IMP

Process View

Rattus norvegicus

19 genes annotated in rat

proteolysis involved in cellular protein catabolic process

The hydrolysis of a peptide bond or bonds within a protein as part of the chemical reactions and pathways resulting in the breakdown of a protein by individual cells.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "proteolysis involved in cellular protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "proteolysis involved in cellular protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
Psma5	proteasome (prosome, macropain) subunit, alpha type 5	0.987	Yeast
Psmb3	proteasome (prosome, macropain) subunit, beta type 3	0.943	Yeast
Psma4	proteasome (prosome, macropain) subunit, alpha type 4	0.902	Yeast
Psma3	proteasome (prosome, macropain) subunit, alpha type 3	0.900	Yeast
Psmc1	proteasome (prosome, macropain) 26S subunit, ATPase, 1	0.710
Dnaja2	DnaJ (Hsp40) homolog, subfamily A, member 2	0.694	Yeast
Psmc2	proteasome (prosome, macropain) 26S subunit, ATPase 2	0.687	Human Yeast
Psma7	proteasome (prosome, macropain) subunit, alpha type 7	0.600	Yeast
Psmb6	proteasome (prosome, macropain) subunit, beta type 6	0.550	Yeast
Ppp1cb	protein phosphatase 1, catalytic subunit, beta isoform	0.536
Eef2	eukaryotic translation elongation factor 2	0.392
Psmc4	proteasome (prosome, macropain) 26S subunit, ATPase, 4	0.364	Yeast
Dnaja1	DnaJ (Hsp40) homolog, subfamily A, member 1	0.358	Yeast
Zfand5	zinc finger, AN1-type domain 5	0.300
Psmb2	proteasome (prosome, macropain) subunit, beta type 2	0.272	Yeast
Psmd6	proteasome (prosome, macropain) 26S subunit, non-ATPase, 6	0.270
Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	0.245
Psme2	proteasome (prosome, macropain) activator subunit 2	0.234
Psmb7	proteasome (prosome, macropain) subunit, beta type 7	0.204	Yeast
Dctn4	dynactin 4	0.194
Dnajb11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.189
Psmb5	proteasome (prosome, macropain) subunit, beta type 5	0.188	Yeast Mouse
Csnk1d	casein kinase 1, delta	0.180	Mouse Fly
Psma6	proteasome (prosome, macropain) subunit, alpha type 6	0.172	Human Yeast
Rpn2	ribophorin II	0.157
Dnajb9	DnaJ (Hsp40) homolog, subfamily B, member 9	0.150	Human Mouse
Rab11a	RAB11a, member RAS oncogene family	0.140
Jtb	jumping translocation breakpoint	0.136
Psmd13	proteasome (prosome, macropain) 26S subunit, non-ATPase, 13	0.127
Vcp	valosin-containing protein	0.124
Pdia4	protein disulfide isomerase family A, member 4	0.122
Psma2	proteasome (prosome, macropain) subunit, alpha type 2	0.122	Yeast
Syngr2	synaptogyrin 2	0.113
Psmc5	proteasome (prosome, macropain) 26S subunit, ATPase, 5	0.110	Human Yeast
Dbp	D site of albumin promoter (albumin D-box) binding protein	0.104
Psmd4	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4	0.103
Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	0.103
Psmb8	proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)	0.100	Yeast
Psmb10	proteasome (prosome, macropain) subunit, beta type 10	0.100	Yeast
Cdc20	cell division cycle 20 homolog (S. cerevisiae)	0.096	Human Yeast Worm Fly
Hsph1	heat shock 105/110 protein 1	0.093
P4hb	prolyl 4-hydroxylase, beta polypeptide	0.090
Traf4af1	TRAF4 associated factor 1	0.085
Psmb4	proteasome (prosome, macropain) subunit, beta type 4	0.082	Yeast
