The network for 'axis elongation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

axis elongation

The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 1.000
HDAC2 histone deacetylase 2 0.945
FGF1 fibroblast growth factor 1 (acidic) 0.889
FGFR1 fibroblast growth factor receptor 1 0.879
BMPR1A bone morphogenetic protein receptor, type IA 0.870
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.853
FGF10 fibroblast growth factor 10 0.840
FSTL1 follistatin-like 1 0.785
CDK19 cyclin-dependent kinase 19 0.776
FZD1 frizzled homolog 1 (Drosophila) 0.593
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.516
S100A4 S100 calcium binding protein A4 0.448
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.374
RHOA ras homolog gene family, member A 0.371
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.364
BBS2 Bardet-Biedl syndrome 2 0.354
SMAD2 SMAD family member 2 0.342
MED24 mediator complex subunit 24 0.327
ZFYVE9 zinc finger, FYVE domain containing 9 0.313
TP53 tumor protein p53 0.301
LRRK2 leucine-rich repeat kinase 2 0.249
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.239
ZMYND11 zinc finger, MYND-type containing 11 0.227
JAM3 junctional adhesion molecule 3 0.225
FGF7 fibroblast growth factor 7 0.224
MED29 mediator complex subunit 29 0.216
EXOC7 exocyst complex component 7 0.213
FRS2 fibroblast growth factor receptor substrate 2 0.207
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.185
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.185
MBNL1 muscleblind-like (Drosophila) 0.182
GSK3B glycogen synthase kinase 3 beta 0.171
AXIN1 axin 1 0.165
PRKCI protein kinase C, iota 0.148
BBS1 Bardet-Biedl syndrome 1 0.146
FGF2 fibroblast growth factor 2 (basic) 0.133
PCM1 pericentriolar material 1 0.131
KLHL2 kelch-like 2, Mayven (Drosophila) 0.129
FZD7 frizzled homolog 7 (Drosophila) 0.129
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.129
MAGEA2 melanoma antigen family A, 2 0.126
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.122
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.120
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.119
CSNK1D casein kinase 1, delta 0.118
WT1 Wilms tumor 1 0.117
TRRAP transformation/transcription domain-associated protein 0.116
CEP164 centrosomal protein 164kDa 0.115
LRP6 low density lipoprotein receptor-related protein 6 0.114
FGF8 fibroblast growth factor 8 (androgen-induced) 0.109
ENG endoglin 0.108
TGFB2 transforming growth factor, beta 2 0.108
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.103
FZD8 frizzled homolog 8 (Drosophila) 0.102
BBS7 Bardet-Biedl syndrome 7 0.099
ERRFI1 ERBB receptor feedback inhibitor 1 0.098
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.097
MDFI MyoD family inhibitor 0.094
COL14A1 collagen, type XIV, alpha 1 0.093
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.092
RIN1 Ras and Rab interactor 1 0.090
HDAC3 histone deacetylase 3 0.089
TTC8 tetratricopeptide repeat domain 8 0.089
GLIS2 GLIS family zinc finger 2 0.084
MED13 mediator complex subunit 13 0.082
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.080
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.079
BBS9 Bardet-Biedl syndrome 9 0.078
F11R F11 receptor 0.078
SFN stratifin 0.078
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.074
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.072
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.072
CSNK1E casein kinase 1, epsilon 0.070
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.068
THBS1 thrombospondin 1 0.067
