The network for 'thymus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

thymus development

The process whose specific outcome is the progression of the thymus over time, from its formation to the mature structure. The thymus is a symmetric bi-lobed organ involved primarily in the differentiation of immature to mature T cells, with unique vascular, nervous, epithelial, and lymphoid cell components.

Homo sapiens
Name Description Probability Func Analog Organism
FGFR2 fibroblast growth factor receptor 2 0.999
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.994
PSEN1 presenilin 1 0.988
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.956
BAD BCL2-associated agonist of cell death 0.948
VEGFA vascular endothelial growth factor A 0.939
FGF10 fibroblast growth factor 10 0.892
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.834
BCL2L1 BCL2-like 1 0.828
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.769
POU5F1 POU class 5 homeobox 1 0.748
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.723
FAS Fas (TNF receptor superfamily, member 6) 0.614
FLNB filamin B, beta 0.603
MCL1 myeloid cell leukemia sequence 1 (BCL2-related) 0.588
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 0.586
TGFB1 transforming growth factor, beta 1 0.552
NR2E3 nuclear receptor subfamily 2, group E, member 3 0.547
FGF1 fibroblast growth factor 1 (acidic) 0.542
MEIS1 Meis homeobox 1 0.520
MEIS2 Meis homeobox 2 0.501
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.476
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.449
AR androgen receptor 0.404
PSEN2 presenilin 2 (Alzheimer disease 4) 0.349
MEOX1 mesenchyme homeobox 1 0.325
FGF7 fibroblast growth factor 7 0.310
CDK9 cyclin-dependent kinase 9 0.273
MED12 mediator complex subunit 12 0.270
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.264
BCL2 B-cell CLL/lymphoma 2 0.254
MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) 0.230
FKBP1A FK506 binding protein 1A, 12kDa 0.187
LDB1 LIM domain binding 1 0.186
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.179
FGF8 fibroblast growth factor 8 (androgen-induced) 0.174
CTBP1 C-terminal binding protein 1 0.169
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.166
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.156
FGFR1 fibroblast growth factor receptor 1 0.151
NCOR1 nuclear receptor corepressor 1 0.151
NLK nemo-like kinase 0.148
CSNK1G1 casein kinase 1, gamma 1 0.147
ATXN3 ataxin 3 0.144
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.141
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 0.139
GATA4 GATA binding protein 4 0.139
TCF4 transcription factor 4 0.136
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.135
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.133
ECSIT ECSIT homolog (Drosophila) 0.125
PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) 0.124
MBD4 methyl-CpG binding domain protein 4 0.121
BAX BCL2-associated X protein 0.120
APH1A anterior pharynx defective 1 homolog A (C. elegans) 0.118
SEC24D SEC24 family, member D (S. cerevisiae) 0.113
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.109
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.107
EP300 E1A binding protein p300 0.107
TGFB3 transforming growth factor, beta 3 0.102
ZNF331 zinc finger protein 331 0.102
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.102
RBL1 retinoblastoma-like 1 (p107) 0.101
DCAF8 DDB1 and CUL4 associated factor 8 0.097
BAK1 BCL2-antagonist/killer 1 0.094
PKP4 plakophilin 4 0.092
CD320 CD320 molecule 0.089
BID BH3 interacting domain death agonist 0.089
GLIS2 GLIS family zinc finger 2 0.088
PRPF31 PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) 0.086
HDAC3 histone deacetylase 3 0.085
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.084
FGFR3 fibroblast growth factor receptor 3 0.083
FOXC1 forkhead box C1 0.081
HNF4A hepatocyte nuclear factor 4, alpha 0.076
ACAN aggrecan 0.076
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 0.075
FGF3 fibroblast growth factor 3 0.075
PGF placental growth factor 0.075
RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) 0.074
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.073
SRI sorcin 0.072
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.072
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.071
SIM2 single-minded homolog 2 (Drosophila) 0.069
HIC1 hypermethylated in cancer 1 0.069
LEF1 lymphoid enhancer-binding factor 1 0.069
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.067
SIX6 SIX homeobox 6 0.066
TGIF1 TGFB-induced factor homeobox 1 0.065
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa 0.065
INHBB inhibin, beta B 0.065
HOXA9 homeobox A9 0.065
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.065
CTNND1 catenin (cadherin-associated protein), delta 1 0.065
WNT1 wingless-type MMTV integration site family, member 1 0.064
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.064
EYA2 eyes absent homolog 2 (Drosophila) 0.064
TCF21 transcription factor 21 0.063
MYBBP1A MYB binding protein (P160) 1a 0.063
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
klf4 Kruppel-like factor 4 0.367
ikzf1 IKAROS family zinc finger 1 (Ikaros) 0.224
wu:fv91b12 wu:fv91b12 0.222
nrp1a neuropilin 1a 0.213
efnb2a ephrin B2a 0.206
sox9a SRY-box containing gene 9a 0.164
nrp2b neuropilin 2b 0.155
pcna proliferating cell nuclear antigen 0.147
cmyb transcription factor cmyb 0.098
rag1 recombination activating gene 1 0.087
runx3 runt-related transcription factor 3 0.074
hoxb3a homeo box B3a 0.069
nkx3.2 NK3 homeobox 2 0.069
tal1 T-cell acute lymphocytic leukemia 1 0.067
hhex hematopoietically expressed homeobox 0.064
cdh2 cadherin 2, neuronal 0.062
nrp1b neuropilin 1b 0.060
gata3 GATA-binding protein 3 0.058
cacnb4b calcium channel, voltage-dependent, beta 4b subunit 0.055
dopey1 dopey family member 1 0.050
foxi1 forkhead box I1 0.050
il7r interleukin 7 receptor 0.046
dntt deoxynucleotidyltransferase, terminal 0.046
twist1a twist1a 0.045
prickle2 prickle-like 2 (Drosophila) 0.045
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.044
pdlim4 PDZ and LIM domain 4 0.044
skia nuclear oncoprotein skia 0.035
foxn4 forkhead box N4 0.035
pcdh8 protocadherin 8 0.035
rag2 recombination activating gene 2 0.034
foxn1 forkhead box N1 0.034
tbx1 T-box 1 0.034
tgfb3 transforming growth factor, beta 3 0.033
top3a topoisomerase (DNA) III alpha 0.032
ephb4b eph receptor B4b 0.030
jag1b jagged 1b 0.030
ighz immunoglobulin heavy constant zeta 0.029
fgf10a fibroblast growth factor 10a 0.027
eya1 eyes absent homolog 1 0.027
nav3 neuron navigator 3 0.027
nrp2a neuropilin 2a 0.026
ighm immunoglobulin heavy constant mu and immunoglobulin heavy constant mu 0.026
rarga retinoic acid receptor gamma a 0.025
msh6 mutS homolog 6 (E. coli) 0.025
pold1 polymerase (DNA directed), delta 1, catalytic subunit 0.025
urod uroporphyrinogen decarboxylase 0.025
cacnb4a calcium channel, voltage-dependent, beta 4a subunit 0.024
ptprf protein tyrosine phosphatase, receptor type, F 0.022
pitx2 paired-like homeodomain transcription factor 2 0.022
smad1 MAD homolog 1 (Drosophila) 0.021
pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.021
egr1 early growth response 1 0.021
six4b sine oculis homeobox homolog 4b 0.021
tbx2a T-box gene 2a 0.020
csf1ra colony stimulating factor 1 receptor, a 0.018
mpx myeloid-specific peroxidase 0.018
hbbe3 hemoglobin beta embryonic-3 0.018
nkx2.7 NK2 transcription factor related 7 0.018
stc1l stanniocalcin 1, like 0.018
znfl2a zinc finger-like gene 2a 0.018
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.018
mecom MDS1 and EVI1 complex locus 0.018
hoxb2a homeo box B2a 0.018
igfbp3 insulin-like growth factor binding protein 3 0.017
ccna2 cyclin A2 0.017
tcf21 transcription factor 21 0.017
myod1 myogenic differentiation 1 0.017
trpm7 transient receptor potential cation channel, subfamily M, member 7 0.017
sema3d semaphorin 3d 0.016
angpt1 angiopoietin 1 0.016
znf703 zinc finger protein 703 0.016
crestin crestin 0.016
pax2a paired box gene 2a 0.016
sumo2 SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae) 0.016
polm polymerase (DNA directed), mu 0.016
msxe muscle segment homeobox E 0.015
lzts2a leucine zipper, putative tumor suppressor 2a 0.015
foxa2 forkhead box A2 0.015
smoc1 SPARC related modular calcium binding 1 0.015
six2a sine oculis-related homeobox 2a 0.015
si:dkeyp-117h8.4 si:dkeyp-117h8.4 0.015
hoxa2b homeo box A2b 0.015
irx5a iroquois homeobox protein 5a 0.015
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.015
hdac4 histone deacetylase 4 0.015
chrm2a cholinergic receptor, muscarinic 2a 0.014
veph ventricular zone expressed PH domain protein 0.014
th tyrosine hydroxylase 0.014
mbtps1 membrane-bound transcription factor protease, site 1 0.014
spry1 sprouty homolog 1 (Drosophila) 0.014
smad7 MAD, mothers against decapentaplegic homolog 7 (Drosophila) 0.014
gata6 GATA-binding protein 6 0.014
ptger4a prostaglandin E receptor 4 (subtype EP4) a 0.014
pnx posterior neuron-specific homeobox 0.014
sox9b SRY-box containing gene 9b 0.013
evx1 even-skipped homeobox 1 0.013
bmp2b bone morphogenetic protein 2b 0.013
rybpa RING1 and YY1 binding protein a 0.013
epor erythropoietin receptor 0.013
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.957
Isl1 ISL1 transcription factor, LIM/homeodomain 0.939
Foxg1 forkhead box G1 0.928
Hoxa1 homeobox A1 0.904
Hoxd3 homeobox D3 0.869
Pten phosphatase and tensin homolog 0.862
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.861
Neurod1 neurogenic differentiation 1 0.837
Trp53 transformation related protein 53 0.826
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.808
Ikzf1 IKAROS family zinc finger 1 0.798
Tcfap2a transcription factor AP-2, alpha 0.742
Cd19 CD19 antigen 0.732
Notch1 Notch gene homolog 1 (Drosophila) 0.692
Ephb2 Eph receptor B2 0.687
Fgfr2 fibroblast growth factor receptor 2 0.683
Pbx1 pre B-cell leukemia transcription factor 1 0.641
Fgf10 fibroblast growth factor 10 0.638
Nkx2-1 NK2 homeobox 1 0.620
Bcl2 B-cell leukemia/lymphoma 2 0.602
Shh sonic hedgehog 0.593
Hoxa2 homeobox A2 0.555
Bmpr1a bone morphogenetic protein receptor, type 1A 0.519
Eya1 eyes absent 1 homolog (Drosophila) 0.508
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.501
Tgfbr2 transforming growth factor, beta receptor II 0.482
Gata4 GATA binding protein 4 0.469
Pax8 paired box gene 8 0.467
Tbx3 T-box 3 0.465
Tlx3 T-cell leukemia, homeobox 3 0.436
Kiss1 KiSS-1 metastasis-suppressor 0.425
Rarg retinoic acid receptor, gamma 0.417
Lef1 lymphoid enhancer binding factor 1 0.410
Hoxa13 homeobox A13 0.404
Neurog2 neurogenin 2 0.399
Prph2 peripherin 2 0.388
Dlx1 distal-less homeobox 1 0.365
Pax3 paired box gene 3 0.337
Gnaq guanine nucleotide binding protein, alpha q polypeptide 0.325
Gbx2 gastrulation brain homeobox 2 0.295
Emx1 empty spiracles homolog 1 (Drosophila) 0.292
Dab1 disabled homolog 1 (Drosophila) 0.292
Meis2 Meis homeobox 2 0.292
Hoxb3 homeobox B3 0.287
Pax1 paired box gene 1 0.286
Neurog1 neurogenin 1 0.284
Smad6 MAD homolog 6 (Drosophila) 0.283
Fgf8 fibroblast growth factor 8 0.274
Pitx1 paired-like homeodomain transcription factor 1 0.268
Hes1 hairy and enhancer of split 1 (Drosophila) 0.267
Snai1 snail homolog 1 (Drosophila) 0.267
Efnb1 ephrin B1 0.264
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.249
Ebf2 early B-cell factor 2 0.249
Efnb2 ephrin B2 0.248
Fgf5 fibroblast growth factor 5 0.246
Tcf21 transcription factor 21 0.244
Myog myogenin 0.232
Bnc1 basonuclin 1 0.231
Hoxb4 homeobox B4 0.227
Dhh desert hedgehog 0.225
Efna2 ephrin A2 0.225
Prrx1 paired related homeobox 1 0.223
Casp8 caspase 8 0.220
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.220
Dll4 delta-like 4 (Drosophila) 0.220
Otx2 orthodenticle homolog 2 (Drosophila) 0.219
Alx3 aristaless-like homeobox 3 0.216
Fgfr1 fibroblast growth factor receptor 1 0.206
Vegfa vascular endothelial growth factor A 0.202
Sox2 SRY-box containing gene 2 0.199
Socs1 suppressor of cytokine signaling 1 0.196
Runx1t1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.194
Fgf15 fibroblast growth factor 15 0.193
Notch2 Notch gene homolog 2 (Drosophila) 0.192
Gata3 GATA binding protein 3 0.189
Dlx5 distal-less homeobox 5 0.187
Ptk2 PTK2 protein tyrosine kinase 2 0.185
Hoxd13 homeobox D13 0.181
Gata6 GATA binding protein 6 0.178
Lhx5 LIM homeobox protein 5 0.177
Pax2 paired box gene 2 0.176
Rag2 recombination activating gene 2 0.176
Zfpm2 zinc finger protein, multitype 2 0.174
Jag1 jagged 1 0.168
Pitx2 paired-like homeodomain transcription factor 2 0.162
Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) 0.160
Mecom MDS1 and EVI1 complex locus 0.156
Hoxa11 homeobox A11 0.155
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.150
Dicer1 Dicer1, Dcr-1 homolog (Drosophila) 0.148
Lhx6 LIM homeobox protein 6 0.146
Tbx2 T-box 2 0.144
Wnt3a wingless-related MMTV integration site 3A 0.144
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.143
Tcfap2b transcription factor AP-2 beta 0.140
Hoxb1 homeobox B1 0.140
Chd7 chromodomain helicase DNA binding protein 7 0.138
Hoxb5 homeobox B5 0.135
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.135
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism