IMP

Process View

Mus musculus

4 genes annotated in mouse

lens fiber cell apoptotic process

GO:1990086

Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "lens fiber cell apoptotic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "lens fiber cell apoptotic process" (in gray)

Name	Description	Probability	Func Analog Organism
Tgfbr2	transforming growth factor, beta receptor II	0.988
Eya1	eyes absent 1 homolog (Drosophila)	0.938
Tgfbr1	transforming growth factor, beta receptor I	0.885	Mouse
Acvr1	activin A receptor, type 1	0.704	Mouse
Foxc1	forkhead box C1	0.653
Pitx2	paired-like homeodomain transcription factor 2	0.640
Vegfa	vascular endothelial growth factor A	0.639
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.387	Mouse
Tcfap2a	transcription factor AP-2, alpha	0.346
Smad3	MAD homolog 3 (Drosophila)	0.338
Gbx2	gastrulation brain homeobox 2	0.314
Arid1b	AT rich interactive domain 1B (SWI-like)	0.285
Prrx1	paired related homeobox 1	0.275
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.253
Apc	adenomatosis polyposis coli	0.226
Atp7a	ATPase, Cu++ transporting, alpha polypeptide	0.207
Sox9	SRY-box containing gene 9	0.171
Ednra	endothelin receptor type A	0.160
Bmp4	bone morphogenetic protein 4	0.157
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.153	Mouse
Rarg	retinoic acid receptor, gamma	0.140
Nf1	neurofibromatosis 1	0.132
Prrx2	paired related homeobox 2	0.132
Shc1	src homology 2 domain-containing transforming protein C1	0.132
Pax3	paired box gene 3	0.131
Hand2	heart and neural crest derivatives expressed transcript 2	0.125
Tbx1	T-box 1	0.121
Fgf8	fibroblast growth factor 8	0.115
Ece1	endothelin converting enzyme 1	0.113
Fgfr1	fibroblast growth factor receptor 1	0.112
Hoxa1	homeobox A1	0.109
Tgfbr3	transforming growth factor, beta receptor III	0.109
Eng	endoglin	0.108
Xiap	X-linked inhibitor of apoptosis	0.093
Efemp2	epidermal growth factor-containing fibulin-like extracellular matrix protein 2	0.088
Smad4	MAD homolog 4 (Drosophila)	0.085
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.084
Tgfb2	transforming growth factor, beta 2	0.078
Pax6	paired box gene 6	0.076
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.074	Mouse
Hic1	hypermethylated in cancer 1	0.073
Gsc	goosecoid homeobox	0.072
Egfr	epidermal growth factor receptor	0.070
Hoxa3	homeobox A3	0.070
Isl1	ISL1 transcription factor, LIM/homeodomain	0.070
Fgfr2	fibroblast growth factor receptor 2	0.069
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.066
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.064
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.063
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.059
Pik3c2a	phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide	0.056
Bmp2	bone morphogenetic protein 2	0.053
Rxra	retinoid X receptor alpha	0.052
Tfdp2	transcription factor Dp 2	0.052
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.051
Fshr	follicle stimulating hormone receptor	0.048
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.047
Fgf10	fibroblast growth factor 10	0.046
Hipk3	homeodomain interacting protein kinase 3	0.045
Diablo	diablo homolog (Drosophila)	0.043
Sox2	SRY-box containing gene 2	0.042
Cdh5	cadherin 5	0.042
Pbx1	pre B-cell leukemia transcription factor 1	0.042
Smad5	MAD homolog 5 (Drosophila)	0.042
Chrd	chordin	0.041
Stk3	serine/threonine kinase 3 (Ste20, yeast homolog)	0.040
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.040
Dlx5	distal-less homeobox 5	0.039
Smo	smoothened homolog (Drosophila)	0.039
Hoxa2	homeobox A2	0.038