SPRY4 sprouty homolog 4 (Drosophila) 0.065
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.065
MED28 mediator complex subunit 28 0.063
TGFBR1 transforming growth factor, beta receptor 1 0.063
NOG noggin 0.061
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.061
LUM lumican 0.061
ARL6 ADP-ribosylation factor-like 6 0.061
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha 0.061
AR androgen receptor 0.060
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.058
PAX2 paired box 2 0.057
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.057
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.057
YAP1 Yes-associated protein 1 0.056
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.055
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.054
FGF3 fibroblast growth factor 3 0.053
KIAA1033 KIAA1033 0.052
FGFR3 fibroblast growth factor receptor 3 0.052
MED16 mediator complex subunit 16 0.051
OSBPL8 oxysterol binding protein-like 8 0.051
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.050
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.050
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.705
hnf1ba HNF1 homeobox Ba 0.687
bmp4 bone morphogenetic protein 4 0.625
bon bonnie and clyde 0.602
wnt5b wingless-type MMTV integration site family, member 5b 0.568
wnt11 wingless-type MMTV integration site family, member 11 0.552
tbx1 T-box 1 0.502
osr2 odd-skipped related 2 (Drosophila) 0.453
pax2a paired box gene 2a 0.385
mib mind bomb 0.355
cdh2 cadherin 2, neuronal 0.310
bmp2a bone morphogenetic protein 2a 0.290
fn1 fibronectin 1 0.282
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.253
flh floating head 0.239
oep one-eyed pinhead 0.224
hoxd4a homeo box D4a 0.200
wnt3a wingless-type MMTV integration site family, member 3A 0.188
chd chordin 0.178
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.161
smad9 MAD homolog 9 (Drosophila) 0.160
brd4 bromodomain containing 4 0.156
tbx5a T-box 5a 0.147
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.145
notch1a notch homolog 1a 0.145
osr1 odd-skipped related 1 (Drosophila) 0.136
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.133
eya1 eyes absent homolog 1 0.131
fgf3 fibroblast growth factor 3 0.129
shhb sonic hedgehog b 0.128
raraa retinoic acid receptor, alpha a 0.124
tbx16 T-box gene 16 0.113
wnt9b wingless-type MMTV integration site family, member 9B 0.102
eomesa eomesodermin homolog a 0.095
smad5 MAD homolog 5 (Drosophila) 0.092
shha sonic hedgehog a 0.086
eng1a engrailed 1a 0.085
wnt4a wingless-type MMTV integration site family, member 4a 0.083
wnt8a wingless-type MMTV integration site family, member 8a 0.082
vent ventral expressed homeobox 0.080
bambib BMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b 0.075
pou5f1 POU domain, class 5, transcription factor 1 0.070
jag2 jagged 2 0.068
ptch2 patched 2 0.068
wnt8b wingless-type MMTV integration site family, member 8b 0.064
foxp1b forkhead box P1b 0.064
rest RE1-silencing transcription factor 0.064
nkx3.2 NK3 homeobox 2 0.062
eve1 even-skipped-like1 0.061
ftr82 finTRIM family, member 82 0.060
pkd2 polycystic kidney disease 2 0.058
col2a1a collagen type II, alpha-1a 0.057
eaf2 ELL associated factor 2 0.055
dlx2a distal-less homeobox gene 2a 0.054
pcdh8 protocadherin 8 0.054
cfl2l cofilin 2, like 0.053
fgf8a fibroblast growth factor 8 a 0.052
nkd2 naked cuticle homolog 2 and naked 2a 0.052
cdx1b caudal type homeobox 1 b 0.051
smo smoothened homolog (Drosophila) 0.050
her5 hairy-related 5 0.050
dharma dharma 0.049
