The network for 'regulation of dna binding' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of dna binding

Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid).

Homo sapiens
Name Description Probability Func Analog Organism
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.957
TAL1 T-cell acute lymphocytic leukemia 1 0.906
ZNF43 zinc finger protein 43 0.899
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.884
SMAD3 SMAD family member 3 0.827
SKIL SKI-like oncogene 0.693
TRAF3 TNF receptor-associated factor 3 0.627
EP300 E1A binding protein p300 0.589
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.549
MYD88 myeloid differentiation primary response gene (88) 0.532
ZNF273 zinc finger protein 273 0.532
RB1 retinoblastoma 1 0.523
SMAD4 SMAD family member 4 0.489
NCOR2 nuclear receptor corepressor 2 0.486
TRAF2 TNF receptor-associated factor 2 0.463
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.461
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.391
NCOR1 nuclear receptor corepressor 1 0.363
ZNF253 zinc finger protein 253 0.339
RBBP4 retinoblastoma binding protein 4 0.315
FOS FBJ murine osteosarcoma viral oncogene homolog 0.298
RUNX1 runt-related transcription factor 1 0.269
HMGA1 high mobility group AT-hook 1 0.267
SOD1 superoxide dismutase 1, soluble 0.265
SETD7 SET domain containing (lysine methyltransferase) 7 0.265
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.261
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.254
HDAC1 histone deacetylase 1 0.226
ZMYND11 zinc finger, MYND-type containing 11 0.222
ZNF675 zinc finger protein 675 0.208
E2F1 E2F transcription factor 1 0.191
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor 0.187
SOCS1 suppressor of cytokine signaling 1 0.170
PML promyelocytic leukemia 0.168
ZNF254 zinc finger protein 254 0.166
PRDX1 peroxiredoxin 1 0.164
SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) 0.164
CENPA centromere protein A 0.156
HDAC2 histone deacetylase 2 0.149
ZNF708 zinc finger protein 708 0.148
RBL1 retinoblastoma-like 1 (p107) 0.148
SETD8 SET domain containing (lysine methyltransferase) 8 0.141
CREBBP CREB binding protein 0.139
ZNF91 zinc finger protein 91 0.131
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.128
TCF4 transcription factor 4 0.126
STAT1 signal transducer and activator of transcription 1, 91kDa 0.124
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.118
SP1 Sp1 transcription factor 0.117
HIST2H3C histone cluster 2, H3c 0.116
MYOD1 myogenic differentiation 1 0.115
ZNF430 zinc finger protein 430 0.115
ZNF85 zinc finger protein 85 0.114
ZNF93 zinc finger protein 93 0.113
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.110
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.107
ZNF117 zinc finger protein 117 0.106
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.106
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 0.106
SUMO3 SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae) 0.103
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.101
SP110 SP110 nuclear body protein 0.093
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.093
SKI v-ski sarcoma viral oncogene homolog (avian) 0.092
ZNF680 zinc finger protein 680 0.092
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.090
TRIM33 tripartite motif containing 33 0.087
ATF3 activating transcription factor 3 0.085
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.082
GNLY granulysin 0.077
SMAD7 SMAD family member 7 0.076
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.074
ITGB1BP3 integrin beta 1 binding protein 3 0.074