Jag1	jagged 1	0.037
Otx2	orthodenticle homolog 2 (Drosophila)	0.037
Dach1	dachshund 1 (Drosophila)	0.036
Foxg1	forkhead box G1	0.036
Msx2	homeobox, msh-like 2	0.034
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.033
Neurod1	neurogenic differentiation 1	0.033
Ar	androgen receptor	0.032
E2f1	E2F transcription factor 1	0.032
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.032
Smad6	MAD homolog 6 (Drosophila)	0.031
Esr1	estrogen receptor 1 (alpha)	0.031
Smad1	MAD homolog 1 (Drosophila)	0.031
Rnf2	ring finger protein 2	0.030
Hes1	hairy and enhancer of split 1 (Drosophila)	0.030
Myf5	myogenic factor 5	0.029
Msx1	homeobox, msh-like 1	0.029
Shh	sonic hedgehog	0.028
Twsg1	twisted gastrulation homolog 1 (Drosophila)	0.027
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.027
Fzd7	frizzled homolog 7 (Drosophila)	0.026
Nodal	nodal	0.025
Vcl	vinculin	0.025
Wrn	Werner syndrome homolog (human)	0.024
Rara	retinoic acid receptor, alpha	0.024
Braf	Braf transforming gene	0.024
Cpd	carboxypeptidase D	0.024
Acvr2a	activin receptor IIA	0.023
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.023
Eya4	eyes absent 4 homolog (Drosophila)	0.023
Smad2	MAD homolog 2 (Drosophila)	0.022
Prkg1	protein kinase, cGMP-dependent, type I	0.022
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.021
E2f3	E2F transcription factor 3	0.021	Mouse
Yap1	yes-associated protein 1	0.021
Med14	mediator complex subunit 14	0.021
Tbx2	T-box 2	0.021
Pou3f4	POU domain, class 3, transcription factor 4	0.021
Bmpr2	bone morphogenic protein receptor, type II (serine/threonine kinase)	0.020	Mouse
Tbx15	T-box 15	0.020
Foxf2	forkhead box F2	0.020
Npc1	Niemann Pick type C1	0.020
Zfp260	zinc finger protein 260	0.020
Ext1	exostoses (multiple) 1	0.020
Ctnnal1	catenin (cadherin associated protein), alpha-like 1	0.020
Ctf1	cardiotrophin 1	0.019
Parp1	poly (ADP-ribose) polymerase family, member 1	0.019
Met	met proto-oncogene	0.019
Grb10	growth factor receptor bound protein 10	0.019
Mkl2	MKL/myocardin-like 2	0.019
Esr2	estrogen receptor 2 (beta)	0.019
Zeb1	zinc finger E-box binding homeobox 1	0.019
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.018
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.018
Pgr	progesterone receptor	0.018
Foxf1a	forkhead box F1a	0.018
Itgav	integrin alpha V	0.018
Nos3	nitric oxide synthase 3, endothelial cell	0.017
Lrp2	low density lipoprotein receptor-related protein 2	0.017
Foxi3	forkhead box I3	0.017
Rab23	RAB23, member RAS oncogene family	0.017
Man1a2	mannosidase, alpha, class 1A, member 2	0.017
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.017
Tcf15	transcription factor 15	0.016
Zfp146	zinc finger protein 146	0.016
Srf	serum response factor	0.016
Foxd2	forkhead box D2	0.016
Tbx3	T-box 3	0.016
Iqgap3	IQ motif containing GTPase activating protein 3	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.015
Ate1	arginyltransferase 1	0.015
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.015
Creb1	cAMP responsive element binding protein 1	0.015
Bmp5	bone morphogenetic protein 5	0.015
Tcfap2c	transcription factor AP-2, gamma	0.015
Btbd3	BTB (POZ) domain containing 3	0.015
Gpc3	glypican 3	0.015
Inha	inhibin alpha	0.015
Ndnl2	necdin-like 2	0.015
Hand1	heart and neural crest derivatives expressed transcript 1	0.015
Rarb	retinoic acid receptor, beta	0.014
Myc	myelocytomatosis oncogene	0.014
Tle4	transducin-like enhancer of split 4, homolog of Drosophila E(spl)	0.014
Bmp7	bone morphogenetic protein 7	0.014
Insm1	insulinoma-associated 1	0.014
Myf6	myogenic factor 6	0.014
Smad7	MAD homolog 7 (Drosophila)	0.014