nipblb novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) 0.049
map2k4a mitogen-activated protein kinase kinase 4a 0.049
hgfa hepatocyte growth factor a 0.048
vangl2 vang-like 2 (van gogh, Drosophila) 0.047
msxc muscle segment homeobox C 0.046
hoxa9b homeo box A9b 0.044
zgc:175195 zgc:175195 0.044
gli1 GLI-Kruppel family member 1 0.044
acvr1l activin A receptor, type I like 0.044
zgc:171495 zgc:171495 0.043
slc30a7 solute carrier family 30 (zinc transporter), member 7 0.042
cdh1 cadherin 1, epithelial 0.042
gpc4 glypican 4 0.041
bmpr1ab bone morphogenetic protein receptor, type 1ab 0.040
col11a2 collagen type XI alpha-2 0.040
twist3 twist3 0.039
rarab retinoic acid receptor, alpha b 0.039
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.038
sema3d semaphorin 3d 0.037
fzd10 frizzled homolog 10 0.037
foxi1 forkhead box I1 0.036
lnx2b ligand of numb-protein X 2b 0.036
tgfb3 transforming growth factor, beta 3 0.035
tbx18 T-box 18 0.034
fzd8b frizzled homolog 8b 0.034
entpd3 ectonucleoside triphosphate diphosphohydrolase 3 0.033
six2a sine oculis-related homeobox 2a 0.033
si:dkey-273o13.1 si:dkey-273o13.1 0.033
klf2b Kruppel-like factor 2b 0.033
pdzk1 PDZ domain containing 1 0.033
vsx1 visual system homeobox 1 homolog, chx10-like 0.031
prkar1aa protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a 0.031
sept6 septin 6 0.030
ndr2 nodal-related 2 0.030
lrp2 low density lipoprotein-related protein 2 0.029
col11a1a collagen, type XI, alpha 1a 0.029
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.028
wnt9a wingless-type MMTV integration site family, member 9A 0.028
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Drosophila melanogaster
Name Description Probability Func Analog Organism
arm armadillo 0.675
stumps CG31317 gene product from transcript CG31317-RC 0.378
Ptp69D Protein tyrosine phosphatase 69D 0.189
eya eyes absent 0.154
shg shotgun 0.149
wg wingless 0.145
NetB Netrin-B 0.116
wb wing blister 0.114
ptc patched 0.102
dsh dishevelled 0.094
hh hedgehog 0.092
Wnt5 Wnt oncogene analog 5 0.091
pk prickle 0.078
Src64B Src oncogene at 64B 0.077
dock dreadlocks 0.071
fz frizzled 0.071
argos CG4531 gene product from transcript CG4531-RA 0.070
csw corkscrew 0.068
da daughterless 0.065
nrv2 nervana 2 0.060
msn misshapen 0.059
Wnt4 Wnt oncogene analog 4 0.056
ci cubitus interruptus 0.054
Cdc42 CG12530 gene product from transcript CG12530-RA 0.053
por porcupine 0.052
sbb scribbler 0.046
bin biniou 0.044
dally division abnormally delayed 0.044
nvy nervy 0.041
baz bazooka 0.041
CadN Cadherin-N 0.040
sd scalloped 0.040
crb crumbs 0.040
pyr pyramus 0.038
spi spitz 0.038
jing CG9397 gene product from transcript CG9397-RI 0.037
Wnt2 Wnt oncogene analog 2 0.037
Mtl Mig-2-like 0.037
fng fringe 0.035
shi shibire 0.034
ft fat 0.033
Shc SHC-adaptor protein 0.033
CG14869 CG14869 gene product from transcript CG14869-RB 0.032
rho rhomboid 0.032
simj simjang 0.031
cg combgap 0.031
Fas3 Fasciclin 3 0.030
bib big brain 0.030
cno canoe 0.030
zfh1 Zn finger homeodomain 1 0.030
kek1 kekkon-1 0.029
aop anterior open 0.029
retn retained 0.028
Tak1 TGF-beta activated kinase 1 0.028
rok Rho-kinase 0.028
dos daughter of sevenless 0.027
bnl branchless 0.027
sli slit 0.026
Mrtf Myocardin-related transcription factor 0.025
Ptpmeg CG1228 gene product from transcript CG1228-RD 0.025
lz lozenge 0.025
dgo diego 0.025
kirre kin of irre 0.025
CBP sarcoplasmic calcium-binding protein 0.024
par-1 CG8201 gene product from transcript CG8201-RA 0.024
vvl ventral veins lacking 0.023
ena enabled 0.023
svp seven up 0.023
fz2 frizzled 2 0.022
ed echinoid 0.022
skd skuld 0.022
Su(var)3-7 Suppressor of variegation 3-7 0.022
Sema-1a CG18405 gene product from transcript CG18405-RD 0.022
mew multiple edematous wings 0.021
mask multiple ankyrin repeats single KH domain 0.021
nkd naked cuticle 0.021
Traf4 TNF-receptor-associated factor 4 0.021
vri vrille 0.021
tld tolloid 0.021
B-H1 BarH1 0.021
Hmgcr HMG Coenzyme A reductase 0.020
rl rolled 0.020
phl pole hole 0.019
tin tinman 0.019
grh grainy head 0.019
elav embryonic lethal abnormal vision 0.019
robo roundabout 0.019
lilli lilliputian 0.018
smo smoothened 0.018
Peb Protein ejaculatory bulb 0.018
kon kon-tiki 0.018
ds dachsous 0.018
G-oalpha47A G protein oalpha 47A 0.017
Fak56D Focal Adhesion Kinase 0.017
trio CG18214 gene product from transcript CG18214-RA 0.017
dac dachshund 0.017
Lim3 CG10699 gene product from transcript CG10699-RB 0.017
CG8526 CG8526 gene product from transcript CG8526-RA 0.017
CG9650 CG9650 gene product from transcript CG9650-RG 0.017
repo reversed polarity 0.017
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Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Gli3 GLI-Kruppel family member GLI3 0.997
Vangl2 vang-like 2 (van gogh, Drosophila) 0.997
Fgf8 fibroblast growth factor 8 0.996
Fgfr2 fibroblast growth factor receptor 2 0.995
Tcfap2a transcription factor AP-2, alpha 0.946
Foxc1 forkhead box C1 0.938
Bmp4 bone morphogenetic protein 4 0.929
Pax3 paired box gene 3 0.886
Prrx1 paired related homeobox 1 0.875
Hand1 heart and neural crest derivatives expressed transcript 1 0.872
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.853
Tbx3 T-box 3 0.846
Fgfr3 fibroblast growth factor receptor 3 0.840
Pitx2 paired-like homeodomain transcription factor 2 0.816
Hoxd13 homeobox D13 0.796
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.748
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.747
Alx4 aristaless-like homeobox 4 0.730
Sfrp2 secreted frizzled-related protein 2 0.707
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.685
Meox2 mesenchyme homeobox 2 0.680
Gli2 GLI-Kruppel family member GLI2 0.641
Msx1 homeobox, msh-like 1 0.637
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.614
Rarg retinoic acid receptor, gamma 0.576
Tbx2 T-box 2 0.576
Fgf10 fibroblast growth factor 10 0.566
Msx2 homeobox, msh-like 2 0.543
Pou3f3 POU domain, class 3, transcription factor 3 0.516
Wnt5a wingless-related MMTV integration site 5A 0.505
Wnt3a wingless-related MMTV integration site 3A 0.502
Lrp6 low density lipoprotein receptor-related protein 6 0.478
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.468
Bmp7 bone morphogenetic protein 7 0.458
Sox11 SRY-box containing gene 11 0.457
Esrrb estrogen related receptor, beta 0.451
Smo smoothened homolog (Drosophila) 0.435
Pax8 paired box gene 8 0.431
Tgfb2 transforming growth factor, beta 2 0.429
Pax9 paired box gene 9 0.393
Spry2 sprouty homolog 2 (Drosophila) 0.389
Hand2 heart and neural crest derivatives expressed transcript 2 0.386
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.382
Pax2 paired box gene 2 0.377
Egfr epidermal growth factor receptor 0.377
Tbx15 T-box 15 0.356
Nodal nodal 0.352
Tgfa transforming growth factor alpha 0.331
Spry4 sprouty homolog 4 (Drosophila) 0.328
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.306
Hes1 hairy and enhancer of split 1 (Drosophila) 0.303
Gas1 growth arrest specific 1 0.282
Sall4 sal-like 4 (Drosophila) 0.274
Pbx1 pre B-cell leukemia transcription factor 1 0.264
Pax7 paired box gene 7 0.263
Fgf3 fibroblast growth factor 3 0.262
Foxf1a forkhead box F1a 0.260
Alx3 aristaless-like homeobox 3 0.247
Zeb1 zinc finger E-box binding homeobox 1 0.247
Runx2 runt related transcription factor 2 0.238
Fgfr1 fibroblast growth factor receptor 1 0.231
Fzd8 frizzled homolog 8 (Drosophila) 0.225
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.225
Eya1 eyes absent 1 homolog (Drosophila) 0.219
Lrp2 low density lipoprotein receptor-related protein 2 0.216
T brachyury 0.215
Ihh Indian hedgehog 0.215
Twist2 twist homolog 2 (Drosophila) 0.214
Efna4 ephrin A4 0.213
Cbx5 chromobox homolog 5 (Drosophila HP1a) 0.184
Rxra retinoid X receptor alpha 0.181
Fgf18 fibroblast growth factor 18 0.178
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.176
Nr2f1 nuclear receptor subfamily 2, group F, member 1 0.173
Prrx2 paired related homeobox 2 0.168
Kl klotho 0.167
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.157
Smad6 MAD homolog 6 (Drosophila) 0.148
Ror1 receptor tyrosine kinase-like orphan receptor 1 0.148
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.148
Pou5f1 POU domain, class 5, transcription factor 1 0.147
Rarb retinoic acid receptor, beta 0.144
Bbs2 Bardet-Biedl syndrome 2 (human) 0.143
Sox9 SRY-box containing gene 9 0.142
Tcf21 transcription factor 21 0.142
Amhr2 anti-Mullerian hormone type 2 receptor 0.138
Pitx1 paired-like homeodomain transcription factor 1 0.132
Foxc2 forkhead box C2 0.130
Sox7 SRY-box containing gene 7 0.130
Otx2 orthodenticle homolog 2 (Drosophila) 0.126
Hoxa13 homeobox A13 0.126
Dlx5 distal-less homeobox 5 0.120
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.116
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.112
Tcf15 transcription factor 15 0.109
Hoxa11 homeobox A11 0.103
En1 engrailed 1 0.103
Six6 sine oculis-related homeobox 6 homolog (Drosophila) 0.102
Bmp2 bone morphogenetic protein 2 0.101
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rbm42 RNA binding motif protein 42 0.033
Mgp matrix Gla protein 0.028
Prrx1 paired related homeobox 1 0.026
Vcan versican 0.024
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.021
Mllt4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.021
Nrp2 neuropilin 2 0.018
Ptpn12 protein tyrosine phosphatase, non-receptor type 12 0.018
Prkaa1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.018
Rasa1 RAS p21 protein activator (GTPase activating protein) 1 0.017
Lum lumican 0.017
Aebp1 AE binding protein 1 0.017
Sf3b4 splicing factor 3b, subunit 4 0.015
Ednrb endothelin receptor type B 0.014
Prkch protein kinase C, eta 0.014
Ppm1g protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform 0.013
Dmd dystrophin 0.013
Met met proto-oncogene 0.013
Cdc42bpa CDC42 binding protein kinase alpha 0.013
Postn periostin, osteoblast specific factor 0.013
Strn striatin, calmodulin binding protein 0.012
Ube3a ubiquitin protein ligase E3A 0.012
Lphn2 latrophilin 2 0.012
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.012
Pdlim5 PDZ and LIM domain 5 0.011
Acvr1 activin A receptor, type I 0.011
Aspn asporin 0.011
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.011
Csnk2a2 casein kinase 2, alpha prime polypeptide 0.011
RGD1565927 similar to 4631422O05Rik protein 0.011
Rab14 RAB14, member RAS oncogene family 0.011
Lamc1 laminin, gamma 1 0.011
Ctsk cathepsin K 0.010
Spp1 secreted phosphoprotein 1 0.010
Npw neuropeptide W 0.010
Manea mannosidase, endo-alpha 0.010
Cdc2l5 cell division cycle 2-like 5 (cholinesterase-related cell division controller) 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism