The network for 'establishment or maintenance of epithelial cell apical basal polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of epithelial cell apical basal polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.

Homo sapiens
Name Description Probability Func Analog Organism
GDA guanine deaminase 0.997
MAPT microtubule-associated protein tau 0.992
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.982
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.981
LCK lymphocyte-specific protein tyrosine kinase 0.972
APC adenomatous polyposis coli 0.963
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.941
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 0.939
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit 0.938
CD3E CD3e molecule, epsilon (CD3-TCR complex) 0.927
ARHGAP1 Rho GTPase activating protein 1 0.914
PARD6A par-6 partitioning defective 6 homolog alpha (C. elegans) 0.912
CSNK1E casein kinase 1, epsilon 0.870
MARK2 MAP/microtubule affinity-regulating kinase 2 0.858
CD247 CD247 molecule 0.845
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 0.823
CD44 CD44 molecule (Indian blood group) 0.815
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 0.766
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.755
RHOA ras homolog gene family, member A 0.717
RHOC ras homolog gene family, member C 0.715
PKP2 plakophilin 2 0.696
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.661
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) 0.617
INADL InaD-like (Drosophila) 0.614
SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 0.549
MCC mutated in colorectal cancers 0.535
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.535
FLNA filamin A, alpha 0.522
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit 0.505
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.465
LRRK2 leucine-rich repeat kinase 2 0.459
VCL vinculin 0.458
PXN paxillin 0.456
TJP2 tight junction protein 2 (zona occludens 2) 0.415
LAT linker for activation of T cells 0.405
JUP junction plakoglobin 0.363
CHMP1A chromatin modifying protein 1A 0.362
LGALS1 lectin, galactoside-binding, soluble, 1 0.360
LIN7C lin-7 homolog C (C. elegans) 0.347
SFN stratifin 0.337
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.331
DLG1 discs, large homolog 1 (Drosophila) 0.326
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.304
CEP250 centrosomal protein 250kDa 0.303
ELL elongation factor RNA polymerase II 0.299
RHOG ras homolog gene family, member G (rho G) 0.296
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.289
AXIN1 axin 1 0.289
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.289
SMAD2 SMAD family member 2 0.281
DVL2 dishevelled, dsh homolog 2 (Drosophila) 0.270
ERBB2IP erbb2 interacting protein 0.265
EZR ezrin 0.256
KIF5B kinesin family member 5B 0.247
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.247
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae) 0.244
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.241
SORBS3 sorbin and SH3 domain containing 3 0.239
CEP164 centrosomal protein 164kDa 0.233
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.229
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.227
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.213
ZNF512B zinc finger protein 512B 0.205
CDH5 cadherin 5, type 2 (vascular endothelium) 0.195
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 0.194
RTKN rhotekin 0.191
WASF2 WAS protein family, member 2 0.186
HDAC7 histone deacetylase 7 0.185
