IMP

Process View

Mus musculus

17 genes annotated in mouse

preganglionic parasympathetic nervous system development

The process whose specific outcome is the progression of the preganglionic portion of the parasympathetic nervous system over time, from its formation to the mature structure. The parasympathetic nervous system is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "preganglionic parasympathetic nervous system development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "preganglionic parasympathetic nervous system development" (in gray)

Name	Description	Probability	Func Analog Organism
Eya1	eyes absent 1 homolog (Drosophila)	0.999
Otx2	orthodenticle homolog 2 (Drosophila)	0.999
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.996
Tcfap2a	transcription factor AP-2, alpha	0.995
Shh	sonic hedgehog	0.995
Gli3	GLI-Kruppel family member GLI3	0.982
Fgfr2	fibroblast growth factor receptor 2	0.968
Hoxa2	homeobox A2	0.962	Mouse
Foxg1	forkhead box G1	0.956
Msx1	homeobox, msh-like 1	0.919
Pax3	paired box gene 3	0.915
Dlx5	distal-less homeobox 5	0.900
Hoxa1	homeobox A1	0.890
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.870	Mouse
Bdnf	brain derived neurotrophic factor	0.867
Ednra	endothelin receptor type A	0.849
Isl1	ISL1 transcription factor, LIM/homeodomain	0.822
Pitx1	paired-like homeodomain transcription factor 1	0.810
Prrx1	paired related homeobox 1	0.806	Mouse
Tbx1	T-box 1	0.794
Erbb2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	0.760
Nog	noggin	0.748
Hand1	heart and neural crest derivatives expressed transcript 1	0.726
Fgf10	fibroblast growth factor 10	0.681
Sox2	SRY-box containing gene 2	0.680
Fgf8	fibroblast growth factor 8	0.672
Chrd	chordin	0.649
Sema6a	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A	0.627	Mouse
Msx2	homeobox, msh-like 2	0.603
Rarg	retinoic acid receptor, gamma	0.599
Bmp7	bone morphogenetic protein 7	0.587
Pitx2	paired-like homeodomain transcription factor 2	0.585
Pax6	paired box gene 6	0.563
Gbx2	gastrulation brain homeobox 2	0.552
Pax2	paired box gene 2	0.527
Hand2	heart and neural crest derivatives expressed transcript 2	0.513
Foxc1	forkhead box C1	0.483
Hoxd3	homeobox D3	0.479
Hoxb1	homeobox B1	0.470
Ret	ret proto-oncogene	0.463
Pbx1	pre B-cell leukemia transcription factor 1	0.462
Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	0.435
Fgfr1	fibroblast growth factor receptor 1	0.429
Nab2	Ngfi-A binding protein 2	0.397
Ntf3	neurotrophin 3	0.372
Emx2	empty spiracles homolog 2 (Drosophila)	0.311
Gdnf	glial cell line derived neurotrophic factor	0.305
Bmp4	bone morphogenetic protein 4	0.302
En1	engrailed 1	0.300
Arhgef11	Rho guanine nucleotide exchange factor (GEF) 11	0.294
Plxna1	plexin A1	0.265	Mouse
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.249
Phox2b	paired-like homeobox 2b	0.248	Mouse
Hmx3	H6 homeobox 3	0.248
Chd7	chromodomain helicase DNA binding protein 7	0.248
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.233
Hes5	hairy and enhancer of split 5 (Drosophila)	0.225	Mouse
Otx1	orthodenticle homolog 1 (Drosophila)	0.221
Bcl2	B-cell leukemia/lymphoma 2	0.210
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.206
Foxc2	forkhead box C2	0.205
Tlx3	T-cell leukemia, homeobox 3	0.204
Lmx1a	LIM homeobox transcription factor 1 alpha	0.188
Hes1	hairy and enhancer of split 1 (Drosophila)	0.186
Ptch1	patched homolog 1	0.183
Hoxb4	homeobox B4	0.170
Dll4	delta-like 4 (Drosophila)	0.157
Gsc	goosecoid homeobox	0.148
Hoxa13	homeobox A13	0.141
Alx1	ALX homeobox 1	0.138
Gfra2	glial cell line derived neurotrophic factor family receptor alpha 2	0.137
Htt	huntingtin	0.136
Hoxa3	homeobox A3	0.136
Lef1	lymphoid enhancer binding factor 1	0.133
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.129
Hoxb3	homeobox B3	0.123
Alx4	aristaless-like homeobox 4	0.123
Lhx3	LIM homeobox protein 3	0.118
Epha4	Eph receptor A4	0.116
Grb10	growth factor receptor bound protein 10	0.116
Vegfa	vascular endothelial growth factor A	0.113
Dlg4	discs, large homolog 4 (Drosophila)	0.106
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.104
Sox11	SRY-box containing gene 11	0.104
Hmx2	H6 homeobox 2	0.104
Sox9	SRY-box containing gene 9	0.101
Lama5	laminin, alpha 5	0.101
Fzd1	frizzled homolog 1 (Drosophila)	0.097
Emx1	empty spiracles homolog 1 (Drosophila)	0.097
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.095
Lhx9	LIM homeobox protein 9	0.094
Hoxb2	homeobox B2	0.093
Lrp6	low density lipoprotein receptor-related protein 6	0.092
Zeb1	zinc finger E-box binding homeobox 1	0.092
Ltbp1	latent transforming growth factor beta binding protein 1	0.088
Cdon	cell adhesion molecule-related/down-regulated by oncogenes	0.086
Tbx3	T-box 3	0.085	Mouse
Fgf3	fibroblast growth factor 3	0.084
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.084
Ngfr	nerve growth factor receptor (TNFR superfamily, member 16)	0.081
Rax	retina and anterior neural fold homeobox	0.080
Cachd1	cache domain containing 1	0.080
Tbx2	T-box 2	0.079	Mouse
Jag1	jagged 1	0.079
Runx2	runt related transcription factor 2	0.076
Nrp1	neuropilin 1	0.073
Zic2	zinc finger protein of the cerebellum 2	0.073
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.072
Egr2	early growth response 2	0.069
Vangl2	vang-like 2 (van gogh, Drosophila)	0.069
Hcn4	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	0.063
Fgfr3	fibroblast growth factor receptor 3	0.063
Cacng7	calcium channel, voltage-dependent, gamma subunit 7	0.062
Wnt1	wingless-related MMTV integration site 1	0.062
Hoxa11	homeobox A11	0.062
Gfra3	glial cell line derived neurotrophic factor family receptor alpha 3	0.061
Nynrin	NYN domain and retroviral integrase containing	0.061
Wnt5a	wingless-related MMTV integration site 5A	0.061
Alx3	aristaless-like homeobox 3	0.060
Sall4	sal-like 4 (Drosophila)	0.057
Efna2	ephrin A2	0.057
Smo	smoothened homolog (Drosophila)	0.057	Rat
Shox2	short stature homeobox 2	0.057
Notch3	Notch gene homolog 3 (Drosophila)	0.056
Hoxd13	homeobox D13	0.056
Lhx1	LIM homeobox protein 1	0.056
Igf2bp1	insulin-like growth factor 2 mRNA binding protein 1	0.056
Cxadr	coxsackie virus and adenovirus receptor	0.055
Gli2	GLI-Kruppel family member GLI2	0.055
Bmp5	bone morphogenetic protein 5	0.053
Pou5f1	POU domain, class 5, transcription factor 1	0.052
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.050
Nanog	Nanog homeobox	0.049
Bnc1	basonuclin 1	0.049
Msi1	Musashi homolog 1(Drosophila)	0.048
Sdc3	syndecan 3	0.048
Hmx1	H6 homeobox 1	0.048
Hoxd1	homeobox D1	0.047	Mouse
Irx3	Iroquois related homeobox 3 (Drosophila)	0.046
Zic1	zinc finger protein of the cerebellum 1	0.046
Hoxd11	homeobox D11	0.046
Ebf3	early B-cell factor 3	0.044
Pou4f2	POU domain, class 4, transcription factor 2	0.044
Fscn1	fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus)	0.043
Col4a3	collagen, type IV, alpha 3	0.043
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.042
Notch1	Notch gene homolog 1 (Drosophila)	0.042
Lbx1	ladybird homeobox homolog 1 (Drosophila)	0.041
Trp63	transformation related protein 63	0.041
Zfhx4	zinc finger homeodomain 4	0.040
Prrx2	paired related homeobox 2	0.040	Mouse
Smad3	MAD homolog 3 (Drosophila)	0.040
Foxd1	forkhead box D1	0.039
Efna4	ephrin A4	0.039
Dach1	dachshund 1 (Drosophila)	0.039
Nrg1	neuregulin 1	0.038
Bmp2	bone morphogenetic protein 2	0.036
Fzd8	frizzled homolog 8 (Drosophila)	0.036
Foxd2	forkhead box D2	0.035
Nrtn	neurturin	0.035
Dlx1	distal-less homeobox 1	0.035
Spry4	sprouty homolog 4 (Drosophila)	0.034
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.034	Mouse
Neurog2	neurogenin 2	0.033
Rybp	RING1 and YY1 binding protein	0.033
Gata3	GATA binding protein 3	0.033
Hoxb6	homeobox B6	0.032
Gria4	glutamate receptor, ionotropic, AMPA4 (alpha 4)	0.032
Efs	embryonal Fyn-associated substrate	0.032
Apc	adenomatosis polyposis coli	0.032
Mab21l2	mab-21-like 2 (C. elegans)	0.032
Ptpn14	protein tyrosine phosphatase, non-receptor type 14	0.031
Gja5	gap junction protein, alpha 5	0.031
Tgfb2	transforming growth factor, beta 2	0.031
Tead3	TEA domain family member 3	0.030
Nrp2	neuropilin 2	0.030
Nhlh1	nescient helix loop helix 1	0.030
Itga3	integrin alpha 3	0.030
Fgf15	fibroblast growth factor 15	0.030
Osr1	odd-skipped related 1 (Drosophila)	0.030
Maf	avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog	0.030
Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	0.029
Tcfap2b	transcription factor AP-2 beta	0.028	Mouse
Lhx5	LIM homeobox protein 5	0.028
Wt1	Wilms tumor 1 homolog	0.028	Mouse
Hoxd9	homeobox D9	0.027
Wnt6	wingless-related MMTV integration site 6	0.027
Tspan9	tetraspanin 9	0.027
Etl4	enhancer trap locus 4	0.027
Smad6	MAD homolog 6 (Drosophila)	0.027
Bcl6b	B-cell CLL/lymphoma 6, member B	0.027
Rarb	retinoic acid receptor, beta	0.026
Arhgef12	Rho guanine nucleotide exchange factor (GEF) 12	0.026
Tbx6	T-box 6	0.025	Mouse
Neurog1	neurogenin 1	0.025
Ptgs2	prostaglandin-endoperoxide synthase 2	0.024
Mgat3	mannoside acetylglucosaminyltransferase 3	0.024
Smad5	MAD homolog 5 (Drosophila)	0.024
Dlx2	distal-less homeobox 2	0.024
Sox10	SRY-box containing gene 10	0.024
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.023
Neurod1	neurogenic differentiation 1	0.023
Flt1	FMS-like tyrosine kinase 1	0.023
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.023
Hesx1	homeobox gene expressed in ES cells	0.022
Hoxa4	homeobox A4	0.021
Pcdh18	protocadherin 18	0.021
Eda	ectodysplasin-A	0.021
Hoxb13	homeobox B13	0.021
Myo1e	myosin IE	0.021
Pax9	paired box gene 9	0.021
Sema3c	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C	0.021	Mouse
Tlx2	T-cell leukemia, homeobox 2	0.021
Gpr27	G protein-coupled receptor 27	0.020
Erbb4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	0.020
Prox1	prospero-related homeobox 1	0.020
Jag2	jagged 2	0.020
Gpc3	glypican 3	0.020
Fign	fidgetin	0.020
Sim2	single-minded homolog 2 (Drosophila)	0.019
Neurod4	neurogenic differentiation 4	0.019
Uncx	UNC homeobox	0.019
Klf3	Kruppel-like factor 3 (basic)	0.019
Fgf18	fibroblast growth factor 18	0.019
Irx4	Iroquois related homeobox 4 (Drosophila)	0.019
Pou3f3	POU domain, class 3, transcription factor 3	0.019
Tcf21	transcription factor 21	0.019
Ptf1a	pancreas specific transcription factor, 1a	0.018
Fgf17	fibroblast growth factor 17	0.018
Scn5a	sodium channel, voltage-gated, type V, alpha	0.018
Gata5	GATA binding protein 5	0.018
Nfatc4	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	0.018
Sall1	sal-like 1 (Drosophila)	0.018
Dlx6	distal-less homeobox 6	0.018
Pou3f4	POU domain, class 3, transcription factor 4	0.018
Itm2c	integral membrane protein 2C	0.018
Irx5	Iroquois related homeobox 5 (Drosophila)	0.018
Hapln1	hyaluronan and proteoglycan link protein 1	0.018
Epha3	Eph receptor A3	0.018
Cdk5r1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	0.017
Artn	artemin	0.017
Col9a1	collagen, type IX, alpha 1	0.017
Hoxc8	homeobox C8	0.017
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.017
Plxna3	plexin A3	0.017
Hoxc4	homeobox C4	0.017
Ighmbp2	immunoglobulin mu binding protein 2	0.017
Zic3	zinc finger protein of the cerebellum 3	0.017
Aif1l	allograft inflammatory factor 1-like	0.017
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.016
Tulp1	tubby like protein 1	0.016
Hs3st3b1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1	0.016
Tpbg	trophoblast glycoprotein	0.016
Pou4f3	POU domain, class 4, transcription factor 3	0.016
Zfp503	zinc finger protein 503	0.016
Sh3rf1	SH3 domain containing ring finger 1	0.016
Nf1	neurofibromatosis 1	0.016
Phox2a	paired-like homeobox 2a	0.015
Dmrt3	doublesex and mab-3 related transcription factor 3	0.015
Eya4	eyes absent 4 homolog (Drosophila)	0.015
Vsx2	visual system homeobox 2	0.015
Sox3	SRY-box containing gene 3	0.015
Fzd2	frizzled homolog 2 (Drosophila)	0.015
Evx2	even skipped homeotic gene 2 homolog	0.015
Nckap5l	NCK-associated protein 5-like	0.014
Mmp15	matrix metallopeptidase 15	0.014
Matn4	matrilin 4	0.014
Bhlhe23	basic helix-loop-helix family, member e23	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Ctf1	cardiotrophin 1	0.014
Fzd6	frizzled homolog 6 (Drosophila)	0.014
Capn6	calpain 6	0.014
Hip1	huntingtin interacting protein 1	0.014
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.014
Hoxb8	homeobox B8	0.014
Myf5	myogenic factor 5	0.014
Rnf2	ring finger protein 2	0.014
Acvr2b	activin receptor IIB	0.013
Bcl2l11	BCL2-like 11 (apoptosis facilitator)	0.013
Myog	myogenin	0.013
En2	engrailed 2	0.013
Cbx2	chromobox homolog 2 (Drosophila Pc class)	0.013
Ptk7	PTK7 protein tyrosine kinase 7	0.013
Col17a1	collagen, type XVII, alpha 1	0.013
Gjd2	gap junction protein, delta 2	0.013
Efnb2	ephrin B2	0.013
Nes	nestin	0.013
Cdh13	cadherin 13	0.013
Wnt10b	wingless related MMTV integration site 10b	0.013
Wnt2b	wingless related MMTV integration site 2b	0.013
Peg10	paternally expressed 10	0.013
Etv2	ets variant gene 2	0.013
Fjx1	four jointed box 1 (Drosophila)	0.013
Foxb1	forkhead box B1	0.013
Snai1	snail homolog 1 (Drosophila)	0.013
Col7a1	collagen, type VII, alpha 1	0.013
Tbx10	T-box 10	0.013	Mouse
Unc5c	unc-5 homolog C (C. elegans)	0.013
Prkci	protein kinase C, iota	0.013
Sall3	sal-like 3 (Drosophila)	0.012
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.012
Acvr1	activin A receptor, type 1	0.012
Wnt7b	wingless-related MMTV integration site 7B	0.012
Neo1	neogenin	0.012
Vipr2	vasoactive intestinal peptide receptor 2	0.012
Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.012
Pofut1	protein O-fucosyltransferase 1	0.012
Axin2	axin2	0.012
Gnaq	guanine nucleotide binding protein, alpha q polypeptide	0.012
Epn2	epsin 2	0.012
Zfp518b	zinc finger protein 518B	0.012
Lrp5	low density lipoprotein receptor-related protein 5	0.012
Lhx4	LIM homeobox protein 4	0.012
Tcfap2c	transcription factor AP-2, gamma	0.011	Mouse
Pax7	paired box gene 7	0.011
Rbpj	recombination signal binding protein for immunoglobulin kappa J region	0.011
Boc	biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein	0.011
Efna5	ephrin A5	0.011
Irx1	Iroquois related homeobox 1 (Drosophila)	0.011
Onecut2	one cut domain, family member 2	0.011
Ntn3	netrin 3	0.011
Fzd9	frizzled homolog 9 (Drosophila)	0.011
Gli1	GLI-Kruppel family member GLI1	0.011	Zebrafish
Dock4	dedicator of cytokinesis 4	0.011
Hoxa9	homeobox A9	0.011
Id1	inhibitor of DNA binding 1	0.011
Plekha7	pleckstrin homology domain containing, family A member 7	0.011
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.011
Rtkn	rhotekin	0.011
Pou4f1	POU domain, class 4, transcription factor 1	0.011
Hoxb5	homeobox B5	0.011
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.011	Mouse
Homer3	homer homolog 3 (Drosophila)	0.011
Zfp36l1	zinc finger protein 36, C3H type-like 1	0.011
Wwc1	WW, C2 and coiled-coil domain containing 1	0.011
Fzd7	frizzled homolog 7 (Drosophila)	0.010
Npnt	nephronectin	0.010
Foxp2	forkhead box P2	0.010
Ptprs	protein tyrosine phosphatase, receptor type, S	0.010
Col13a1	collagen, type XIII, alpha 1	0.010
Fos	FBJ osteosarcoma oncogene	0.010
Hoxa7	homeobox A7	0.010
Lrp2	low density lipoprotein receptor-related protein 2	0.010
Mnx1	motor neuron and pancreas homeobox 1	0.010
Esrrb	estrogen related receptor, beta	0.010
Fosb	FBJ osteosarcoma oncogene B	0.010
Eya2	eyes absent 2 homolog (Drosophila)	0.010
Hoxc6	homeobox C6	0.010
Insm1	insulinoma-associated 1	0.010
Notch4	Notch gene homolog 4 (Drosophila)	0.010
Fosl2	fos-like antigen 2	0.010