IMP

Process View

Mus musculus

1 genes annotated in mouse

Multi-species View

negative regulation of heart looping

GO:1901208

Any process that stops, prevents or reduces the frequency, rate or extent of heart looping.

Loading network...

In addition to gene-name show these genes:

Known genes in the process in mouse Include functional analogs

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network

Save Options

Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of heart looping"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of heart looping" (in gray)

Name	Description	Probability	Func Analog Organism
Pitx2	paired-like homeodomain transcription factor 2	0.999
Shh	sonic hedgehog	0.998
Dlx5	distal-less homeobox 5	0.997
Fgfr2	fibroblast growth factor receptor 2	0.993
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.979
Hoxa1	homeobox A1	0.973
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.972
Foxc1	forkhead box C1	0.954
Foxc2	forkhead box C2	0.946
Eya1	eyes absent 1 homolog (Drosophila)	0.928
Pax3	paired box gene 3	0.922
Tcfap2a	transcription factor AP-2, alpha	0.883
Fgf8	fibroblast growth factor 8	0.878
Bmp4	bone morphogenetic protein 4	0.869
Foxg1	forkhead box G1	0.869
Hand2	heart and neural crest derivatives expressed transcript 2	0.865
Pitx1	paired-like homeodomain transcription factor 1	0.854
Jag1	jagged 1	0.850
Pax2	paired box gene 2	0.833
Gli3	GLI-Kruppel family member GLI3	0.774
Prrx2	paired related homeobox 2	0.771
Sox9	SRY-box containing gene 9	0.755
Prrx1	paired related homeobox 1	0.750
Chd7	chromodomain helicase DNA binding protein 7	0.695
Vangl2	vang-like 2 (van gogh, Drosophila)	0.685
Otx2	orthodenticle homolog 2 (Drosophila)	0.631
Chrd	chordin	0.594
Fgf10	fibroblast growth factor 10	0.588
Hand1	heart and neural crest derivatives expressed transcript 1	0.565
Msx1	homeobox, msh-like 1	0.516
Zeb1	zinc finger E-box binding homeobox 1	0.453
Tbx5	T-box 5	0.448	Mouse
Vegfa	vascular endothelial growth factor A	0.428
Tbx1	T-box 1	0.423	Mouse
Rarg	retinoic acid receptor, gamma	0.407
Efnb2	ephrin B2	0.396
Tbx3	T-box 3	0.361	Mouse
Rarb	retinoic acid receptor, beta	0.356
Isl1	ISL1 transcription factor, LIM/homeodomain	0.356
Smo	smoothened homolog (Drosophila)	0.352
Fgfr1	fibroblast growth factor receptor 1	0.336
Tgfb2	transforming growth factor, beta 2	0.322
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.319
Hoxa3	homeobox A3	0.318
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.315
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.283
Gbx2	gastrulation brain homeobox 2	0.272
Gsc	goosecoid homeobox	0.258
Rxra	retinoid X receptor alpha	0.200
Gata4	GATA binding protein 4	0.194
Ednra	endothelin receptor type A	0.190
Sox2	SRY-box containing gene 2	0.178
Fgfr3	fibroblast growth factor receptor 3	0.177
Tbx4	T-box 4	0.169	Mouse
Ntf3	neurotrophin 3	0.164
Hoxa2	homeobox A2	0.161
Lrp6	low density lipoprotein receptor-related protein 6	0.137
Pou5f1	POU domain, class 5, transcription factor 1	0.134
Zic3	zinc finger protein of the cerebellum 3	0.134
Bmp7	bone morphogenetic protein 7	0.129
Gata3	GATA binding protein 3	0.129
Emx2	empty spiracles homolog 2 (Drosophila)	0.125
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.121
Sall4	sal-like 4 (Drosophila)	0.117
Runx2	runt related transcription factor 2	0.116
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.111
Msx2	homeobox, msh-like 2	0.108
Lmx1a	LIM homeobox transcription factor 1 alpha	0.107
Pax9	paired box gene 9	0.105
Alx1	ALX homeobox 1	0.104
Wnt3a	wingless-related MMTV integration site 3A	0.104
Tcf21	transcription factor 21	0.097
Wt1	Wilms tumor 1 homolog	0.082
Ece1	endothelin converting enzyme 1	0.082
Lef1	lymphoid enhancer binding factor 1	0.079
Hoxb3	homeobox B3	0.079
Gli2	GLI-Kruppel family member GLI2	0.078
Nodal	nodal	0.075
Bmp5	bone morphogenetic protein 5	0.075
Hoxa13	homeobox A13	0.074
Nog	noggin	0.067
Sox11	SRY-box containing gene 11	0.062
Hmx3	H6 homeobox 3	0.061
Gata6	GATA binding protein 6	0.060
Mesp1	mesoderm posterior 1	0.057
Smad6	MAD homolog 6 (Drosophila)	0.057
Meox2	mesenchyme homeobox 2	0.057
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.053
Trp63	transformation related protein 63	0.051
Pbx1	pre B-cell leukemia transcription factor 1	0.051
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.050
Ighmbp2	immunoglobulin mu binding protein 2	0.050
Hoxd3	homeobox D3	0.050
Bdnf	brain derived neurotrophic factor	0.049
Gja5	gap junction protein, alpha 5	0.049
Wnt5a	wingless-related MMTV integration site 5A	0.048
Twist2	twist homolog 2 (Drosophila)	0.048
Acvr1	activin A receptor, type 1	0.047
Egfr	epidermal growth factor receptor	0.046
Myf5	myogenic factor 5	0.044
Mecom	MDS1 and EVI1 complex locus	0.041
Otx1	orthodenticle homolog 1 (Drosophila)	0.041
Nkx3-2	NK3 homeobox 2	0.041
Scn5a	sodium channel, voltage-gated, type V, alpha	0.040
Mn1	meningioma 1	0.040
Gata5	GATA binding protein 5	0.040
Dlx2	distal-less homeobox 2	0.039
Rara	retinoic acid receptor, alpha	0.038
Myl2	myosin, light polypeptide 2, regulatory, cardiac, slow	0.036
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.036
Dll4	delta-like 4 (Drosophila)	0.035
Fgf3	fibroblast growth factor 3	0.035
Pou4f3	POU domain, class 4, transcription factor 3	0.035
Alx4	aristaless-like homeobox 4	0.033
Pax6	paired box gene 6	0.032
Lrp5	low density lipoprotein receptor-related protein 5	0.031
Hoxd1	homeobox D1	0.030
Irx3	Iroquois related homeobox 3 (Drosophila)	0.030
Hoxd11	homeobox D11	0.030
Zfpm2	zinc finger protein, multitype 2	0.029
Notch1	Notch gene homolog 1 (Drosophila)	0.029
Shox2	short stature homeobox 2	0.028
Hoxb4	homeobox B4	0.027
Col13a1	collagen, type XIII, alpha 1	0.027
Foxh1	forkhead box H1	0.027
Foxf1a	forkhead box F1a	0.026
Hoxa10	homeobox A10	0.026
Tgfbr2	transforming growth factor, beta receptor II	0.026
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.025
Hoxd9	homeobox D9	0.025
Prdm6	PR domain containing 6	0.024
Ret	ret proto-oncogene	0.024
Vstm2b	V-set and transmembrane domain containing 2B	0.023
Foxi3	forkhead box I3	0.023
Ptk7	PTK7 protein tyrosine kinase 7	0.023
Hoxb1	homeobox B1	0.023
Mks1	Meckel syndrome, type 1	0.022
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.022
Ptch1	patched homolog 1	0.022
Myf6	myogenic factor 6	0.021
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.021
Nf1	neurofibromatosis 1	0.021
En1	engrailed 1	0.020
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.020
Nos3	nitric oxide synthase 3, endothelial cell	0.020
Ctnnb1	catenin (cadherin associated protein), beta 1	0.020
Hoxb2	homeobox B2	0.020
Hoxa11	homeobox A11	0.020
Pax1	paired box gene 1	0.019
Psen1	presenilin 1	0.019
Bmp2	bone morphogenetic protein 2	0.019
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.019
Notch2	Notch gene homolog 2 (Drosophila)	0.019
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
Sox4	SRY-box containing gene 4	0.018
Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	0.018
Gdnf	glial cell line derived neurotrophic factor	0.017
Hoxd13	homeobox D13	0.017
Tbx20	T-box 20	0.017	Mouse
Noto	notochord homolog (Xenopus laevis)	0.017
Rdh10	retinol dehydrogenase 10 (all-trans)	0.016
Lhx1	LIM homeobox protein 1	0.016
Foxa2	forkhead box A2	0.016
Gata2	GATA binding protein 2	0.016
Nanog	Nanog homeobox	0.016