ACACA acetyl-CoA carboxylase alpha 0.184
STK11 serine/threonine kinase 11 0.171
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.165
EMP3 epithelial membrane protein 3 0.161
PRKCI protein kinase C, iota 0.160
BAD BCL2-associated agonist of cell death 0.158
CSNK1D casein kinase 1, delta 0.153
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.152
BTBD10 BTB (POZ) domain containing 10 0.149
UBE3A ubiquitin protein ligase E3A 0.139
CDC73 cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.134
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.132
TWF2 twinfilin, actin-binding protein, homolog 2 (Drosophila) 0.130
TBC1D10A TBC1 domain family, member 10A 0.129
JUB jub, ajuba homolog (Xenopus laevis) 0.128
PKP4 plakophilin 4 0.127
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.126
CSNK1A1 casein kinase 1, alpha 1 0.123
TRIP6 thyroid hormone receptor interactor 6 0.121
ZYX zyxin 0.120
ARHGAP5 Rho GTPase activating protein 5 0.118
CDC42 cell division cycle 42 (GTP binding protein, 25kDa) 0.118
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.117
EXOC5 exocyst complex component 5 0.111
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 0.108
IREB2 iron-responsive element binding protein 2 0.107
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.106
SH3BP2 SH3-domain binding protein 2 0.105
SMAD3 SMAD family member 3 0.102
MARK1 MAP/microtubule affinity-regulating kinase 1 0.100
FYN FYN oncogene related to SRC, FGR, YES 0.098
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
nid-1 Protein NID-1 0.094
sur-5 Protein SUR-5 0.069
pyc-1 Protein PYC-1 0.043
gei-4 Protein GEI-4 0.036
par-1 Protein PAR-1 0.036
CELE_T04H1.2 Protein T04H1.2 0.033
chd-7 Protein CHD-7 0.029
F21A10.2 Protein F21A10.2 0.028
ain-1 Protein AIN-1 0.018
fasn-1 Protein FASN-1 0.015
elo-2 Protein ELO-2 0.014
T26C12.1 Protein T26C12.1 0.013
hlh-30 Protein HLH-30 0.013
atg-2 Protein ATG-2 0.013
lat-1 Protein LAT-1 0.012
hbl-1 Protein HBL-1 0.010
mrp-5 Protein MRP-5 0.010
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Danio rerio
Name Description Probability Func Analog Organism
crb2a crumbs homolog 2a 0.986
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.955
dag1 dystroglycan 1 0.849
csad cysteine sulfinic acid decarboxylase 0.502
prkci protein kinase C, iota 0.402
lrp2 low density lipoprotein-related protein 2 0.256
guca1c guanylate cyclase activator 1C 0.170
cdh2 cadherin 2, neuronal 0.167
mstna myostatin a 0.146
gro2 groucho 2 0.144
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.143
pitpnb phosphotidylinositol transfer protein, beta 0.139
ythdf1 YTH domain family, member 1 0.124
scrib scribbled homolog (Drosophila) 0.123
crx cone-rod homeobox 0.106
dlg4 discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila) 0.104
hmgcrb 3-hydroxy-3-methylglutaryl-Coenzyme A reductase b 0.097
si:dkey-97i18.2 si:dkey-97i18.2 0.096
mib mind bomb 0.091
skia nuclear oncoprotein skia 0.087
opn4x1 opsin 4x1 0.080
celsr2 cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila) 0.078
lama1 laminin, alpha 1 0.071
ppp1r12a protein phosphatase 1, regulatory (inhibitor) subunit 12A 0.068
homez homeodomain leucine zipper gene 0.068
celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 0.067
dtng dystrobrevin, gamma and dystrobrevin, gamma-like 0.065
tcf7l1a transcription factor 7-like 1a (T-cell specific, HMG-box) 0.064
pxn paxillin 0.064
acsl4a acyl-CoA synthetase long-chain family member 4a 0.057
rras related RAS viral (r-ras) oncogene homolog 0.057
lamb1a laminin, beta 1a 0.056
ptprf protein tyrosine phosphatase, receptor type, F 0.055
sall4 sal-like 4 (Drosophila) 0.054
fn1 fibronectin 1 0.053
ywhabl tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like 0.053
zgc:63721 zgc:63721 0.052
cxadr coxsackie virus and adenovirus receptor 0.050
frmd6 FERM domain containing 6 0.050
fam43b family with sequence similarity 43, member B 0.048
rp2 retinitis pigmentosa 2 (X-linked recessive) 0.048
bhmt betaine-homocysteine methyltransferase 0.045
prickle1a prickle-like 1 (Drosophila) a 0.041
sema3aa semaphorin 3aa 0.040
slc4a4a solute carrier family 4, member 4a 0.040
waca WW domain containing adaptor with coiled-coil a 0.040
sb:cb472 sb:cb472 0.039
cntn1b contactin 1b 0.039
zgc:110298 zgc:110298 0.037
sema6d sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 0.036
six4.3 sine oculis homeobox homolog 4.3 0.036
myf5 myogenic factor 5 0.036
perp PERP, TP53 apoptosis effector 0.035
sdcbp syndecan binding protein (syntenin) 0.033
enpp6 ectonucleotide pyrophosphatase/phosphodiesterase 6 0.033
tfec transcription factor EC 0.033
hgfa hepatocyte growth factor a 0.033
axin1 axin 1 0.032
LOC100003514 protein kinase C alpha type-like 0.032
crb3b crumbs homolog 3b 0.032
nrxn1a neurexin 1a 0.032
casz1 castor zinc finger 1 0.032
rtn4a reticulon 4a 0.031
zgc:114199 zgc:114199 0.031
cast calpastatin 0.031
prkcz protein kinase C, zeta 0.031
src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.031
si:ch211-272f3.4 si:ch211-272f3.4 0.030
krt8 keratin 8 0.029
apc adenomatosis polyposis coli 0.029
arpc5b actin related protein 2/3 complex, subunit 5B 0.028
vcl vinculin 0.028
kif7 kinesin family member 7 0.027
LOC100331502 melanopsin-B-like 0.026
zfpl1 zinc finger protein-like 1 0.026
lman2 lectin, mannose-binding 2 0.026
zgc:153148 zgc:153148 0.026
lamc1 laminin, gamma 1 0.026
mxi1 max interacting protein 0.026
synj1 synaptojanin 1 0.025
nras neuroblastoma RAS viral (v-ras) oncogene homolog 0.025
pacsin3 protein kinase C and casein kinase substrate in neurons 3 0.025
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.024
olfm1b olfactomedin 1b 0.024
LOC100007758 novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3) 0.023
ehd1 EH-domain containing 1 0.023
dopey1 dopey family member 1 0.023
itga5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.023
tm9sf2 transmembrane 9 superfamily member 2 0.022
lmx1b.2 LIM homeobox transcription factor 1, beta 2 0.022
si:ch211-134j6.3 si:ch211-134j6.3 0.022
dlg1 discs, large (Drosophila) homolog 1 0.022
fgfrl1a fibroblast growth factor receptor-like 1a 0.022
cyfip2 cytoplasmic FMR1 interacting protein 2 0.022
si:rp71-1p14.10 si:rp71-1p14.10 0.021
utrn utrophin 0.021
ptk2.1 protein tyrosine kinase 2a 0.021
dvl3 dishevelled, dsh homolog 3 (Drosophila) 0.021
chm choroideremia 0.021
crb3a crumbs homolog 3a 0.021
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Drosophila melanogaster
Name Description Probability Func Analog Organism
fz frizzled 0.641
crb crumbs 0.545
Gug Grunge 0.347
fj four-jointed 0.332
ds dachsous 0.224
ft fat 0.220
Lis-1 Lissencephaly-1 0.177
Dhc64C Dynein heavy chain 64C 0.160
cora coracle 0.143
pk prickle 0.142
dlg1 discs large 1 0.138
kug kugelei 0.123
frc fringe connection 0.118
Dlic Dynein light intermediate chain 0.105
trc tricornered 0.096
stan starry night 0.086
sktl skittles 0.082
baz bazooka 0.078
Rac1 CG2248 gene product from transcript CG2248-RA 0.076
Rala Ras-related protein 0.075
Vang Van Gogh 0.061
ex expanded 0.056
ric8a CG15797 gene product from transcript CG15797-RA 0.054
Wnt4 Wnt oncogene analog 4 0.050
klar klarsicht 0.047
hpo hippo 0.047
scrib scribbled 0.047
kst karst 0.045
Khc Kinesin heavy chain 0.043
msn misshapen 0.043
sno strawberry notch 0.041
dgo diego 0.041
aPKC atypical protein kinase C 0.041
Cdc42 CG12530 gene product from transcript CG12530-RA 0.040
mys myospheroid 0.038
l(2)gl lethal (2) giant larvae 0.037
fng fringe 0.037
Nrx-IV Neurexin IV 0.037
D Dichaete 0.036
Sop2 Suppressor of profilin 2 0.035
MYPT-75D CG6896 gene product from transcript CG6896-RA 0.034
Rbsn-5 Rabenosyn-5 0.034
LIMK1 LIM-kinase1 0.031
Vps28 Vacuolar protein sorting 28 0.030
ttk tramtrack 0.029
CG32556 CG32556 gene product from transcript CG32556-RB 0.029
sgg shaggy 0.029
sano serrano 0.029
fry furry 0.029
Vhl von Hippel-Lindau 0.029
CG13144 CG13144 gene product from transcript CG13144-RA 0.028
mew multiple edematous wings 0.028
grh grainy head 0.027
flr flare 0.026
gammaCop gamma-coatomer protein 0.025
Pkn Protein kinase related to protein kinase N 0.024
schlank CG3576 gene product from transcript CG3576-RB 0.024
bs blistered 0.024
cpb capping protein beta 0.023
vps2 CG14542 gene product from transcript CG14542-RA 0.023
nct nicastrin 0.023
cdi center divider 0.022
Dmn Dynamitin 0.022
in inturned 0.022
stck steamer duck 0.021
par-6 CG5884 gene product from transcript CG5884-RA 0.021
CG11138 CG11138 gene product from transcript CG11138-RC 0.021
fz2 frizzled 2 0.020
CG34168 CG34168 gene product from transcript CG34168-RA 0.020
CG31740 CG31740 gene product from transcript CG31740-RA 0.020
Chc Clathrin heavy chain 0.019
Krn Keren 0.019
dia diaphanous 0.019
Jra Jun-related antigen 0.019
Gef26 CG9491 gene product from transcript CG9491-RB 0.018
dbo diablo 0.018
mirr mirror 0.018
sinah sina homologue 0.018
ImpE1 Ecdysone-inducible gene E1 0.018
CG6116 CG6116 gene product from transcript CG6116-RA 0.018
Rab2 Rab-protein 2 0.018
Vps20 Vacuolar protein sorting 20 0.018
rok Rho-kinase 0.017
yki yorkie 0.017
JIL-1 CG6297 gene product from transcript CG6297-RA 0.017
gho ghost 0.017
Pld Phospholipase D 0.017
bun bunched 0.017
kay kayak 0.017
Patj CG12021 gene product from transcript CG12021-RC 0.017
term terminus 0.016
mfrn mitoferrin 0.016
Myd88 CG2078 gene product from transcript CG2078-RA 0.016
R Roughened 0.016
Hop Hsp70/Hsp90 organizing protein homolog 0.016
Usf CG17592 gene product from transcript CG17592-RB 0.016
bowl brother of odd with entrails limited 0.016
bcd bicoid 0.016
drm drumstick 0.016
insc inscuteable 0.015
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Mus musculus
Name Description Probability Func Analog Organism
Vangl2 vang-like 2 (van gogh, Drosophila) 0.998
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.881
Pax6 paired box gene 6 0.836
Neurod1 neurogenic differentiation 1 0.698
Crb2 crumbs homolog 2 (Drosophila) 0.693
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.466
Dvl1 dishevelled, dsh homolog 1 (Drosophila) 0.427
Ret ret proto-oncogene 0.412
Mecom MDS1 and EVI1 complex locus 0.403
Cd151 CD151 antigen 0.395
Otx2 orthodenticle homolog 2 (Drosophila) 0.350
Neurod4 neurogenic differentiation 4 0.340
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.336
Gdnf glial cell line derived neurotrophic factor 0.284
Neurog2 neurogenin 2 0.267
Pdx1 pancreatic and duodenal homeobox 1 0.229
Itga3 integrin alpha 3 0.222
Atoh7 atonal homolog 7 (Drosophila) 0.214
Vangl1 vang-like 1 (van gogh, Drosophila) 0.213
Prph2 peripherin 2 0.197
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.194
Cask calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.173
Sox11 SRY-box containing gene 11 0.166
Emx2 empty spiracles homolog 2 (Drosophila) 0.166
Foxc2 forkhead box C2 0.157
T brachyury 0.153
Erbb2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.148
Irs2 insulin receptor substrate 2 0.145
Lmx1b LIM homeobox transcription factor 1 beta 0.118
Kiss1 KiSS-1 metastasis-suppressor 0.116
Wdr1 WD repeat domain 1 0.114
Phox2b paired-like homeobox 2b 0.099
Ldb1 LIM domain binding 1 0.097
Lhx1 LIM homeobox protein 1 0.093
Ptk7 PTK7 protein tyrosine kinase 7 0.092
Dab1 disabled homolog 1 (Drosophila) 0.090
Hand1 heart and neural crest derivatives expressed transcript 1 0.088
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.088
Emx1 empty spiracles homolog 1 (Drosophila) 0.083
Shh sonic hedgehog 0.082
Tcfap2a transcription factor AP-2, alpha 0.080
Ptf1a pancreas specific transcription factor, 1a 0.077
Pitx2 paired-like homeodomain transcription factor 2 0.076
Ina internexin neuronal intermediate filament protein, alpha 0.075
Pax3 paired box gene 3 0.073
Col4a3 collagen, type IV, alpha 3 0.072
Rac1 RAS-related C3 botulinum substrate 1 0.071
Arx aristaless related homeobox 0.071
Wt1 Wilms tumor 1 homolog 0.064
Lhx9 LIM homeobox protein 9 0.061
Ush1g Usher syndrome 1G homolog (human) 0.060
Pou4f2 POU domain, class 4, transcription factor 2 0.058
Insm1 insulinoma-associated 1 0.057
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.055
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.053
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.052
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.047
Tlx3 T-cell leukemia, homeobox 3 0.045
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.044
Lhx3 LIM homeobox protein 3 0.043
Gata6 GATA binding protein 6 0.043
Crb1 crumbs homolog 1 (Drosophila) 0.043
Nkx3-2 NK3 homeobox 2 0.041
Srrm4 serine/arginine repetitive matrix 4 0.040
Pax2 paired box gene 2 0.038
Dlg3 discs, large homolog 3 (Drosophila) 0.036
Etv4 ets variant gene 4 (E1A enhancer binding protein, E1AF) 0.036
Sox2 SRY-box containing gene 2 0.034
Lhcgr luteinizing hormone/choriogonadotropin receptor 0.034
Snai1 snail homolog 1 (Drosophila) 0.033
Nkd1 naked cuticle 1 homolog (Drosophila) 0.033
Gsc goosecoid homeobox 0.032
Mmp24 matrix metallopeptidase 24 0.031
Rag2 recombination activating gene 2 0.031
Vegfa vascular endothelial growth factor A 0.031
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.030
Bmp4 bone morphogenetic protein 4 0.030
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.030
Wwtr1 WW domain containing transcription regulator 1 0.029
Myh10 myosin, heavy polypeptide 10, non-muscle 0.029
Kiss1r KISS1 receptor 0.028
Myh9 myosin, heavy polypeptide 9, non-muscle 0.028
Smad2 MAD homolog 2 (Drosophila) 0.028
Gata1 GATA binding protein 1 0.027
Fzd1 frizzled homolog 1 (Drosophila) 0.027
Lamb1 laminin B1 0.027
Pou4f3 POU domain, class 4, transcription factor 3 0.027
Fgf8 fibroblast growth factor 8 0.026
Cdx2 caudal type homeobox 2 0.025
Zic2 zinc finger protein of the cerebellum 2 0.025
Nkx6-1 NK6 homeobox 1 0.025
Smad4 MAD homolog 4 (Drosophila) 0.024
Lhx6 LIM homeobox protein 6 0.024
En1 engrailed 1 0.024
Onecut1 one cut domain, family member 1 0.024
Hoxa1 homeobox A1 0.024
Gbx2 gastrulation brain homeobox 2 0.023
Foxd1 forkhead box D1 0.023
Crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.023
Shank2 SH3/ankyrin domain gene 2 0.023
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism