The network for 'endothelial cell proliferation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endothelial cell proliferation

The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

Homo sapiens
Name Description Probability Func Analog Organism
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.997
FGFR2 fibroblast growth factor receptor 2 0.990
EGFR epidermal growth factor receptor 0.989
CCR5 chemokine (C-C motif) receptor 5 0.982
CAV1 caveolin 1, caveolae protein, 22kDa 0.981
RARA retinoic acid receptor, alpha 0.979
VEGFA vascular endothelial growth factor A 0.978
TGFB1 transforming growth factor, beta 1 0.978
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.972
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.962
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.959
NCF1 neutrophil cytosolic factor 1 0.958
NRP1 neuropilin 1 0.929
BMPR1A bone morphogenetic protein receptor, type IA 0.920
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.912
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.912
CCL5 chemokine (C-C motif) ligand 5 0.910
RXRA retinoid X receptor, alpha 0.844
IL2RB interleukin 2 receptor, beta 0.815
ERBB4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.786
FGFR1 fibroblast growth factor receptor 1 0.772
THBS1 thrombospondin 1 0.741
IL4R interleukin 4 receptor 0.735
MPDZ multiple PDZ domain protein 0.706
FGF1 fibroblast growth factor 1 (acidic) 0.667
EGR1 early growth response 1 0.651
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.582
ANGPT2 angiopoietin 2 0.577
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.553
NCOA1 nuclear receptor coactivator 1 0.536
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.528
BMP2 bone morphogenetic protein 2 0.526
MED25 mediator complex subunit 25 0.508
CXCL9 chemokine (C-X-C motif) ligand 9 0.488
ENG endoglin 0.466
FKBP1A FK506 binding protein 1A, 12kDa 0.464
EGR3 early growth response 3 0.463
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.457
PTEN phosphatase and tensin homolog 0.455
CD2 CD2 molecule 0.442
CCL2 chemokine (C-C motif) ligand 2 0.427
TIMP2 TIMP metallopeptidase inhibitor 2 0.426
FSTL1 follistatin-like 1 0.419
GDA guanine deaminase 0.415
EGR2 early growth response 2 0.411
COL5A1 collagen, type V, alpha 1 0.405
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.363
TTR transthyretin 0.336
CREBBP CREB binding protein 0.314
RND1 Rho family GTPase 1 0.313
PDGFC platelet derived growth factor C 0.304
BMPR1B bone morphogenetic protein receptor, type IB 0.302
PRKCA protein kinase C, alpha 0.287
CCL4 chemokine (C-C motif) ligand 4 0.277
GDF5 growth differentiation factor 5 0.276
CTGF connective tissue growth factor 0.275
CCL22 chemokine (C-C motif) ligand 22 0.268
PRKCD protein kinase C, delta 0.265
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.253
SORBS3 sorbin and SH3 domain containing 3 0.251
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.251
JAK1 Janus kinase 1 0.250
APOC1 apolipoprotein C-I 0.246
CCR4 chemokine (C-C motif) receptor 4 0.239
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.228
YAP1 Yes-associated protein 1 0.225
NOXA1 NADPH oxidase activator 1 0.222
CSNK1A1 casein kinase 1, alpha 1 0.221
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.204
ANG angiogenin, ribonuclease, RNase A family, 5 0.199
INSR insulin receptor 0.197
COL6A1 collagen, type VI, alpha 1 0.193
TGFB3 transforming growth factor, beta 3 0.190
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.187
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.177
PROX1 prospero homeobox 1 0.174
FOS FBJ murine osteosarcoma viral oncogene homolog 0.173
CAV2 caveolin 2 0.171
CCR2 chemokine (C-C motif) receptor 2 0.170
IRF4 interferon regulatory factor 4 0.168
DSG2 desmoglein 2 0.168
PBK PDZ binding kinase 0.166
CCL7 chemokine (C-C motif) ligand 7 0.165
SETD7 SET domain containing (lysine methyltransferase) 7 0.162
ARRDC3 arrestin domain containing 3 0.160
IL6ST interleukin 6 signal transducer (gp130, oncostatin M receptor) 0.159
IFNG interferon, gamma 0.156
RNASE4 ribonuclease, RNase A family, 4 0.148
GSK3B glycogen synthase kinase 3 beta 0.143
SP1 Sp1 transcription factor 0.143
CCL13 chemokine (C-C motif) ligand 13 0.142
ADAM17 ADAM metallopeptidase domain 17 0.138
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.137
SNAI1 snail homolog 1 (Drosophila) 0.137
TIMP3 TIMP metallopeptidase inhibitor 3 0.135
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.131
CCR7 chemokine (C-C motif) receptor 7 0.131
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.130
A2M alpha-2-macroglobulin 0.128
CDH5 cadherin 5, type 2 (vascular endothelium) 0.127
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
notch3 notch homolog 3 0.983
bmp2b bone morphogenetic protein 2b 0.889
kdrl kinase insert domain receptor like 0.887
nf1a neurofibromin 1a 0.634
dlx5a distal-less homeobox gene 5a 0.626
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.364
bmp4 bone morphogenetic protein 4 0.364
prox1b prospero-related homeobox gene 1b 0.348
tie2 endothelium-specific receptor tyrosine kinase 2 0.331
col4a6 collagen, type IV, alpha 6 0.308
flt1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.306
vegfaa vascular endothelial growth factor Aa 0.262
efnb2a ephrin B2a 0.260
ccm2 cerebral cavernous malformation 2 0.199
dld deltaD 0.197
flt4 fms-related tyrosine kinase 4 0.181
apobl apolipoprotein B, like 0.173
nrp2b neuropilin 2b 0.166
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.152
hbbe1.1 hemoglobin beta embryonic-1.1 0.151
sox9a SRY-box containing gene 9a 0.148
vegfc vascular endothelial growth factor c 0.148
cdh5 cadherin 5 0.144
col4a3 collagen, type IV, alpha 3 0.139
dla deltaA 0.133
dlb deltaB 0.133
wu:fv91b12 wu:fv91b12 0.122
ccbe1 collagen and calcium binding EGF domains 1 0.117
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.115
zgc:111961 zgc:111961 0.114
cyp26a1 cytochrome P450, subfamily XXVIA, polypeptide 1 0.104
dlc deltaC 0.098
evx1 even-skipped homeobox 1 0.094
etv2 ets variant gene 2 0.093
ptprb protein tyrosine phosphatase, receptor type, b 0.087
neurog1 neurogenin 1 0.078
kdr kinase insert domain receptor (a type III receptor tyrosine kinase) 0.078
nf1b neurofibromin 1b 0.077
lamc1 laminin, gamma 1 0.076
hoxd4a homeo box D4a 0.075
notch2 notch homolog 2 0.075
jag1b jagged 1b 0.075
si:ch73-60e21.1 si:ch73-60e21.1 0.072
lama5 laminin, alpha 5 0.070
edn1 endothelin 1 0.069
ahr2 aryl hydrocarbon receptor 2 0.066
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.065
dab2 disabled homolog 2 (Drosophila) 0.064
aox3 aldehyde oxidase 3 0.060
lmo4a LIM domain only 4a 0.058
hmgb2b high-mobility group box 2b 0.058
mtmr8 myotubularin related protein 8 0.055
emilin1a elastin microfibril interfacer 1a 0.053
junbl jun B proto-oncogene, like 0.052
mmp14a matrix metalloproteinase 14a (membrane-inserted) 0.051
fos v-fos FBJ murine osteosarcoma viral oncogene homolog 0.047
