Process View
The network for 'cdc42 protein signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
MLLT4 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | 0.999 | |
TRAF5 | TNF receptor-associated factor 5 | 0.994 | |
APOC1 | apolipoprotein C-I | 0.984 | |
TRAF2 | TNF receptor-associated factor 2 | 0.966 | |
HP | haptoglobin | 0.966 | |
SNTB2 | syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) | 0.952 | |
A2M | alpha-2-macroglobulin | 0.934 | |
APOA1 | apolipoprotein A-I | 0.908 | |
ATP7A | ATPase, Cu++ transporting, alpha polypeptide | 0.870 | |
PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 | 0.866 | |
ALB | albumin | 0.861 | |
EFNA1 | ephrin-A1 | 0.802 | |
GRB7 | growth factor receptor-bound protein 7 | 0.796 | |
TRAF1 | TNF receptor-associated factor 1 | 0.746 | |
TRAF3 | TNF receptor-associated factor 3 | 0.737 | |
EFNA5 | ephrin-A5 | 0.735 | |
ERBB3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.706 | |
ECT2 | epithelial cell transforming sequence 2 oncogene | 0.686 | |
LCAT | lecithin-cholesterol acyltransferase | 0.667 | |
RALB | v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) | 0.633 | |
APOC3 | apolipoprotein C-III | 0.613 | |
ZNF746 | zinc finger protein 746 | 0.566 | |
KIF23 | kinesin family member 23 | 0.552 | |
TNFRSF14 | tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) | 0.483 | |
SH3KBP1 | SH3-domain kinase binding protein 1 | 0.459 | |
FGA | fibrinogen alpha chain | 0.453 | |
APOA2 | apolipoprotein A-II | 0.453 | |
INPP5D | inositol polyphosphate-5-phosphatase, 145kDa | 0.373 | |
RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) | 0.338 | |
TRADD | TNFRSF1A-associated via death domain | 0.322 | |
TNFRSF10C | tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain | 0.314 | |
PVRL2 | poliovirus receptor-related 2 (herpesvirus entry mediator B) | 0.310 | |
PVRL1 | poliovirus receptor-related 1 (herpesvirus entry mediator C) | 0.304 | |
PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.229 | |
TNF | tumor necrosis factor | 0.219 | |
SH3BP2 | SH3-domain binding protein 2 | 0.201 | |
PRC1 | protein regulator of cytokinesis 1 | 0.196 | |
BCR | breakpoint cluster region | 0.192 | |
PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.187 | |
ZMYND11 | zinc finger, MYND-type containing 11 | 0.180 | |
CD14 | CD14 molecule | 0.159 | |
LMO2 | LIM domain only 2 (rhombotin-like 1) | 0.157 | |
IL4R | interleukin 4 receptor | 0.156 | |
GRB10 | growth factor receptor-bound protein 10 | 0.155 | |
FAM118B | family with sequence similarity 118, member B | 0.149 | |
LY6G6F | lymphocyte antigen 6 complex, locus G6F | 0.145 | |
DCK | deoxycytidine kinase | 0.141 | |
NUMBL | numb homolog (Drosophila)-like | 0.140 | |
ERBB2 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 0.134 | |
LBR | lamin B receptor | 0.130 | |
ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.125 | |
TTR | transthyretin | 0.122 | |
SH3RF3 | SH3 domain containing ring finger 3 | 0.122 | |
TNFRSF1A | tumor necrosis factor receptor superfamily, member 1A | 0.115 | |
SYNJ2 | synaptojanin 2 | 0.115 | |
APP | amyloid beta (A4) precursor protein | 0.113 | |
TNFRSF9 | tumor necrosis factor receptor superfamily, member 9 | 0.113 | |
TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | 0.112 | |
TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 | 0.112 | |
SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | 0.109 | |
PVRL3 | poliovirus receptor-related 3 | 0.109 | |
EPHA7 | EPH receptor A7 | 0.107 | |
CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.106 | |
TIFA | TRAF-interacting protein with forkhead-associated domain | 0.105 | |
TXNDC2 | thioredoxin domain containing 2 (spermatozoa) | 0.103 | |
APOC2 | apolipoprotein C-II | 0.102 | |
EPHB3 | EPH receptor B3 | 0.101 | |
LRP1 | low density lipoprotein receptor-related protein 1 | 0.100 | |
APOE | apolipoprotein E | 0.100 | |
AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.098 | |
TJP1 | tight junction protein 1 (zona occludens 1) | 0.097 | |
FMNL1 | formin-like 1 | 0.096 | |
SH3RF1 | SH3 domain containing ring finger 1 | 0.096 | |
NCKAP1 | NCK-associated protein 1 | 0.093 | |
MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.092 | |
IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.091 | |
CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.089 | |
PLTP | phospholipid transfer protein | 0.087 | |
PRKCA | protein kinase C, alpha | 0.087 | |
EGFR | epidermal growth factor receptor | 0.082 | |
TRAF3IP1 | TNF receptor-associated factor 3 interacting protein 1 | 0.081 | |
SPRY2 | sprouty homolog 2 (Drosophila) | 0.080 | |
SFN | stratifin | 0.074 | |
TCIRG1 | T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 | 0.073 | |
PTPN5 | protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched) | 0.073 | |
CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 0.073 | |
FES | feline sarcoma oncogene | 0.069 | |
PLD2 | phospholipase D2 | 0.068 | |
TCEA2 | transcription elongation factor A (SII), 2 | 0.067 | |
FHOD1 | formin homology 2 domain containing 1 | 0.066 | |
ZBTB48 | zinc finger and BTB domain containing 48 | 0.065 | |
STAU1 | staufen, RNA binding protein, homolog 1 (Drosophila) | 0.065 | |
TRAF3IP2 | TRAF3 interacting protein 2 | 0.065 | |
RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.064 | |
RACGAP1 | Rac GTPase activating protein 1 | 0.064 | |
C12orf48 | chromosome 12 open reading frame 48 | 0.064 | |
GAS2L3 | growth arrest-specific 2 like 3 | 0.062 | |
TNFRSF11A | tumor necrosis factor receptor superfamily, member 11a, NFKB activator | 0.062 | |
STAB1 | stabilin 1 | 0.060 | |
GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.060 |
Name | Description | Probability | Func Analog Organism |
---|---|---|---|
Pafah1b1 | platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 | 0.999 | |
Ccl2 | chemokine (C-C motif) ligand 2 | 0.994 | |
Ifng | interferon gamma | 0.972 | |
Lyz2 | lysozyme 2 | 0.961 | |
Apoe | apolipoprotein E | 0.895 | |
Tnf | tumor necrosis factor | 0.855 | |
Ccl8 | chemokine (C-C motif) ligand 8 | 0.852 | |
Ccr2 | chemokine (C-C motif) receptor 2 | 0.765 | |
Ccr1 | chemokine (C-C motif) receptor 1 | 0.709 | |
Cttn | cortactin | 0.706 | |
Npc1 | Niemann Pick type C1 | 0.643 | |
Ccl7 | chemokine (C-C motif) ligand 7 | 0.548 | |
Il1b | interleukin 1 beta | 0.543 | |
C3 | complement component 3 | 0.542 | |
Batf | basic leucine zipper transcription factor, ATF-like | 0.538 | |
Tnfrsf4 | tumor necrosis factor receptor superfamily, member 4 | 0.507 | |
Ccl12 | chemokine (C-C motif) ligand 12 | 0.504 | |
Ccl3 | chemokine (C-C motif) ligand 3 | 0.475 | |
Mmp12 | matrix metallopeptidase 12 | 0.451 | |
Gzma | granzyme A | 0.442 | |
Abcg1 | ATP-binding cassette, sub-family G (WHITE), member 1 | 0.414 | |
Ccl9 | chemokine (C-C motif) ligand 9 | 0.400 | |
Il1rn | interleukin 1 receptor antagonist | 0.375 | |
Ccl22 | chemokine (C-C motif) ligand 22 | 0.368 | |
Ccr5 | chemokine (C-C motif) receptor 5 | 0.364 | |
Lrp1 | low density lipoprotein receptor-related protein 1 | 0.348 | |
Folr2 | folate receptor 2 (fetal) | 0.345 | |
Cxcl9 | chemokine (C-X-C motif) ligand 9 | 0.337 | |
Cxcl2 | chemokine (C-X-C motif) ligand 2 | 0.332 | |
Irg1 | immunoresponsive gene 1 | 0.327 | |
Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | 0.319 | |
Cxcl10 | chemokine (C-X-C motif) ligand 10 | 0.299 | |
Socs1 | suppressor of cytokine signaling 1 | 0.295 | |
Ch25h | cholesterol 25-hydroxylase | 0.290 | |
Fcgr2b | Fc receptor, IgG, low affinity IIb | 0.274 | |
Epha4 | Eph receptor A4 | 0.268 | |
Batf2 | basic leucine zipper transcription factor, ATF-like 2 | 0.263 | |
Ldlr | low density lipoprotein receptor | 0.261 | |
Ubd | ubiquitin D | 0.260 | |
C1qc | complement component 1, q subcomponent, C chain | 0.259 | |
Fcer1g | Fc receptor, IgE, high affinity I, gamma polypeptide | 0.251 | |
Fcgr1 | Fc receptor, IgG, high affinity I | 0.246 | |
Itgax | integrin alpha X | 0.231 | |
Ctsw | cathepsin W | 0.231 | |
Sh2d2a | SH2 domain protein 2A | 0.223 | |
C3ar1 | complement component 3a receptor 1 | 0.222 | |
Tnfrsf1b | tumor necrosis factor receptor superfamily, member 1b | 0.219 | |
Fas | Fas (TNF receptor superfamily member 6) | 0.207 | |
Pdcd1 | programmed cell death 1 | 0.198 | |
Cxcl1 | chemokine (C-X-C motif) ligand 1 | 0.180 | |
Gzmb | granzyme B | 0.178 | |
Clec4d | C-type lectin domain family 4, member d | 0.176 | |
Nfkb2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100 | 0.175 | |
Btk | Bruton agammaglobulinemia tyrosine kinase | 0.174 | |
Pkp3 | plakophilin 3 | 0.172 | |
Pik3cd | phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.169 | |
Dck | deoxycytidine kinase | 0.167 | |
Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.164 | |
Ccr7 | chemokine (C-C motif) receptor 7 | 0.163 | |
Fasl | Fas ligand (TNF superfamily, member 6) | 0.160 | |
Lag3 | lymphocyte-activation gene 3 | 0.155 | |
Efnb2 | ephrin B2 | 0.155 | |
Lta | lymphotoxin A | 0.153 | |
Xcl1 | chemokine (C motif) ligand 1 | 0.152 | |
Il6 | interleukin 6 | 0.149 | |
Mx2 | myxovirus (influenza virus) resistance 2 | 0.149 | |
Csf2 | colony stimulating factor 2 (granulocyte-macrophage) | 0.148 | |
Cep55 | centrosomal protein 55 | 0.145 | |
Selp | selectin, platelet | 0.143 | |
Cd8a | CD8 antigen, alpha chain | 0.142 | |
Ccl17 | chemokine (C-C motif) ligand 17 | 0.138 | |
Icos | inducible T-cell co-stimulator | 0.138 | |
Hcst | hematopoietic cell signal transducer | 0.136 | |
Cdc7 | cell division cycle 7 (S. cerevisiae) | 0.129 | |
Msr1 | macrophage scavenger receptor 1 | 0.128 | |
Ifngr1 | interferon gamma receptor 1 | 0.125 | |
Saa3 | serum amyloid A 3 | 0.125 | |
Ccl11 | chemokine (C-C motif) ligand 11 | 0.119 | |
Batf3 | basic leucine zipper transcription factor, ATF-like 3 | 0.117 | |
Cd3e | CD3 antigen, epsilon polypeptide | 0.114 | |
Cd7 | CD7 antigen | 0.108 | |
Ccl4 | chemokine (C-C motif) ligand 4 | 0.104 | |
Lox | lysyl oxidase | 0.102 | |
Anln | anillin, actin binding protein | 0.099 | |
Efemp2 | epidermal growth factor-containing fibulin-like extracellular matrix protein 2 | 0.095 | |
Slamf8 | SLAM family member 8 | 0.095 | |
Tnfrsf18 | tumor necrosis factor receptor superfamily, member 18 | 0.094 | |
Cd14 | CD14 antigen | 0.093 | |
Traf1 | TNF receptor-associated factor 1 | 0.090 | |
Ctla4 | cytotoxic T-lymphocyte-associated protein 4 | 0.089 | |
Tnfrsf9 | tumor necrosis factor receptor superfamily, member 9 | 0.088 | |
Tbxas1 | thromboxane A synthase 1, platelet | 0.086 | |
Cxcl13 | chemokine (C-X-C motif) ligand 13 | 0.085 | |
Retnla | resistin like alpha | 0.085 | |
Itch | itchy, E3 ubiquitin protein ligase | 0.083 | |
Des | desmin | 0.081 | |
Mmp3 | matrix metallopeptidase 3 | 0.080 | |
Ccnb2 | cyclin B2 | 0.080 | |
Kif20a | kinesin family member 20A | 0.079 | |
Tnfaip3 | tumor necrosis factor, alpha-induced protein 3 | 0.077 |