The network for 'negative regulation of synaptic transmission' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of synaptic transmission

Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.

Homo sapiens
Name Description Probability Func Analog Organism
C1QA complement component 1, q subcomponent, A chain 0.999
CFLAR CASP8 and FADD-like apoptosis regulator 0.979
ADORA2A adenosine A2a receptor 0.852
C1QC complement component 1, q subcomponent, C chain 0.758
SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.687
PICK1 protein interacting with PRKCA 1 0.680
FAS Fas (TNF receptor superfamily, member 6) 0.634
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.630
C1QB complement component 1, q subcomponent, B chain 0.502
VAC14 Vac14 homolog (S. cerevisiae) 0.500
APP amyloid beta (A4) precursor protein 0.489
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.467
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.450
LRRK2 leucine-rich repeat kinase 2 0.420
MYOCD myocardin 0.368
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.358
MYOG myogenin (myogenic factor 4) 0.311
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.285
NCOA3 nuclear receptor coactivator 3 0.273
PRKCE protein kinase C, epsilon 0.263
MKL1 megakaryoblastic leukemia (translocation) 1 0.245
SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 0.244
DLG4 discs, large homolog 4 (Drosophila) 0.243
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.216
TAC1 tachykinin, precursor 1 0.189
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.182
ACCN2 amiloride-sensitive cation channel 2, neuronal 0.176
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 0.151
VIM vimentin 0.143
DRD2 dopamine receptor D2 0.139
SNCAIP synuclein, alpha interacting protein 0.135
PRKCG protein kinase C, gamma 0.135
PRLHR prolactin releasing hormone receptor 0.134
WBP11 WW domain binding protein 11 0.130
PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B 0.126
KSR1 kinase suppressor of ras 1 0.112
MAP2K1 mitogen-activated protein kinase kinase 1 0.111
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.109
MYOD1 myogenic differentiation 1 0.108
SH3GL3 SH3-domain GRB2-like 3 0.106
CYTH2 cytohesin 2 0.105
NLK nemo-like kinase 0.101
RHEB Ras homolog enriched in brain 0.101
GRIA2 glutamate receptor, ionotropic, AMPA 2 0.098
PUM2 pumilio homolog 2 (Drosophila) 0.098
MAPT microtubule-associated protein tau 0.095
ARAF v-raf murine sarcoma 3611 viral oncogene homolog 0.092
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2 0.091
SH3RF1 SH3 domain containing ring finger 1 0.084
SYN1 synapsin I 0.082
RABAC1 Rab acceptor 1 (prenylated) 0.078
DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 0.075
CCL14 chemokine (C-C motif) ligand 14 0.075
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.074
PEBP4 phosphatidylethanolamine-binding protein 4 0.073
IL8 interleukin 8 0.070
PRKCZ protein kinase C, zeta 0.069
CASP10 caspase 10, apoptosis-related cysteine peptidase 0.069
FABP4 fatty acid binding protein 4, adipocyte 0.068
KALRN kalirin, RhoGEF kinase 0.068
MED31 mediator complex subunit 31 0.066
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.064
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 0.063
DNM1 dynamin 1 0.061
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.061
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.060
KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.060
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 0.059
PCDHA4 protocadherin alpha 4 0.059
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 0.057
KCNA1 potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia) 0.056
BAG1 BCL2-associated athanogene 0.056
SPRR2A small proline-rich protein 2A 0.055
MKL2 MKL/myocardin-like 2 0.055
HIST1H3B histone cluster 1, H3b 0.054
C4orf14 chromosome 4 open reading frame 14 0.054
SLC9A3 solute carrier family 9 (sodium/hydrogen exchanger), member 3 0.053
KCNB1 potassium voltage-gated channel, Shab-related subfamily, member 1 0.053
RALGDS ral guanine nucleotide dissociation stimulator 0.052
ADAM11 ADAM metallopeptidase domain 11 0.052
USP38 ubiquitin specific peptidase 38 0.052
SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 0.051
DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 0.050
CAV2 caveolin 2 0.050
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide 0.050
NELL1 NEL-like 1 (chicken) 0.050
BMI1 BMI1 polycomb ring finger oncogene 0.050
ATXN7L3 ataxin 7-like 3 0.049
COPG2 coatomer protein complex, subunit gamma 2 0.048
SLC6A4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 0.047
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O 0.047
DLG2 discs, large homolog 2 (Drosophila) 0.047
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.046
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.046
TAOK1 TAO kinase 1 0.046
MAP3K1 mitogen-activated protein kinase kinase kinase 1 0.045
FNBP1 formin binding protein 1 0.045
TUB tubby homolog (mouse) 0.045
DRD1 dopamine receptor D1 0.045
KCND2 potassium voltage-gated channel, Shal-related subfamily, member 2 0.042
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
jeb jelly belly 0.188
CG42629 CG42629 gene product from transcript CG42629-RB 0.165
nwk nervous wreck 0.160
Alk CG8250 gene product from transcript CG8250-RA 0.109
CG13253 CG13253 gene product from transcript CG13253-RB 0.098
caz cabeza 0.094
Ras85D Ras oncogene at 85D 0.067
imd immune deficiency 0.055
brp bruchpilot 0.045
BG4 CG12297 gene product from transcript CG12297-RA 0.036
dnc dunce 0.033
Caki Calcium/calmodulin-dependent protein kinase 0.027
CrebB-17A Cyclic-AMP response element binding protein B at 17A 0.025
Dsk Drosulfakinin 0.024
Nrx-1 Neurexin 1 0.023
RanBPM Ran-binding protein M 0.023
MESK2 Misexpression suppressor of KSR 2 0.022
Snap25 Synapse protein 25 0.022
oa2 octopamine receptor 2 0.020
tipE temperature-induced paralytic E 0.019
Rdl Resistant to dieldrin 0.019
rpr reaper 0.019
Tbh Tyramine beta hydroxylase 0.019
th thread 0.018
Shab Shaker cognate b 0.017
rut rutabaga 0.016
comt comatose 0.015
Ank2 Ankyrin 2 0.015
Octbeta2R CG33976 gene product from transcript CG33976-RA 0.014
nAcRalpha-30D nicotinic Acetylcholine Receptor alpha 30D 0.013
nAcRbeta-96A nicotinic Acetylcholine Receptor beta 96A 0.013
fusl fuseless 0.013
Nmdar1 NMDA receptor 1 0.013
Actbeta Activin-beta 0.013
slo slowpoke 0.012
per period 0.012
Gycalpha99B Guanylyl cyclase alpha-subunit at 99B 0.012
CG34400 CG34400 gene product from transcript CG34400-RD 0.011
gukh GUK-holder 0.011
CCKLR-17D1 CCK-like receptor at 17D1 0.011
PIP5K59B CG3682 gene product from transcript CG3682-RE 0.011
mtt mangetout 0.010
CaMKII Calcium/calmodulin-dependent protein kinase II 0.010
Pde8 Phosphodiesterase 8 0.010
Trim9 CG31721 gene product from transcript CG31721-RB 0.010
5-HT1B Serotonin receptor 1B 0.010
tai taiman 0.010
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Mus musculus
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
Gria2 glutamate receptor, ionotropic, AMPA 2 0.143
Grm7 glutamate receptor, metabotropic 7 0.085
Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 0.064
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.063
Serp1 stress-associated endoplasmic reticulum protein 1 0.063
Trpm1 transient receptor potential cation channel, subfamily M, member 1 0.056
Kcnq3 potassium voltage-gated channel, KQT-like subfamily, member 3 0.056
Mag myelin-associated glycoprotein 0.056
Gria1 glutamate receptor, ionotropic, AMPA 1 0.053
Pou3f1 POU class 3 homeobox 1 0.045
Slc8a3 solute carrier family 8 (sodium/calcium exchanger), member 3 0.044
Olr226 olfactory receptor 226 0.040
Ndst1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.038
Adora1 adenosine A1 receptor 0.037
Chrna1 cholinergic receptor, nicotinic, alpha 1 (muscle) 0.035
Nr4a3 nuclear receptor subfamily 4, group A, member 3 0.034
Cops7a COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) 0.033
Gria3 glutamate receptor, ionotrophic, AMPA 3 0.033
Dlgap1 discs, large (Drosophila) homolog-associated protein 1 0.032
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.031
Kcnh7 potassium voltage-gated channel, subfamily H (eag-related), member 7 0.031
Kcnj4 potassium inwardly-rectifying channel, subfamily J, member 4 0.031
Kcnc2 potassium voltage gated channel, Shaw-related subfamily, member 2 0.029
Eef2 eukaryotic translation elongation factor 2 0.029
Sept3 septin 3 0.028
Smad3 SMAD family member 3 0.028
Cyth1 cytohesin 1 0.028
Elovl5 ELOVL family member 5, elongation of long chain fatty acids (yeast) 0.027
Gng7 guanine nucleotide binding protein (G protein), gamma 7 0.027
Ptafr platelet-activating factor receptor 0.027
Gast gastrin 0.026
Npy5r neuropeptide Y receptor Y5 0.026
Ywhaz tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide 0.025
Gpr6 G protein-coupled receptor 6 0.024
Calcr calcitonin receptor 0.024
Pafah1b2 platelet-activating factor acetylhydrolase, isoform 1b, subunit 2 0.024
Mpp2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.024
Drd2 dopamine receptor D2 0.024
Adora2a adenosine A2a receptor 0.023
Grip2 glutamate receptor interacting protein 2 0.023
Gzmk granzyme K 0.023
Pmfbp1 polyamine modulated factor 1 binding protein 1 0.023
Sdcbp syndecan binding protein 0.023
Grin2b glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.022
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 0.022
Gabrg1 gamma-aminobutyric acid (GABA) A receptor, gamma 1 0.022
Nmbr neuromedin B receptor 0.022
Grk4 G protein-coupled receptor kinase 4 0.021
Reg1a regenerating islet-derived 1 alpha 0.021
Lphn1 latrophilin 1 0.021
Fzd4 frizzled homolog 4 (Drosophila) 0.021
Cntn3 contactin 3 (plasmacytoma associated) 0.021
Prkcg protein kinase C, gamma 0.020
Pip5k1c phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 0.020
Celsr3 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) 0.019
Apba2 amyloid beta (A4) precursor protein-binding, family A, member 2 0.019
Il13 interleukin 13 0.019
Hpca hippocalcin 0.019
Cnksr2 connector enhancer of kinase suppressor of Ras 2 0.019
Folh1 folate hydrolase 1 0.019
Gabra5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.019
Cxcr5 chemokine (C-X-C motif) receptor 5 0.019
Cntn5 contactin 5 0.019
Gpr83 G protein-coupled receptor 83 0.019
Trhr2 thyrotropin releasing hormone receptor 2 0.018
Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.018
Sstr2 somatostatin receptor 2 0.018
Fam83f family with sequence similarity 83, member F 0.018
Gabra2 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 2 0.018
Neurod2 neurogenic differentiation 2 0.018
Sec61a1 Sec61 alpha 1 subunit (S. cerevisiae) 0.018
Cnr1 cannabinoid receptor 1 (brain) 0.018
Vamp2 vesicle-associated membrane protein 2 0.018
Mtpn myotrophin 0.018
Slc2a3 solute carrier family 2 (facilitated glucose transporter), member 3 0.018
Gucy2d guanylate cyclase 2d 0.018
Atp4a ATPase, H+/K+ exchanging, alpha polypeptide 0.018
Hpcal4 hippocalcin-like 4 0.018
Gad2 glutamate decarboxylase 2 0.018
Sv2c synaptic vesicle glycoprotein 2c 0.017
Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 0.017
Kalrn kalirin, RhoGEF kinase 0.017
Mmp13 matrix metallopeptidase 13 0.017
Slc6a9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 0.017
Fev FEV (ETS oncogene family) 0.017
Gal galanin prepropeptide 0.017
Fgf14 fibroblast growth factor 14 0.017
Aqp4 aquaporin 4 0.017
Oprd1 opioid receptor, delta 1 0.017
Gria4 glutamate receptor, ionotrophic, AMPA 4 0.017
Tacr2 tachykinin receptor 2 0.017
Fgfr2 fibroblast growth factor receptor 2 0.016
Homer3 homer homolog 3 (Drosophila) 0.016
Syt4 synaptotagmin IV 0.016
Pfn1 profilin 1 0.016
Cckar cholecystokinin A receptor 0.016
Gpr12 G protein-coupled receptor 12 0.016
Ifrd1 interferon-related developmental regulator 1 0.016
Htr3a 5-hydroxytryptamine (serotonin) receptor 3a 0.016
Atp2a1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.016
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism