IMP

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Mus musculus

18 genes annotated in mouse

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negative regulation of histone modification

GO:0031057

Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of histone modification"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of histone modification" (in gray)

Name	Description	Probability	Func Analog Organism
Trp53	transformation related protein 53	0.659
Neurod1	neurogenic differentiation 1	0.659	Mouse
Zeb1	zinc finger E-box binding homeobox 1	0.643
Gli2	GLI-Kruppel family member GLI2	0.344
Dnmt3a	DNA methyltransferase 3A	0.335
Kdm2b	lysine (K)-specific demethylase 2B	0.333
Shh	sonic hedgehog	0.317
Hdac1	histone deacetylase 1	0.290
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.261
Atg12	autophagy-related 12 (yeast)	0.234
Otx2	orthodenticle homolog 2 (Drosophila)	0.208
Suz12	suppressor of zeste 12 homolog (Drosophila)	0.189
Sin3a	transcriptional regulator, SIN3A (yeast)	0.175	Human
Rnf2	ring finger protein 2	0.159
Ikzf1	IKAROS family zinc finger 1	0.143
Igh	immunoglobulin heavy chain complex	0.132
Pax6	paired box gene 6	0.124
Kdm1a	lysine (K)-specific demethylase 1A	0.115
Gata1	GATA binding protein 1	0.111
Kiss1	KiSS-1 metastasis-suppressor	0.109
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.108
Pten	phosphatase and tensin homolog	0.086
Pax3	paired box gene 3	0.085
Hand1	heart and neural crest derivatives expressed transcript 1	0.084	Mouse
Hand2	heart and neural crest derivatives expressed transcript 2	0.083	Mouse
Prrx1	paired related homeobox 1	0.077
Tcf3	transcription factor 3	0.077
Runx1	runt related transcription factor 1	0.076
Cd19	CD19 antigen	0.076
Gsc	goosecoid homeobox	0.071
Pax9	paired box gene 9	0.068	Mouse
Msx1	homeobox, msh-like 1	0.067	Mouse
Foxn1	forkhead box N1	0.063
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.061
En1	engrailed 1	0.061
Slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.061
Dlx5	distal-less homeobox 5	0.060
Nhlh1	nescient helix loop helix 1	0.057	Mouse
Emx1	empty spiracles homolog 1 (Drosophila)	0.055
Rag1	recombination activating gene 1	0.055
Hoxd11	homeobox D11	0.049
Mdm2	transformed mouse 3T3 cell double minute 2	0.049
Dlx2	distal-less homeobox 2	0.045
Ptf1a	pancreas specific transcription factor, 1a	0.043	Mouse
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.043
Tal1	T-cell acute lymphocytic leukemia 1	0.042	Mouse
Zfp292	zinc finger protein 292	0.042
Jarid2	jumonji, AT rich interactive domain 2	0.042
Eya1	eyes absent 1 homolog (Drosophila)	0.041
Runx2	runt related transcription factor 2	0.040
Lef1	lymphoid enhancer binding factor 1	0.039
Zfp362	zinc finger protein 362	0.039
Alx4	aristaless-like homeobox 4	0.035
Smc1a	structural maintenance of chromosomes 1A	0.034
Twist2	twist homolog 2 (Drosophila)	0.033	Mouse
Arid1a	AT rich interactive domain 1A (SWI-like)	0.033
Pdx1	pancreatic and duodenal homeobox 1	0.032
Alx3	aristaless-like homeobox 3	0.032
Pou4f3	POU domain, class 4, transcription factor 3	0.032
Pitx3	paired-like homeodomain transcription factor 3	0.032
Clk4	CDC like kinase 4	0.031
Isl1	ISL1 transcription factor, LIM/homeodomain	0.031
Neurod4	neurogenic differentiation 4	0.031	Mouse
Lhx3	LIM homeobox protein 3	0.030
Kdm5b	lysine (K)-specific demethylase 5B	0.030	Mouse
Rag2	recombination activating gene 2	0.030
Onecut1	one cut domain, family member 1	0.029
Hr	hairless	0.029	Mouse
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.029
Pml	promyelocytic leukemia	0.029
Gfi1b	growth factor independent 1B	0.028
Gdf11	growth differentiation factor 11	0.028
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.028
Prrx2	paired related homeobox 2	0.028
ND6	NADH dehydrogenase subunit 6	0.027
Hmx1	H6 homeobox 1	0.026
Clk1	CDC-like kinase 1	0.026
Pou4f2	POU domain, class 4, transcription factor 2	0.026
Map3k7	mitogen-activated protein kinase kinase kinase 7	0.025
Smo	smoothened homolog (Drosophila)	0.025
Tcfap2a	transcription factor AP-2, alpha	0.025
Nfe2	nuclear factor, erythroid derived 2	0.025
Mbtd1	mbt domain containing 1	0.025
Phox2b	paired-like homeobox 2b	0.025
Hba-x	hemoglobin X, alpha-like embryonic chain in Hba complex	0.025
Dicer1	Dicer1, Dcr-1 homolog (Drosophila)	0.024
Neurog2	neurogenin 2	0.024	Mouse
Srrm4	serine/arginine repetitive matrix 4	0.024
Gpr50	G-protein-coupled receptor 50	0.024
Atrx	alpha thalassemia/mental retardation syndrome X-linked homolog (human)	0.023
Hoxb1	homeobox B1	0.023
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.023
Nkx2-9	NK2 transcription factor related, locus 9 (Drosophila)	0.022
Morf4l1	mortality factor 4 like 1	0.022
Runx1t1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	0.022
Prph2	peripherin 2	0.022
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.022
Sox2	SRY-box containing gene 2	0.022
Foxd4	forkhead box D4	0.022
Trim33	tripartite motif-containing 33	0.022
Asxl1	additional sex combs like 1 (Drosophila)	0.021
Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	0.021
Nkx3-2	NK3 homeobox 2	0.021
Mdm4	transformed mouse 3T3 cell double minute 4	0.021
Chrnb2	cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)	0.021
Lhx5	LIM homeobox protein 5	0.021
Gnai2	guanine nucleotide binding protein (G protein), alpha inhibiting 2	0.021
Huwe1	HECT, UBA and WWE domain containing 1	0.020
Foxg1	forkhead box G1	0.020
Gnrh1	gonadotropin releasing hormone 1	0.020
Sox11	SRY-box containing gene 11	0.020
Mecom	MDS1 and EVI1 complex locus	0.020
Foxd2	forkhead box D2	0.019
Fgfr2	fibroblast growth factor receptor 2	0.019
Ncor1	nuclear receptor co-repressor 1	0.019
Crebbp	CREB binding protein	0.019
Efna2	ephrin A2	0.019
Socs1	suppressor of cytokine signaling 1	0.018
Mdfi	MyoD family inhibitor	0.018
Trim10	tripartite motif-containing 10	0.018
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.018
Pou3f2	POU domain, class 3, transcription factor 2	0.018
Rhag	Rhesus blood group-associated A glycoprotein	0.017
Dsg4	desmoglein 4	0.017
Prkdc	protein kinase, DNA activated, catalytic polypeptide	0.017
A930001N09Rik	RIKEN cDNA A930001N09 gene	0.017
Neurog3	neurogenin 3	0.017	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.017
Cdh23	cadherin 23 (otocadherin)	0.017
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.017
Hoxa1	homeobox A1	0.017
Smad4	MAD homolog 4 (Drosophila)	0.017
Prf1	perforin 1 (pore forming protein)	0.016
Zfp740	zinc finger protein 740	0.016
Ptch1	patched homolog 1	0.016
Chd2	chromodomain helicase DNA binding protein 2	0.016
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.016
Atg3	autophagy-related 3 (yeast)	0.016
Gp9	glycoprotein 9 (platelet)	0.016
Csnk2a1	casein kinase 2, alpha 1 polypeptide	0.016
Evx1	even skipped homeotic gene 1 homolog	0.015
Atm	ataxia telangiectasia mutated homolog (human)	0.015
Cbfa2t3	core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human)	0.015
Atg10	autophagy-related 10 (yeast)	0.015
Fgr	Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog	0.015
Bmp7	bone morphogenetic protein 7	0.015
Notch1	Notch gene homolog 1 (Drosophila)	0.015
Col2a1	collagen, type II, alpha 1	0.015
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.014
Lhx9	LIM homeobox protein 9	0.014
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.014
Gypa	glycophorin A	0.014
Prg2	proteoglycan 2, bone marrow	0.014