JUNB jun B proto-oncogene 0.070
CD40 CD40 molecule, TNF receptor superfamily member 5 0.069
SP100 SP100 nuclear antigen 0.068
SMAD9 SMAD family member 9 0.066
PRF1 perforin 1 (pore forming protein) 0.061
S100B S100 calcium binding protein B 0.061
CDK9 cyclin-dependent kinase 9 0.059
SUMO2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.059
RIPK2 receptor-interacting serine-threonine kinase 2 0.056
TCF12 transcription factor 12 0.055
YBX1 Y box binding protein 1 0.055
NCF1 neutrophil cytosolic factor 1 0.054
RANGAP1 Ran GTPase activating protein 1 0.053
NME2 non-metastatic cells 2, protein (NM23B) expressed in 0.053
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.053
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 0.053
NCL nucleolin 0.051
SAMD9 sterile alpha motif domain containing 9 0.051
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 0.050
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.050
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.049
HTT huntingtin 0.048
TRADD TNFRSF1A-associated via death domain 0.048
MYBL2 v-myb myeloblastosis viral oncogene homolog (avian)-like 2 0.047
GATA2 GATA binding protein 2 0.047
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.046
NFIB nuclear factor I/B 0.046
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Moe Moesin 0.078
sax saxophone 0.059
ci cubitus interruptus 0.055
shn schnurri 0.051
tim timeless 0.038
east enhanced adult sensory threshold 0.035
usp ultraspiracle 0.029
Uba1 Ubiquitin activating enzyme 1 0.029
Nrt Neurotactin 0.028
CG12424 CG12424 gene product from transcript CG12424-RC 0.024
Mad Mothers against dpp 0.023
SoxN SoxNeuro 0.021
per period 0.020
zfh1 Zn finger homeodomain 1 0.017
slp1 sloppy paired 1 0.016
slou slouch 0.016
hig hikaru genki 0.016
osa CG7467 gene product from transcript CG7467-RD 0.016
Btk29A Btk family kinase at 29A 0.015
Spc105R Spc105-related 0.015
sna snail 0.015
fas faint sausage 0.014
pnr pannier 0.014
stau staufen 0.014
Ras85D Ras oncogene at 85D 0.013
grh grainy head 0.013
gcm glial cells missing 0.013
hth homothorax 0.012
byn brachyenteron 0.012
Socs36E Suppressor of cytokine signaling at 36E 0.012
cwo clockwork orange 0.012
bowl brother of odd with entrails limited 0.012
Taf4 TBP-associated factor 4 0.012
cry cryptochrome 0.011
btl breathless 0.011
ems empty spiracles 0.011
Mef2 Myocyte enhancer factor 2 0.010
CG34449 CG34449 gene product from transcript CG34449-RB 0.010
Nrg Neuroglian 0.010
robl roadblock 0.010
Ptp69D Protein tyrosine phosphatase 69D 0.010
srp serpent 0.010
fs(1)M3 female sterile (1) M3 0.010
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Mus musculus
Name Description Probability Func Analog Organism
Tbx3 T-box 3 0.834
Otx2 orthodenticle homolog 2 (Drosophila) 0.813
Fgf8 fibroblast growth factor 8 0.786
Tcf3 transcription factor 3 0.656
Tal1 T-cell acute lymphocytic leukemia 1 0.562
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.541
Emx2 empty spiracles homolog 2 (Drosophila) 0.534
Tcf4 transcription factor 4 0.446
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.431
Neurod1 neurogenic differentiation 1 0.423
Emx1 empty spiracles homolog 1 (Drosophila) 0.406
Lhx3 LIM homeobox protein 3 0.370
Id1 inhibitor of DNA binding 1 0.348
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.346
Pax6 paired box gene 6 0.323
Id3 inhibitor of DNA binding 3 0.315
Sox2 SRY-box containing gene 2 0.306
Per2 period homolog 2 (Drosophila) 0.304
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.294
Cry2 cryptochrome 2 (photolyase-like) 0.282
Mdm2 transformed mouse 3T3 cell double minute 2 0.264
En1 engrailed 1 0.262
Msx1 homeobox, msh-like 1 0.241
Socs1 suppressor of cytokine signaling 1 0.234
Pitx2 paired-like homeodomain transcription factor 2 0.228
Hes5 hairy and enhancer of split 5 (Drosophila) 0.208
Hand2 heart and neural crest derivatives expressed transcript 2 0.207
Shh sonic hedgehog 0.197
Fst follistatin 0.193
Lep leptin 0.191
Gsk3b glycogen synthase kinase 3 beta 0.183
Per1 period homolog 1 (Drosophila) 0.182
Smad6 MAD homolog 6 (Drosophila) 0.173
Ldb1 LIM domain binding 1 0.167
Nhlh1 nescient helix loop helix 1 0.155
Axin1 axin 1 0.155
Gata4 GATA binding protein 4 0.151
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.151
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.143
Bmpr1a bone morphogenetic protein receptor, type 1A 0.141
Neurog2 neurogenin 2 0.136
Neurod4 neurogenic differentiation 4 0.127
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.126
Cyld cylindromatosis (turban tumor syndrome) 0.120
Sox4 SRY-box containing gene 4 0.118
Rbl1 retinoblastoma-like 1 (p107) 0.118
Hes1 hairy and enhancer of split 1 (Drosophila) 0.116
Rbl2 retinoblastoma-like 2 0.109
Hand1 heart and neural crest derivatives expressed transcript 1 0.102
Ptf1a pancreas specific transcription factor, 1a 0.100
Foxf1a forkhead box F1a 0.097
Gsc goosecoid homeobox 0.097
Hdac2 histone deacetylase 2 0.094
Rb1 retinoblastoma 1 0.093
Apaf1 apoptotic peptidase activating factor 1 0.084
Pten phosphatase and tensin homolog 0.083
Trp53 transformation related protein 53 0.081
Hmx1 H6 homeobox 1 0.079
Atoh7 atonal homolog 7 (Drosophila) 0.079
Irs2 insulin receptor substrate 2 0.078
Gli3 GLI-Kruppel family member GLI3 0.077
Acvr1 activin A receptor, type 1 0.074
Gata1 GATA binding protein 1 0.074
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.074
Kiss1 KiSS-1 metastasis-suppressor 0.072
Hoxd13 homeobox D13 0.071
Gli2 GLI-Kruppel family member GLI2 0.071
Chd7 chromodomain helicase DNA binding protein 7 0.071
Pax3 paired box gene 3 0.067
Neurog3 neurogenin 3 0.067
Tbx4 T-box 4 0.067
Stat2 signal transducer and activator of transcription 2 0.063
Uba7 ubiquitin-like modifier activating enzyme 7 0.062
Dsg4 desmoglein 4 0.062
Gata6 GATA binding protein 6 0.062
Srrm4 serine/arginine repetitive matrix 4 0.061
Epor erythropoietin receptor 0.061
Arntl aryl hydrocarbon receptor nuclear translocator-like 0.060
Mll1 myeloid/lymphoid or mixed-lineage leukemia 1 0.059
Esr1 estrogen receptor 1 (alpha) 0.059
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.057
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.055
E2f1 E2F transcription factor 1 0.054
Gpr50 G-protein-coupled receptor 50 0.054
Chmp2a chromatin modifying protein 2A 0.054
Msx2 homeobox, msh-like 2 0.054
Tal2 T-cell acute lymphocytic leukemia 2 0.053
Hif3a hypoxia inducible factor 3, alpha subunit 0.053
Glrx3 glutaredoxin 3 0.051
Csnk1e casein kinase 1, epsilon 0.051
Lhx9 LIM homeobox protein 9 0.051
Fgfr1 fibroblast growth factor receptor 1 0.051
Arid1a AT rich interactive domain 1A (SWI-like) 0.051
Mesp1 mesoderm posterior 1 0.050
Pax2 paired box gene 2 0.050
Trrap transformation/transcription domain-associated protein 0.049
Ece1 endothelin converting enzyme 1 0.049
Nkx2-9 NK2 transcription factor related, locus 9 (Drosophila) 0.049
Tulp1 tubby like protein 1 0.048
Id4 inhibitor of DNA binding 4 0.048
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Rattus norvegicus
Name Description Probability Func Analog Organism
Ndufb6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6 0.011
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism