IMP

Process View

Mus musculus

1 genes annotated in mouse

protein refolding

GO:0042026

The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "protein refolding"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "protein refolding" (in gray)

Name	Description	Probability	Func Analog Organism
Hspa8	heat shock protein 8	1.000	Human Yeast
Hsph1	heat shock 105kDa/110kDa protein 1	1.000	Yeast
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	1.000	Yeast
Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	1.000
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	1.000	Yeast
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.998
Cacybp	calcyclin binding protein	0.998
Iqcb1	IQ calmodulin-binding motif containing 1	0.989
Stip1	stress-induced phosphoprotein 1	0.972
Nphp4	nephronophthisis 4 (juvenile) homolog (human)	0.961
Rpgrip1l	Rpgrip1-like	0.924
Hspd1	heat shock protein 1 (chaperonin)	0.837	Human Yeast
Hspa5	heat shock protein 5	0.767
Nphp1	nephronophthisis 1 (juvenile) homolog (human)	0.715
Hsp90b1	heat shock protein 90, beta (Grp94), member 1	0.678
Hspa1b	heat shock protein 1B	0.662
Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	0.627
Hspe1	heat shock protein 1 (chaperonin 10)	0.623
Cct6a	chaperonin containing Tcp1, subunit 6a (zeta)	0.618
Hspa4	heat shock protein 4	0.495	Yeast
Pno1	partner of NOB1 homolog (S. cerevisiae)	0.471
Psmd12	proteasome (prosome, macropain) 26S subunit, non-ATPase, 12	0.385
H2-K1	histocompatibility 2, K1, K region	0.385
Hspa1a	heat shock protein 1A	0.350
Cct5	chaperonin containing Tcp1, subunit 5 (epsilon)	0.309
Cct7	chaperonin containing Tcp1, subunit 7 (eta)	0.308
Hspa9	heat shock protein 9	0.306	Yeast
Hspa4l	heat shock protein 4 like	0.297
Ncbp2	nuclear cap binding protein subunit 2	0.290
Lrpprc	leucine-rich PPR-motif containing	0.281
H2-D1	histocompatibility 2, D region locus 1	0.280
Ahsa1	AHA1, activator of heat shock protein ATPase homolog 1 (yeast)	0.274
Dnajb1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.228	Human
Tra2b	transformer 2 beta homolog (Drosophila)	0.220
Skp1a	S-phase kinase-associated protein 1A	0.219
Hnrnpc	heterogeneous nuclear ribonucleoprotein C	0.203
Ahi1	Abelson helper integration site 1	0.197
Fam98a	family with sequence similarity 98, member A	0.184
Mrfap1	Morf4 family associated protein 1	0.184
Dnajb4	DnaJ (Hsp40) homolog, subfamily B, member 4	0.182
Pcbp1	poly(rC) binding protein 1	0.182
Ahsa2	AHA1, activator of heat shock protein ATPase homolog 2 (yeast)	0.176
Psmc5	protease (prosome, macropain) 26S subunit, ATPase 5	0.174
Eed	embryonic ectoderm development	0.173
Pfdn2	prefoldin 2	0.172
Cct4	chaperonin containing Tcp1, subunit 4 (delta)	0.169
Tcp1	t-complex protein 1	0.167
St13	suppression of tumorigenicity 13	0.164	Rat
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.158
Fkbp4	FK506 binding protein 4	0.148
Tmem33	transmembrane protein 33	0.144
Serbp1	serpine1 mRNA binding protein 1	0.140
Dnajb2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.129	Human
Cfh	complement component factor h	0.116
Ubqln1	ubiquilin 1	0.113
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (yeast)	0.108
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.099
Canx	calnexin	0.099
Bag3	BCL2-associated athanogene 3	0.093
Lamp3	lysosomal-associated membrane protein 3	0.077
P4ha1	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide	0.075
Caprin1	cell cycle associated protein 1	0.066
Mks1	Meckel syndrome, type 1	0.066
Vcp	valosin containing protein	0.059
Cct8	chaperonin containing Tcp1, subunit 8 (theta)	0.058
Dynll1	dynein light chain LC8-type 1	0.058
Pole4	polymerase (DNA-directed), epsilon 4 (p12 subunit)	0.057
Ywhaz	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.057
Hnrnph1	heterogeneous nuclear ribonucleoprotein H1	0.053
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.052	Human
Eprs	glutamyl-prolyl-tRNA synthetase	0.050
Ywhag	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.049
Eif3j	eukaryotic translation initiation factor 3, subunit J	0.049
Hnrnph3	heterogeneous nuclear ribonucleoprotein H3	0.046
Ncl	nucleolin	0.045
Impa1	inositol (myo)-1(or 4)-monophosphatase 1	0.044
Smarca5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	0.042
Paf1	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)	0.042
Ccdc117	coiled-coil domain containing 117	0.041
Dnaja4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.040	Human
Dnaja3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.039
Atp5b	ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit	0.038
H2-Q7	histocompatibility 2, Q region locus 7	0.037
Gtpbp4	GTP binding protein 4	0.034
Atp2a2	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	0.032
Rp2h	retinitis pigmentosa 2 homolog (human)	0.031
Cct2	chaperonin containing Tcp1, subunit 2 (beta)	0.031
Mat2a	methionine adenosyltransferase II, alpha	0.031
Ddit3	DNA-damage inducible transcript 3	0.030
Pcmt1	protein-L-isoaspartate (D-aspartate) O-methyltransferase 1	0.030
Tbca	tubulin cofactor A	0.030
Sfpq	splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)	0.030
Syf2	SYF2 homolog, RNA splicing factor (S. cerevisiae)	0.030
Eif2c2	eukaryotic translation initiation factor 2C, 2	0.029
Bag2	BCL2-associated athanogene 2	0.028
Nxf1	nuclear RNA export factor 1 homolog (S. cerevisiae)	0.028
Rheb	Ras homolog enriched in brain	0.028
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.027
Vps4a	vacuolar protein sorting 4a (yeast)	0.027
Mobkl3	MOB1, Mps One Binder kinase activator-like 3 (yeast)	0.027
Tubb3	tubulin, beta 3	0.027
2310044G17Rik	RIKEN cDNA 2310044G17 gene	0.027
Actr6	ARP6 actin-related protein 6 homolog (yeast)	0.026
Fnta	farnesyltransferase, CAAX box, alpha	0.026
Pdia6	protein disulfide isomerase associated 6	0.026
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.025
Ywhaq	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	0.025
Pgam2	phosphoglycerate mutase 2	0.025
Arl3	ADP-ribosylation factor-like 3	0.025
Tprgl	transformation related protein 63 regulated like	0.024
Nudt9	nudix (nucleoside diphosphate linked moiety X)-type motif 9	0.024
Pfn2	profilin 2	0.024
Ppa1	pyrophosphatase (inorganic) 1	0.024
l7Rn6	lethal, Chr 7, Rinchik 6	0.024
Metap1	methionyl aminopeptidase 1	0.024
Glrx3	glutaredoxin 3	0.023
Arpp19	cAMP-regulated phosphoprotein 19	0.023
Invs	inversin	0.023
Pcmtd2	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2	0.022
Kpna1	karyopherin (importin) alpha 1	0.022
Otud6b	OTU domain containing 6B	0.022
Eif5	eukaryotic translation initiation factor 5	0.021
Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	0.021
Dynll2	dynein light chain LC8-type 2	0.021
Khdrbs3	KH domain containing, RNA binding, signal transduction associated 3	0.020
Arfrp1	ADP-ribosylation factor related protein 1	0.020
Snx3	sorting nexin 3	0.020
Tuba4a	tubulin, alpha 4A	0.020
Wdr35	WD repeat domain 35	0.020
Cfdp1	craniofacial development protein 1	0.020
Cep290	centrosomal protein 290	0.019
Leng1	leukocyte receptor cluster (LRC) member 1	0.019
Fpgt	fucose-1-phosphate guanylyltransferase	0.019
Mapk1	mitogen-activated protein kinase 1	0.019
Eif1b	eukaryotic translation initiation factor 1B	0.019
Try10	trypsin 10	0.019
Ppa2	pyrophosphatase (inorganic) 2	0.019
Sepp1	selenoprotein P, plasma, 1	0.018
Sod2	superoxide dismutase 2, mitochondrial	0.018
Eif1	eukaryotic translation initiation factor 1	0.018
Nap1l4	nucleosome assembly protein 1-like 4	0.018
Camsap1	calmodulin regulated spectrin-associated protein 1	0.018
Csde1	cold shock domain containing E1, RNA binding	0.017
Tubb6	tubulin, beta 6	0.017
Ube2f	ubiquitin-conjugating enzyme E2F (putative)	0.017
Banp	BTG3 associated nuclear protein	0.017
Farsb	phenylalanyl-tRNA synthetase, beta subunit	0.017
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.016
Amd1	S-adenosylmethionine decarboxylase 1	0.016
Cdr2	cerebellar degeneration-related 2	0.016
Usp9x	ubiquitin specific peptidase 9, X chromosome	0.016
Itgb1bp2	integrin beta 1 binding protein 2	0.016
Wbp4	WW domain binding protein 4	0.016
Fxr1	fragile X mental retardation gene 1, autosomal homolog	0.016
Brd2	bromodomain containing 2	0.015
Etf1	eukaryotic translation termination factor 1	0.015
Vti1b	vesicle transport through interaction with t-SNAREs 1B homolog	0.015
Psmd7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.015
Klc1	kinesin light chain 1	0.015
Cand1	cullin associated and neddylation disassociated 1	0.015
Cnbp	cellular nucleic acid binding protein	0.015
Vamp7	vesicle-associated membrane protein 7	0.015
Pdia3	protein disulfide isomerase associated 3	0.014
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.014
Napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.014
Hspa2	heat shock protein 2	0.014	Human Yeast
Tmem66	transmembrane protein 66	0.014
Arcn1	archain 1	0.014
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.014
Dnajb6	DnaJ (Hsp40) homolog, subfamily B, member 6	0.014
Safb	scaffold attachment factor B	0.013
6330409N04Rik	RIKEN cDNA 6330409N04 gene	0.013
Ppp2ca	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	0.013
Otud7b	OTU domain containing 7B	0.013
Tmem93	transmembrane protein 93	0.013
Ddx1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.013
BC046331	cDNA sequence BC046331	0.013
Abce1	ATP-binding cassette, sub-family E (OABP), member 1	0.013
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.013	Human Yeast
Vdac3	voltage-dependent anion channel 3	0.013
1700021F05Rik	RIKEN cDNA 1700021F05 gene	0.013
Inpp5a	inositol polyphosphate-5-phosphatase A	0.013
Larp1	La ribonucleoprotein domain family, member 1	0.013
Ipo7	importin 7	0.012
Rab3ip	RAB3A interacting protein	0.012
Cycs	cytochrome c, somatic	0.012
Dnajc21	DnaJ (Hsp40) homolog, subfamily C, member 21	0.012
Mapkapk5	MAP kinase-activated protein kinase 5	0.012
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.012
Fam18b	family with sequence similarity 18, member B	0.012
Map3k6	mitogen-activated protein kinase kinase kinase 6	0.012
Bpgm	2,3-bisphosphoglycerate mutase	0.012
Bcl7b	B-cell CLL/lymphoma 7B	0.012
Ubc	ubiquitin C	0.012
Tmcc2	transmembrane and coiled-coil domains 2	0.012
Sap30l	SAP30-like	0.012
Rab18	RAB18, member RAS oncogene family	0.012
1700088E04Rik	RIKEN cDNA 1700088E04 gene	0.012
8430410K20Rik	RIKEN cDNA 8430410K20 gene	0.012
Slmo2	slowmo homolog 2 (Drosophila)	0.011
Ift122	intraflagellar transport 122 homolog (Chlamydomonas)	0.011
Kpna4	karyopherin (importin) alpha 4	0.011
March5	membrane-associated ring finger (C3HC4) 5	0.011
Phospho2	phosphatase, orphan 2	0.011
Sucla2	succinate-Coenzyme A ligase, ADP-forming, beta subunit	0.011
Isca1	iron-sulfur cluster assembly 1 homolog (S. cerevisiae)	0.011
Ift172	intraflagellar transport 172 homolog (Chlamydomonas)	0.011
H2-Ab1	histocompatibility 2, class II antigen A, beta 1	0.011
Ndufaf1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1	0.011
Prdx6	peroxiredoxin 6	0.011
Irgm2	immunity-related GTPase family M member 2	0.011
Blcap	bladder cancer associated protein homolog (human)	0.011
Zscan2	zinc finger and SCAN domain containing 2	0.011
Ormdl3	ORM1-like 3 (S. cerevisiae)	0.011
Nxt2	nuclear transport factor 2-like export factor 2	0.011
Bag1	BCL2-associated athanogene 1	0.011	Human
Nars	asparaginyl-tRNA synthetase	0.011
Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	0.011
Ubfd1	ubiquitin family domain containing 1	0.011
Tbc1d4	TBC1 domain family, member 4	0.011
Ssr3	signal sequence receptor, gamma	0.011
Ubxn4	UBX domain protein 4	0.011
Zc3h14	zinc finger CCCH type containing 14	0.011
Hk1	hexokinase 1	0.010
Eif4g2	eukaryotic translation initiation factor 4, gamma 2	0.010
Fam162a	family with sequence similarity 162, member A	0.010
Ghitm	growth hormone inducible transmembrane protein	0.010
Pygl	liver glycogen phosphorylase	0.010
Dap3	death associated protein 3	0.010
Sbds	Shwachman-Bodian-Diamond syndrome homolog (human)	0.010
Lap3	leucine aminopeptidase 3	0.010
Hspb1	heat shock protein 1	0.010
Uspl1	ubiquitin specific peptidase like 1	0.010
Mrps6	mitochondrial ribosomal protein S6	0.010
Calm2	calmodulin 2	0.010
Defa24	defensin, alpha, 24	0.010
1700017N19Rik	RIKEN cDNA 1700017N19 gene	0.010
Gpbp1	GC-rich promoter binding protein 1	0.010