Cxadr	coxsackie virus and adenovirus receptor	0.016
Alx3	aristaless-like homeobox 3	0.016
Dll1	delta-like 1 (Drosophila)	0.016
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.016
Bnc1	basonuclin 1	0.016
Fgfrl1	fibroblast growth factor receptor-like 1	0.016
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.015
Dlx6	distal-less homeobox 6	0.015
Myl3	myosin, light polypeptide 3	0.015
Sall1	sal-like 1 (Drosophila)	0.015
Kcne1	potassium voltage-gated channel, Isk-related subfamily, member 1	0.015
Foxi1	forkhead box I1	0.015
Ripply3	ripply3 homolog (zebrafish)	0.015
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.014
Edar	ectodysplasin-A receptor	0.014
Wnt1	wingless-related MMTV integration site 1	0.014
Foxa1	forkhead box A1	0.014
Foxf2	forkhead box F2	0.014
Pcdh12	protocadherin 12	0.014
Col4a3	collagen, type IV, alpha 3	0.014
Tlx3	T-cell leukemia, homeobox 3	0.014
Hoxa4	homeobox A4	0.014
Col2a1	collagen, type II, alpha 1	0.014
Actc1	actin, alpha, cardiac muscle 1	0.014
Lmx1b	LIM homeobox transcription factor 1 beta	0.013
Hoxb6	homeobox B6	0.013
Hmx2	H6 homeobox 2	0.013
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.013
She	src homology 2 domain-containing transforming protein E	0.013
Plin4	perilipin 4	0.013
Hmga2	high mobility group AT-hook 2	0.013
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.013
Irx5	Iroquois related homeobox 5 (Drosophila)	0.013
Pax7	paired box gene 7	0.013
Tnnt3	troponin T3, skeletal, fast	0.013
Gpc3	glypican 3	0.013
Cd27	CD27 antigen	0.012
Apc	adenomatosis polyposis coli	0.012
Zbtb16	zinc finger and BTB domain containing 16	0.012
Hrc	histidine rich calcium binding protein	0.012
Axin2	axin2	0.012
Gja1	gap junction protein, alpha 1	0.012
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.012
Zfp503	zinc finger protein 503	0.012
Hoxb5	homeobox B5	0.012
Snai1	snail homolog 1 (Drosophila)	0.012
Plac1	placental specific protein 1	0.012
Wnt11	wingless-related MMTV integration site 11	0.012
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.012
Lrp2	low density lipoprotein receptor-related protein 2	0.012
Gpr182	G protein-coupled receptor 182	0.012
Xirp1	xin actin-binding repeat containing 1	0.012
T	brachyury	0.012	Mouse
Hes1	hairy and enhancer of split 1 (Drosophila)	0.012
Klf3	Kruppel-like factor 3 (basic)	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Fzd6	frizzled homolog 6 (Drosophila)	0.012
Hoxa5	homeobox A5	0.011
Msc	musculin	0.011
Cox4i2	cytochrome c oxidase subunit IV isoform 2	0.011
Sim2	single-minded homolog 2 (Drosophila)	0.011
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.011
Ltbp1	latent transforming growth factor beta binding protein 1	0.011
Acvr2b	activin receptor IIB	0.011
Sox7	SRY-box containing gene 7	0.011
Hoxc6	homeobox C6	0.011
Hesx1	homeobox gene expressed in ES cells	0.011
Bmper	BMP-binding endothelial regulator	0.011
Slc27a3	solute carrier family 27 (fatty acid transporter), member 3	0.011
Efna1	ephrin A1	0.011
Efna2	ephrin A2	0.011
Fgf15	fibroblast growth factor 15	0.011
Tead1	TEA domain family member 1	0.011
Myh7	myosin, heavy polypeptide 7, cardiac muscle, beta	0.011
Hoxa9	homeobox A9	0.011
Tbx15	T-box 15	0.011	Mouse
Osr1	odd-skipped related 1 (Drosophila)	0.011
Bcl6	B-cell leukemia/lymphoma 6	0.010
Atoh8	atonal homolog 8 (Drosophila)	0.010
Ybx2	Y box protein 2	0.010
BC020535	cDNA sequence BC020535	0.010
Uncx	UNC homeobox	0.010
Hoxd10	homeobox D10	0.010
Myh6	myosin, heavy polypeptide 6, cardiac muscle, alpha	0.010
Hoxc8	homeobox C8	0.010
Asb12	ankyrin repeat and SOCS box-containing 12	0.010
Ky	kyphoscoliosis peptidase	0.010
Asb10	ankyrin repeat and SOCS box-containing 10	0.010
Efnb1	ephrin B1	0.010