The network for 'negative regulation of phosphatidylinositol 3 kinase signaling' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of phosphatidylinositol 3 kinase signaling

Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.

Homo sapiens
Name Description Probability Func Analog Organism
TBC1D10A TBC1 domain family, member 10A 0.998
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.998
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 0.996
TSC1 tuberous sclerosis 1 0.977
EZR ezrin 0.950
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.925
RUNX1 runt-related transcription factor 1 0.887
PAG1 phosphoprotein associated with glycosphingolipid microdomains 1 0.885
PTEN phosphatase and tensin homolog 0.882
KLF6 Kruppel-like factor 6 0.876
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.777
GATA2 GATA binding protein 2 0.764
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.763
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.760
SETD8 SET domain containing (lysine methyltransferase) 8 0.729
CCL3 chemokine (C-C motif) ligand 3 0.729
CREBBP CREB binding protein 0.723
HDAC4 histone deacetylase 4 0.700
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.576
PPARA peroxisome proliferator-activated receptor alpha 0.571
ADRB2 adrenergic, beta-2-, receptor, surface 0.475
NCOR2 nuclear receptor corepressor 2 0.403
YAP1 Yes-associated protein 1 0.402
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.380
TAL1 T-cell acute lymphocytic leukemia 1 0.376
PDZK1 PDZ domain containing 1 0.320
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 0.308
GOPC golgi-associated PDZ and coiled-coil motif containing 0.289
NCOA1 nuclear receptor coactivator 1 0.284
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.282
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.273
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.221
KAT2B K(lysine) acetyltransferase 2B 0.215
EP300 E1A binding protein p300 0.211
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.201
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.168
CHMP1B chromatin modifying protein 1B 0.155
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.146
BTN3A1 butyrophilin, subfamily 3, member A1 0.142
TCF12 transcription factor 12 0.141
P2RY1 purinergic receptor P2Y, G-protein coupled, 1 0.120
MYOD1 myogenic differentiation 1 0.120
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 0.114
BTN2A2 butyrophilin, subfamily 2, member A2 0.114
BTN2A1 butyrophilin, subfamily 2, member A1 0.110
AR androgen receptor 0.110
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.104
NCOA2 nuclear receptor coactivator 2 0.090
FOXO1 forkhead box O1 0.090
FOS FBJ murine osteosarcoma viral oncogene homolog 0.090
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.086
ZMYND11 zinc finger, MYND-type containing 11 0.079
CTBP1 C-terminal binding protein 1 0.073
PDX1 pancreatic and duodenal homeobox 1 0.073
BTN3A3 butyrophilin, subfamily 3, member A3 0.068
USP8 ubiquitin specific peptidase 8 0.065
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.063
JUN jun proto-oncogene 0.061
LGALS7 lectin, galactoside-binding, soluble, 7 0.058
BTN3A2 butyrophilin, subfamily 3, member A2 0.053
LYL1 lymphoblastic leukemia derived sequence 1 0.053
LRRN2 leucine rich repeat neuronal 2 0.052
GATA4 GATA binding protein 4 0.052
FOXO3 forkhead box O3 0.051
DUSP1 dual specificity phosphatase 1 0.051
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.049
NCOA3 nuclear receptor coactivator 3 0.049
LHX5 LIM homeobox 5 0.049
CDK9 cyclin-dependent kinase 9 0.049
HDAC7 histone deacetylase 7 0.049
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.048
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.048
HIPK2 homeodomain interacting protein kinase 2 0.047
NF2 neurofibromin 2 (merlin) 0.046
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.045
RARA retinoic acid receptor, alpha 0.045
POU4F3 POU class 4 homeobox 3 0.044
RNF32 ring finger protein 32 0.044
HDAC3 histone deacetylase 3 0.043
SP1 Sp1 transcription factor 0.043
MPRIP myosin phosphatase Rho interacting protein 0.043
PHOX2A paired-like homeobox 2a 0.043
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.042
KCTD15 potassium channel tetramerisation domain containing 15 0.040
GUF1 GUF1 GTPase homolog (S. cerevisiae) 0.039
CAV1 caveolin 1, caveolae protein, 22kDa 0.039
KIF1C kinesin family member 1C 0.038
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.038
SKIL SKI-like oncogene 0.037
POU4F2 POU class 4 homeobox 2 0.036
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.035
HOXD12 homeobox D12 0.033
RXRA retinoid X receptor, alpha 0.033
HAND2 heart and neural crest derivatives expressed 2 0.033
MYB v-myb myeloblastosis viral oncogene homolog (avian) 0.033
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 0.033
SOCS1 suppressor of cytokine signaling 1 0.033
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 0.032
TRIM38 tripartite motif containing 38 0.032
RAI14 retinoic acid induced 14 0.031
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Atg18 Autophagy-specific gene 18 0.868
Pi3K59F Phosphotidylinositol 3 kinase 59F 0.708
Atg2 Autophagy-specific gene 2 0.670
S6k RPS6-p70-protein kinase 0.534
Atg4 Autophagy-specific gene 4 0.420
Pi3K92E CG4141 gene product from transcript CG4141-RB 0.302
ird1 immune response deficient 1 0.248
Atg9 Autophagy-specific gene 9 0.240
Marf Mitochondrial assembly regulatory factor 0.139
Atg7 Autophagy-specific gene 7 0.126
Lk6 CG17342 gene product from transcript CG17342-RA 0.106
Pk61C Protein kinase 61C 0.077
Rheb CG1081 gene product from transcript CG1081-RA 0.074
Wnk CG7177 gene product from transcript CG7177-RA 0.071
chico CG5686 gene product from transcript CG5686-RB 0.068
Atg1 Autophagy-specific gene 1 0.066
HLH106 Helix loop helix protein 106 0.056
CG5794 CG5794 gene product from transcript CG5794-RB 0.046
Atg8a Autophagy-specific gene 8a 0.042
dm diminutive 0.042
pix pixie 0.036
Akt1 CG4006 gene product from transcript CG4006-RA 0.034
Hrs Hepatocyte growth factor regulated tyrosine kinase substrate 0.033
Lnk CG17367 gene product from transcript CG17367-RC 0.031
Tak1 TGF-beta activated kinase 1 0.030
NFAT NFAT homolog 0.029
Fak56D Focal Adhesion Kinase 0.029
hppy happyhour 0.027
Thor CG8846 gene product from transcript CG8846-RA 0.026
Hcf Host cell factor 0.025
CG31033 CG31033 gene product from transcript CG31033-RC 0.023
Xe7 CG2179 gene product from transcript CG2179-RA 0.022
gig gigas 0.021
CG5508 CG5508 gene product from transcript CG5508-RA 0.021
CG6191 CG6191 gene product from transcript CG6191-RA 0.021
egr eiger 0.020
Tsc1 CG6147 gene product from transcript CG6147-RA 0.020
CG14299 CG14299 gene product from transcript CG14299-RC 0.016
Letm1 CG4589 gene product from transcript CG4589-RB 0.016
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.016
yki yorkie 0.016
SNF1A SNF1A/AMP-activated protein kinase 0.015
CG8678 CG8678 gene product from transcript CG8678-RA 0.015
CG9063 CG9063 gene product from transcript CG9063-RA 0.015
path pathetic 0.015
Cip4 CG15015 gene product from transcript CG15015-RA 0.014
shrb shrub 0.014
CG1347 CG1347 gene product from transcript CG1347-RB 0.013
raptor CG4320 gene product from transcript CG4320-RA 0.013
Smg6 CG6369 gene product from transcript CG6369-RA 0.013
slik Sterile20-like kinase 0.013
CG7611 CG7611 gene product from transcript CG7611-RJ 0.013
HDAC6 CG6170 gene product from transcript CG6170-RA 0.013
Dcr-1 Dicer-1 0.013
Rpn2 CG11888 gene product from transcript CG11888-RA 0.012
kibra kibra ortholog 0.012
CG4699 CG4699 gene product from transcript CG4699-RJ 0.012
kto kohtalo 0.012
dve defective proventriculus 0.011
mop myopic 0.011
sxc super sex combs 0.011
Sdc Syndecan 0.011
Atg6 Autophagy-specific gene 6 0.011
Stam Signal transducing adaptor molecule 0.010
kst karst 0.010
CG11877 CG11877 gene product from transcript CG11877-RA 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism