The network for 'renal tubule development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal tubule development

The progression of the renal tubule over time from its formation to the mature form. A renal tubule is a tube that filters, re-absorbs and secretes substances to rid an organism of waste and to play a role in fluid homeostasis.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
JAG1 jagged 1 0.990
NOTCH1 notch 1 0.935
NOTCH3 notch 3 0.931
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.926
SMAD3 SMAD family member 3 0.924
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.904
FSTL1 follistatin-like 1 0.881
VEGFA vascular endothelial growth factor A 0.786
EGR3 early growth response 3 0.771
FGF10 fibroblast growth factor 10 0.768
COL4A2 collagen, type IV, alpha 2 0.717
FGF1 fibroblast growth factor 1 (acidic) 0.716
NRP1 neuropilin 1 0.704
WNK4 WNK lysine deficient protein kinase 4 0.642
KLHL3 kelch-like 3 (Drosophila) 0.641
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.601
CUL3 cullin 3 0.567
PAX8 paired box 8 0.565
BMPR1A bone morphogenetic protein receptor, type IA 0.564
INSR insulin receptor 0.552
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.532
ENG endoglin 0.521
MEIS1 Meis homeobox 1 0.504
COL4A4 collagen, type IV, alpha 4 0.461
EGR2 early growth response 2 0.455
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 0.447
EGR1 early growth response 1 0.404
MEIS2 Meis homeobox 2 0.400
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.371
SKIL SKI-like oncogene 0.364
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.342
COL4A5 collagen, type IV, alpha 5 0.340
IFNAR1 interferon (alpha, beta and omega) receptor 1 0.336
JAK1 Janus kinase 1 0.332
HDAC4 histone deacetylase 4 0.322
TSC22D4 TSC22 domain family, member 4 0.321
NKX2-1 NK2 homeobox 1 0.251
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.242
FGF8 fibroblast growth factor 8 (androgen-induced) 0.233
DAPK1 death-associated protein kinase 1 0.214
MSN moesin 0.212
SMAD9 SMAD family member 9 0.204
ADAM17 ADAM metallopeptidase domain 17 0.184
TIMP3 TIMP metallopeptidase inhibitor 3 0.180
COL4A1 collagen, type IV, alpha 1 0.178
FGFR1 fibroblast growth factor receptor 1 0.177
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.157
IL4R interleukin 4 receptor 0.151
MEOX1 mesenchyme homeobox 1 0.136
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.133
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.127
THBS1 thrombospondin 1 0.124
COL4A6 collagen, type IV, alpha 6 0.123
IRF9 interferon regulatory factor 9 0.119
TGFB2 transforming growth factor, beta 2 0.117
NOTCH2 notch 2 0.116
TCF4 transcription factor 4 0.110
GLIS2 GLIS family zinc finger 2 0.100
RUNX1 runt-related transcription factor 1 0.097
WNT1 wingless-type MMTV integration site family, member 1 0.095
BMP7 bone morphogenetic protein 7 0.095
PRMT6 protein arginine methyltransferase 6 0.094
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.094
FGF3 fibroblast growth factor 3 0.092
FGF18 fibroblast growth factor 18 0.091
JAG2 jagged 2 0.083
BCL2L1 BCL2-like 1 0.083
COL2A1 collagen, type II, alpha 1 0.082
SPTBN1 spectrin, beta, non-erythrocytic 1 0.080
PJA1 praja ring finger 1 0.075
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.073
MAGED2 melanoma antigen family D, 2 0.071
NID1 nidogen 1 0.064
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.062
COL7A1 collagen, type VII, alpha 1 0.062
PARVA parvin, alpha 0.061
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.060
STAP2 signal transducing adaptor family member 2 0.060
EPAS1 endothelial PAS domain protein 1 0.058
LAPTM5 lysosomal protein transmembrane 5 0.054
FGF7 fibroblast growth factor 7 0.054
