IMP

Process View

Rattus norvegicus

41 genes annotated in rat

negative regulation of proteolysis

Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.

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Known genes in the process in rat Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of proteolysis"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of proteolysis" (in gray)

Name	Description	Probability	Func Analog Organism
F2	coagulation factor II (thrombin)	0.090	Human
Hpx	hemopexin	0.084
Fga	fibrinogen alpha chain	0.076
A2m	alpha-2-macroglobulin	0.074
Itih4	inter alpha-trypsin inhibitor, heavy chain 4	0.067
Proc	protein C	0.051
Fgfr2	fibroblast growth factor receptor 2	0.048
Arpc1b	actin related protein 2/3 complex, subunit 1B	0.043
Mbl1	mannose-binding lectin (protein A) 1	0.043
Gja1	gap junction protein, alpha 1	0.041
Apoa2	apolipoprotein A-II	0.039
Taok1	TAO kinase 1	0.039
Cd63	Cd63 molecule	0.038
Dctn4	dynactin 4	0.035
S100a6	S100 calcium binding protein A6	0.034
Lgals3	lectin, galactoside-binding, soluble, 3	0.034
Ifitm3	interferon induced transmembrane protein 3	0.034
Pkn2	protein kinase N2	0.033
C4bpa	complement component 4 binding protein, alpha	0.032
Gna12	guanine nucleotide binding protein (G protein) alpha 12	0.032
Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	0.032	Human Mouse Rat
Dnaja4	DnaJ (Hsp40) homolog, subfamily A, member 4	0.031
Fgfr1	Fibroblast growth factor receptor 1	0.030
Spink1	serine peptidase inhibitor, Kazal type 1	0.030	Mouse Rat
Jak1	Janus kinase 1	0.030
Nr4a3	nuclear receptor subfamily 4, group A, member 3	0.030
Cpb2	carboxypeptidase B2 (plasma)	0.030
Fgg	fibrinogen gamma chain	0.030
Cd9	CD9 molecule	0.030
Apoa5	apolipoprotein A-V	0.030
Ahsg	alpha-2-HS-glycoprotein	0.029
Dlg1	discs, large homolog 1 (Drosophila)	0.029
Hspb1	heat shock protein 1	0.028
Ripk3	receptor-interacting serine-threonine kinase 3	0.028
Mapk3	mitogen activated protein kinase 3	0.027
Slc10a1	solute carrier family 10 (sodium/bile acid cotransporter family), member 1	0.027
Fabp1	fatty acid binding protein 1, liver	0.027	Human
Serpina3n	serine (or cysteine) peptidase inhibitor, clade A, member 3N	0.027	Rat
C9	complement component 9	0.027
Kng2	kininogen 2	0.027
Emp1	epithelial membrane protein 1	0.026
Gnrhr	gonadotropin releasing hormone receptor	0.026
Cp	ceruloplasmin	0.026
C4bpb	complement component 4 binding protein, beta	0.026
Apoh	apolipoprotein H (beta-2-glycoprotein I)	0.024
Spp2	secreted phosphoprotein 2	0.024
Nek9	NIMA (never in mitosis gene a)- related kinase 9	0.024
Foxe1	forkhead box E1 (thyroid transcription factor 2)	0.023
Apob	apolipoprotein B	0.023
Plg	plasminogen	0.023
Cdc42bpb	CDC42 binding protein kinase beta (DMPK-like)	0.023
Pemt	phosphatidylethanolamine N-methyltransferase	0.023
Hp	haptoglobin	0.023
Afp	alpha-fetoprotein	0.023
Cfi	complement factor I	0.022
Utrn	utrophin	0.022
Serpina11	serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11	0.022	Rat
Apcs	amyloid P component, serum	0.022
Mxra8	matrix-remodelling associated 8	0.022
Hk1	hexokinase 1	0.022
Nedd4	neural precursor cell expressed, developmentally down-regulated 4	0.021
Hist1h1a	histone cluster 1, H1a	0.021
C1s	complement component 1, s subcomponent	0.021
Ddr1	discoidin domain receptor tyrosine kinase 1	0.021
Spag5	sperm associated antigen 5	0.021
Pnliprp2	pancreatic lipase-related protein 2	0.021
Git1	G protein-coupled receptor kinase interacting ArfGAP 1	0.021
Cyp2b12	cytochrome P450, family 2, subfamily b, polypeptide 12	0.021
Gzmk	granzyme K	0.021
Tcf12	transcription factor 12	0.021
Msx2	msh homeobox 2	0.020
Tmsb10	thymosin, beta 10	0.020
Lbp	lipopolysaccharide binding protein	0.020
Gjb3	gap junction protein, beta 3	0.020
Spink3	serine peptidase inhibitor, Kazal type 3	0.020
Iapp	islet amyloid polypeptide	0.020
Apoe	apolipoprotein E	0.020
Acpp	acid phosphatase, prostate	0.020
Tdo2	tryptophan 2,3-dioxygenase	0.020
Pik3r2	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	0.020	Rat
Ptch1	patched homolog 1 (Drosophila)	0.020
Adam10	ADAM metallopeptidase domain 10	0.019
Anxa1	annexin A1	0.019
Aqp9	aquaporin 9	0.019
Ppt1	palmitoyl-protein thioesterase 1	0.019
C4b	complement component 4B (Chido blood group)	0.019	Rat
Znf76	zinc finger protein 76 (expressed in testis)	0.018
Cyp2c13	cytochrome P450, family 2, subfamily c, polypeptide 13	0.018
Serpina7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	0.018	Rat
Ptms	parathymosin	0.018	Rat
Timp2	TIMP metallopeptidase inhibitor 2	0.018
Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	0.018
LOC100360986	mCG1035404-like	0.017
Cxcl1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	0.017
Orm1	orosomucoid 1	0.017
Gapdh	glyceraldehyde-3-phosphate dehydrogenase	0.017
Atp5b	ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide	0.017
Lcn2	lipocalin 2	0.017
Myo1b	myosin Ib	0.017
Serpina1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	0.016
Adrbk1	adrenergic, beta, receptor kinase 1	0.016
Hcrt	hypocretin	0.016
Pkm2	pyruvate kinase, muscle	0.016
Apoa1	apolipoprotein A-I	0.016
Il7	interleukin 7	0.016
Nsf	N-ethylmaleimide-sensitive factor	0.016
Cyp2a2	cytochrome P450, family 2, subfamily a, polypeptide 2	0.016
Smad7	SMAD family member 7	0.016
Ece1	endothelin converting enzyme 1	0.016
Serpina6	serine (or cysteine) peptidase inhibitor, clade A, member 6	0.016	Rat
Trim23	tripartite motif-containing 23	0.015
Stat5b	signal transducer and activator of transcription 5B	0.015
Pcnxl3	pecanex-like 3 (Drosophila)	0.015
Tpi1	triosephosphate isomerase 1	0.015
Vim	vimentin	0.015
Mib1	mindbomb homolog 1 (Drosophila)	0.015
Ptprs	protein tyrosine phosphatase, receptor type, S	0.015
Ptgs2	prostaglandin-endoperoxide synthase 2	0.015
Cyp3a2	cytochrome P450, family 3, subfamily a, polypeptide 2	0.015
Alb	albumin	0.015
Spam1	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	0.015
Ccnd3	cyclin D3	0.015
Podxl2	podocalyxin-like 2	0.015
Gnb2	guanine nucleotide binding protein (G protein), beta polypeptide 2	0.015
Serpina4	serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4	0.015	Rat
Reg3a	regenerating islet-derived 3 alpha	0.015
Slc2a3	solute carrier family 2 (facilitated glucose transporter), member 3	0.014
Cxcr7	chemokine (C-X-C motif) receptor 7	0.014
Metap2	methionyl aminopeptidase 2	0.014
Cfb	complement factor B	0.014
Atp1b2	ATPase, Na+/K+ transporting, beta 2 polypeptide	0.014
Azgp1	alpha-2-glycoprotein 1, zinc-binding	0.014
Ptpn7	protein tyrosine phosphatase, non-receptor type 7	0.014
Pcdhgc3	protocadherin gamma subfamily C, 3	0.014
Tspo	translocator protein	0.014
Ifit3	interferon-induced protein with tetratricopeptide repeats 3	0.014
Prlr	prolactin receptor	0.014
Fn1	fibronectin 1	0.014
Fgl2	fibrinogen-like 2	0.014
Arih1	ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1 (Drosophila)	0.014
Olr1641	olfactory receptor 1641	0.014
Anxa2	annexin A2	0.014
Timp1	TIMP metallopeptidase inhibitor 1	0.014	Human Rat
Tgfb1	transforming growth factor, beta 1	0.014
Lamc1	laminin, gamma 1	0.014
Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	0.014
Nr2f6	nuclear receptor subfamily 2, group F, member 6	0.013
Bcl7c	B-cell CLL/lymphoma 7C	0.013
P22k15	cystatin related protein 2	0.013
Itm2c	integral membrane protein 2C	0.013
Pea15a	phosphoprotein enriched in astrocytes 15A	0.013
Nbl1	neuroblastoma, suppression of tumorigenicity 1	0.013
Spink5	serine peptidase inhibitor, Kazal type 5	0.013
Rnase1	ribonuclease, RNase A family, 1 (pancreatic)	0.013
Sptan1	spectrin, alpha, non-erythrocytic 1	0.013
Sqstm1	sequestosome 1	0.013
Asgr1	asialoglycoprotein receptor 1	0.013
Ambp	alpha-1-microglobulin/bikunin precursor	0.013
Mybl2	myeloblastosis oncogene-like 2	0.013
Aebp1	AE binding protein 1	0.013
Kctd17	potassium channel tetramerisation domain containing 17	0.013
Plbd2	phospholipase B domain containing 2	0.013
Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	0.013
Sphk1	sphingosine kinase 1	0.013
Dctn2	dynactin 2	0.013
S100a10	S100 calcium binding protein A10	0.013
Igfbp7	insulin-like growth factor binding protein 7	0.012
Hdgfl1	hepatoma derived growth factor-like 1	0.012
Serpind1	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	0.012	Rat Fly
Cela1	chymotrypsin-like elastase family, member 1	0.012
Bub1b	budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)	0.012
LOC60591	calcium-activated potassium channel beta subunit	0.012
Troap	trophinin associated protein	0.012
Trh	thyrotropin releasing hormone	0.012
Sult1c3	sulfotransferase family, cytosolic, 1C, member 3	0.012
Met	met proto-oncogene	0.012
Bgn	biglycan	0.012
Aldoa	aldolase A, fructose-bisphosphate	0.012
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.012
Nos3	nitric oxide synthase 3, endothelial cell	0.012
Ctsh	cathepsin H	0.012
Kif1b	kinesin family member 1B	0.012
Tgoln1	trans-golgi network protein	0.012
Kng1	kininogen 1	0.012
Cyp2f4	cytochrome P450, family 2, subfamily f, polypeptide 4	0.012
Fndc3c1	fibronectin type III domain containing 3C1	0.012
Foxm1	forkhead box M1	0.012
Slc39a2	solute carrier family 39 (zinc transporter), member 2	0.012
Crk	v-crk sarcoma virus CT10 oncogene homolog (avian)	0.012
Amy2	amylase 2, pancreatic	0.012
Gucy1a2	guanylate cyclase 1, soluble, alpha 2	0.012
Chchd3	coiled-coil-helix-coiled-coil-helix domain containing 3	0.012
Ust5r	integral membrane transport protein UST5r	0.012
Pgm1	phosphoglucomutase 1	0.012
Rgs19	regulator of G-protein signaling 19	0.012
Myod1	myogenic differentiation 1	0.012
Flot2	flotillin 2	0.012
C2	complement component 2	0.012
Ptafr	platelet-activating factor receptor	0.012
Rbp2	retinol binding protein 2, cellular	0.012
Clec4f	C-type lectin domain family 4, member f	0.012
Serpinf2	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2	0.012
Mgea5	meningioma expressed antigen 5 (hyaluronidase)	0.012
Cbl	Cas-Br-M (murine) ecotropic retroviral transforming sequence	0.012
F10	coagulation factor X	0.012
Dusp1	dual specificity phosphatase 1	0.012
Fzd2	frizzled homolog 2 (Drosophila)	0.012
Pitx1	paired-like homeodomain 1	0.012
Mcf2l	MCF.2 cell line derived transforming sequence-like	0.012
Il1rn	interleukin 1 receptor antagonist	0.012
Mprip	myosin phosphatase Rho interacting protein	0.012
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.012
Sval1	seminal vesicle antigen-like 1	0.012
Cript	cysteine-rich PDZ-binding protein	0.012
Agtr1a	angiotensin II receptor, type 1a	0.012
Sirpa	signal-regulatory protein alpha	0.012
Mtch1	mitochondrial carrier homolog 1 (C. elegans)	0.011
Foxa3	forkhead box A3	0.011
Tmf1	TATA element modulatory factor 1	0.011
Mxd4	Max dimerization protein 4	0.011
Syt8	synaptotagmin VIII	0.011
Timm23	translocase of inner mitochondrial membrane 23 homolog (yeast)	0.011
Vsnl1	visinin-like 1	0.011
Otc	ornithine carbamoyltransferase	0.011
Guca1b	guanylate cyclase activator 1B	0.011
Agxt2	alanine-glyoxylate aminotransferase 2	0.011
