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Danio rerio

2 genes annotated in zebrafish

negative regulation of hormone secretion

Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a hormone from a cell.

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Known genes in the process in zebrafish Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of hormone secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of hormone secretion" (in gray)

Name	Description	Probability	Func Analog Organism
per2	period homolog 2 (Drosophila)	0.382
igf3	insulin-like growth factor 3	0.302
mchr1b	melanin-concentrating hormone receptor 1b	0.278
cyp19a1a	cytochrome P450, family 19, subfamily A, polypeptide 1a	0.239
mchr1a	melanin-concentrating hormone receptor 1a	0.235
uts1	urotensin 1	0.202
drd2b	dopamine receptor D2b	0.192	Rat
gfra1a	gdnf family receptor alpha 1a	0.177
nlgn1	neuroligin 1	0.158
spry4	sprouty (Drosophila) homolog 4	0.157
hcrt	hypocretin (orexin) neuropeptide precursor	0.151
myh11a	myosin, heavy polypeptide 11, smooth muscle a	0.143
col7a1l	collagen type VII alpha 1-like	0.143
fabp11a	fatty acid binding protein 11a	0.126
ptgs2a	prostaglandin-endoperoxide synthase 2a	0.123
cldn2	claudin 2	0.122
gfra1b	gdnf family receptor alpha 1b	0.116
nr1d2b	nuclear receptor subfamily 1, group D, member 2b	0.114
bmp15	bone morphogenetic protein 15	0.112
cyp19a1b	cytochrome P450, family 19, subfamily A, polypeptide 1b	0.111
LOC100332193	growth hormone secretagogue receptor type 1-like	0.110
xgb	x globin	0.110
inhbaa	inhibin, beta Aa	0.096
mao	monoamine oxidase	0.095
foxa3	forkhead box A3	0.091
fshb	follicle stimulating hormone, beta polypeptide	0.080
gsdf	gonadal somatic cell derived factor	0.078
slc17a7	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7	0.077
tef	thyrotroph embryonic factor	0.074
pgr	progesterone receptor	0.073
ncam2	neural cell adhesion molecule 2	0.069
sst2	somatostatin 2	0.069
glud1b	glutamate dehydrogenase 1b	0.068
si:dkey-258f14.5	si:dkey-258f14.5	0.067
gli2b	GLI-Kruppel family member GLI2b	0.066
drd2l	dopamine receptor D2 like	0.066
ghsra	growth hormone secretagogue receptor a	0.062	Rat
hcrtr2	hypocretin (orexin) receptor 2	0.062
dab1a	disabled homolog 1a (Drosophila)	0.055
dbh	dopamine beta hydroxylase	0.055
mtnr1ba	melatonin receptor type 1B a	0.054	Rat
rag2	recombination activating gene 2	0.054
slc8a4b	solute carrier family 8 (sodium/calcium exchanger), member 4b	0.054
ddb2	damage-specific DNA binding protein 2	0.053
paqr7b	progestin and adipoQ receptor family member VII, b	0.053
ghrl	ghrelin/obestatin preprohormone	0.053	Mouse
uts2a	urotensin 2, alpha	0.051
tnfa	tumor necrosis factor a (TNF superfamily, member 2)	0.050
htr1aa	5-hydroxytryptamine (serotonin) receptor 1A a	0.049
neurog3	neurogenin 3	0.049
kiss1rb	KISS1 receptor b	0.049
cry-dash	cryptochrome DASH	0.047
zp3	zona pellucida glycoprotein 3	0.047
col4a6	collagen, type IV, alpha 6	0.046
si:dkey-228g21.4	si:dkey-228g21.4	0.046
fshr	follicle stimulating hormone receptor	0.046
prok2	prokineticin 2	0.046
lhcgr	luteinizing hormone/choriogonadotropin receptor	0.046
mc4r	melanocortin 4 receptor	0.046
hsd17b1	hydroxysteroid (17-beta) dehydrogenase 1	0.045
or111-10	odorant receptor, family D, subfamily 111, member 10	0.045
LOC100006361	galanin-like	0.045
fzd7b	frizzled homolog 7b	0.044
cry5	cryptochrome 5	0.044