IL2RB interleukin 2 receptor, beta 0.052
LBX1 ladybird homeobox 1 0.052
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.051
FGF4 fibroblast growth factor 4 0.051
SMAD7 SMAD family member 7 0.051
TGFBR1 transforming growth factor, beta receptor 1 0.051
STAT1 signal transducer and activator of transcription 1, 91kDa 0.047
HOXA10 homeobox A10 0.047
HMGA2 high mobility group AT-hook 2 0.046
BBS4 Bardet-Biedl syndrome 4 0.046
CXXC5 CXXC finger protein 5 0.044
NCOR1 nuclear receptor corepressor 1 0.044
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.043
TAOK1 TAO kinase 1 0.042
IL12RB2 interleukin 12 receptor, beta 2 0.041
NFE2L2 nuclear factor (erythroid-derived 2)-like 2 0.040
NCOR2 nuclear receptor corepressor 2 0.040
TP53BP2 tumor protein p53 binding protein, 2 0.039
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
pax2a paired box gene 2a 0.928
osr2 odd-skipped related 2 (Drosophila) 0.846
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.564
jag1b jagged 1b 0.545
notch3 notch homolog 3 0.539
prdm1a PR domain containing 1a, with ZNF domain 0.476
wt1b wilms tumor 1b 0.444
cdh2 cadherin 2, neuronal 0.401
dla deltaA 0.377
mecom MDS1 and EVI1 complex locus 0.342
gdnf glial cell derived neurotrophic factor 0.314
hnf1bb HNF1 homeobox Bb 0.293
mib mind bomb 0.279
tbx1 T-box 1 0.276
her12 hairy-related 12 0.193
lhx1a LIM homeobox 1a 0.184
wt1a wilms tumor 1a 0.172
pax8 paired box gene 8 0.170
foxc1a forkhead box C1a 0.151
eya1 eyes absent homolog 1 0.149
dlc deltaC 0.148
nkx3.2 NK3 homeobox 2 0.147
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.145
kdrl kinase insert domain receptor like 0.143
spry1 sprouty homolog 1 (Drosophila) 0.136
fli1a friend leukemia integration 1a 0.134
gbx2 gastrulation brain homeo box 2 0.125
gyltl1b glycosyltransferase-like 1b 0.121
rfx2 regulatory factor X, 2 (influences HLA class II expression) 0.109
foxn4 forkhead box N4 0.108
osr1 odd-skipped related 1 (Drosophila) 0.094
chd chordin 0.089
notch1a notch homolog 1a 0.085
lrrc50 leucine rich repeat containing 50 0.085
wnt1 wingless-type MMTV integration site family, member 1 0.085
bmp4 bone morphogenetic protein 4 0.084
notch1b notch homolog 1b 0.082
traf4a tnf receptor-associated factor 4a 0.081
wnt3a wingless-type MMTV integration site family, member 3A 0.073
aplnrb apelin receptor b 0.072
tbx18 T-box 18 0.071
etv2 ets variant gene 2 0.067
tbx5a T-box 5a 0.065
shha sonic hedgehog a 0.063
hoxa9a homeo box A9a 0.062
jag2 jagged 2 0.058
wnt5b wingless-type MMTV integration site family, member 5b 0.053
isl2a islet2a 0.053
sall1a sal-like 1a (Drosophila) 0.049
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.048
slc12a2 solute carrier family 12 (potassium/chloride transporters), member 2 0.045
sim1a single-minded homolog 1a (Drosophila) 0.044
neurod4 neurogenic differentiation 4 0.042
pitx3 paired-like homeodomain transcription factor 3 0.039
ascl1a achaete-scute complex-like 1a (Drosophila) 0.039
hoxd4a homeo box D4a 0.036
ascl1b achaete-scute complex-like 1b (Drosophila) 0.036
onecutl one cut domain, family member, like 0.035
hoxa2b homeo box A2b 0.034
bmp2a bone morphogenetic protein 2a 0.034
fgf17 fibroblast growth factor 17 0.033
boc brother of CDO 0.033
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.032
hnf1ba HNF1 homeobox Ba 0.032
myod1 myogenic differentiation 1 0.031
fgf8a fibroblast growth factor 8 a 0.031
wnt10a wingless-type MMTV integration site family, member 10a 0.030
ism1 isthmin 1 0.030
ahi1 Abelson helper integration site 1 0.030
flr fleer 0.028
hoxd12a homeo box D12a 0.028
igfbp3 insulin-like growth factor binding protein 3 0.027
evx1 even-skipped homeobox 1 0.027
fgfr4 fibroblast growth factor receptor 4 0.026
her8a hairy-related 8a 0.026
hoxa13a homeo box A13a 0.026
hoxa10b homeo box A10b 0.026
pou3f3b POU class 3 homeobox 3b 0.025
wnt2ba wingless-type MMTV integration site family, member 2Ba 0.025
gli1 GLI-Kruppel family member 1 0.025
dld deltaD 0.025
hoxa9b homeo box A9b 0.024
klf2a Kruppel-like factor 2a 0.024
tac1 tachykinin 1 0.024
foxj1a forkhead box J1a 0.024
emx1 empty spiracles homeobox 1 0.022
sox2 SRY-box containing gene 2 0.022
pdlim7 PDZ and LIM domain 7 0.021
wnt4a wingless-type MMTV integration site family, member 4a 0.021
lft1 lefty1 0.021
grhl2a grainyhead-like 2a (Drosophila) 0.021
podxl podocalyxin-like 0.020
hoxa11a homeo box A11a 0.020
nrarpa notch-regulated ankyrin repeat protein a 0.020
hoxb2a homeo box B2a 0.020
vsx2 visual system homeobox 2 0.019
clic4 chloride intracellular channel 4 0.019
itgav integrin, alpha V 0.019
foxd3 forkhead box D3 0.018
hmx3 homeo box (H6 family) 3 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
tkv thickveins 0.997
dpp decapentaplegic 0.995
emc extra macrochaetae 0.993
Ras85D Ras oncogene at 85D 0.989
Egfr Epidermal growth factor receptor 0.989
Ubx Ultrabithorax 0.981
E(spl) Enhancer of split 0.975
slp1 sloppy paired 1 0.972
N Notch 0.966
sna snail 0.961
wg wingless 0.960
l(2)gl lethal (2) giant larvae 0.956
shn schnurri 0.955
argos CG4531 gene product from transcript CG4531-RA 0.912
bib big brain 0.879
hkb huckebein 0.877
H Hairless 0.861
aop anterior open 0.851
en engrailed 0.842
lin lines 0.835
rst roughest 0.831
ci cubitus interruptus 0.830
HLHmgamma E(spl) region transcript mgamma 0.810
ato atonal 0.807
byn brachyenteron 0.783
pnt pointed 0.774
rho rhomboid 0.770
slou slouch 0.754
hbs hibris 0.738
eve even skipped 0.728
Dfd Deformed 0.719
abd-A abdominal A 0.718
tin tinman 0.706
sog short gastrulation 0.695
ac achaete 0.673
LanA Laminin A 0.672
sqh spaghetti squash 0.672
sc scute 0.652
srp serpent 0.641
babo baboon 0.634
Dll Distal-less 0.612
ara araucan 0.609
gbb glass bottom boat 0.601
eyg eyegone 0.580
Mad Mothers against dpp 0.570
rols rolling pebbles 0.562
HLHm5 E(spl) region transcript m5 0.528
ss spineless 0.482
os outstretched 0.478
Abd-B Abdominal B 0.466
if inflated 0.451
kni knirps 0.449
kek1 kekkon-1 0.444
HLHmdelta E(spl) region transcript mdelta 0.439
sns sticks and stones 0.437
raw CG12437 gene product from transcript CG12437-RB 0.433
pan pangolin 0.428
twi twist 0.424
Optix CG18455 gene product from transcript CG18455-RA 0.424
fas faint sausage 0.422
shg shotgun 0.418
rib ribbon 0.414
tll tailless 0.412
scb scab 0.407
ptc patched 0.404
zip zipper 0.403
dm diminutive 0.402
fkh fork head 0.396
so sine oculis 0.395
HLHmbeta E(spl) region transcript mbeta 0.395
arr arrow 0.395
btl breathless 0.394
disco disconnected 0.387
Ser Serrate 0.385
run runt 0.380
nmo nemo 0.379
Rac1 CG2248 gene product from transcript CG2248-RA 0.378
da daughterless 0.376
hh hedgehog 0.371
opa odd paired 0.363
klu klumpfuss 0.359
HLHm7 E(spl) region transcript m7 0.359
Stat92E Signal-transducer and activator of transcription protein at 92E 0.358
kirre kin of irre 0.358
baz bazooka 0.354
scw screw 0.351
Mef2 Myocyte enhancer factor 2 0.348
Doc2 Dorsocross2 0.344
bin biniou 0.308
put punt 0.302
CtBP C-terminal Binding Protein 0.298
lab labial 0.288
ds dachsous 0.286
Rala Ras-related protein 0.280
mid midline 0.275
sca scabrous 0.268
crb crumbs 0.265
Antp Antennapedia 0.257
bi bifid 0.251
mirr mirror 0.248
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Wt1 Wilms tumor 1 homolog 1.000
Sox2 SRY-box containing gene 2 1.000
Bcl2 B-cell leukemia/lymphoma 2 1.000
Pax8 paired box gene 8 1.000
Lhx1 LIM homeobox protein 1 1.000
Emx2 empty spiracles homolog 2 (Drosophila) 1.000
Hoxa11 homeobox A11 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Meox2 mesenchyme homeobox 2 0.999
Foxc1 forkhead box C1 0.999
Gdnf glial cell line derived neurotrophic factor 0.998
Pitx2 paired-like homeodomain transcription factor 2 0.998
Pbx1 pre B-cell leukemia transcription factor 1 0.998
Emx1 empty spiracles homolog 1 (Drosophila) 0.998
Bmp4 bone morphogenetic protein 4 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.998
Ren1 renin 1 structural 0.996
Ret ret proto-oncogene 0.995
Lhx3 LIM homeobox protein 3 0.995
Pax6 paired box gene 6 0.995
Notch1 Notch gene homolog 1 (Drosophila) 0.995
Vegfa vascular endothelial growth factor A 0.994
Pax3 paired box gene 3 0.991
Hoxd11 homeobox D11 0.991
Nog noggin 0.988
Sall4 sal-like 4 (Drosophila) 0.987
Hes5 hairy and enhancer of split 5 (Drosophila) 0.987
Wnt4 wingless-related MMTV integration site 4 0.986
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.986
Fgfr1 fibroblast growth factor receptor 1 0.984
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.984
Rarg retinoic acid receptor, gamma 0.983
Gli2 GLI-Kruppel family member GLI2 0.983
Hes1 hairy and enhancer of split 1 (Drosophila) 0.982
Ctnnb1 catenin (cadherin associated protein), beta 1 0.981
Tbx2 T-box 2 0.980
Fgf8 fibroblast growth factor 8 0.980
Wnt6 wingless-related MMTV integration site 6 0.974
Otx1 orthodenticle homolog 1 (Drosophila) 0.971
Notch2 Notch gene homolog 2 (Drosophila) 0.971
Isl1 ISL1 transcription factor, LIM/homeodomain 0.971
Foxc2 forkhead box C2 0.970
Nos3 nitric oxide synthase 3, endothelial cell 0.970
Lef1 lymphoid enhancer binding factor 1 0.965
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.963
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.962
Gbx2 gastrulation brain homeobox 2 0.953
Tcf21 transcription factor 21 0.951
Lhx9 LIM homeobox protein 9 0.947
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.939
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.935
Gata6 GATA binding protein 6 0.935
Hoxd13 homeobox D13 0.932
Sox7 SRY-box containing gene 7 0.931
Ptgs2 prostaglandin-endoperoxide synthase 2 0.930
Rara retinoic acid receptor, alpha 0.922
Hoxa5 homeobox A5 0.920
Uncx UNC homeobox 0.920
Dll1 delta-like 1 (Drosophila) 0.917
Hoxa10 homeobox A10 0.911
Hand1 heart and neural crest derivatives expressed transcript 1 0.908
Hand2 heart and neural crest derivatives expressed transcript 2 0.907
Hoxd9 homeobox D9 0.901
En1 engrailed 1 0.899
Snai1 snail homolog 1 (Drosophila) 0.897
Msx1 homeobox, msh-like 1 0.893
Alx4 aristaless-like homeobox 4 0.893
Foxf1a forkhead box F1a 0.893
Pou3f3 POU domain, class 3, transcription factor 3 0.878
Tcfap2a transcription factor AP-2, alpha 0.871
Nkx2-1 NK2 homeobox 1 0.870
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.867
Foxg1 forkhead box G1 0.866
Tbx3 T-box 3 0.865
Umod uromodulin 0.863
Hoxa13 homeobox A13 0.849
Esr1 estrogen receptor 1 (alpha) 0.846
Msx2 homeobox, msh-like 2 0.843
Nodal nodal 0.839
Hoxd4 homeobox D4 0.828
Gata4 GATA binding protein 4 0.823
Bnc1 basonuclin 1 0.823
Hoxb3 homeobox B3 0.817
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.807
Jag1 jagged 1 0.795
Tead3 TEA domain family member 3 0.790
Pkd1 polycystic kidney disease 1 homolog 0.788
Psen1 presenilin 1 0.785
Hoxa9 homeobox A9 0.781
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.779
Lmx1a LIM homeobox transcription factor 1 alpha 0.770
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.768
Pten phosphatase and tensin homolog 0.765
Smad6 MAD homolog 6 (Drosophila) 0.764
Bax BCL2-associated X protein 0.762
Invs inversin 0.741
Gas1 growth arrest specific 1 0.738
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism