IMP

Process View

Mus musculus

17 genes annotated in mouse

regulation of platelet activation

Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of platelet activation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of platelet activation" (in gray)

Name	Description	Probability	Func Analog Organism
Lck	lymphocyte protein tyrosine kinase	0.910	Mouse
Ldb3	LIM domain binding 3	0.887
Ptprc	protein tyrosine phosphatase, receptor type, C	0.832
Fas	Fas (TNF receptor superfamily member 6)	0.622
Selp	selectin, platelet	0.579
Prkce	protein kinase C, epsilon	0.446	Mouse
Lat	linker for activation of T cells	0.444
Il2rg	interleukin 2 receptor, gamma chain	0.399
Blnk	B-cell linker	0.373
Lyz2	lysozyme 2	0.358
Fyn	Fyn proto-oncogene	0.342	Mouse
Ikzf1	IKAROS family zinc finger 1	0.312
Rag2	recombination activating gene 2	0.302
Cd28	CD28 antigen	0.246
Nos3	nitric oxide synthase 3, endothelial cell	0.238
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.222	Mouse
Cd19	CD19 antigen	0.212
Tcra	T-cell receptor alpha chain	0.174
Ccr2	chemokine (C-C motif) receptor 2	0.171
Sykb	spleen tyrosine kinase	0.138
Igh	immunoglobulin heavy chain complex	0.124
Ush1g	Usher syndrome 1G homolog (human)	0.116
Src	Rous sarcoma oncogene	0.112	Mouse
Itgb3	integrin beta 3	0.095
Lcp1	lymphocyte cytosolic protein 1	0.083
Zap70	zeta-chain (TCR) associated protein kinase	0.079	Mouse
Ush1c	Usher syndrome 1C homolog (human)	0.078
Pparg	peroxisome proliferator activated receptor gamma	0.076
Sele	selectin, endothelial cell	0.075	Mouse
Actn2	actinin alpha 2	0.070
Prkcb	protein kinase C, beta	0.069	Mouse
Cdh5	cadherin 5	0.066
Sell	selectin, lymphocyte	0.065	Mouse
Tnf	tumor necrosis factor	0.065
Alox5ap	arachidonate 5-lipoxygenase activating protein	0.062
Was	Wiskott-Aldrich syndrome homolog (human)	0.062
Fyb	FYN binding protein	0.059
Mmp9	matrix metallopeptidase 9	0.059
Ptpre	protein tyrosine phosphatase, receptor type, E	0.058
Orai1	ORAI calcium release-activated calcium modulator 1	0.057
Bcl2	B-cell leukemia/lymphoma 2	0.057
Il7r	interleukin 7 receptor	0.057
Spib	Spi-B transcription factor (Spi-1/PU.1 related)	0.055
Nfam1	Nfat activating molecule with ITAM motif 1	0.054
Grxcr1	glutaredoxin, cysteine rich 1	0.053
Sirpa	signal-regulatory protein alpha	0.051
Ptk2b	PTK2 protein tyrosine kinase 2 beta	0.051
Cbl	Casitas B-lineage lymphoma	0.050
Pik3r1	phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)	0.049
Plcd1	phospholipase C, delta 1	0.049
Pten	phosphatase and tensin homolog	0.049
Cd79a	CD79A antigen (immunoglobulin-associated alpha)	0.049
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.048
Cd4	CD4 antigen	0.048
Ptk2	PTK2 protein tyrosine kinase 2	0.047
Cd14	CD14 antigen	0.047
Vhl	von Hippel-Lindau tumor suppressor	0.042
Grb2	growth factor receptor bound protein 2	0.042
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.042
Myo6	myosin VI	0.041
Whrn	whirlin	0.039
Ticam1	toll-like receptor adaptor molecule 1	0.038
Ncoa3	nuclear receptor coactivator 3	0.036
ND6	NADH dehydrogenase subunit 6	0.036
Cx3cr1	chemokine (C-X3-C) receptor 1	0.035
Rasgrp1	RAS guanyl releasing protein 1	0.034
Rag1	recombination activating gene 1	0.034
Cd22	CD22 antigen	0.034
Blk	B lymphoid kinase	0.033	Mouse
Sla	src-like adaptor	0.033
Rgs14	regulator of G-protein signaling 14	0.033
Notch2	Notch gene homolog 2 (Drosophila)	0.033
Itgb2	integrin beta 2	0.033
Csf1	colony stimulating factor 1 (macrophage)	0.032
Il2rb	interleukin 2 receptor, beta chain	0.032
LOC100503041	PDZ domain-containing protein 7-like	0.031
Foxn1	forkhead box N1	0.030
Itk	IL2-inducible T-cell kinase	0.030
Pik3cg	phosphoinositide-3-kinase, catalytic, gamma polypeptide	0.029
Tnfrsf13b	tumor necrosis factor receptor superfamily, member 13b	0.028
Inpp5d	inositol polyphosphate-5-phosphatase D	0.028
Akt1	thymoma viral proto-oncogene 1	0.028	Mouse
Ptpn22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	0.026
Asprv1	aspartic peptidase, retroviral-like 1	0.025
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.025
Ccl4	chemokine (C-C motif) ligand 4	0.025
Cd247	CD247 antigen	0.025	Mouse
Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	0.024
Cd40	CD40 antigen	0.023
Fcgr1	Fc receptor, IgG, high affinity I	0.023
Fbxw7	F-box and WD-40 domain protein 7	0.022
Myo7a	myosin VIIA	0.022
Lair1	leukocyte-associated Ig-like receptor 1	0.022
Cmklr1	chemokine-like receptor 1	0.022
Hcst	hematopoietic cell signal transducer	0.021
Fam65b	family with sequence similarity 65, member B	0.021
Nfib	nuclear factor I/B	0.021
Ms4a4c	membrane-spanning 4-domains, subfamily A, member 4C	0.021
Itga2b	integrin alpha 2b	0.020
Myo15	myosin XV	0.020
Il10ra	interleukin 10 receptor, alpha	0.019
Npr1	natriuretic peptide receptor 1	0.019
Csf3r	colony stimulating factor 3 receptor (granulocyte)	0.019
Il1rn	interleukin 1 receptor antagonist	0.019
Clock	circadian locomotor output cycles kaput	0.019
Plcg2	phospholipase C, gamma 2	0.019
Myd88	myeloid differentiation primary response gene 88	0.018
Il15	interleukin 15	0.018
Calcrl	calcitonin receptor-like	0.018
Mrvi1	MRV integration site 1	0.018
Pnpla2	patatin-like phospholipase domain containing 2	0.018
Il1r1	interleukin 1 receptor, type I	0.017
Pdgfrb	platelet derived growth factor receptor, beta polypeptide	0.017
Ncr1	natural cytotoxicity triggering receptor 1	0.017
Bcar1	breast cancer anti-estrogen resistance 1	0.017
Gp9	glycoprotein 9 (platelet)	0.016
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.016
Dtx1	deltex 1 homolog (Drosophila)	0.016
Cfh	complement component factor h	0.016
Apoa1	apolipoprotein A-I	0.016
Mcoln2	mucolipin 2	0.015
Prkcc	protein kinase C, gamma	0.015	Mouse
Pou2af1	POU domain, class 2, associating factor 1	0.015
Clec1b	C-type lectin domain family 1, member b	0.015
Epor	erythropoietin receptor	0.015
Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	0.015
Nrgn	neurogranin	0.015
Hcls1	hematopoietic cell specific Lyn substrate 1	0.015
Jak3	Janus kinase 3	0.014
Pdgfb	platelet derived growth factor, B polypeptide	0.014	Human
Dnm1	dynamin 1	0.014
S1pr3	sphingosine-1-phosphate receptor 3	0.014
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.014
Vav1	vav 1 oncogene	0.014
Gpr97	G protein-coupled receptor 97	0.014
Pdgfc	platelet-derived growth factor, C polypeptide	0.014
Mat1a	methionine adenosyltransferase I, alpha	0.014
Slfn1	schlafen 1	0.014
Osmr	oncostatin M receptor	0.014
Wnt7b	wingless-related MMTV integration site 7B	0.014
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.014
Plxnc1	plexin C1	0.014
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.013
Tyrobp	TYRO protein tyrosine kinase binding protein	0.013
Gp1ba	glycoprotein 1b, alpha polypeptide	0.013
Adrb1	adrenergic receptor, beta 1	0.013
Cd33	CD33 antigen	0.013
Ptpra	protein tyrosine phosphatase, receptor type, A	0.013
Sla2	Src-like-adaptor 2	0.013
Cd44	CD44 antigen	0.013
Irak4	interleukin-1 receptor-associated kinase 4	0.012
BC013712	cDNA sequence BC013712	0.012
Slfn4	schlafen 4	0.012
Cdh23	cadherin 23 (otocadherin)	0.012
Cyr61	cysteine rich protein 61	0.012
Wisp2	WNT1 inducible signaling pathway protein 2	0.012
Akt2	thymoma viral proto-oncogene 2	0.012	Mouse
Epb4.1l2	erythrocyte protein band 4.1-like 2	0.012
Itgam	integrin alpha M	0.012
Ldlr	low density lipoprotein receptor	0.012
Crb2	crumbs homolog 2 (Drosophila)	0.011
Prkca	protein kinase C, alpha	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Kl	klotho	0.011
Laptm5	lysosomal-associated protein transmembrane 5	0.011
Ncf1	neutrophil cytosolic factor 1	0.011
Pcdh15	protocadherin 15	0.011
Spnb2	spectrin beta 2	0.011
Cdk14	cyclin-dependent kinase 14	0.011
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.011
Gpr182	G protein-coupled receptor 182	0.011
Alox12	arachidonate 12-lipoxygenase	0.011
Il15ra	interleukin 15 receptor, alpha chain	0.011
Treml1	triggering receptor expressed on myeloid cells-like 1	0.011
Npy1r	neuropeptide Y receptor Y1	0.011
Ptprj	protein tyrosine phosphatase, receptor type, J	0.011
Tmem40	transmembrane protein 40	0.011
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
C5ar1	complement component 5a receptor 1	0.011
Ptgs2	prostaglandin-endoperoxide synthase 2	0.011
Lepr	leptin receptor	0.011
Ptprm	protein tyrosine phosphatase, receptor type, M	0.011
Mmp8	matrix metallopeptidase 8	0.010
Il6	interleukin 6	0.010
Zeb1	zinc finger E-box binding homeobox 1	0.010
Adrb3	adrenergic receptor, beta 3	0.010
Lcp2	lymphocyte cytosolic protein 2	0.010
Ids	iduronate 2-sulfatase	0.010
Cd96	CD96 antigen	0.010