IMP

Process View

Mus musculus

4 genes annotated in mouse

ventral midline development

The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "ventral midline development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "ventral midline development" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000	Zebrafish Fly
Gli2	GLI-Kruppel family member GLI2	0.999
Gli3	GLI-Kruppel family member GLI3	0.997	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.977
En1	engrailed 1	0.977	Fly
Otx2	orthodenticle homolog 2 (Drosophila)	0.945
Sox9	SRY-box containing gene 9	0.929
Fgfr2	fibroblast growth factor receptor 2	0.705
Nodal	nodal	0.701
Otx1	orthodenticle homolog 1 (Drosophila)	0.652
Fgf8	fibroblast growth factor 8	0.648
Gdf1	growth differentiation factor 1	0.593
Lmx1b	LIM homeobox transcription factor 1 beta	0.572
Col2a1	collagen, type II, alpha 1	0.508
En2	engrailed 2	0.483	Fly
Dnahc11	dynein, axonemal, heavy chain 11	0.460
Pthlh	parathyroid hormone-like peptide	0.407
Msx1	homeobox, msh-like 1	0.401
Bmp7	bone morphogenetic protein 7	0.390
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.389
Foxc2	forkhead box C2	0.318
Msx2	homeobox, msh-like 2	0.308
Wnt1	wingless-related MMTV integration site 1	0.307	Fly
Chrd	chordin	0.306
Ihh	Indian hedgehog	0.274	Fly
Fgfr3	fibroblast growth factor receptor 3	0.258
Insm1	insulinoma-associated 1	0.257
Lhx1	LIM homeobox protein 1	0.253
Pdx1	pancreatic and duodenal homeobox 1	0.229
Vangl2	vang-like 2 (van gogh, Drosophila)	0.228
Smo	smoothened homolog (Drosophila)	0.196
Twist2	twist homolog 2 (Drosophila)	0.167
Gbx2	gastrulation brain homeobox 2	0.163
Nkx6-1	NK6 homeobox 1	0.156
Fgf9	fibroblast growth factor 9	0.137
Nog	noggin	0.133
Hoxa11	homeobox A11	0.131
Bmp4	bone morphogenetic protein 4	0.131
Ptch1	patched homolog 1	0.124
Hoxd9	homeobox D9	0.115
Pax2	paired box gene 2	0.114
Emx2	empty spiracles homolog 2 (Drosophila)	0.104
Hoxa2	homeobox A2	0.104
Pten	phosphatase and tensin homolog	0.103
Zic3	zinc finger protein of the cerebellum 3	0.101
Kl	klotho	0.100
Gdnf	glial cell line derived neurotrophic factor	0.099
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.092	Zebrafish
Foxj1	forkhead box J1	0.087
Hoxd13	homeobox D13	0.081
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.078
Wnt6	wingless-related MMTV integration site 6	0.076
Bnc1	basonuclin 1	0.074
Zic2	zinc finger protein of the cerebellum 2	0.074
Sox3	SRY-box containing gene 3	0.072
Lepr	leptin receptor	0.072
Mks1	Meckel syndrome, type 1	0.071
Hoxa10	homeobox A10	0.067
Hoxd10	homeobox D10	0.067
Lmx1a	LIM homeobox transcription factor 1 alpha	0.064
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.061
Hand1	heart and neural crest derivatives expressed transcript 1	0.061
Unc5c	unc-5 homolog C (C. elegans)	0.060
Pax3	paired box gene 3	0.060
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.059
Hoxa4	homeobox A4	0.058
Ptch2	patched homolog 2	0.057
Lefty1	left right determination factor 1	0.057
Emx1	empty spiracles homolog 1 (Drosophila)	0.057
Fgf17	fibroblast growth factor 17	0.056
Kif3a	kinesin family member 3A	0.056
Fgfr1	fibroblast growth factor receptor 1	0.055
Wnt3a	wingless-related MMTV integration site 3A	0.055
Wnt3	wingless-related MMTV integration site 3	0.054
Tcfap2a	transcription factor AP-2, alpha	0.052
Hoxd8	homeobox D8	0.051
Wt1	Wilms tumor 1 homolog	0.051
Jarid2	jumonji, AT rich interactive domain 2	0.050
Hoxc8	homeobox C8	0.050
Sim2	single-minded homolog 2 (Drosophila)	0.049	Fly
Foxc1	forkhead box C1	0.049
Arvcf	armadillo repeat gene deleted in velo-cardio-facial syndrome	0.048
Emid2	EMI domain containing 2	0.046
Pitx3	paired-like homeodomain transcription factor 3	0.046
Pax6	paired box gene 6	0.045
Gsc	goosecoid homeobox	0.045
Tbx6	T-box 6	0.045
Hoxd3	homeobox D3	0.044
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.043
Hoxb2	homeobox B2	0.042
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.042
Ezh1	enhancer of zeste homolog 1 (Drosophila)	0.041
Isl1	ISL1 transcription factor, LIM/homeodomain	0.040
Fzd9	frizzled homolog 9 (Drosophila)	0.039
Zfp423	zinc finger protein 423	0.039
Lhx5	LIM homeobox protein 5	0.038
Ephb2	Eph receptor B2	0.038
Neurod1	neurogenic differentiation 1	0.038
Drd2	dopamine receptor D2	0.037
Six5	sine oculis-related homeobox 5 homolog (Drosophila)	0.036
Efs	embryonal Fyn-associated substrate	0.036
Foxa1	forkhead box A1	0.035
Zic1	zinc finger protein of the cerebellum 1	0.034
Gjb4	gap junction protein, beta 4	0.034
Hoxa5	homeobox A5	0.034
Hoxb6	homeobox B6	0.034
Trp53	transformation related protein 53	0.033
Hoxd4	homeobox D4	0.033
Tcfap2c	transcription factor AP-2, gamma	0.033
Hoxd11	homeobox D11	0.033
Disp1	dispatched homolog 1 (Drosophila)	0.032
Neurog3	neurogenin 3	0.032
Fgf10	fibroblast growth factor 10	0.032
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.031
Foxd2	forkhead box D2	0.031
Cldn6	claudin 6	0.030
Fzd8	frizzled homolog 8 (Drosophila)	0.030
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.030
Neurog2	neurogenin 2	0.030
Foxb1	forkhead box B1	0.029
Apc	adenomatosis polyposis coli	0.029
Gata4	GATA binding protein 4	0.029
Sim1	single-minded homolog 1 (Drosophila)	0.029	Fly
Nkx2-1	NK2 homeobox 1	0.029
Nkx3-2	NK3 homeobox 2	0.029
Hmga2	high mobility group AT-hook 2	0.029
Foxa2	forkhead box A2	0.028	Zebrafish
Npr2	natriuretic peptide receptor 2	0.028
Vav1	vav 1 oncogene	0.028
Pla2g10	phospholipase A2, group X	0.028
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.027
Lef1	lymphoid enhancer binding factor 1	0.027
Hmx1	H6 homeobox 1	0.027
Tbx15	T-box 15	0.027
Clcnka	chloride channel Ka	0.027
Amhr2	anti-Mullerian hormone type 2 receptor	0.027
Hes3	hairy and enhancer of split 3 (Drosophila)	0.026
5730559C18Rik	RIKEN cDNA 5730559C18 gene	0.026
Slc12a3	solute carrier family 12, member 3	0.025
Tbx20	T-box 20	0.025
Pitx1	paired-like homeodomain transcription factor 1	0.025
Matn3	matrilin 3	0.025
Hmha1	histocompatibility (minor) HA-1	0.024
Zeb1	zinc finger E-box binding homeobox 1	0.024
Nrk	Nik related kinase	0.023
Obsl1	obscurin-like 1	0.023
Hoxb9	homeobox B9	0.023
Myod1	myogenic differentiation 1	0.023
Amh	anti-Mullerian hormone	0.023
Ncoa3	nuclear receptor coactivator 3	0.022
Gsx1	GS homeobox 1	0.022
Tbx2	T-box 2	0.022
Irx1	Iroquois related homeobox 1 (Drosophila)	0.022
Bdnf	brain derived neurotrophic factor	0.022
Fgf4	fibroblast growth factor 4	0.022
Tbx4	T-box 4	0.021
Col4a3	collagen, type IV, alpha 3	0.021
Aqp7	aquaporin 7	0.021
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.021
Smad2	MAD homolog 2 (Drosophila)	0.021
Sox11	SRY-box containing gene 11	0.020
Hoxb1	homeobox B1	0.020
Runx2	runt related transcription factor 2	0.020
Foxl2	forkhead box L2	0.020
Pkdcc	protein kinase domain containing, cytoplasmic	0.020
Otog	otogelin	0.020
Art5	ADP-ribosyltransferase 5	0.020
Nynrin	NYN domain and retroviral integrase containing	0.020
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.020
Ptk7	PTK7 protein tyrosine kinase 7	0.020
Ebf3	early B-cell factor 3	0.020
Efna2	ephrin A2	0.020
Lyn	Yamaguchi sarcoma viral (v-yes-1) oncogene homolog	0.019
Pax8	paired box gene 8	0.019
Jph3	junctophilin 3	0.019
Tgif2	TGFB-induced factor homeobox 2	0.019
Otp	orthopedia homolog (Drosophila)	0.019
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.019
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.019
Folr1	folate receptor 1 (adult)	0.019
Rarg	retinoic acid receptor, gamma	0.019
Ybx2	Y box protein 2	0.019
Wnt10b	wingless related MMTV integration site 10b	0.019
Nos3	nitric oxide synthase 3, endothelial cell	0.018
Hoxc6	homeobox C6	0.018
Ren1	renin 1 structural	0.018
Wnt5a	wingless-related MMTV integration site 5A	0.018
Pou3f2	POU domain, class 3, transcription factor 2	0.018
C1qtnf3	C1q and tumor necrosis factor related protein 3	0.018
Foxm1	forkhead box M1	0.018
Zbtb46	zinc finger and BTB domain containing 46	0.018
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.018
Sult5a1	sulfotransferase family 5A, member 1	0.018
Hoxb5	homeobox B5	0.017
Zp3	zona pellucida glycoprotein 3	0.017
Setx	senataxin	0.017
Dhh	desert hedgehog	0.017	Fly
Foxo1	forkhead box O1	0.017
Padi3	peptidyl arginine deiminase, type III	0.017
Cftr	cystic fibrosis transmembrane conductance regulator homolog	0.017
Ctf1	cardiotrophin 1	0.017
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.017
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.017
Pax1	paired box gene 1	0.017
Gli1	GLI-Kruppel family member GLI1	0.017
Epha8	Eph receptor A8	0.017
Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	0.017
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.016
Sykb	spleen tyrosine kinase	0.016
Ace	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	0.016
Ccdc96	coiled-coil domain containing 96	0.016
Sox21	SRY-box containing gene 21	0.016
Dlx5	distal-less homeobox 5	0.016
Wnt9a	wingless-type MMTV integration site 9A	0.016
Hoxb7	homeobox B7	0.016
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.016
Naa11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	0.016
Tbx1	T-box 1	0.016
Dmrt1	doublesex and mab-3 related transcription factor 1	0.016
Nxn	nucleoredoxin	0.016
Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	0.016
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.016
T	brachyury	0.016
Acan	aggrecan	0.016
Chad	chondroadherin	0.016
Cldn11	claudin 11	0.016
Ar	androgen receptor	0.016
Nrtn	neurturin	0.016
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.016
Efna4	ephrin A4	0.016
Lhx9	LIM homeobox protein 9	0.016
Lefty2	left-right determination factor 2	0.015
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.015
Syt9	synaptotagmin IX	0.015
Ntf5	neurotrophin 5	0.015
Sema3b	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B	0.015
Tead2	TEA domain family member 2	0.015
Dlx3	distal-less homeobox 3	0.015
Kif12	kinesin family member 12	0.015
Grb7	growth factor receptor bound protein 7	0.015
Fgf18	fibroblast growth factor 18	0.015
Myog	myogenin	0.015
Smad6	MAD homolog 6 (Drosophila)	0.015
Tbx3	T-box 3	0.015
Aif1l	allograft inflammatory factor 1-like	0.015
Cst9	cystatin 9	0.015
Crlf1	cytokine receptor-like factor 1	0.015
Col22a1	collagen, type XXII, alpha 1	0.015
Mlph	melanophilin	0.015
Dusp9	dual specificity phosphatase 9	0.014
Grb2	growth factor receptor bound protein 2	0.014
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.014
Adra2b	adrenergic receptor, alpha 2b	0.014
Tlx3	T-cell leukemia, homeobox 3	0.014
Pax9	paired box gene 9	0.014
Cdx1	caudal type homeobox 1	0.014
Kif7	kinesin family member 7	0.014
Hoxa1	homeobox A1	0.014
Bmp2	bone morphogenetic protein 2	0.014
Hoxa7	homeobox A7	0.014
Hoxb8	homeobox B8	0.014
Phex	phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets)	0.014
Nhlh1	nescient helix loop helix 1	0.014
Hoxc4	homeobox C4	0.014
Hoxa9	homeobox A9	0.014
Lamc3	laminin gamma 3	0.014
Nos1	nitric oxide synthase 1, neuronal	0.014
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.014
Nf1	neurofibromatosis 1	0.014
Ctnnb1	catenin (cadherin associated protein), beta 1	0.014
Vhl	von Hippel-Lindau tumor suppressor	0.014
Bmper	BMP-binding endothelial regulator	0.014
Wdr78	WD repeat domain 78	0.014
Gcm1	glial cells missing homolog 1 (Drosophila)	0.014
Rarb	retinoic acid receptor, beta	0.014
Neurod4	neurogenic differentiation 4	0.013
Invs	inversin	0.013
Tecta	tectorin alpha	0.013
Umod	uromodulin	0.013
Prima1	proline rich membrane anchor 1	0.013
Pax7	paired box gene 7	0.013
Cdh3	cadherin 3	0.013
Slc5a11	solute carrier family 5 (sodium/glucose cotransporter), member 11	0.013
Slc12a1	solute carrier family 12, member 1	0.013
Fgf6	fibroblast growth factor 6	0.013
Sspo	SCO-spondin	0.013
Tbxa2r	thromboxane A2 receptor	0.013
Azi1	5-azacytidine induced gene 1	0.013
Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	0.013
Foxd1	forkhead box D1	0.013
Agrp	agouti related protein	0.013
Alx4	aristaless-like homeobox 4	0.013
Megf8	multiple EGF-like-domains 8	0.013
Actn3	actinin alpha 3	0.013
Cbln3	cerebellin 3 precursor protein	0.013
D630037F22Rik	RIKEN cDNA D630037F22 gene	0.013
Abca3	ATP-binding cassette, sub-family A (ABC1), member 3	0.012
Btbd17	BTB (POZ) domain containing 17	0.012
Cited1	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	0.012
Mipol1	mirror-image polydactyly gene 1 homolog (human)	0.012
Emid1	EMI domain containing 1	0.012
Shbg	sex hormone binding globulin	0.012
Lrp2	low density lipoprotein receptor-related protein 2	0.012
Sall3	sal-like 3 (Drosophila)	0.012
Kcnj5	potassium inwardly-rectifying channel, subfamily J, member 5	0.012
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.012
Evx2	even skipped homeotic gene 2 homolog	0.012
Insr	insulin receptor	0.012
Slc22a2	solute carrier family 22 (organic cation transporter), member 2	0.012
Krtap13	keratin associated protein 13	0.012
Llgl1	lethal giant larvae homolog 1 (Drosophila)	0.012
Foxo4	forkhead box O4	0.012
Prrx1	paired related homeobox 1	0.012
Rab17	RAB17, member RAS oncogene family	0.012
Igsf9	immunoglobulin superfamily, member 9	0.012
Col13a1	collagen, type XIII, alpha 1	0.012
Kremen2	kringle containing transmembrane protein 2	0.012
Fam101a	family with sequence similarity 101, member A	0.012
Tead3	TEA domain family member 3	0.012
Prrx2	paired related homeobox 2	0.012
Sox2	SRY-box containing gene 2	0.012
1500031L02Rik	RIKEN cDNA 1500031L02 gene	0.012
Col4a4	collagen, type IV, alpha 4	0.012
Ugt8a	UDP galactosyltransferase 8A	0.012
Esr2	estrogen receptor 2 (beta)	0.012
Eya4	eyes absent 4 homolog (Drosophila)	0.012
Dao	D-amino acid oxidase	0.012
Glis3	GLIS family zinc finger 3	0.012	Mouse
Kap	kidney androgen regulated protein	0.012
Syngr4	synaptogyrin 4	0.011
Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	0.011
Phlda2	pleckstrin homology-like domain, family A, member 2	0.011
Inhbb	inhibin beta-B	0.011
Hoxb4	homeobox B4	0.011
Fgfr4	fibroblast growth factor receptor 4	0.011
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.011
Rhpn1	rhophilin, Rho GTPase binding protein 1	0.011
Bmp8a	bone morphogenetic protein 8a	0.011
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.011
Capn6	calpain 6	0.011
Hapln1	hyaluronan and proteoglycan link protein 1	0.011
Aqp2	aquaporin 2	0.011
Cilp2	cartilage intermediate layer protein 2	0.011
Lhx6	LIM homeobox protein 6	0.011
Mageb3	melanoma antigen, family B, 3	0.011
Klf5	Kruppel-like factor 5	0.011
2810422O20Rik	RIKEN cDNA 2810422O20 gene	0.011
Dmc1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.011
Kcnk7	potassium channel, subfamily K, member 7	0.011
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.011
Hif1a	hypoxia inducible factor 1, alpha subunit	0.011
Nkx3-1	NK-3 transcription factor, locus 1 (Drosophila)	0.011
Ier5l	immediate early response 5-like	0.011
Ino80b	INO80 complex subunit B	0.011
Igfbp1	insulin-like growth factor binding protein 1	0.011
Gm98	predicted gene 98	0.011
Wwc2	WW, C2 and coiled-coil domain containing 2	0.011
Hoxc5	homeobox C5	0.011
Klk6	kallikrein related-peptidase 6	0.011
Mst1r	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	0.010
Was	Wiskott-Aldrich syndrome homolog (human)	0.010
Bcam	basal cell adhesion molecule	0.010
Lhb	luteinizing hormone beta	0.010
Plac1	placental specific protein 1	0.010
Phox2b	paired-like homeobox 2b	0.010
Sox1	SRY-box containing gene 1	0.010
Lrrc56	leucine rich repeat containing 56	0.010
Sftpb	surfactant associated protein B	0.010
Hhip	Hedgehog-interacting protein	0.010
Cd72	CD72 antigen	0.010
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.010
Tigd5	tigger transposable element derived 5	0.010
Hpd	4-hydroxyphenylpyruvic acid dioxygenase	0.010
Hoxb3	homeobox B3	0.010
Tcl1	T-cell lymphoma breakpoint 1	0.010