esama endothelial cell adhesion molecule a 0.047
krit1 KRIT1, ankyrin repeat containing 0.046
eya1 eyes absent homolog 1 0.045
si:ch211-212m21.5 si:ch211-212m21.5 0.044
scinla scinderin like a 0.043
prox1 prospero-related homeobox gene 1 0.043
LOC557062 hypothetical protein LOC557062 0.042
fgfr2 fibroblast growth factor receptor 2 0.042
nphs2 nephrosis 2, idiopathic, steroid-resistant (podocin) 0.040
ren renin 0.039
hand2 heart and neural crest derivatives expressed transcript 2 0.039
emx2 empty spiracles homeobox 2 0.037
cxcr4a chemokine (C-X-C motif) receptor 4a 0.037
nr4a3 nuclear receptor subfamily 4, group A, member 3 0.037
efemp2 EGF-containing fibulin-like extracellular matrix protein 2 0.036
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.035
alpi alkaline phosphatase, intestinal 0.035
ntn1a netrin 1a 0.035
tgfb1a transforming growth factor, beta 1a 0.035
pax2a paired box gene 2a 0.035
fgf8a fibroblast growth factor 8 a 0.034
nphs1l nephrosis 1, congenital, Finnish type (nephrin)-like 0.034
mmp2 matrix metalloproteinase 2 0.033
LOC569128 hypothetical protein LOC569128 0.033
h3f3a H3 histone, family 3A 0.033
fmnl2a formin-like 2a 0.033
tgfbr2 transforming growth factor, beta receptor II 0.033
zgc:194131 zgc:194131 0.032
mrc1a mannose receptor, C type 1a 0.032
h2afvl H2A histone family, member V, like 0.032
dlx3b distal-less homeobox gene 3b 0.031
msxd muscle segment homeobox D 0.031
thbs1 thrombospondin 1 0.030
sulf1 sulfatase 1 0.029
mmd2 progestin and adipoQ receptor 10 0.028
rbp4 retinol binding protein 4, plasma 0.028
hmgb2a high-mobility group box 2a 0.028
wtip Wilms tumor 1 interacting protein 0.027
col1a1a collagen, type I, alpha 1a 0.026
ntn4 netrin 4 0.026
mbp myelin basic protein 0.026
e2f7 E2F transcription factor 7 0.026
nfkbiab nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b 0.025
stab2 stabilin 2 0.024
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.893
Ctnnb1 catenin (cadherin associated protein), beta 1 0.848
Tgfbr2 transforming growth factor, beta receptor II 0.826
Acvr1 activin A receptor, type 1 0.643
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.562
Fgfr2 fibroblast growth factor receptor 2 0.549
Fos FBJ osteosarcoma oncogene 0.545
Flt4 FMS-like tyrosine kinase 4 0.520
Pnpla2 patatin-like phospholipase domain containing 2 0.487
Adrb1 adrenergic receptor, beta 1 0.476
Egr1 early growth response 1 0.435
Eng endoglin 0.373
Shh sonic hedgehog 0.370
Pparg peroxisome proliferator activated receptor gamma 0.368
Nodal nodal 0.322
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.319
Fbn1 fibrillin 1 0.289
Sox9 SRY-box containing gene 9 0.288
Acvrl1 activin A receptor, type II-like 1 0.273
Csf1 colony stimulating factor 1 (macrophage) 0.272
Jag1 jagged 1 0.264
Cdh5 cadherin 5 0.248
Vegfa vascular endothelial growth factor A 0.247
Fgfr1 fibroblast growth factor receptor 1 0.222
Cd44 CD44 antigen 0.220
Bmpr1a bone morphogenetic protein receptor, type 1A 0.202
Dusp1 dual specificity phosphatase 1 0.183
Ccr2 chemokine (C-C motif) receptor 2 0.175
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.174
Ccl2 chemokine (C-C motif) ligand 2 0.174
Thbs2 thrombospondin 2 0.170
Smad3 MAD homolog 3 (Drosophila) 0.168
Fgfr3 fibroblast growth factor receptor 3 0.163
Col1a1 collagen, type I, alpha 1 0.161
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.159
Nos3 nitric oxide synthase 3, endothelial cell 0.158
Rb1 retinoblastoma 1 0.156
Foxc1 forkhead box C1 0.155
Rarg retinoic acid receptor, gamma 0.152
Htr7 5-hydroxytryptamine (serotonin) receptor 7 0.121
Prrx1 paired related homeobox 1 0.120
Apoe apolipoprotein E 0.118
Ptrf polymerase I and transcript release factor 0.115
Apob apolipoprotein B 0.114
Ret ret proto-oncogene 0.110
Nos1 nitric oxide synthase 1, neuronal 0.110
Notch1 Notch gene homolog 1 (Drosophila) 0.107
Bmp5 bone morphogenetic protein 5 0.105
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.101
Hand2 heart and neural crest derivatives expressed transcript 2 0.099
Apc adenomatosis polyposis coli 0.098
Htr1d 5-hydroxytryptamine (serotonin) receptor 1D 0.095
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.094
Sox18 SRY-box containing gene 18 0.091
Tcf21 transcription factor 21 0.089
Ptgs2 prostaglandin-endoperoxide synthase 2 0.086
Tgfb2 transforming growth factor, beta 2 0.084
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.084
Nog noggin 0.084
Tgfbr3 transforming growth factor, beta receptor III 0.082
Chrd chordin 0.082
Bdkrb1 bradykinin receptor, beta 1 0.080
Vcl vinculin 0.080
Pten phosphatase and tensin homolog 0.078
Fgf8 fibroblast growth factor 8 0.078
Pax2 paired box gene 2 0.076
Gli3 GLI-Kruppel family member GLI3 0.075
Bdkrb2 bradykinin receptor, beta 2 0.075
Egfr epidermal growth factor receptor 0.072
Bmp4 bone morphogenetic protein 4 0.071
Zfp36 zinc finger protein 36 0.069
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.069
Cav1 caveolin 1, caveolae protein 0.064
Flt1 FMS-like tyrosine kinase 1 0.063
Cckbr cholecystokinin B receptor 0.063
Snai1 snail homolog 1 (Drosophila) 0.063
Tlr4 toll-like receptor 4 0.063
Braf Braf transforming gene 0.063
Itgb3 integrin beta 3 0.060
Fcrla Fc receptor-like A 0.060
Ccr1 chemokine (C-C motif) receptor 1 0.060
Rnase4 ribonuclease, RNase A family 4 0.060
Smad4 MAD homolog 4 (Drosophila) 0.060
Thrb thyroid hormone receptor beta 0.060
Lmna lamin A 0.058
Cyr61 cysteine rich protein 61 0.058
P2rx7 purinergic receptor P2X, ligand-gated ion channel, 7 0.057
Btg2 B-cell translocation gene 2, anti-proliferative 0.056
Tbx3 T-box 3 0.056
Fzd4 frizzled homolog 4 (Drosophila) 0.055
Tbx1 T-box 1 0.053
Shc3 src homology 2 domain-containing transforming protein C3 0.052
Lox lysyl oxidase 0.052
Spry4 sprouty homolog 4 (Drosophila) 0.051
Bmp2 bone morphogenetic protein 2 0.050
Prrx2 paired related homeobox 2 0.050
Smad6 MAD homolog 6 (Drosophila) 0.049
Tgfb1 transforming growth factor, beta 1 0.049
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.049
Fgf7 fibroblast growth factor 7 0.049
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Rattus norvegicus
Name Description Probability Func Analog Organism
Cav1 caveolin 1, caveolae protein 0.339
Dusp1 dual specificity phosphatase 1 0.195
LOC100362824 caveolin 2-like 0.168
Serpina3k serine (or cysteine) peptidase inhibitor, clade A, member 3K 0.130
Ahsg alpha-2-HS-glycoprotein 0.081
Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 0.066
Hpx hemopexin 0.060
Cav2 caveolin 2 0.059
Fga fibrinogen alpha chain 0.059
Col8a1 collagen, type VIII, alpha 1 0.057
Slc27a5 solute carrier family 27 (fatty acid transporter), member 5 0.050
Icam2 intercellular adhesion molecule 2 0.045
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.043
Foxd3 forkhead box D3 0.041
Itih3 inter-alpha trypsin inhibitor, heavy chain 3 0.039
Asgr2 asialoglycoprotein receptor 2 0.038
Alb albumin 0.037
Vegp2 von Ebners gland protein 2 0.036
Anxa1 annexin A1 0.032
Apoa2 apolipoprotein A-II 0.032
Myo1b myosin Ib 0.032
Apoa5 apolipoprotein A-V 0.031
Cald1 caldesmon 1 0.030
Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 0.029
Gpr182 G protein-coupled receptor 182 0.027
Olr1500 olfactory receptor 1500 0.027
Ambp alpha-1-microglobulin/bikunin precursor 0.027
Apcs amyloid P component, serum 0.027
Pgr progesterone receptor 0.027
Gsg1l GSG1-like 0.027
Ppap2b phosphatidic acid phosphatase type 2B 0.026
Inhba inhibin beta-A 0.025
Dnm1l dynamin 1-like 0.025
A2m alpha-2-macroglobulin 0.025
Nos3 nitric oxide synthase 3, endothelial cell 0.025
Foxs1 forkhead box S1 0.024
Smoc2 SPARC related modular calcium binding 2 0.024
Pdgfrb platelet derived growth factor receptor, beta polypeptide 0.023
Gper G protein-coupled estrogen receptor 1 0.023
Nradd neurotrophin receptor associated death domain 0.023
Marcks myristoylated alanine rich protein kinase C substrate 0.022
Pim1 pim-1 oncogene 0.022
Foxi2 forkhead box I2 0.021
Kcnj8 potassium inwardly-rectifying channel, subfamily J, member 8 0.021
Nfia nuclear factor I/A 0.021
F13a1 coagulation factor XIII, A1 polypeptide 0.020
Aqp9 aquaporin 9 0.020
Ccl4 chemokine (C-C motif) ligand 4 0.020
Fosl1 fos-like antigen 1 0.020
Mmp2 matrix metallopeptidase 2 0.020
Cga glycoprotein hormones, alpha polypeptide 0.019
Camkk2 calcium/calmodulin-dependent protein kinase kinase 2, beta 0.019
Crhr2 corticotropin releasing hormone receptor 2 0.019
Tff1 trefoil factor 1 0.018
RGD1559896 similar to RIKEN cDNA 2310022B05 0.018
Igf2 insulin-like growth factor 2 0.018
Fos FBJ osteosarcoma oncogene 0.018
Serpine2 serine (or cysteine) peptidase inhibitor, clade E, member 2 0.018
Pkn2 protein kinase N2 0.018
Lepr leptin receptor 0.018
Prrx1 paired related homeobox 1 0.018
Proc protein C 0.018
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.018
Kng2 kininogen 2 0.017
Jak1 Janus kinase 1 0.017
Sox17 SRY (sex determining region Y)-box 17 0.017
Mapre1 microtubule-associated protein, RP/EB family, member 1 0.017
Pzp pregnancy-zone protein 0.017
Gpr116 G protein-coupled receptor 116 0.017
Gc group specific component 0.017
Fmod fibromodulin 0.017
Itgad integrin, alpha D 0.017
Gzmk granzyme K 0.016
Ins1 insulin 1 0.016
Tnni1 troponin I type 1 (skeletal, slow) 0.016
Serpina3m serine (or cysteine) proteinase inhibitor, clade A, member 3M 0.016
Avp arginine vasopressin 0.016
Serpinh1 serine (or cysteine) peptidase inhibitor, clade H, member 1 0.016
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.015
Mdk midkine 0.015
Mbl1 mannose-binding lectin (protein A) 1 0.015
Ifit3 interferon-induced protein with tetratricopeptide repeats 3 0.015
Mapk1 mitogen activated protein kinase 1 0.015
Cpxm2 carboxypeptidase X (M14 family), member 2 0.015
Alx3 aristaless-like homeobox 3 0.015
Col10a1 collagen, type X, alpha 1 0.014
Trh thyrotropin releasing hormone 0.014
Klf6 Kruppel-like factor 6 0.014
Slc10a1 solute carrier family 10 (sodium/bile acid cotransporter family), member 1 0.014
Nr4a2 nuclear receptor subfamily 4, group A, member 2 0.014
C8b complement component 8, beta polypeptide 0.014
Nrp1 neuropilin 1 0.013
Colq collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 0.013
Mmp9 matrix metallopeptidase 9 0.013
Has2 hyaluronan synthase 2 0.013
Gja1 gap junction protein, alpha 1 0.013
Ptgfr prostaglandin F receptor 0.013
Cast calpastatin 0.013
Gal galanin prepropeptide 0.013
Tsx testis specific X-linked gene 0.013
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism