IMP

Process View

Mus musculus

9 genes annotated in mouse

Multi-species View

negative regulation of dendrite development

GO:2000171

Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of dendrite development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of dendrite development" (in gray)

Name	Description	Probability	Func Analog Organism
Ctnnb1	catenin (cadherin associated protein), beta 1	1.000
Ephb2	Eph receptor B2	0.999
Efnb2	ephrin B2	0.984	Mouse
Epha4	Eph receptor A4	0.930
Gli3	GLI-Kruppel family member GLI3	0.915
Sez6l	seizure related 6 homolog like	0.878	Mouse
Trp53	transformation related protein 53	0.735
Fgfr2	fibroblast growth factor receptor 2	0.695
Foxc1	forkhead box C1	0.619
Jag1	jagged 1	0.597
Psen1	presenilin 1	0.438
Dock1	dedicator of cytokinesis 1	0.418
Ephb3	Eph receptor B3	0.393
Apc	adenomatosis polyposis coli	0.392
Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	0.391
Kras	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	0.381
Grin1	glutamate receptor, ionotropic, NMDA1 (zeta 1)	0.311
Notch1	Notch gene homolog 1 (Drosophila)	0.306
Emx1	empty spiracles homolog 1 (Drosophila)	0.304
Pax2	paired box gene 2	0.291
Shh	sonic hedgehog	0.274
Ntf3	neurotrophin 3	0.271
Sox2	SRY-box containing gene 2	0.266
Foxg1	forkhead box G1	0.252
Chd7	chromodomain helicase DNA binding protein 7	0.209
Hes1	hairy and enhancer of split 1 (Drosophila)	0.204
Nos1	nitric oxide synthase 1, neuronal	0.184
Fmr1	fragile X mental retardation syndrome 1 homolog	0.182	Fly
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.163
Adam19	a disintegrin and metallopeptidase domain 19 (meltrin beta)	0.145
Rb1	retinoblastoma 1	0.145
Chrd	chordin	0.144
Npc1	Niemann Pick type C1	0.143
Sox11	SRY-box containing gene 11	0.139
Grip1	glutamate receptor interacting protein 1	0.137
Zeb1	zinc finger E-box binding homeobox 1	0.123
Nf1	neurofibromatosis 1	0.122
Arid4b	AT rich interactive domain 4B (RBP1-like)	0.111
Cbln1	cerebellin 1 precursor protein	0.109
Tead3	TEA domain family member 3	0.096
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.095
Shank3	SH3/ankyrin domain gene 3	0.090
Sez6	seizure related gene 6	0.090
Fgf8	fibroblast growth factor 8	0.089
Sox9	SRY-box containing gene 9	0.081
Hif1a	hypoxia inducible factor 1, alpha subunit	0.081
Lrp6	low density lipoprotein receptor-related protein 6	0.080
Lepr	leptin receptor	0.079
Lrrk2	leucine-rich repeat kinase 2	0.076
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.073
Pax6	paired box gene 6	0.072
Bdnf	brain derived neurotrophic factor	0.070
Zfpm2	zinc finger protein, multitype 2	0.069
Dll1	delta-like 1 (Drosophila)	0.067
Braf	Braf transforming gene	0.066
Dlx1	distal-less homeobox 1	0.065
Lhx5	LIM homeobox protein 5	0.065
Eya1	eyes absent 1 homolog (Drosophila)	0.062
Tbx3	T-box 3	0.061
Otx2	orthodenticle homolog 2 (Drosophila)	0.061
Hoxa1	homeobox A1	0.061
Dcc	deleted in colorectal carcinoma	0.058
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.057
Pbx1	pre B-cell leukemia transcription factor 1	0.056
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.056
Lhx1	LIM homeobox protein 1	0.055
Efna4	ephrin A4	0.054
Meis2	Meis homeobox 2	0.052
Ina	internexin neuronal intermediate filament protein, alpha	0.052
Efna2	ephrin A2	0.050	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.049
Sez6l2	seizure related 6 homolog like 2	0.049	Mouse
Tbx1	T-box 1	0.048
Pard3	par-3 (partitioning defective 3) homolog (C. elegans)	0.045
Fxr1	fragile X mental retardation gene 1, autosomal homolog	0.045	Fly
Ret	ret proto-oncogene	0.044
Neurod1	neurogenic differentiation 1	0.044
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.043
Isl1	ISL1 transcription factor, LIM/homeodomain	0.042
Hes5	hairy and enhancer of split 5 (Drosophila)	0.042
Dlx2	distal-less homeobox 2	0.042
Krt14	keratin 14	0.041
Wnt7b	wingless-related MMTV integration site 7B	0.039
Cdkn1a	cyclin-dependent kinase inhibitor 1A (P21)	0.039
Emx2	empty spiracles homolog 2 (Drosophila)	0.039
Foxc2	forkhead box C2	0.039
Cux2	cut-like homeobox 2	0.038
Notch2	Notch gene homolog 2 (Drosophila)	0.038
Tcfap2c	transcription factor AP-2, gamma	0.038
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.036
Tead1	TEA domain family member 1	0.035
Dlx5	distal-less homeobox 5	0.034
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.033
Foxo1	forkhead box O1	0.033
Pax3	paired box gene 3	0.030
Tcfap2a	transcription factor AP-2, alpha	0.029
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.028
Pou3f3	POU domain, class 3, transcription factor 3	0.028
Cxcr4	chemokine (C-X-C motif) receptor 4	0.028
Ikzf1	IKAROS family zinc finger 1	0.027
Phlda2	pleckstrin homology-like domain, family A, member 2	0.026
Celf4	CUGBP, Elav-like family member 4	0.026
Ctnna1	catenin (cadherin associated protein), alpha 1	0.026
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.024
Plxna3	plexin A3	0.023
C77080	expressed sequence C77080	0.023
Syt5	synaptotagmin V	0.023
Cntrob	centrobin, centrosomal BRCA2 interacting protein	0.023
Unc5c	unc-5 homolog C (C. elegans)	0.022
Col2a1	collagen, type II, alpha 1	0.022
Phox2a	paired-like homeobox 2a	0.022
Cdc42	cell division cycle 42 homolog (S. cerevisiae)	0.022
Insm1	insulinoma-associated 1	0.022
L1cam	L1 cell adhesion molecule	0.022
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.021
Lef1	lymphoid enhancer binding factor 1	0.021
Fgf10	fibroblast growth factor 10	0.021
Pparg	peroxisome proliferator activated receptor gamma	0.021
Elavl4	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)	0.021
Cntn1	contactin 1	0.021
Foxn1	forkhead box N1	0.020
Bcl2	B-cell leukemia/lymphoma 2	0.020
Efnb1	ephrin B1	0.020	Mouse
Msx2	homeobox, msh-like 2	0.020
C77370	expressed sequence C77370	0.020
Ctnnd2	catenin (cadherin associated protein), delta 2	0.020
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.020
Lhx9	LIM homeobox protein 9	0.020
Mycl1	v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian)	0.020
Foxa2	forkhead box A2	0.020
Far1	fatty acyl CoA reductase 1	0.019
Ptch1	patched homolog 1	0.019
Pclo	piccolo (presynaptic cytomatrix protein)	0.019
Nog	noggin	0.019
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.019
Adam11	a disintegrin and metallopeptidase domain 11	0.019
Nfia	nuclear factor I/A	0.018
Uncx	UNC homeobox	0.018
Fgf9	fibroblast growth factor 9	0.018
Vhl	von Hippel-Lindau tumor suppressor	0.018
Epha5	Eph receptor A5	0.018
Hmga2	high mobility group AT-hook 2	0.018
Adam17	a disintegrin and metallopeptidase domain 17	0.018
Bai1	brain-specific angiogenesis inhibitor 1	0.018
Kalrn	kalirin, RhoGEF kinase	0.018
Nos3	nitric oxide synthase 3, endothelial cell	0.018
Smad6	MAD homolog 6 (Drosophila)	0.018
Kcnk2	potassium channel, subfamily K, member 2	0.017
Epha7	Eph receptor A7	0.017
Tgfb2	transforming growth factor, beta 2	0.017
Kif2a	kinesin family member 2A	0.017
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.017
Prox1	prospero-related homeobox 1	0.017
St8sia2	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2	0.017
Gata3	GATA binding protein 3	0.017
Plxna2	plexin A2	0.016
Fgfr3	fibroblast growth factor receptor 3	0.016
Odz4	odd Oz/ten-m homolog 4 (Drosophila)	0.016
Irx3	Iroquois related homeobox 3 (Drosophila)	0.016
Cenpc1	centromere protein C1	0.016
Zic1	zinc finger protein of the cerebellum 1	0.016
Epha2	Eph receptor A2	0.016
Foxd2	forkhead box D2	0.016
Lgr5	leucine rich repeat containing G protein coupled receptor 5	0.016
Otx1	orthodenticle homolog 1 (Drosophila)	0.016
Il1r1	interleukin 1 receptor, type I	0.016
Fbn2	fibrillin 2	0.016
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.015
Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	0.015
Src	Rous sarcoma oncogene	0.015
Cacng2	calcium channel, voltage-dependent, gamma subunit 2	0.015
Syt7	synaptotagmin VII	0.015
Efna3	ephrin A3	0.015	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.015
