IMP

Process View

Mus musculus

23 genes annotated in mouse

negative regulation of nucleocytoplasmic transport

Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances between the cytoplasm and the nucleus.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of nucleocytoplasmic transport"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of nucleocytoplasmic transport" (in gray)

Name	Description	Probability	Func Analog Organism
Grb10	growth factor receptor bound protein 10	0.430
Rara	retinoic acid receptor, alpha	0.406	Mouse
Yap1	yes-associated protein 1	0.382
Ctnnb1	catenin (cadherin associated protein), beta 1	0.330
Trp63	transformation related protein 63	0.242	Fly
Gbp2	guanylate binding protein 2	0.230	Mouse
Iigp1	interferon inducible GTPase 1	0.222
Rarg	retinoic acid receptor, gamma	0.187	Mouse
Gbp7	guanylate binding protein 7	0.166	Mouse
Gli2	GLI-Kruppel family member GLI2	0.143
Apc	adenomatosis polyposis coli	0.106
Fgfr2	fibroblast growth factor receptor 2	0.103
Gbp3	guanylate binding protein 3	0.088	Mouse
Htt	huntingtin	0.086
Trp53	transformation related protein 53	0.077	Fly
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.070
Rxra	retinoid X receptor alpha	0.065
Gopc	golgi associated PDZ and coiled-coil motif containing	0.056
Bcl2	B-cell leukemia/lymphoma 2	0.056
Irgm2	immunity-related GTPase family M member 2	0.055
Gbp10	guanylate-binding protein 10	0.053	Mouse
Tgtp2	T-cell specific GTPase 2	0.052
Gli3	GLI-Kruppel family member GLI3	0.050
Kitl	kit ligand	0.050
Meox2	mesenchyme homeobox 2	0.049
Igtp	interferon gamma induced GTPase	0.049
Fzd8	frizzled homolog 8 (Drosophila)	0.046	Mouse
Gbp6	guanylate binding protein 6	0.045	Mouse
Pax8	paired box gene 8	0.043
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.042
Bcl3	B-cell leukemia/lymphoma 3	0.042
Ikbkb	inhibitor of kappaB kinase beta	0.041
Rictor	RPTOR independent companion of MTOR, complex 2	0.041
Ar	androgen receptor	0.040
Ghr	growth hormone receptor	0.038
Pkd1	polycystic kidney disease 1 homolog	0.037
Ifi47	interferon gamma inducible protein 47	0.035
Axin1	axin 1	0.033
Dlg2	discs, large homolog 2 (Drosophila)	0.029
Slc2a4	solute carrier family 2 (facilitated glucose transporter), member 4	0.029
Ifi203	interferon activated gene 203	0.029
H2-Q7	histocompatibility 2, Q region locus 7	0.028
Ret	ret proto-oncogene	0.028
Wnt5a	wingless-related MMTV integration site 5A	0.028
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.027
Vegfa	vascular endothelial growth factor A	0.027
Mapk3	mitogen-activated protein kinase 3	0.026
Serpinb9	serine (or cysteine) peptidase inhibitor, clade B, member 9	0.026
Hoxa3	homeobox A3	0.026
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.025
Slc12a6	solute carrier family 12, member 6	0.025
Dvl3	dishevelled 3, dsh homolog (Drosophila)	0.025
Duox2	dual oxidase 2	0.025
Esr1	estrogen receptor 1 (alpha)	0.024
Fgfr1	fibroblast growth factor receptor 1	0.024
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.024
Notch2	Notch gene homolog 2 (Drosophila)	0.024
Ifih1	interferon induced with helicase C domain 1	0.024
Pten	phosphatase and tensin homolog	0.023	Worm
Il6st	interleukin 6 signal transducer	0.023
Smad3	MAD homolog 3 (Drosophila)	0.023
Coro1b	coronin, actin binding protein 1B	0.023
Rnf115	ring finger protein 115	0.023
Mapkap1	mitogen-activated protein kinase associated protein 1	0.023
Cuedc1	CUE domain containing 1	0.022
Efnb1	ephrin B1	0.022
Cav1	caveolin 1, caveolae protein	0.021
Rptor	regulatory associated protein of MTOR, complex 1	0.021
Lrp5	low density lipoprotein receptor-related protein 5	0.021
Dlg4	discs, large homolog 4 (Drosophila)	0.021
Flot2	flotillin 2	0.021
Neo1	neogenin	0.020
Tbx3	T-box 3	0.020
Oasl2	2'-5' oligoadenylate synthetase-like 2	0.020
F2r	coagulation factor II (thrombin) receptor	0.020
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.019
Bcl6	B-cell leukemia/lymphoma 6	0.019
Casp12	caspase 12	0.019
Irgm1	immunity-related GTPase family M member 1	0.019
Gimap4	GTPase, IMAP family member 4	0.019
Ncoa3	nuclear receptor coactivator 3	0.019
Trim30a	tripartite motif-containing 30A	0.019
Tnfsf10	tumor necrosis factor (ligand) superfamily, member 10	0.019
Parp14	poly (ADP-ribose) polymerase family, member 14	0.018
Fzd1	frizzled homolog 1 (Drosophila)	0.018
Igbp1	immunoglobulin (CD79A) binding protein 1	0.018
Kif1b	kinesin family member 1B	0.018
Aim2	absent in melanoma 2	0.017
Rras	Harvey rat sarcoma oncogene, subgroup R	0.017
Ikbkg	inhibitor of kappaB kinase gamma	0.017