Ldlr	low density lipoprotein receptor	0.014
Hoxd13	homeobox D13	0.014
Ids	iduronate 2-sulfatase	0.014
Zfhx4	zinc finger homeodomain 4	0.013
Irf2bp1	interferon regulatory factor 2 binding protein 1	0.013
Kiss1	KiSS-1 metastasis-suppressor	0.013
Eya3	eyes absent 3 homolog (Drosophila)	0.013
Mapk9	mitogen-activated protein kinase 9	0.013
Nf2	neurofibromatosis 2	0.013
Ptch1	patched homolog 1	0.013
Lcor	ligand dependent nuclear receptor corepressor	0.013
Dlx6	distal-less homeobox 6	0.013
Ntf3	neurotrophin 3	0.013
Usp12	ubiquitin specific peptidase 12	0.013
Sav1	salvador homolog 1 (Drosophila)	0.013
Mecom	MDS1 and EVI1 complex locus	0.013
Bmi1	Bmi1 polycomb ring finger oncogene	0.013
Mybl2	myeloblastosis oncogene-like 2	0.013
Gata4	GATA binding protein 4	0.012
Zfp518b	zinc finger protein 518B	0.012
Rfwd2	ring finger and WD repeat domain 2	0.012
Zfp60	zinc finger protein 60	0.012
Lgr4	leucine-rich repeat-containing G protein-coupled receptor 4	0.012
Gnptab	N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits	0.012
Tulp1	tubby like protein 1	0.012
Hoxb1	homeobox B1	0.012
Akt3	thymoma viral proto-oncogene 3	0.012
Gab2	growth factor receptor bound protein 2-associated protein 2	0.012
Nfic	nuclear factor I/C	0.012
Trove2	TROVE domain family, member 2	0.012
Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	0.012
Gdf5	growth differentiation factor 5	0.012
Tpbg	trophoblast glycoprotein	0.012
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.011
Hrc	histidine rich calcium binding protein	0.011
Alx3	aristaless-like homeobox 3	0.011
Phka1	phosphorylase kinase alpha 1	0.011
Fgf15	fibroblast growth factor 15	0.011
Gja1	gap junction protein, alpha 1	0.011
Homer1	homer homolog 1 (Drosophila)	0.011
Prkar2a	protein kinase, cAMP dependent regulatory, type II alpha	0.011
Mib1	mindbomb homolog 1 (Drosophila)	0.011
Pax2	paired box gene 2	0.011
En1	engrailed 1	0.011
Aff1	AF4/FMR2 family, member 1	0.011
Zfp40	zinc finger protein 40	0.011
Ckmt2	creatine kinase, mitochondrial 2	0.011
Dlx1	distal-less homeobox 1	0.011
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.011
Dhh	desert hedgehog	0.011
Csf1	colony stimulating factor 1 (macrophage)	0.011
Hsf2	heat shock factor 2	0.011
Itga8	integrin alpha 8	0.011
Fzd4	frizzled homolog 4 (Drosophila)	0.011
Pten	phosphatase and tensin homolog	0.011
Spred1	sprouty protein with EVH-1 domain 1, related sequence	0.011
Slc12a2	solute carrier family 12, member 2	0.011
Neo1	neogenin	0.011
Ctnnb1	catenin (cadherin associated protein), beta 1	0.011
Ctnnd1	catenin (cadherin associated protein), delta 1	0.010
B3galt1	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1	0.010
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.010
Atp11c	ATPase, class VI, type 11C	0.010
Wnt3	wingless-related MMTV integration site 3	0.010
Pknox1	Pbx/knotted 1 homeobox	0.010
Pofut1	protein O-fucosyltransferase 1	0.010
Cdc73	cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	0.010
Cdk14	cyclin-dependent kinase 14	0.010
Hoxa10	homeobox A10	0.010
Ehmt1	euchromatic histone methyltransferase 1	0.010
Rxrg	retinoid X receptor gamma	0.010
Alx1	ALX homeobox 1	0.010
Fzd8	frizzled homolog 8 (Drosophila)	0.010
Wbp1	WW domain binding protein 1	0.010
Arhgef2	rho/rac guanine nucleotide exchange factor (GEF) 2	0.010
Pikfyve	phosphoinositide kinase, FYVE finger containing	0.010
Fv1	Friend virus susceptibility 1	0.010
Gata2	GATA binding protein 2	0.010
Gata6	GATA binding protein 6	0.010
Adam10	a disintegrin and metallopeptidase domain 10	0.010
Myod1	myogenic differentiation 1	0.010