Psmd7	proteasome (prosome, macropain) 26S subunit, non-ATPase, 7	0.080
Cnbp	CCHC-type zinc finger, nucleic acid binding protein	0.075
Manf	mesencephalic astrocyte-derived neurotrophic factor	0.075
Txnl1	thioredoxin-like 1	0.074
Hsp90ab1	heat shock protein 90 alpha (cytosolic), class B member 1	0.073
Prdx1	peroxiredoxin 1	0.073
Cltc	clathrin, heavy chain (Hc)	0.072
Psmd3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	0.071
Dusp11	dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)	0.070
Psmb1	proteasome (prosome, macropain) subunit, beta type 1	0.069	Yeast
Ptges3	prostaglandin E synthase 3 (cytosolic)	0.069
Hprt1	hypoxanthine phosphoribosyltransferase 1	0.069
Ypel5	yippee-like 5 (Drosophila)	0.068
Hspa5	heat shock protein 5	0.067	Yeast Mouse
Nudt3	nudix (nucleoside diphosphate linked moiety X)-type motif 3	0.064
Ccnb1	cyclin B1	0.063
Usp47	ubiquitin specific peptidase 47	0.060
Rab21	RAB21, member RAS oncogene family	0.058
Hspe1	heat shock protein 1 (chaperonin 10)	0.058
Tax1bp1	Tax1 (human T-cell leukemia virus type I) binding protein 1	0.058
Ppp1r2	protein phosphatase 1, regulatory (inhibitor) subunit 2	0.057
Psmd1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.056
Lman1	lectin, mannose-binding, 1	0.055
Cand1	cullin-associated and neddylation-dissociated 1	0.054
Cops2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	0.054
Rbbp7	retinoblastoma binding protein 7	0.053
Psma1	proteasome (prosome, macropain) subunit, alpha type 1	0.052	Yeast
Plk1	polo-like kinase 1 (Drosophila)	0.052	Human Rat
Mgat2	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	0.051
Rfc1	replication factor C (activator 1) 1	0.050
Creld2	cysteine-rich with EGF-like domains 2	0.050
Lamp2	lysosomal-associated membrane protein 2	0.048
Cast	calpastatin	0.048
Cenpi	centromere protein I	0.047
Calr	calreticulin	0.046
Tcf12	transcription factor 12	0.045
Ubc	ubiquitin C	0.045
Kars	lysyl-tRNA synthetase	0.044
Wdr26	WD repeat domain 26	0.043
Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	0.043
Pkn2	protein kinase N2	0.042
Tle4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	0.041
Sec61a1	Sec61 alpha 1 subunit (S. cerevisiae)	0.041
Mdm2	Mdm2 p53 binding protein homolog (mouse)	0.041
Ube2d3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.039
Senp2	Sumo1/sentrin/SMT3 specific peptidase 2	0.038
Foxm1	forkhead box M1	0.038
Usp15	ubiquitin specific peptidase 15	0.037
Grasp	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein	0.036
Sdf2l1	stromal cell-derived factor 2-like 1	0.036
Dlg1	discs, large homolog 1 (Drosophila)	0.035
Cdc37	cell division cycle 37 homolog (S. cerevisiae)	0.034
Eif2s2	eukaryotic translation initiation factor 2, subunit 2 beta	0.034
Vapa	VAMP (vesicle-associated membrane protein)-associated protein A	0.034
Serp1	stress-associated endoplasmic reticulum protein 1	0.033
Taok1	TAO kinase 1	0.032
Pdia6	protein disulfide isomerase family A, member 6	0.031
Asf1b	ASF1 anti-silencing function 1 homolog B (S. cerevisiae)	0.030
Pomp	proteasome maturation protein	0.030
Psap	prosaposin	0.030
Rnf2	ring finger protein 2	0.029
Eny2	enhancer of yellow 2 homolog (Drosophila)	0.029
Usp14	ubiquitin specific peptidase 14	0.028
Nsfl1c	NSFL1 (p97) cofactor (p47)	0.028
Akt1s1	AKT1 substrate 1 (proline-rich)	0.028
Usf2	upstream transcription factor 2, c-fos interacting	0.028
Csnk1a1	casein kinase 1, alpha 1	0.028	Fly
Ube2g1	ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)	0.027
Ube2d2	ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)	0.027
Rps5	ribosomal protein S5	0.027
Ndrg2	N-myc downstream regulated gene 2	0.027
Stip1	stress-induced phosphoprotein 1	0.027
Vps35	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.026
Ppp2r1a	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	0.026
Cct5	chaperonin containing Tcp1, subunit 5 (epsilon)	0.026
Brcc3	BRCA1/BRCA2-containing complex, subunit 3	0.026
Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	0.026
Axin1	axin 1	0.025
Rcn2	reticulocalbin 2, EF-hand calcium binding domain	0.025
Ube2i	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.025
Exoc5	exocyst complex component 5	0.025
Hsp90b1	heat shock protein 90, beta, member 1	0.025	Human
Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.025
LOC100362155	cysteine and histidine rich 1	0.025
Golph3	golgi phosphoprotein 3 (coat-protein)	0.024
Phax	phosphorylated adaptor for RNA export	0.024
Man1a1	mannosidase, alpha, class 1A, member 1	0.024
Zfp91	zinc finger protein 91	0.024
Dlg3	discs, large homolog 3 (Drosophila)	0.024
St13	suppression of tumorigenicity 13	0.024
Tomm70a	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	0.024
Lbr	lamin B receptor	0.023
Vps37a	vacuolar protein sorting 37 homolog A (S. cerevisiae)	0.023	Human
Arfip1	ADP-ribosylation factor interacting protein 1	0.023
Rpl7a	ribosomal protein L7a	0.023
Foxj3	forkhead box J3	0.023
Coro1b	coronin, actin-binding protein, 1B	0.022
LOC100310874	antisense RNA overlapping MCH	0.022
Myo1b	myosin Ib	0.022
Cyfip1	cytoplasmic FMR1 interacting protein 1	0.021
Troap	trophinin associated protein	0.021
Ppp2r4	protein phosphatase 2A activator, regulatory subunit 4	0.021
Kpna2	karyopherin alpha 2	0.021
Grin1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	0.021
Azi2	5-azacytidine induced 2	0.021
Irf1	interferon regulatory factor 1	0.021
Maf1	MAF1 homolog (S. cerevisiae)	0.021
Tbpl1	TATA box binding protein-like 1	0.021
RGD1309102	similar to TRS85 homolog	0.020
Eif5a	eukaryotic translation initiation factor 5A	0.020
Aamp	angio-associated, migratory cell protein	0.020
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.020	Mouse
Pgam2	phosphoglycerate mutase 2 (muscle)	0.020
Ube2h	ubiquitin-conjugating enzyme E2H	0.020
Pdk2	pyruvate dehydrogenase kinase, isozyme 2	0.020
Hmmr	hyaluronan mediated motility receptor (RHAMM)	0.019
Rars	arginyl-tRNA synthetase	0.019
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.019
Haus4	HAUS augmin-like complex, subunit 4	0.019
Cct3	chaperonin containing Tcp1, subunit 3 (gamma)	0.019
Ide	insulin degrading enzyme	0.019
Psmb9	proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)	0.019	Yeast
LOC684800	similar to stromal membrane-associated protein 1	0.018
Higd1a	HIG1 hypoxia inducible domain family, member 1A	0.018
Efr3a	EFR3 homolog A (S. cerevisiae)	0.018
Smad4	SMAD family member 4	0.018
Ube2c	ubiquitin-conjugating enzyme E2C	0.018
Canx	calnexin	0.018
Sepw1	selenoprotein W, 1	0.018
Tagln3	transgelin 3	0.018
Rab5a	RAB5A, member RAS oncogene family	0.017
Tiprl	TIP41, TOR signaling pathway regulator-like (S. cerevisiae)	0.017
Tomm20	translocase of outer mitochondrial membrane 20 homolog (yeast)	0.017
Kif22	kinesin family member 22	0.017
Rbm18	RNA binding motif protein 18	0.017
LOC362855	P55	0.017
Lamc1	laminin, gamma 1	0.017
Ccdc47	coiled-coil domain containing 47	0.016
Shank2	SH3 and multiple ankyrin repeat domains 2	0.016
Hk1	hexokinase 1	0.016
Ccnf	cyclin F	0.016	Human
Dr1	down-regulator of transcription 1	0.016
Magt1	magnesium transporter 1	0.016
Alkbh5	alkB, alkylation repair homolog 5 (E. coli)	0.016
Dnajb1	DnaJ (Hsp40) homolog, subfamily B, member 1	0.016
Pdia3	protein disulfide isomerase family A, member 3	0.016
Birc5	baculoviral IAP repeat-containing 5	0.016
P22k15	cystatin related protein 2	0.016
Ky	kyphoscoliosis peptidase	0.016
Pex13	peroxisomal biogenesis factor 13	0.015
Gabarapl1	GABA(A) receptor-associated protein like 1	0.015
Erp29	endoplasmic reticulum protein 29	0.015
Casp7	caspase 7	0.015
Cops5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	0.015
Clic4	chloride intracellular channel 4	0.015
Espl1	extra spindle pole bodies homolog 1 (S. cerevisiae)	0.015
Actr10	actin-related protein 10 homolog (S. cerevisiae)	0.015
Kpnb1	karyopherin (importin) beta 1	0.015
Pdap1	PDGFA associated protein 1	0.015
Atg4c	ATG4 autophagy related 4 homolog C (S. cerevisiae)	0.015
Hapln1	hyaluronan and proteoglycan link protein 1	0.015
LOC687711	similar to small nuclear ribonucleoprotein D3	0.015
Lap3	leucine aminopeptidase 3	0.015
Tor1aip2	torsin A interacting protein 2	0.015
RT1-N3	RT1 class Ib, locus N3	0.015
Gga2	golgi associated, gamma adaptin ear containing, ARF binding protein 2	0.015
Nab1	Ngfi-A binding protein 1	0.014
Rpl28	ribosomal protein L28	0.014
Chmp2a	chromatin modifying protein 2A	0.014
Dcaf5	DDB1 and CUL4 associated factor 5	0.014
Txn1	thioredoxin 1	0.014
Cul1	cullin 1	0.014	Human Mouse
Psmc6	proteasome (prosome, macropain) 26S subunit, ATPase, 6	0.014
RGD1310351	similar to RIKEN cDNA 4732418C07	0.014
Caprin1	cell cycle associated protein 1	0.014
Senp7	SUMO1/sentrin specific peptidase 7	0.014
Ireb2	iron responsive element binding protein 2	0.014
Chordc1	cysteine and histidine-rich domain (CHORD)-containing 1	0.014
B2m	beta-2 microglobulin	0.014
Map3k3	mitogen activated protein kinase kinase kinase 3	0.014
Spcs3	signal peptidase complex subunit 3 homolog (S. cerevisiae)	0.014
Irak1	interleukin-1 receptor-associated kinase 1	0.013
Zfp364	zinc finger protein 364	0.013	Human
Rbm8a	RNA binding motif protein 8A	0.013
Ifi35	interferon-induced protein 35	0.013
Rab35	RAB35, member RAS oncogene family	0.013
Top2a	topoisomerase (DNA) II alpha	0.013
Mbd2	methyl-CpG binding domain protein 2	0.013
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.013
Dync1i2	dynein cytoplasmic 1 intermediate chain 2	0.013
Ralbp1	ralA binding protein 1	0.013
Kif18b	kinesin family member 18B	0.013
Parp14	poly (ADP-ribose) polymerase family, member 14	0.013
March5	membrane-associated ring finger (C3HC4) 5	0.013
Rnf146	ring finger protein 146	0.013	Human
Gorasp2	golgi reassembly stacking protein 2	0.013
LOC687090	hypothetical protein LOC687090	0.013
Metap2	methionyl aminopeptidase 2	0.013
Fxr2	fragile X mental retardation, autosomal homolog 2	0.013
Pfn1	profilin 1	0.013
Ctxn1	cortexin 1	0.013
Atp6v1f	ATPase, H transporting, lysosomal V1 subunit F	0.013
Slc39a1	solute carrier family 39 (zinc transporter), member 1	0.013
Mllt4	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	0.013
Adfp	adipose differentiation related protein	0.012
Pds5a	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	0.012
Bles03	basophilic leukemia expressed protein BLES03	0.012
Acyp2	acylphosphatase 2, muscle type	0.012
Basp1	brain abundant, membrane attached signal protein 1	0.012
Uggt1	UDP-glucose glycoprotein glucosyltransferase 1	0.012
Ptpru	protein tyrosine phosphatase, receptor type, U	0.012
Morf4l1	mortality factor 4 like 1	0.012
Tspyl1	TSPY-like 1	0.012
Rybp	RING1 and YY1 binding protein	0.012
Toe1	target of EGR1, member 1 (nuclear)	0.012
Tcta	T-cell leukemia translocation altered gene	0.012
Ifi27l2b	interferon, alpha-inducible protein 27 like 2B	0.012
Dnajc5	DnaJ (Hsp40) homolog, subfamily C, member 5	0.012
Ctsz	cathepsin Z	0.012
Prdm4	PR domain containing 4	0.012
Kif20b	kinesin family member 20B	0.012
Thoc3	THO complex 3	0.012
Afp	alpha-fetoprotein	0.012
RT1-DMb	RT1 class II, locus DMb	0.012
Lig3	ligase III, DNA, ATP-dependent	0.011
Spcs2	signal peptidase complex subunit 2 homolog (S. cerevisiae)	0.011
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.011
Pak2	p21 protein (Cdc42/Rac)-activated kinase 2	0.011
Cstb	cystatin B (stefin B)	0.011
Chkb	choline kinase beta	0.011
Bard1	BRCA1 associated RING domain 1	0.011
Myo1c	myosin IC	0.011
Capza2	capping protein (actin filament) muscle Z-line, alpha 2	0.011
Rgs19	regulator of G-protein signaling 19	0.011
Slc35b1	solute carrier family 35, member B1	0.011
Dnajc21	DnaJ (Hsp40) homolog, subfamily C, member 21	0.011
Akirin1	akirin 1	0.011
Dcaf15	DDB1 and CUL4 associated factor 15	0.011
Psmc3	proteasome (prosome, macropain) 26S subunit, ATPase 3	0.011	Yeast
Arih2	ariadne homolog 2 (Drosophila)	0.011	Human Mouse
Cdca3	cell division cycle associated 3	0.011
Pctk2	PCTAIRE protein kinase 2	0.011
Trdn	triadin	0.011
Eif3e	eukaryotic translation initiation factor 3, subunit E	0.011
Grn	granulin	0.011
Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	0.011
Ccdc117	coiled-coil domain containing 117	0.011
Rab11fip3	RAB11 family interacting protein 3 (class II)	0.011
Nploc4	nuclear protein localization 4 homolog (S. cerevisiae)	0.011
Nat12	N-acetyltransferase 12 (GCN5-related, putative)	0.010
Cx3cl1	chemokine (C-X3-C motif) ligand 1	0.010
Nrbp	nuclear receptor binding protein	0.010
Pttg1	pituitary tumor-transforming 1	0.010
Ckap2	cytoskeleton associated protein 2	0.010
Psmd5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 5	0.010
LOC100364212	heterogeneous nuclear ribonucleoprotein K-like	0.010
Cdh22	cadherin 22	0.010
Tcea2	transcription elongation factor A (SII), 2	0.010
Nhp2	NHP2 ribonucleoprotein homolog (yeast)	0.010
Arpc5	actin related protein 2/3 complex, subunit 5	0.010
Txnrd1	thioredoxin reductase 1	0.010
Psmd14	proteasome (prosome, macropain) 26S subunit, non-ATPase, 14	0.010
Tap2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0.010
Grik5	glutamate receptor, ionotropic, kainate 5	0.010
Nars	asparaginyl-tRNA synthetase	0.010
Aldh1a2	aldehyde dehydrogenase 1 family, member A2	0.010
Eif4g2	eukaryotic translation initiation factor 4, gamma 2	0.010
Ufd1l	ubiquitin fusion degradation 1 like (yeast)	0.010
N-pac	cytokine-like nuclear factor n-pac	0.010