Smo	smoothened homolog (Drosophila)	0.017
Bicc1	bicaudal C homolog 1 (Drosophila)	0.017
B2m	beta-2 microglobulin	0.017
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.017
Pdgfb	platelet derived growth factor, B polypeptide	0.017
Cys1	cystin 1	0.017
Ap2m1	adaptor protein complex AP-2, mu1	0.017
Ddr1	discoidin domain receptor family, member 1	0.017
Irf1	interferon regulatory factor 1	0.017
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.017
Zfp358	zinc finger protein 358	0.016
Islr	immunoglobulin superfamily containing leucine-rich repeat	0.016
H2afx	H2A histone family, member X	0.016
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.016
Marveld1	MARVEL (membrane-associating) domain containing 1	0.016
Gata3	GATA binding protein 3	0.016
Hoxb3	homeobox B3	0.016
Csnk1e	casein kinase 1, epsilon	0.015
Apoe	apolipoprotein E	0.015
Rarb	retinoic acid receptor, beta	0.015	Mouse
Itch	itchy, E3 ubiquitin protein ligase	0.015
Mdm2	transformed mouse 3T3 cell double minute 2	0.015
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.015
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.015
Bmp4	bone morphogenetic protein 4	0.015
Hr	hairless	0.015
Smoc2	SPARC related modular calcium binding 2	0.015
Wnt9b	wingless-type MMTV integration site 9B	0.015
Plk1	polo-like kinase 1 (Drosophila)	0.014
Tgfbr3	transforming growth factor, beta receptor III	0.014
Nmi	N-myc (and STAT) interactor	0.014
Hoxb6	homeobox B6	0.014
Lrp6	low density lipoprotein receptor-related protein 6	0.014
Cfl2	cofilin 2, muscle	0.014
Pias1	protein inhibitor of activated STAT 1	0.014
Ptch1	patched homolog 1	0.014
Col4a5	collagen, type IV, alpha 5	0.013
Sap18	Sin3-associated polypeptide 18	0.013
Rab34	RAB34, member of RAS oncogene family	0.013
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.013
Irs1	insulin receptor substrate 1	0.013
Anapc2	anaphase promoting complex subunit 2	0.013
Hdac6	histone deacetylase 6	0.013
Lef1	lymphoid enhancer binding factor 1	0.013
Mndal	myeloid nuclear differentiation antigen like	0.013
Ifit1	interferon-induced protein with tetratricopeptide repeats 1	0.013
Hoxa5	homeobox A5	0.013
Sqstm1	sequestosome 1	0.013
Cd274	CD274 antigen	0.013
Nek8	NIMA (never in mitosis gene a)-related expressed kinase 8	0.013
Arhgap29	Rho GTPase activating protein 29	0.013
Rab5a	RAB5A, member RAS oncogene family	0.013
Kif20a	kinesin family member 20A	0.012
Mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae)	0.012
Wwox	WW domain-containing oxidoreductase	0.012
Gas1	growth arrest specific 1	0.012
Pcdh18	protocadherin 18	0.012
Efna1	ephrin A1	0.012
Zfhx3	zinc finger homeobox 3	0.012
Ifi44	interferon-induced protein 44	0.012
Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	0.012	Human
Card11	caspase recruitment domain family, member 11	0.012
Nf1	neurofibromatosis 1	0.012
AW112010	expressed sequence AW112010	0.012
Ptk7	PTK7 protein tyrosine kinase 7	0.012
Gtse1	G two S phase expressed protein 1	0.012
Ece1	endothelin converting enzyme 1	0.012
Cdkn2c	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
H2-K1	histocompatibility 2, K1, K region	0.011
Pdlim4	PDZ and LIM domain 4	0.011
Fabp4	fatty acid binding protein 4, adipocyte	0.011
Cd81	CD81 antigen	0.011
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.011
Ep300	E1A binding protein p300	0.011
Ifit2	interferon-induced protein with tetratricopeptide repeats 2	0.011
Mpdz	multiple PDZ domain protein	0.011
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Siah2	seven in absentia 2	0.011
Ptgfr	prostaglandin F receptor	0.011
Gbp9	guanylate-binding protein 9	0.011	Mouse
Mybl2	myeloblastosis oncogene-like 2	0.011
Sox9	SRY-box containing gene 9	0.011
Tspan12	tetraspanin 12	0.011
Anxa7	annexin A7	0.011
Mfap2	microfibrillar-associated protein 2	0.011
Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	0.011
Emx2	empty spiracles homolog 2 (Drosophila)	0.011
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.011
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)	0.010
Arhgef25	Rho guanine nucleotide exchange factor (GEF) 25	0.010
Megf8	multiple EGF-like-domains 8	0.010
Tgm2	transglutaminase 2, C polypeptide	0.010
Fzd7	frizzled homolog 7 (Drosophila)	0.010	Mouse
Rhoq	ras homolog gene family, member Q	0.010
Bche	butyrylcholinesterase	0.010
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.010
Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	0.010
Capn1	calpain 1	0.010
Gbp4	guanylate binding protein 4	0.010
Ctnnd1	catenin (cadherin associated protein), delta 1	0.010