Msx1	homeobox, msh-like 1	0.015
Hapln1	hyaluronan and proteoglycan link protein 1	0.015
Gpr162	G protein-coupled receptor 162	0.015
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.015
Arid4a	AT rich interactive domain 4A (RBP1-like)	0.015
Eif2c2	eukaryotic translation initiation factor 2C, 2	0.015
Rgs4	regulator of G-protein signaling 4	0.015
Neurod2	neurogenic differentiation 2	0.014
Hcn1	hyperpolarization-activated, cyclic nucleotide-gated K+ 1	0.014
Trpc5	transient receptor potential cation channel, subfamily C, member 5	0.014
Nlgn3	neuroligin 3	0.014
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.014
Tbx10	T-box 10	0.014
Odz2	odd Oz/ten-m homolog 2 (Drosophila)	0.014
Magel2	melanoma antigen, family L, 2	0.014
Foxq1	forkhead box Q1	0.014
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.013
Gdf11	growth differentiation factor 11	0.013
Dll3	delta-like 3 (Drosophila)	0.013
Rcan1	regulator of calcineurin 1	0.013
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.013
Lrp5	low density lipoprotein receptor-related protein 5	0.013
Kit	kit oncogene	0.013
Cxadr	coxsackie virus and adenovirus receptor	0.013
Mark1	MAP/microtubule affinity-regulating kinase 1	0.013
Ikzf4	IKAROS family zinc finger 4	0.013
Irx5	Iroquois related homeobox 5 (Drosophila)	0.013
Efna1	ephrin A1	0.013
Slc26a4	solute carrier family 26, member 4	0.013
Prkg2	protein kinase, cGMP-dependent, type II	0.013
Igf2	insulin-like growth factor 2	0.013
Egfr	epidermal growth factor receptor	0.013
Gbx2	gastrulation brain homeobox 2	0.013
Rims2	regulating synaptic membrane exocytosis 2	0.013
Wiz	widely-interspaced zinc finger motifs	0.012
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.012
Rprm	reprimo, TP53 dependent G2 arrest mediator candidate	0.012
Pou3f1	POU domain, class 3, transcription factor 1	0.012
Hmx1	H6 homeobox 1	0.012
Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	0.012
Tcfap2b	transcription factor AP-2 beta	0.012
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
Zic4	zinc finger protein of the cerebellum 4	0.012
Slc4a1	solute carrier family 4 (anion exchanger), member 1	0.012
Sh3rf1	SH3 domain containing ring finger 1	0.012
Hmx3	H6 homeobox 3	0.012
Pten	phosphatase and tensin homolog	0.012
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.012
Tox3	TOX high mobility group box family member 3	0.012
Bmpr1a	bone morphogenetic protein receptor, type 1A	0.012
Bmp7	bone morphogenetic protein 7	0.012
Efs	embryonal Fyn-associated substrate	0.012
Mgat3	mannoside acetylglucosaminyltransferase 3	0.012
Atoh7	atonal homolog 7 (Drosophila)	0.011
Sall3	sal-like 3 (Drosophila)	0.011
Tcte1	t-complex-associated testis expressed 1	0.011
Pou3f4	POU domain, class 3, transcription factor 4	0.011
Vegfa	vascular endothelial growth factor A	0.011
Syt1	synaptotagmin I	0.011
Tcf7l2	transcription factor 7-like 2, T-cell specific, HMG-box	0.011
Lhx6	LIM homeobox protein 6	0.011
Rtkn	rhotekin	0.011
Mmp15	matrix metallopeptidase 15	0.011
Mmp17	matrix metallopeptidase 17	0.011
Fgf3	fibroblast growth factor 3	0.011
Egr1	early growth response 1	0.011
Rarb	retinoic acid receptor, beta	0.011
Cnih2	cornichon homolog 2 (Drosophila)	0.011
Ddx6	DEAD (Asp-Glu-Ala-Asp) box polypeptide 6	0.011
Cdh3	cadherin 3	0.010
Auts2	autism susceptibility candidate 2	0.010
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.010
Kif1a	kinesin family member 1A	0.010
Htr5b	5-hydroxytryptamine (serotonin) receptor 5B	0.010
Epb4.1l4b	erythrocyte protein band 4.1-like 4b	0.010
Rxra	retinoid X receptor alpha	0.010
Grik2	glutamate receptor, ionotropic, kainate 2 (beta 2)	0.010
Ntrk3	neurotrophic tyrosine kinase, receptor, type 3	0.010
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.010
Fas	Fas (TNF receptor superfamily member 6)	0.010
Ptpn13	protein tyrosine phosphatase, non-receptor type 13	0.010
Sept3	septin 3	0.010
Sema5a	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	0.010