IMP

Process View

Mus musculus

13 genes annotated in mouse

regulation of lyase activity

Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of lyase activity"

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Name	Description	Probability	Func Analog Organism
Drd2	dopamine receptor D2	0.978	Human Rat
Cckbr	cholecystokinin B receptor	0.725
Pten	phosphatase and tensin homolog	0.672
Esr1	estrogen receptor 1 (alpha)	0.606
Adrb1	adrenergic receptor, beta 1	0.593	Mouse Rat
Kl	klotho	0.579
Pnpla2	patatin-like phospholipase domain containing 2	0.521
Adora2a	adenosine A2a receptor	0.488	Human Mouse
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.364	Yeast
Pparg	peroxisome proliferator activated receptor gamma	0.293
Ar	androgen receptor	0.269
Ghr	growth hormone receptor	0.248
Tshr	thyroid stimulating hormone receptor	0.234	Mouse
Cdkn1b	cyclin-dependent kinase inhibitor 1B	0.234
Crhr1	corticotropin releasing hormone receptor 1	0.232
Kcna4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.223
Sstr4	somatostatin receptor 4	0.212
Ctnnb1	catenin (cadherin associated protein), beta 1	0.179
Thra	thyroid hormone receptor alpha	0.177
Pax8	paired box gene 8	0.175
Oprk1	opioid receptor, kappa 1	0.167
Actr3	ARP3 actin-related protein 3 homolog (yeast)	0.164
Tpo	thyroid peroxidase	0.154
Npy2r	neuropeptide Y receptor Y2	0.152
Tgfb1	transforming growth factor, beta 1	0.143
Kcnq2	potassium voltage-gated channel, subfamily Q, member 2	0.140
Nras	neuroblastoma ras oncogene	0.138	Yeast
Lhcgr	luteinizing hormone/choriogonadotropin receptor	0.131
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.125	Mouse
Chrm1	cholinergic receptor, muscarinic 1, CNS	0.118
Gpr27	G protein-coupled receptor 27	0.118
Kcnj4	potassium inwardly-rectifying channel, subfamily J, member 4	0.113
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.110
Oprm1	opioid receptor, mu 1	0.109	Rat
Pgr	progesterone receptor	0.103
Lep	leptin	0.093
Lepr	leptin receptor	0.089
Mc5r	melanocortin 5 receptor	0.089
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.086
Adra2c	adrenergic receptor, alpha 2c	0.086	Mouse
Vip	vasoactive intestinal polypeptide	0.084
Ywhab	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide	0.084
Ptms	parathymosin	0.084
Hrh1	histamine receptor H1	0.082
Thrb	thyroid hormone receptor beta	0.081
Prop1	paired like homeodomain factor 1	0.080
Htr1a	5-hydroxytryptamine (serotonin) receptor 1A	0.073	Mouse
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.073
Kiss1	KiSS-1 metastasis-suppressor	0.071
Htr1b	5-hydroxytryptamine (serotonin) receptor 1B	0.070	Mouse
Grid1	glutamate receptor, ionotropic, delta 1	0.069
Nfatc2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.069
Duox2	dual oxidase 2	0.068
Nos3	nitric oxide synthase 3, endothelial cell	0.068
Adra2a	adrenergic receptor, alpha 2a	0.064	Zebrafish Mouse
Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	0.059
Shc3	src homology 2 domain-containing transforming protein C3	0.057
Nr3c1	nuclear receptor subfamily 3, group C, member 1	0.055
Ltc4s	leukotriene C4 synthase	0.055
Kcnj11	potassium inwardly rectifying channel, subfamily J, member 11	0.054
Neurog3	neurogenin 3	0.053
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.053
Bai1	brain-specific angiogenesis inhibitor 1	0.052
Hif1a	hypoxia inducible factor 1, alpha subunit	0.050
Gsx1	GS homeobox 1	0.049
Kctd17	potassium channel tetramerisation domain containing 17	0.048
Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	0.047	Mouse
Gjb5	gap junction protein, beta 5	0.046
Mmp24	matrix metallopeptidase 24	0.045
Mtch1	mitochondrial carrier homolog 1 (C. elegans)	0.045
Cav1	caveolin 1, caveolae protein	0.044
Tacr2	tachykinin receptor 2	0.043
Acan	aggrecan	0.043
Krt86	keratin 86	0.042
Trfr2	transferrin receptor 2	0.041
Fshr	follicle stimulating hormone receptor	0.041	Mouse
Kcna2	potassium voltage-gated channel, shaker-related subfamily, member 2	0.041
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.041
Kcnd1	potassium voltage-gated channel, Shal-related family, member 1	0.041
Icam5	intercellular adhesion molecule 5, telencephalin	0.040
Tpm4	tropomyosin 4	0.040
Csf3	colony stimulating factor 3 (granulocyte)	0.040
Slc12a1	solute carrier family 12, member 1	0.038
Pcsk2	proprotein convertase subtilisin/kexin type 2	0.037
Cga	glycoprotein hormones, alpha subunit	0.037
Tacr1	tachykinin receptor 1	0.037
Opn1sw	opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)	0.037
Chrna6	cholinergic receptor, nicotinic, alpha polypeptide 6	0.036
Crtac1	cartilage acidic protein 1	0.036
Otp	orthopedia homolog (Drosophila)	0.036
Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	0.036
Adrb2	adrenergic receptor, beta 2	0.035	Human Mouse
Ptafr	platelet-activating factor receptor	0.035
Gng4	guanine nucleotide binding protein (G protein), gamma 4	0.034
Oprd1	opioid receptor, delta 1	0.034
Htr7	5-hydroxytryptamine (serotonin) receptor 7	0.034
Trp53	transformation related protein 53	0.033
Pdyn	prodynorphin	0.033
Rgs8	regulator of G-protein signaling 8	0.033
Syn2	synapsin II	0.033
Ikzf4	IKAROS family zinc finger 4	0.032
Adrb3	adrenergic receptor, beta 3	0.032	Human Mouse
Cbln1	cerebellin 1 precursor protein	0.032
Ptprn2	protein tyrosine phosphatase, receptor type, N polypeptide 2	0.032
Slc34a1	solute carrier family 34 (sodium phosphate), member 1	0.031
Htr4	5 hydroxytryptamine (serotonin) receptor 4	0.031	Mouse
Rgs9	regulator of G-protein signaling 9	0.031
Braf	Braf transforming gene	0.031
Gabra2	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2	0.031
Npy5r	neuropeptide Y receptor Y5	0.031
Syt5	synaptotagmin V	0.031
Dlg4	discs, large homolog 4 (Drosophila)	0.031
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.030
Rac1	RAS-related C3 botulinum substrate 1	0.030
Plxna1	plexin A1	0.030
Ptprn	protein tyrosine phosphatase, receptor type, N	0.030
Has1	hyaluronan synthase1	0.030
Lag3	lymphocyte-activation gene 3	0.030
Ern2	endoplasmic reticulum (ER) to nucleus signalling 2	0.029
Nrg3	neuregulin 3	0.029
Foxf2	forkhead box F2	0.029
Prkar1b	protein kinase, cAMP dependent regulatory, type I beta	0.028
Mas1	MAS1 oncogene	0.028
Htr1f	5-hydroxytryptamine (serotonin) receptor 1F	0.028	Mouse
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1	0.028
Mmp17	matrix metallopeptidase 17	0.028
Sult4a1	sulfotransferase family 4A, member 1	0.028
Glra4	glycine receptor, alpha 4 subunit	0.026
Gnrh1	gonadotropin releasing hormone 1	0.026
Galnt6	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6	0.026
Npy	neuropeptide Y	0.026
Gpr3	G-protein coupled receptor 3	0.025
Cntn4	contactin 4	0.025
Hrh3	histamine receptor H3	0.025	Rat
Gnrhr	gonadotropin releasing hormone receptor	0.025
Fshb	follicle stimulating hormone beta	0.025
Bglap	bone gamma carboxyglutamate protein	0.025
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.024
Pomc	pro-opiomelanocortin-alpha	0.024
Elk1	ELK1, member of ETS oncogene family	0.024
Grm2	glutamate receptor, metabotropic 2	0.024
Gabrb2	gamma-aminobutyric acid (GABA) A receptor, subunit beta 2	0.024
Lhx6	LIM homeobox protein 6	0.024
Adam17	a disintegrin and metallopeptidase domain 17	0.024
Arl4d	ADP-ribosylation factor-like 4D	0.024
Sstr1	somatostatin receptor 1	0.024
Syt6	synaptotagmin VI	0.024
Gabrg3	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3	0.024
Tgfbr3	transforming growth factor, beta receptor III	0.023
Khdc1b	KH domain containing 1B	0.023
Grm1	glutamate receptor, metabotropic 1	0.023
Prkaca	protein kinase, cAMP dependent, catalytic, alpha	0.023
Slc12a5	solute carrier family 12, member 5	0.023
Mapk3	mitogen-activated protein kinase 3	0.023
Gria1	glutamate receptor, ionotropic, AMPA1 (alpha 1)	0.023
Btn1a1	butyrophilin, subfamily 1, member A1	0.023
Fxyd7	FXYD domain-containing ion transport regulator 7	0.023
Grm8	glutamate receptor, metabotropic 8	0.023
Rb1	retinoblastoma 1	0.022
Slc5a5	solute carrier family 5 (sodium iodide symporter), member 5	0.022
Nxph2	neurexophilin 2	0.022
Apc	adenomatosis polyposis coli	0.022
Cplx1	complexin 1	0.022
Pea15a	phosphoprotein enriched in astrocytes 15A	0.022
Wnt2b	wingless related MMTV integration site 2b	0.021
Kcnc1	potassium voltage gated channel, Shaw-related subfamily, member 1	0.021
Pitx2	paired-like homeodomain transcription factor 2	0.021
C1ql1	complement component 1, q subcomponent-like 1	0.021
Il5	interleukin 5	0.021
Grik5	glutamate receptor, ionotropic, kainate 5 (gamma 2)	0.021
Apln	apelin	0.021
Apoa5	apolipoprotein A-V	0.021
Zfr2	zinc finger RNA binding protein 2	0.021
Pik3ca	phosphatidylinositol 3-kinase, catalytic, alpha polypeptide	0.020
Dpp6	dipeptidylpeptidase 6	0.020
Nhedc2	Na+/H+ exchanger domain containing 2	0.020
Rcvrn	recoverin	0.020
Cyb5r3	cytochrome b5 reductase 3	0.020
Dr1	down-regulator of transcription 1	0.020
Lin7b	lin-7 homolog B (C. elegans)	0.020
Htr2c	5-hydroxytryptamine (serotonin) receptor 2C	0.020	Mouse
Chst2	carbohydrate sulfotransferase 2	0.020
Pde6a	phosphodiesterase 6A, cGMP-specific, rod, alpha	0.020
Rnf208	ring finger protein 208	0.020
Cacng5	calcium channel, voltage-dependent, gamma subunit 5	0.019
Rax	retina and anterior neural fold homeobox	0.019
Lmx1b	LIM homeobox transcription factor 1 beta	0.019
Psd	pleckstrin and Sec7 domain containing	0.019
Galr1	galanin receptor 1	0.019
Camk2a	calcium/calmodulin-dependent protein kinase II alpha	0.019
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.019
Ncam1	neural cell adhesion molecule 1	0.019
Prlr	prolactin receptor	0.019
Kcnd3	potassium voltage-gated channel, Shal-related family, member 3	0.019
Cyp27b1	cytochrome P450, family 27, subfamily b, polypeptide 1	0.018
Ptpn20	protein tyrosine phosphatase, non-receptor type 20	0.018
Ddah1	dimethylarginine dimethylaminohydrolase 1	0.018
Jph3	junctophilin 3	0.018
Slc30a3	solute carrier family 30 (zinc transporter), member 3	0.018
Vstm2b	V-set and transmembrane domain containing 2B	0.018
Prkcc	protein kinase C, gamma	0.018
Pthlh	parathyroid hormone-like peptide	0.018
Slc32a1	solute carrier family 32 (GABA vesicular transporter), member 1	0.018
Sntb1	syntrophin, basic 1	0.018
Sim1	single-minded homolog 1 (Drosophila)	0.018
Tac2	tachykinin 2	0.018
Klf6	Kruppel-like factor 6	0.018
Hrh2	histamine receptor H2	0.018	Mouse
Syp	synaptophysin	0.017
Rap2c	RAP2C, member of RAS oncogene family	0.017
Rxra	retinoid X receptor alpha	0.017
Kcnc4	potassium voltage gated channel, Shaw-related subfamily, member 4	0.017
Raf1	v-raf-leukemia viral oncogene 1	0.017
Ceacam11	carcinoembryonic antigen-related cell adhesion molecule 11	0.017
Gsx2	GS homeobox 2	0.017
Snx6	sorting nexin 6	0.017
Tubb4	tubulin, beta 4	0.017
Gng3	guanine nucleotide binding protein (G protein), gamma 3	0.017	Mouse
Gpr12	G-protein coupled receptor 12	0.017
Sstr3	somatostatin receptor 3	0.017
Matn1	matrilin 1, cartilage matrix protein	0.017
Irs3	insulin receptor substrate 3	0.017
Calb2	calbindin 2	0.017
Glg1	golgi apparatus protein 1	0.017
Nrgn	neurogranin	0.017
Bcl10	B-cell leukemia/lymphoma 10	0.017
Lhx3	LIM homeobox protein 3	0.017
Drd3	dopamine receptor D3	0.016	Human Rat
Cacna1b	calcium channel, voltage-dependent, N type, alpha 1B subunit	0.016
Gpr26	G protein-coupled receptor 26	0.016
Kif5a	kinesin family member 5A	0.016
Mlf2	myeloid leukemia factor 2	0.016
Ccnd1	cyclin D1	0.016
Prlhr	prolactin releasing hormone receptor	0.016
Aanat	arylalkylamine N-acetyltransferase	0.016
Krt12	keratin 12	0.016
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.016
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.016
Hpca	hippocalcin	0.015
Ryr3	ryanodine receptor 3	0.015
Ltk	leukocyte tyrosine kinase	0.015
Ugcg	UDP-glucose ceramide glucosyltransferase	0.015
Cdh6	cadherin 6	0.015
Elf4	E74-like factor 4 (ets domain transcription factor)	0.015
Csmd1	CUB and Sushi multiple domains 1	0.015
Cntnap1	contactin associated protein-like 1	0.015
Otog	otogelin	0.015
Vdr	vitamin D receptor	0.015
Agrp	agouti related protein	0.015
Clpp	caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)	0.015
F2rl2	coagulation factor II (thrombin) receptor-like 2	0.014
Cnr1	cannabinoid receptor 1 (brain)	0.014
Clcnka	chloride channel Ka	0.014
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.014
Kifc2	kinesin family member C2	0.014
Rhbdl3	rhomboid, veinlet-like 3 (Drosophila)	0.014
Cux2	cut-like homeobox 2	0.014
Napb	N-ethylmaleimide sensitive fusion protein attachment protein beta	0.014
Mgat3	mannoside acetylglucosaminyltransferase 3	0.014
Ckb	creatine kinase, brain	0.014
Ctnnbip1	catenin beta interacting protein 1	0.014
Trpm1	transient receptor potential cation channel, subfamily M, member 1	0.014
Cryaa	crystallin, alpha A	0.014
Sez6	seizure related gene 6	0.014
Ugdh	UDP-glucose dehydrogenase	0.014
L1cam	L1 cell adhesion molecule	0.014
Doc2b	double C2, beta	0.014
Smad2	MAD homolog 2 (Drosophila)	0.014
Cntn3	contactin 3	0.014
Fgf10	fibroblast growth factor 10	0.014
Axl	AXL receptor tyrosine kinase	0.014
Prl	prolactin	0.014
Kif1a	kinesin family member 1A	0.014
Naa11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	0.014
Sst	somatostatin	0.014
Pdx1	pancreatic and duodenal homeobox 1	0.014
Slc18a3	solute carrier family 18 (vesicular monoamine), member 3	0.014
Tectb	tectorin beta	0.014
Cer1	cerberus 1 homolog (Xenopus laevis)	0.013
Trim46	tripartite motif-containing 46	0.013
Htr5a	5-hydroxytryptamine (serotonin) receptor 5A	0.013	Mouse
Ambn	ameloblastin	0.013
Gab2	growth factor receptor bound protein 2-associated protein 2	0.013
Sstr2	somatostatin receptor 2	0.013
Itgb5	integrin beta 5	0.013
Rorb	RAR-related orphan receptor beta	0.013
Dmc1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.013
Prss30	protease, serine, 30	0.013
Trh	thyrotropin releasing hormone	0.013
Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	0.013
Nefh	neurofilament, heavy polypeptide	0.013
Itga6	integrin alpha 6	0.013
Mapre1	microtubule-associated protein, RP/EB family, member 1	0.013
Glra1	glycine receptor, alpha 1 subunit	0.013
Atp4a	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	0.013
Ssr3	signal sequence receptor, gamma	0.013
Cnih2	cornichon homolog 2 (Drosophila)	0.013
Tmod3	tropomodulin 3	0.013
Ccr1l1	chemokine (C-C motif) receptor 1-like 1	0.013
Efna5	ephrin A5	0.013
Inha	inhibin alpha	0.013
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.012
Rit2	Ras-like without CAAX 2	0.012
Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	0.012	Mouse
Onecut1	one cut domain, family member 1	0.012
Gna11	guanine nucleotide binding protein, alpha 11	0.012	Mouse
Pkdrej	polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin homolog)-like	0.012
Epha8	Eph receptor A8	0.012
Rgnef	Rho-guanine nucleotide exchange factor	0.012
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.012
Itgb2l	integrin beta 2-like	0.012
Cd99	CD99 antigen	0.012
Cplx3	complexin 3	0.012
B3gat1	beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)	0.012
Dbn1	drebrin 1	0.012
Sox3	SRY-box containing gene 3	0.012
Mrps15	mitochondrial ribosomal protein S15	0.012
Kcns2	K+ voltage-gated channel, subfamily S, 2	0.012
Epha6	Eph receptor A6	0.012
Anxa5	annexin A5	0.012
Cbl	Casitas B-lineage lymphoma	0.012
Bzw1	basic leucine zipper and W2 domains 1	0.012
Avp	arginine vasopressin	0.012
Ptp4a2	protein tyrosine phosphatase 4a2	0.012
Capza1	capping protein (actin filament) muscle Z-line, alpha 1	0.012
Tpbpa	trophoblast specific protein alpha	0.011
Acr	acrosin prepropeptide	0.011	Human
Rnf112	ring finger protein 112	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Egfr	epidermal growth factor receptor	0.011
Cacna1e	calcium channel, voltage-dependent, R type, alpha 1E subunit	0.011
Zp1	zona pellucida glycoprotein 1	0.011
Mtpn	myotrophin	0.011
Stx1b	syntaxin 1B	0.011
Npy6r	neuropeptide Y receptor Y6	0.011
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.011
Slc13a3	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3	0.011
Rtbdn	retbindin	0.011
Mchr1	melanin-concentrating hormone receptor 1	0.011
Ptpn5	protein tyrosine phosphatase, non-receptor type 5	0.011
Gpr83	G protein-coupled receptor 83	0.011
Fam163b	family with sequence similarity 163, member B	0.011
Upp2	uridine phosphorylase 2	0.011
St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	0.011
Scrg1	scrapie responsive gene 1	0.011
Fosb	FBJ osteosarcoma oncogene B	0.011
Alx3	aristaless-like homeobox 3	0.011
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.011
Srcin1	SRC kinase signaling inhibitor 1	0.011
Ly6h	lymphocyte antigen 6 complex, locus H	0.011
Rgs4	regulator of G-protein signaling 4	0.011
Wnt1	wingless-related MMTV integration site 1	0.010
Npdc1	neural proliferation, differentiation and control gene 1	0.010
Kcnt1	potassium channel, subfamily T, member 1	0.010
Adam11	a disintegrin and metallopeptidase domain 11	0.010
Adcyap1r1	adenylate cyclase activating polypeptide 1 receptor 1	0.010	Mouse
Igf2	insulin-like growth factor 2	0.010
Gast	gastrin	0.010
Syt1	synaptotagmin I	0.010
Gcgr	glucagon receptor	0.010	Mouse
Epas1	endothelial PAS domain protein 1	0.010
Guca2b	guanylate cyclase activator 2b (retina)	0.010
Pde1b	phosphodiesterase 1B, Ca2+-calmodulin dependent	0.010
Cox8c	cytochrome c oxidase, subunit VIIIc	0.010
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.010
Klk6	kallikrein related-peptidase 6	0.010
Nf2	neurofibromatosis 2	0.010