Pitx1	paired-like homeodomain transcription factor 1	0.014
Msx2	homeobox, msh-like 2	0.014	Mouse
Aebp2	AE binding protein 2	0.014
Zic1	zinc finger protein of the cerebellum 1	0.014
Hoxa10	homeobox A10	0.014
Uncx	UNC homeobox	0.014
Tlx3	T-cell leukemia, homeobox 3	0.013
Col9a1	collagen, type IX, alpha 1	0.013
Zic4	zinc finger protein of the cerebellum 4	0.013
Aff4	AF4/FMR2 family, member 4	0.013
Rnf38	ring finger protein 38	0.013
Chd4	chromodomain helicase DNA binding protein 4	0.013
Gata3	GATA binding protein 3	0.013
Ermap	erythroblast membrane-associated protein	0.013
Hoxd13	homeobox D13	0.013
Arx	aristaless related homeobox	0.013
Gtf2ird1	general transcription factor II I repeat domain-containing 1	0.013
Hoxa11	homeobox A11	0.013
Ccnt2	cyclin T2	0.013
Ccng2	cyclin G2	0.013
Zic2	zinc finger protein of the cerebellum 2	0.013
Hoxc5	homeobox C5	0.013
Ptpn6	protein tyrosine phosphatase, non-receptor type 6	0.013
Sykb	spleen tyrosine kinase	0.013
Hbb-y	hemoglobin Y, beta-like embryonic chain	0.013
Nkx2-1	NK2 homeobox 1	0.013
Gpsm3	G-protein signalling modulator 3 (AGS3-like, C. elegans)	0.013
Srsf4	serine/arginine-rich splicing factor 4	0.013
Col22a1	collagen, type XXII, alpha 1	0.013
Trp63	transformation related protein 63	0.013
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.012
Mapk8	mitogen-activated protein kinase 8	0.012
Cd4	CD4 antigen	0.012
Kdm3a	lysine (K)-specific demethylase 3A	0.012
Mab21l2	mab-21-like 2 (C. elegans)	0.012
Prl	prolactin	0.012
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.012
Mpo	myeloperoxidase	0.012
March7	membrane-associated ring finger (C3HC4) 7	0.012
Lmx1b	LIM homeobox transcription factor 1 beta	0.012
P2rx1	purinergic receptor P2X, ligand-gated ion channel, 1	0.012
Apc	adenomatosis polyposis coli	0.012
Pou2f2	POU domain, class 2, transcription factor 2	0.012
Inpp5d	inositol polyphosphate-5-phosphatase D	0.012
Fgf15	fibroblast growth factor 15	0.012
Cxcr2	chemokine (C-X-C motif) receptor 2	0.012
Trim28	tripartite motif-containing 28	0.012
Rara	retinoic acid receptor, alpha	0.012
Brd4	bromodomain containing 4	0.012
Fgfr1	fibroblast growth factor receptor 1	0.012
Il4	interleukin 4	0.011
Robo3	roundabout homolog 3 (Drosophila)	0.011
Sox9	SRY-box containing gene 9	0.011
Brca2	breast cancer 2	0.011
Brd8	bromodomain containing 8	0.011
Rhd	Rh blood group, D antigen	0.011
Cnot4	CCR4-NOT transcription complex, subunit 4	0.011
Pum2	pumilio 2 (Drosophila)	0.011
Numa1	nuclear mitotic apparatus protein 1	0.011
Epc1	enhancer of polycomb homolog 1 (Drosophila)	0.011
Rlf	rearranged L-myc fusion sequence	0.011
Krt14	keratin 14	0.011
Bod1l	biorientation of chromosomes in cell division 1-like	0.011
Card11	caspase recruitment domain family, member 11	0.011
Hbb-bh1	hemoglobin Z, beta-like embryonic chain	0.011
Madcam1	mucosal vascular addressin cell adhesion molecule 1	0.011
Ebf2	early B-cell factor 2	0.011
Lmo2	LIM domain only 2	0.011
Dcx	doublecortin	0.011
Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	0.011
Tet2	tet oncogene family member 2	0.011
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.011
Aplnr	apelin receptor	0.011
Dlx6	distal-less homeobox 6	0.011
Rb1	retinoblastoma 1	0.010
Myog	myogenin	0.010
Epb4.2	erythrocyte protein band 4.2	0.010
Commd6	COMM domain containing 6	0.010
Matn1	matrilin 1, cartilage matrix protein	0.010
Hmga2	high mobility group AT-hook 2	0.010
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.010
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.010
Grid2	glutamate receptor, ionotropic, delta 2	0.010
Mcl1	myeloid cell leukemia sequence 1	0.010
Gli3	GLI-Kruppel family member GLI3	0.010
Phf21a	PHD finger protein 21A	0.010