The network for 'cdc42 protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cdc42 protein signal transduction

A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.

Name Description Probability Func Analog Organism
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.999
TRAF5 TNF receptor-associated factor 5 0.994
APOC1 apolipoprotein C-I 0.984
TRAF2 TNF receptor-associated factor 2 0.966
HP haptoglobin 0.966
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 0.952
A2M alpha-2-macroglobulin 0.934
APOA1 apolipoprotein A-I 0.908
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.870
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.866
ALB albumin 0.861
EFNA1 ephrin-A1 0.802
GRB7 growth factor receptor-bound protein 7 0.796
TRAF1 TNF receptor-associated factor 1 0.746
TRAF3 TNF receptor-associated factor 3 0.737
EFNA5 ephrin-A5 0.735
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.706
ECT2 epithelial cell transforming sequence 2 oncogene 0.686
LCAT lecithin-cholesterol acyltransferase 0.667
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) 0.633
APOC3 apolipoprotein C-III 0.613
ZNF746 zinc finger protein 746 0.566
KIF23 kinesin family member 23 0.552
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) 0.483
SH3KBP1 SH3-domain kinase binding protein 1 0.459
FGA fibrinogen alpha chain 0.453
APOA2 apolipoprotein A-II 0.453
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 0.373
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.338
TRADD TNFRSF1A-associated via death domain 0.322
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain 0.314
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.310
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C) 0.304
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.229
TNF tumor necrosis factor 0.219
SH3BP2 SH3-domain binding protein 2 0.201
PRC1 protein regulator of cytokinesis 1 0.196
BCR breakpoint cluster region 0.192
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.187
ZMYND11 zinc finger, MYND-type containing 11 0.180
CD14 CD14 molecule 0.159
LMO2 LIM domain only 2 (rhombotin-like 1) 0.157
IL4R interleukin 4 receptor 0.156
GRB10 growth factor receptor-bound protein 10 0.155
FAM118B family with sequence similarity 118, member B 0.149
LY6G6F lymphocyte antigen 6 complex, locus G6F 0.145
DCK deoxycytidine kinase 0.141
NUMBL numb homolog (Drosophila)-like 0.140
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.134
LBR lamin B receptor 0.130
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.125
TTR transthyretin 0.122
SH3RF3 SH3 domain containing ring finger 3 0.122
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.115
SYNJ2 synaptojanin 2 0.115
APP amyloid beta (A4) precursor protein 0.113
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 0.113
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.112
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.112
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.109
PVRL3 poliovirus receptor-related 3 0.109
EPHA7 EPH receptor A7 0.107
CD40 CD40 molecule, TNF receptor superfamily member 5 0.106
TIFA TRAF-interacting protein with forkhead-associated domain 0.105
TXNDC2 thioredoxin domain containing 2 (spermatozoa) 0.103
APOC2 apolipoprotein C-II 0.102
EPHB3 EPH receptor B3 0.101
LRP1 low density lipoprotein receptor-related protein 1 0.100
APOE apolipoprotein E 0.100
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.098
TJP1 tight junction protein 1 (zona occludens 1) 0.097
FMNL1 formin-like 1 0.096
SH3RF1 SH3 domain containing ring finger 1 0.096
NCKAP1 NCK-associated protein 1 0.093
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.092
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.091
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.089
PLTP phospholipid transfer protein 0.087
PRKCA protein kinase C, alpha 0.087
EGFR epidermal growth factor receptor 0.082
TRAF3IP1 TNF receptor-associated factor 3 interacting protein 1 0.081
SPRY2 sprouty homolog 2 (Drosophila) 0.080
SFN stratifin 0.074
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 0.073
PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) 0.073
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 0.073
FES feline sarcoma oncogene 0.069
PLD2 phospholipase D2 0.068
TCEA2 transcription elongation factor A (SII), 2 0.067
FHOD1 formin homology 2 domain containing 1 0.066
ZBTB48 zinc finger and BTB domain containing 48 0.065
STAU1 staufen, RNA binding protein, homolog 1 (Drosophila) 0.065
TRAF3IP2 TRAF3 interacting protein 2 0.065
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 0.064
RACGAP1 Rac GTPase activating protein 1 0.064
C12orf48 chromosome 12 open reading frame 48 0.064
GAS2L3 growth arrest-specific 2 like 3 0.062
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 0.062
STAB1 stabilin 1 0.060
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) 0.060
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 0.999
Ccl2 chemokine (C-C motif) ligand 2 0.994
Ifng interferon gamma 0.972
Lyz2 lysozyme 2 0.961
Apoe apolipoprotein E 0.895
Tnf tumor necrosis factor 0.855
Ccl8 chemokine (C-C motif) ligand 8 0.852
Ccr2 chemokine (C-C motif) receptor 2 0.765
Ccr1 chemokine (C-C motif) receptor 1 0.709
Cttn cortactin 0.706
Npc1 Niemann Pick type C1 0.643
Ccl7 chemokine (C-C motif) ligand 7 0.548
Il1b interleukin 1 beta 0.543
C3 complement component 3 0.542
Batf basic leucine zipper transcription factor, ATF-like 0.538
Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 0.507
Ccl12 chemokine (C-C motif) ligand 12 0.504
Ccl3 chemokine (C-C motif) ligand 3 0.475
Mmp12 matrix metallopeptidase 12 0.451
Gzma granzyme A 0.442
Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 0.414
Ccl9 chemokine (C-C motif) ligand 9 0.400
Il1rn interleukin 1 receptor antagonist 0.375
Ccl22 chemokine (C-C motif) ligand 22 0.368
Ccr5 chemokine (C-C motif) receptor 5 0.364
Lrp1 low density lipoprotein receptor-related protein 1 0.348
Folr2 folate receptor 2 (fetal) 0.345
Cxcl9 chemokine (C-X-C motif) ligand 9 0.337
Cxcl2 chemokine (C-X-C motif) ligand 2 0.332
Irg1 immunoresponsive gene 1 0.327
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.319
Cxcl10 chemokine (C-X-C motif) ligand 10 0.299
Socs1 suppressor of cytokine signaling 1 0.295
Ch25h cholesterol 25-hydroxylase 0.290
Fcgr2b Fc receptor, IgG, low affinity IIb 0.274
Epha4 Eph receptor A4 0.268
Batf2 basic leucine zipper transcription factor, ATF-like 2 0.263
Ldlr low density lipoprotein receptor 0.261
Ubd ubiquitin D 0.260
C1qc complement component 1, q subcomponent, C chain 0.259
Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide 0.251
Fcgr1 Fc receptor, IgG, high affinity I 0.246
Itgax integrin alpha X 0.231
Ctsw cathepsin W 0.231
Sh2d2a SH2 domain protein 2A 0.223
C3ar1 complement component 3a receptor 1 0.222
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.219
Fas Fas (TNF receptor superfamily member 6) 0.207
Pdcd1 programmed cell death 1 0.198
Cxcl1 chemokine (C-X-C motif) ligand 1 0.180
Gzmb granzyme B 0.178
Clec4d C-type lectin domain family 4, member d 0.176
Nfkb2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 0.175
Btk Bruton agammaglobulinemia tyrosine kinase 0.174
Pkp3 plakophilin 3 0.172
Pik3cd phosphatidylinositol 3-kinase catalytic delta polypeptide 0.169
Dck deoxycytidine kinase 0.167
Abca1 ATP-binding cassette, sub-family A (ABC1), member 1 0.164
Ccr7 chemokine (C-C motif) receptor 7 0.163
Fasl Fas ligand (TNF superfamily, member 6) 0.160
Lag3 lymphocyte-activation gene 3 0.155
Efnb2 ephrin B2 0.155
Lta lymphotoxin A 0.153
Xcl1 chemokine (C motif) ligand 1 0.152
Il6 interleukin 6 0.149
Mx2 myxovirus (influenza virus) resistance 2 0.149
Csf2 colony stimulating factor 2 (granulocyte-macrophage) 0.148
Cep55 centrosomal protein 55 0.145
Selp selectin, platelet 0.143
Cd8a CD8 antigen, alpha chain 0.142
Ccl17 chemokine (C-C motif) ligand 17 0.138
Icos inducible T-cell co-stimulator 0.138
Hcst hematopoietic cell signal transducer 0.136
Cdc7 cell division cycle 7 (S. cerevisiae) 0.129
Msr1 macrophage scavenger receptor 1 0.128
Ifngr1 interferon gamma receptor 1 0.125
Saa3 serum amyloid A 3 0.125
Ccl11 chemokine (C-C motif) ligand 11 0.119
Batf3 basic leucine zipper transcription factor, ATF-like 3 0.117
Cd3e CD3 antigen, epsilon polypeptide 0.114
Cd7 CD7 antigen 0.108
Ccl4 chemokine (C-C motif) ligand 4 0.104
Lox lysyl oxidase 0.102
Anln anillin, actin binding protein 0.099
Efemp2 epidermal growth factor-containing fibulin-like extracellular matrix protein 2 0.095
Slamf8 SLAM family member 8 0.095
Tnfrsf18 tumor necrosis factor receptor superfamily, member 18 0.094
Cd14 CD14 antigen 0.093
Traf1 TNF receptor-associated factor 1 0.090
Ctla4 cytotoxic T-lymphocyte-associated protein 4 0.089
Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 0.088
Tbxas1 thromboxane A synthase 1, platelet 0.086
Cxcl13 chemokine (C-X-C motif) ligand 13 0.085
Retnla resistin like alpha 0.085
Itch itchy, E3 ubiquitin protein ligase 0.083
Des desmin 0.081
Mmp3 matrix metallopeptidase 3 0.080
Ccnb2 cyclin B2 0.080
Kif20a kinesin family member 20A 0.079
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.077
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism