IMP

Process View

Mus musculus

16 genes annotated in mouse

centrosome duplication

The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "centrosome duplication"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "centrosome duplication" (in gray)

Name	Description	Probability	Func Analog Organism
Cdc25c	cell division cycle 25 homolog C (S. pombe)	0.994	Fly
Pafah1b1	platelet-activating factor acetylhydrolase, isoform 1b, subunit 1	0.887
Kif4	kinesin family member 4	0.696
Plk1	polo-like kinase 1 (Drosophila)	0.660
Brca1	breast cancer 1	0.553
Anln	anillin, actin binding protein	0.512
Kif20a	kinesin family member 20A	0.501
Rpgrip1l	Rpgrip1-like	0.459
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.418
Ccnb1	cyclin B1	0.417
Ccna2	cyclin A2	0.362
Kif11	kinesin family member 11	0.338	Fly
Rplp0	ribosomal protein, large, P0	0.319
Prc1	protein regulator of cytokinesis 1	0.298	Fly
Spag5	sperm associated antigen 5	0.297
Ccnb2	cyclin B2	0.296
Aurka	aurora kinase A	0.245
Cdk1	cyclin-dependent kinase 1	0.242
Hspa8	heat shock protein 8	0.228
Kif2c	kinesin family member 2C	0.216	Fly
Gtse1	G two S phase expressed protein 1	0.205
Dlgap5	discs, large (Drosophila) homolog-associated protein 5	0.192
Aurkb	aurora kinase B	0.187	Fly
Tacc3	transforming, acidic coiled-coil containing protein 3	0.186
Cdc25b	cell division cycle 25 homolog B (S. pombe)	0.171	Fly
Cep55	centrosomal protein 55	0.163
Ndc80	NDC80 homolog, kinetochore complex component (S. cerevisiae)	0.147
Ttk	Ttk protein kinase	0.143
Plk4	polo-like kinase 4 (Drosophila)	0.143
Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	0.142
Incenp	inner centromere protein	0.136
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.126
Ccnf	cyclin F	0.124	Human
Tmpo	thymopoietin	0.119
Aspm	asp (abnormal spindle)-like, microcephaly associated (Drosophila)	0.115
Bub1	budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)	0.109
Mis18bp1	MIS18 binding protein 1	0.103
Ckap2	cytoskeleton associated protein 2	0.103
Mxd3	Max dimerization protein 3	0.096
Top2a	topoisomerase (DNA) II alpha	0.095
Rad51ap1	RAD51 associated protein 1	0.094
Cdca5	cell division cycle associated 5	0.092
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.089
Kif23	kinesin family member 23	0.087	Fly
Ccdc99	coiled-coil domain containing 99	0.086
Ube2c	ubiquitin-conjugating enzyme E2C	0.082
Smc4	structural maintenance of chromosomes 4	0.077
Blm	Bloom syndrome, RecQ helicase-like	0.072
Kif22	kinesin family member 22	0.071
Birc5	baculoviral IAP repeat-containing 5	0.070
Fam64a	family with sequence similarity 64, member A	0.065
Cdkn3	cyclin-dependent kinase inhibitor 3	0.064
C330027C09Rik	RIKEN cDNA C330027C09 gene	0.063
Mns1	meiosis-specific nuclear structural protein 1	0.062
Strn3	striatin, calmodulin binding protein 3	0.061
Gsg2	germ cell-specific gene 2	0.060
Cdc7	cell division cycle 7 (S. cerevisiae)	0.058
Cdt1	chromatin licensing and DNA replication factor 1	0.057	Fly
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.055
Per2	period homolog 2 (Drosophila)	0.055
Racgap1	Rac GTPase-activating protein 1	0.054	Fly
Arhgap21	Rho GTPase activating protein 21	0.054
Ncaph	non-SMC condensin I complex, subunit H	0.051
Sass6	spindle assembly 6 homolog (C. elegans)	0.051	Fly
Gnb2l1	guanine nucleotide binding protein (G protein), beta polypeptide 2 like 1	0.051
Chaf1b	chromatin assembly factor 1, subunit B (p60)	0.051
Rabep1	rabaptin, RAB GTPase binding effector protein 1	0.050
Rasa1	RAS p21 protein activator 1	0.049
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	0.048
Cdca8	cell division cycle associated 8	0.047
Chek1	checkpoint kinase 1 homolog (S. pombe)	0.047
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.044
Wdhd1	WD repeat and HMG-box DNA binding protein 1	0.044
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform	0.043
Kif2a	kinesin family member 2A	0.042	Fly
E2f8	E2F transcription factor 8	0.040
Iqgap3	IQ motif containing GTPase activating protein 3	0.040
Ireb2	iron responsive element binding protein 2	0.039
Dtl	denticleless homolog (Drosophila)	0.039
Tcp1	t-complex protein 1	0.039
H2afx	H2A histone family, member X	0.038
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.037
Stil	Scl/Tal1 interrupting locus	0.037
Lmnb1	lamin B1	0.037
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.036
Rps3a	ribosomal protein S3A	0.036
Foxm1	forkhead box M1	0.035
Eea1	early endosome antigen 1	0.034
Kif5b	kinesin family member 5B	0.034
Cenpf	centromere protein F	0.034
Cks2	CDC28 protein kinase regulatory subunit 2	0.033
Cenpe	centromere protein E	0.032
Cul3	cullin 3	0.032
Haus5	HAUS augmin-like complex, subunit 5	0.032
Cenpn	centromere protein N	0.031
Wdr26	WD repeat domain 26	0.030
Sgol1	shugoshin-like 1 (S. pombe)	0.030
LOC100044627	60S ribosomal protein L23-like	0.030
Exo1	exonuclease 1	0.030
Brsk1	BR serine/threonine kinase 1	0.029
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.029
Invs	inversin	0.028
Stag2	stromal antigen 2	0.028
Haus4	HAUS augmin-like complex, subunit 4	0.028
Htt	huntingtin	0.028
Jak2	Janus kinase 2	0.027
Ncapd2	non-SMC condensin I complex, subunit D2	0.025
Trip13	thyroid hormone receptor interactor 13	0.025
Orc4	origin recognition complex, subunit 4	0.023
Sacm1l	SAC1 (suppressor of actin mutations 1, homolog)-like (S. cerevisiae)	0.022
Lancl2	LanC (bacterial lantibiotic synthetase component C)-like 2	0.022
Mki67	antigen identified by monoclonal antibody Ki 67	0.022
Ckap5	cytoskeleton associated protein 5	0.022
Ppp4r2	protein phosphatase 4, regulatory subunit 2	0.021
Cops2	COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana)	0.021
Trim59	tripartite motif-containing 59	0.021
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.021
Hspa4l	heat shock protein 4 like	0.021
Arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	0.021
Ppp2r2a	protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform	0.021
B230308N11Rik	RIKEN cDNA B230308N11 gene	0.021
Cenpa	centromere protein A	0.021
Kpna3	karyopherin (importin) alpha 3	0.021
E130303B06Rik	RIKEN cDNA E130303B06 gene	0.020
Stag1	stromal antigen 1	0.020
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.020
Cenpk	centromere protein K	0.020
4930427A07Rik	RIKEN cDNA 4930427A07 gene	0.019
Cdc25a	cell division cycle 25 homolog A (S. pombe)	0.019	Fly
Tcf19	transcription factor 19	0.019
Ccne1	cyclin E1	0.019
Nde1	nuclear distribution gene E homolog 1 (A nidulans)	0.019
Dnm1l	dynamin 1-like	0.018
Igbp1	immunoglobulin (CD79A) binding protein 1	0.018
Trip12	thyroid hormone receptor interactor 12	0.018
D2Ertd750e	DNA segment, Chr 2, ERATO Doi 750, expressed	0.018
Hnrpll	heterogeneous nuclear ribonucleoprotein L-like	0.018
Mcm10	minichromosome maintenance deficient 10 (S. cerevisiae)	0.018
Rpl4	ribosomal protein L4	0.017
Tpr	translocated promoter region	0.017
Nbn	nibrin	0.017
Ndel1	nuclear distribution gene E-like homolog 1 (A. nidulans)	0.016	Mouse
Gpbp1	GC-rich promoter binding protein 1	0.016
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.016
Zranb2	zinc finger, RAN-binding domain containing 2	0.016
Actg1	actin, gamma, cytoplasmic 1	0.015
Mastl	microtubule associated serine/threonine kinase-like	0.015
Rnf26	ring finger protein 26	0.015
Bard1	BRCA1 associated RING domain 1	0.015
Bod1l	biorientation of chromosomes in cell division 1-like	0.015
Wee1	WEE 1 homolog 1 (S. pombe)	0.015
Wrn	Werner syndrome homolog (human)	0.014
Ranbp9	RAN binding protein 9	0.014
Smap1	stromal membrane-associated protein 1	0.014
2810417H13Rik	RIKEN cDNA 2810417H13 gene	0.014
Rpl10a	ribosomal protein L10A	0.014
Smc2	structural maintenance of chromosomes 2	0.014
Tyms	thymidylate synthase	0.013
Ift80	intraflagellar transport 80 homolog (Chlamydomonas)	0.013
Rttn	rotatin	0.013
Cdc6	cell division cycle 6 homolog (S. cerevisiae)	0.013
Atm	ataxia telangiectasia mutated homolog (human)	0.013
1500010J02Rik	RIKEN cDNA 1500010J02 gene	0.013
Nedd1	neural precursor cell expressed, developmentally down-regulated gene 1	0.012	Fly
Rab10	RAB10, member RAS oncogene family	0.012
Nusap1	nucleolar and spindle associated protein 1	0.012
Smc6	structural maintenance of chromosomes 6	0.012
Lmnb2	lamin B2	0.012
Hsph1	heat shock 105kDa/110kDa protein 1	0.012
Lin9	lin-9 homolog (C. elegans)	0.011
Wbp4	WW domain binding protein 4	0.011
Rbl1	retinoblastoma-like 1 (p107)	0.011
Ccdc123	coiled-coil domain containing 123	0.011
Mybl2	myeloblastosis oncogene-like 2	0.011	Fly
Cdc45	cell division cycle 45 homolog (S. cerevisiae)	0.011
Agfg1	ArfGAP with FG repeats 1	0.011
BC005537	cDNA sequence BC005537	0.011
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.011
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.011
Pkn2	protein kinase N2	0.011
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.011
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.010
Atf2	activating transcription factor 2	0.010
Actr6	ARP6 actin-related protein 6 homolog (yeast)	0.010
Fancg	Fanconi anemia, complementation group G	0.010
2700078E11Rik	RIKEN cDNA 2700078E11 gene	0.010
Mphosph9	M-phase phosphoprotein 9	0.010
Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	0.010