Fos	FBJ osteosarcoma oncogene	0.011
Stxbp1	syntaxin binding protein 1	0.011
Cd3g	CD3 molecule, gamma	0.011
Atp6v0b	ATPase, H+ transporting, lysosomal V0 subunit B	0.011
LOC293103	similar to RIKEN cDNA 0610007P06	0.011
Gadd45a	growth arrest and DNA-damage-inducible, alpha	0.011
Pdzk1ip1	PDZK1 interacting protein 1	0.011
Use1	unconventional SNARE in the ER 1 homolog (S. cerevisiae)	0.011
Top1	topoisomerase (DNA) I	0.011
Ifng	interferon gamma	0.011
Tg	thyroglobulin	0.011
Calm2	calmodulin 2	0.011
Pgr	progesterone receptor	0.011
Skp1	S-phase kinase-associated protein 1	0.011
Baiap2	BAI1-associated protein 2	0.011
Glra3	glycine receptor, alpha 3	0.011
Lifr	leukemia inhibitory factor receptor alpha	0.011
Prok2	prokineticin 2	0.011
Klf12	Kruppel-like factor 12	0.011
Foxg1	forkhead box G1	0.011
Pfkl	phosphofructokinase, liver	0.011
Ccl7	chemokine (C-C motif) ligand 7	0.011
Impg2	interphotoreceptor matrix proteoglycan 2	0.011
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.011
Ubtf	upstream binding transcription factor, RNA polymerase I	0.011
Lipogenin	Lipogenin	0.011
Fgfbp1	fibroblast growth factor binding protein 1	0.011
A1i3	alpha-1-inhibitor III	0.011
Cdkn1a	cyclin-dependent kinase inhibitor 1A	0.011
Slco1a1	solute carrier organic anion transporter family, member 1a1	0.011
Olr1	oxidized low density lipoprotein (lectin-like) receptor 1	0.011
LOC690020	similar to killer cell lectin-like receptor, subfamily A, member 17	0.011
Gulo	gulonolactone (L-) oxidase	0.011
Gsn	gelsolin	0.011
Hpcal1	hippocalcin-like 1	0.011
Cyp2b3	cytochrome P450, family 2, subfamily b, polypeptide 3	0.011
Grpr	gastrin releasing peptide receptor	0.011
Sell	selectin L	0.011
Tdh	L-threonine dehydrogenase	0.011
LOC100360501	ribonuclease inhibitor-like	0.011
Gpx5	glutathione peroxidase 5	0.011
Rarres2	retinoic acid receptor responder (tazarotene induced) 2	0.011
Cxcl12	chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)	0.011
Hmgb1	high mobility group box 1	0.011
C1r	complement component 1, r subcomponent	0.011
Pth	parathyroid hormone	0.011
Uhmk1	U2AF homology motif (UHM) kinase 1	0.010
Fbxo6	F-box protein 6	0.010
Igfl3	IGF-like family member 3	0.010
Vcan	versican	0.010
Pou3f1	POU class 3 homeobox 1	0.010
Ndrg2	N-myc downstream regulated gene 2	0.010
Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	0.010
Ppp1r9b	protein phosphatase 1, regulatory subunit 9B	0.010
Gc	group specific component	0.010
Esr1	estrogen receptor 1	0.010
Tcf21	transcription factor 21	0.010
Prp2l1	proline rich protein 2-like 1	0.010
F12	coagulation factor XII (Hageman factor)	0.010
Pld3	phospholipase D family, member 3	0.010
LOC100361261	rCG23560-like	0.010
Ttr	transthyretin	0.010
Fgl1	fibrinogen-like 1	0.010
P4ha1	prolyl 4-hydroxylase, alpha polypeptide I	0.010
Olig1	oligodendrocyte transcription factor 1	0.010
Apbb1	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	0.010
Tmem37	transmembrane protein 37	0.010
Cyp2b15	cytochrome P450, family 2, subfamily b, polypeptide 15	0.010
Chrm2	cholinergic receptor, muscarinic 2	0.010
Serpinb5	serpin peptidase inhibitor, clade B (ovalbumin), member 5	0.010	Rat
Fdxr	ferredoxin reductase	0.010
Lgals2	lectin, galactoside-binding, soluble, 2	0.010
Car7	carbonic anhydrase 7	0.010
Cebpd	CCAAT/enhancer binding protein (C/EBP), delta	0.010
Cav1	caveolin 1, caveolae protein	0.010
Ctsl1	cathepsin L1	0.010
Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	0.010
C8b	complement component 8, beta polypeptide	0.010
Lipc	lipase, hepatic	0.010
Prl	prolactin	0.010
Jak2	Janus kinase 2	0.010
Tmem120a	transmembrane protein 120A	0.010