mef2a	myocyte enhancer factor 2a	0.043
mapk6	mitogen-activated protein kinase 6	0.042
fancl	Fanconi anemia, complementation group L	0.042
mc2r	melanocortin 2 receptor	0.041
cpla2	cytosolic phospholipase a2	0.041
LOC100003330	melanocortin-2 receptor accessory protein 2-like	0.041
aldob	aldolase b, fructose-bisphosphate	0.039
slc6a3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	0.039
hoxc12b	homeo box C12b	0.038
htr1ab	5-hydroxytryptamine (serotonin) receptor 1A b	0.038
ryr2a	ryanodine receptor 2a (cardiac)	0.037
gata6	GATA-binding protein 6	0.037
th2	tyrosine hydroxylase 2	0.037
ddc	dopa decarboxylase	0.036
cry1b	cryptochrome 1b	0.035	Mouse
gcm2	glial cells missing homolog 2 (Drosophila)	0.035
ptgesl	prostaglandin E synthase 2-like	0.034
bcl2l1	bcl2-like 1	0.034
hspb6	heat shock protein, alpha-crystallin-related, b6	0.033
tlr3	toll-like receptor 3	0.033
oprk1	opioid receptor, kappa 1	0.033
dedd1	death effector domain-containing 1	0.033
inha	inhibin, alpha	0.033	Rat
pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.032
gdf11	growth differentiation factor 11	0.032
vipr2	vasoactive intestinal peptide receptor 2	0.032
ins	preproinsulin	0.032
npas2	neuronal PAS domain protein 2	0.031
lyz	lysozyme	0.031
trpv6	transient receptor potential cation channel, subfamily V, member 6	0.031
cxcl12a	chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)	0.030
duox	dual oxidase	0.029
krt18	keratin 18	0.029
ap1m2	adaptor-related protein complex 1, mu 2 subunit	0.028
chat	choline acetyltransferase	0.028
LOC799612	prolactin 2	0.027
dmrt1	doublesex and mab-3 related transcription factor 1	0.027
mnx1	motor neuron and pancreas homeobox 1	0.027
hsf2	heat shock factor 2	0.027
uts2b	urotensin 2, beta	0.027
figla	factor in the germline alpha	0.027
limk1	LIM domain kinase 1	0.027
ahr1a	aryl hydrocarbon receptor 1a	0.026
egr2b	early growth response 2b	0.026
gabbr1a	gamma-aminobutyric acid (GABA) B receptor, 1a	0.026
vtg1	vitellogenin 1	0.026
csnk1db	casein kinase 1, delta b	0.025
slc43a2a	solute carrier family 43, member 2a	0.025
oxtl	oxytocin-like	0.025
esr1	estrogen receptor 1	0.025
adra2c	adrenergic, alpha-2C-, receptor	0.025
pou1f1	POU domain, class 1, transcription factor 1	0.025
slc15a1b	solute carrier family 15 (oligopeptide transporter), member 1b	0.025
zgc:171553	zgc:171553	0.025
adra2b	adrenergic, alpha-2B-, receptor	0.024
znf395b	zinc finger protein 395b	0.024
rmnd5b	required for meiotic nuclear division 5 homolog B (S. cerevisiae)	0.024
dmrt3a	doublesex and mab-3 related transcription factor 3a	0.024
drd2a	dopamine receptor D2a	0.023	Rat
ucp3	uncoupling protein 3	0.023
abhd2a	abhydrolase domain containing 2a	0.023
aanat1	arylalkylamine N-acetyltransferase 1	0.023
cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.023
stk35l	serine/threonine kinase 35, like	0.023
cyp11a1	cytochrome P450, subfamily XIA, polypeptide 1	0.022
hspb9	heat shock protein, alpha-crystallin-related, 9	0.022
il8	interleukin 8	0.022
gper	G protein-coupled estrogen receptor 1	0.022
slc25a14	solute carrier family 25 (mitochondrial carrier, brain), member 14	0.022
star	steroidogenic acute regulatory protein	0.022
htr1bd	5-hydroxytryptamine (serotonin) receptor 1bd	0.022
cldna	claudin a	0.022
cnr1	cannabinoid receptor 1	0.022
bsk146	brain specific kinase 146	0.022
nr5a1b	nuclear receptor subfamily 5, group A, member 1b	0.022
ptgds	prostaglandin D2 synthase	0.021
si:rp71-39b20.7	si:rp71-39b20.7	0.021
roraa	RAR-related orphan receptor A, paralog a	0.021
gcga	glucagon a and glucagon a-like	0.021
avpl	arginine vasopressin-like	0.021
aldh2b	aldehyde dehydrogenase 2b	0.021
ctsl1a	cathepsin L, 1 a	0.021
zfyve26	zinc finger, FYVE domain containing 26	0.021
rag1	recombination activating gene 1	0.021
dao.2	D-amino-acid oxidase 2	0.021
or111-5	odorant receptor, family D, subfamily 111, member 5	0.021
cry3	cryptochrome 3	0.021	Mouse
LOC100537723	hypothetical protein LOC100537723	0.021
wif1	wnt inhibitory factor 1	0.020
fbln1	fibulin 1	0.020
rnasel1	ribonuclease like 1	0.020
arntl1b	aryl hydrocarbon receptor nuclear translocator-like 1b	0.020
mgp	matrix Gla protein	0.020
nlgn4b	neuroligin 4b	0.019
adrb2a	adrenergic receptor, beta 2a	0.019
pcsk9	proprotein convertase subtilisin/kexin type 9	0.019
slc6a4b	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4B	0.019
mapk3	mitogen-activated protein kinase 3	0.019
bactin2	bactin2	0.019
adssl	adenylosuccinate synthase, like	0.019
hsd17b3	hydroxysteroid (17-beta) dehydrogenase 3	0.019
kiss1	KiSS-1 metastasis-suppressor	0.019
pmch	pro-melanin concentrating hormone	0.019
cdx1b	caudal type homeobox 1 b	0.019
or115-10	odorant receptor, family F, subfamily 115, member 10	0.019
casp8	caspase 8, apoptosis-related cysteine peptidase	0.018
atoh1b	atonal homolog 1b	0.018
blm	Bloom syndrome	0.018
pdx1	pancreatic and duodenal homeobox 1	0.018
ntf7	neurotrophin 7	0.018
grid2	glutamate receptor, ionotropic, delta 2	0.018
hsd3b1	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.018
cldn8	claudin 8	0.018
bmp7a	bone morphogenetic protein 7a	0.018
rnd1l	Rho family GTPase 1 like	0.018
cldn12	claudin 12	0.018
LOC100151245	regulator of G-protein signaling 4-like	0.018
pdca	phosducin a	0.017
nlgn2b	neuroligin 2b	0.017
rasl11b	RAS-like, family 11, member B	0.017
pomca	proopiomelanocortin a	0.017
pnx	posterior neuron-specific homeobox	0.017
cbr1l	carbonyl reductase 1-like	0.017
slco1f1	solute carrier organic anion transporter family, member 1F1	0.017
wnt7ba	wingless-type MMTV integration site family, member 7Ba	0.017
zgc:101598	zgc:101598	0.017
or102-1	odorant receptor, family C, subfamily 102, member 1	0.017
mcl1a	myeloid cell leukemia sequence 1a	0.016
or107-1	odorant receptor, family D, subfamily 107, member 1	0.016
insl3	insulin-like 3 (Leydig cell)	0.016
cx52.6	connexin 52.6	0.016
ahsg	alpha-2-HS-glycoprotein	0.016
insl5b	insulin-like 5b	0.016
cldn11b	claudin 11b	0.016
mcl1b	myeloid cell leukemia sequence 1b	0.016
cyp2p6	cytochrome P450, family 2, subfamily P, polypeptide 6	0.016
mpz	myelin protein zero	0.016
cpsf6	cleavage and polyadenylation specific factor 6	0.016
lats1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.016
grm1a	glutamate receptor, metabotropic 1a	0.016
cldn1	claudin 1	0.016
col2a1a	collagen type II, alpha-1a	0.015
cxcr4a	chemokine (C-X-C motif) receptor 4a	0.015
cnga5	cyclic nucleotide gated channel alpha 5	0.015
itln3	intelectin 3	0.015
zgc:171495	zgc:171495	0.015
krt8	keratin 8	0.015
ghrhrl	growth hormone releasing hormone receptor, like	0.015
rxfp1	relaxin/insulin-like family peptide receptor 1	0.015
spata2	spermatogenesis associated 2	0.015
arl4ab	ADP-ribosylation factor-like 4ab	0.015
mtnr1bb	melatonin receptor 1B b and melatonin receptor 1B	0.015
LOC793458	peptide Y-like	0.015
syce2	synaptonemal complex central element protein 2	0.015
aqp1a.2	aquaporin 1a, tandem duplicate 2	0.015
upf3b	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.015
gadd45bb	growth arrest and DNA-damage-inducible, beta b	0.014
bon	bonnie and clyde	0.014
vdrb	vitamin D receptor b	0.014
prkcq	protein kinase C, theta	0.014
mc5rb	melanocortin 5b receptor	0.014
slc25a27	solute carrier family 25, member 27	0.014
fanca	Fanconi anemia, complementation group A	0.014
lepr	leptin receptor	0.014
mesp2	mesoderm posterior 2 homolog (mouse)	0.014
paqr8	progestin and adipoQ receptor family member VIII	0.014
mcoln1	mucolipin 1	0.014
mmp13a	matrix metalloproteinase 13a	0.014
rhcgb	Rhesus blood group, C glycoprotein b	0.014
sox21b	SRY-box containing gene 21 b	0.014
crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	0.014
bzw1b	basic leucine zipper and W2 domains 1b	0.014
spi1l	spleen focus forming virus (SFFV) proviral integration oncogene spi1 like	0.014
coq10b	coenzyme Q10 homolog B (S. cerevisiae)	0.014
cyp3c1	cytochrome P450, family 3, subfamily c, polypeptide 1	0.014
faslg	Fas ligand (TNF superfamily, member 6)	0.014
cyp17a1	cytochrome P450, family 17, subfamily A, polypeptide 1	0.014
si:ch211-209p5.2	si:ch211-209p5.2	0.014
acp5b	acid phosphatase 5b, tartrate resistant	0.014
ints6	integrator complex subunit 6	0.014
bcl2	B-cell leukemia/lymphoma 2	0.014
th	tyrosine hydroxylase	0.013
syncripl	synaptotagmin binding, cytoplasmic RNA interacting protein, like	0.013
slc22a7b	solute carrier family 22 (organic anion transporter), member 7b	0.013
jag1b	jagged 1b	0.013
nlgn3b	neuroligin 3b	0.013
mbp	myelin basic protein	0.013
crhbp	corticotropin releasing hormone binding protein	0.013
ercc2	excision repair cross-complementing rodent repair deficiency, complementation group 2	0.013
bmp8a	bone morphogenetic protein 8a	0.013	Human
hsp70	heat shock cognate 70-kd protein	0.013
mhc2dcb	major histocompatibility complex class II DCB gene	0.013
sycp3l	synaptonemal complex protein 3 like	0.013
slc12a2	solute carrier family 12 (potassium/chloride transporters), member 2	0.013
thraa	thyroid hormone receptor alpha a	0.013
sst1.1	somatostatin 1, tandem duplicate 1	0.013
nkx6.2	NK6 transcription factor related, locus 2	0.013
wu:fk76c08	wu:fk76c08	0.013
mga	MAX gene associated	0.013
notum3	notum 3	0.013
wnt3	wingless-type MMTV integration site family, member 3	0.013
mmp9	matrix metalloproteinase 9	0.013
si:ch73-60e21.1	si:ch73-60e21.1	0.013
ctsf	cathepsin F	0.013
zgc:77714	zgc:77714	0.013
aldh1l1	aldehyde dehydrogenase 1 family, member L1	0.012
wu:fb80a07	wu:fb80a07	0.012
cpne3	copine III	0.012
wu:fj37c10	wu:fj37c10	0.012
slc6a5	solute carrier family 6 (neurotransmitter transporter, glycine), member 5	0.012
itgb1a	integrin, beta 1a	0.012
prpf8	pre-mRNA processing factor 8	0.012
ca15a	carbonic anhydrase XV a	0.012
zgc:77517	zgc:77517	0.012
hgfb	hepatocyte growth factor b	0.012
plaua	plasminogen activator, urokinase a	0.012
csf3r	colony stimulating factor 3 receptor (granulocyte)	0.012
phex	phosphate regulating gene with homologues to endopeptidases on the X chromosome	0.012
ar	androgen receptor	0.012
faf2	Fas associated factor family member 2	0.012
adh8a	alcohol dehydrogenase 8a	0.012
si:ch211-101l18.3	si:ch211-101l18.3	0.012
tagln2	transgelin 2	0.012
tp53bp2	tumor protein p53 binding protein, 2	0.012
fabp7b	fatty acid binding protein 7, brain, b	0.012
atoh1c	atonal homolog 1c	0.012
adipoql	adiponectin, C1Q and collagen domain containing, like	0.012
ifng1-2	interferon, gamma 1-2	0.012
grk5	G protein-coupled receptor kinase 5	0.012
slc2a1b	solute carrier family 2 (facilitated glucose transporter), member 1b	0.012
nfs1	NFS1 nitrogen fixation 1 (S. cerevisiae)	0.012
tshb	thyroid stimulating hormone, beta subunit	0.012
slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	0.012
lhb	luteinizing hormone, beta polypeptide	0.012
lipc	lipase, hepatic	0.012
zgc:113293	zgc:113293	0.012
hspb11	heat shock protein, alpha-crystallin-related, b11	0.011
gnb1a	guanine nucleotide binding protein (G protein), beta polypeptide 1a	0.011
kal1b	Kallmann syndrome 1b sequence	0.011
mbnl1	muscleblind-like (Drosophila)	0.011
ccnl1	cyclin L1	0.011
aplnrb	apelin receptor b	0.011
mafba	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	0.011
ugt2a5	UDP glucuronosyltransferase 2 family, polypeptide A5	0.011
gata4	GATA-binding protein 4	0.011
si:ch211-191i18.3	si:ch211-191i18.3	0.011
hbbe1.1	hemoglobin beta embryonic-1.1	0.011
opn1mw4	opsin 1 (cone pigments), medium-wave-sensitive, 4	0.011
heatr3	HEAT repeat containing 3	0.011
or111-7	odorant receptor, family D, subfamily 111, member 7	0.011
LOC100003514	protein kinase C alpha type-like	0.011
mxtx2	mix-type homeobox gene 2	0.011
fabp6	fatty acid binding protein 6, ileal (gastrotropin)	0.011
dcst1	DC-STAMP domain containing 1	0.011
si:ch211-214j24.10	si:ch211-214j24.10	0.011
si:dkey-21e7.2	si:dkey-21e7.2	0.011
abcb3l1	ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 1	0.011
pcsk5b	proprotein convertase subtilisin/kexin type 5b	0.011
cul2	cullin 2	0.011
hsd17b12a	hydroxysteroid (17-beta) dehydrogenase 12a	0.011
LOC100330224	fatty acid binding protein 1b-like	0.011
lctla	lactase-like a	0.011
hlxb9la	homeo box HB9 like a	0.011
apoeb	apolipoprotein Eb	0.011
a2ml	alpha-2-macroglobulin-like	0.011
polr2d	polymerase (RNA) II (DNA directed) polypeptide D	0.011
zgc:92880	zgc:92880	0.011
rhoad	ras homolog gene family, member Ad	0.011
ing4	inhibitor of growth family, member 4	0.011
pvrl1b	poliovirus receptor-related 1b	0.011
mid2	midline 2	0.011
fas	Fas (TNF receptor superfamily, member 6)	0.011
chrm2a	cholinergic receptor, muscarinic 2a	0.011
esf1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	0.011
adra2da	adrenergic, alpha-2D-, receptor a	0.011
bmf1	Bcl2 modifying factor 1	0.011
xrcc5	X-ray repair complementing defective repair in Chinese hamster cells 5	0.010
ildr1b	immunoglobulin-like domain containing receptor 1b	0.010
acvr2a	activin receptor IIa	0.010
scrib	scribbled homolog (Drosophila)	0.010
cyp11b2	cytochrome P450, family 11, subfamily B, polypeptide 2	0.010
srfl	serum response factor like	0.010
rtn4rl2a	reticulon 4 receptor-like 2 a	0.010
cd247l	CD247 antigen like	0.010
pomt2	protein-O-mannosyltransferase 2	0.010
men1	multiple endocrine neoplasia type 1 and multiple endocrine neoplasia I	0.010
mbnl3	muscleblind-like 3 (Drosophila)	0.010
si:ch211-191i18.1	si:ch211-191i18.1	0.010
hrh1	histamine receptor H1	0.010
mbtps1	membrane-bound transcription factor protease, site 1	0.010
LOC567678	avidin-like	0.010
zgc:171872	zgc:171872	0.010
esr2b	estrogen receptor 2b	0.010
piwil1	piwi-like 1 (Drosophila)	0.010
cldnd	claudin d	0.010
rnf144ab	ring finger protein 144ab	0.010