The network for 'eye photoreceptor cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

eye photoreceptor cell differentiation

The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Pax2 paired box gene 2 1.000
Pax6 paired box gene 6 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Isl1 ISL1 transcription factor, LIM/homeodomain 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Atoh7 atonal homolog 7 (Drosophila) 0.998
Crb2 crumbs homolog 2 (Drosophila) 0.997
Tcfap2a transcription factor AP-2, alpha 0.995
Fgfr2 fibroblast growth factor receptor 2 0.994
Crx cone-rod homeobox containing gene 0.994
Prph2 peripherin 2 0.992
Sox2 SRY-box containing gene 2 0.983
Pax3 paired box gene 3 0.979
Fgf8 fibroblast growth factor 8 0.969
Pitx2 paired-like homeodomain transcription factor 2 0.960
Dlx5 distal-less homeobox 5 0.958
Emx1 empty spiracles homolog 1 (Drosophila) 0.954
Rho rhodopsin 0.948
Foxc1 forkhead box C1 0.945
Stat5a signal transducer and activator of transcription 5A 0.931
Ift88 intraflagellar transport 88 homolog (Chlamydomonas) 0.919
Stat5b signal transducer and activator of transcription 5B 0.916
Lepr leptin receptor 0.896
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.895
Pou4f2 POU domain, class 4, transcription factor 2 0.895
Gbx2 gastrulation brain homeobox 2 0.894
Hoxa1 homeobox A1 0.886
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.884
Foxc2 forkhead box C2 0.877
Bcl2 B-cell leukemia/lymphoma 2 0.869
Bbs2 Bardet-Biedl syndrome 2 (human) 0.864
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.860
Eya1 eyes absent 1 homolog (Drosophila) 0.859
Lhx1 LIM homeobox protein 1 0.845
Fgfr1 fibroblast growth factor receptor 1 0.833
Nr2e1 nuclear receptor subfamily 2, group E, member 1 0.828
Nos3 nitric oxide synthase 3, endothelial cell 0.826
Emx2 empty spiracles homolog 2 (Drosophila) 0.820
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.802
Cd2ap CD2-associated protein 0.791
Dcx doublecortin 0.791
Hand1 heart and neural crest derivatives expressed transcript 1 0.788
Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 0.783
Hand2 heart and neural crest derivatives expressed transcript 2 0.781
Otx1 orthodenticle homolog 1 (Drosophila) 0.772
Zeb1 zinc finger E-box binding homeobox 1 0.752
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.704
Nf1 neurofibromatosis 1 0.696
Neurod1 neurogenic differentiation 1 0.694
Neurog2 neurogenin 2 0.694
Atp2b2 ATPase, Ca++ transporting, plasma membrane 2 0.678
Pcm1 pericentriolar material 1 0.678
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.675
Chd7 chromodomain helicase DNA binding protein 7 0.672
Ret ret proto-oncogene 0.670
Pde6g phosphodiesterase 6G, cGMP-specific, rod, gamma 0.661
Ntf3 neurotrophin 3 0.660
Bmp4 bone morphogenetic protein 4 0.656
Irf9 interferon regulatory factor 9 0.653
Ush1g Usher syndrome 1G homolog (human) 0.650
Tbx3 T-box 3 0.649
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.629
Sox9 SRY-box containing gene 9 0.627
Gata3 GATA binding protein 3 0.619
Pten phosphatase and tensin homolog 0.612
Flt4 FMS-like tyrosine kinase 4 0.581
Trpm1 transient receptor potential cation channel, subfamily M, member 1 0.572
En2 engrailed 2 0.566
Arl6 ADP-ribosylation factor-like 6 0.564
Atp6v1a ATPase, H+ transporting, lysosomal V1 subunit A 0.557
Reln reelin 0.547
Sult4a1 sulfotransferase family 4A, member 1 0.542
Unc5c unc-5 homolog C (C. elegans) 0.536
Sox4 SRY-box containing gene 4 0.534
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.531
Ntn1 netrin 1 0.531
Tgfb1 transforming growth factor, beta 1 0.530
Wnt1 wingless-related MMTV integration site 1 0.527
Gucy2d guanylate cyclase 2d 0.523
Ndel1 nuclear distribution gene E-like homolog 1 (A. nidulans) 0.520
Pkd1 polycystic kidney disease 1 homolog 0.518
Dclk1 doublecortin-like kinase 1 0.499
Rxra retinoid X receptor alpha 0.474
Pax8 paired box gene 8 0.450
Kit kit oncogene 0.443
Rpgrip1l Rpgrip1-like 0.430
Flt1 FMS-like tyrosine kinase 1 0.415
Lmx1a LIM homeobox transcription factor 1 alpha 0.412
Kl klotho 0.412
Ctnnb1 catenin (cadherin associated protein), beta 1 0.410
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.409
Rax retina and anterior neural fold homeobox 0.408
En1 engrailed 1 0.406
Alx4 aristaless-like homeobox 4 0.402
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.396
Myd88 myeloid differentiation primary response gene 88 0.394
Tbx5 T-box 5 0.393
Flii flightless I homolog (Drosophila) 0.389
Hbegf heparin-binding EGF-like growth factor 0.387
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
otx2 orthodenticle homolog 2 0.990
pax2a paired box gene 2a 0.989
hnf1ba HNF1 homeobox Ba 0.989
ift88 intraflagellar transport 88 homolog 0.980
kif17 kinesin family member 17 0.974
pax6b paired box gene 6b 0.948
tfap2a transcription factor AP-2 alpha 0.908
shha sonic hedgehog a 0.902
crx cone-rod homeobox 0.894
rx3 retinal homeobox gene 3 0.871
tbx2b T-box 2b 0.845
epb41l5 erythrocyte membrane protein band 4.1 like 5 0.818
neurod neurogenic differentiation 0.800
cdh2 cadherin 2, neuronal 0.794
flh floating head 0.789
foxi1 forkhead box I1 0.765
gbx2 gastrulation brain homeo box 2 0.719
dctn1a dynactin 1a 0.657
dcc deleted in colorectal carcinoma 0.630
rxraa retinoid X receptor, alpha a 0.614
neurog1 neurogenin 1 0.609
six3a sine oculis homeobox homolog 3a 0.589
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.566
her1 hairy-related 1 0.562
otx5 orthodenticle homolog 5 0.553
ndr2 nodal-related 2 0.541
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.532
chd chordin 0.526
otx1b orthodenticle homolog 1b 0.522
meis2.1 myeloid ecotropic viral integration site 2.1 0.497
six3b sine oculis homeobox homolog 3b 0.492
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.483
bmp4 bone morphogenetic protein 4 0.458
jag2 jagged 2 0.430
crb2a crumbs homolog 2a 0.425
cc2d2a coiled-coil and C2 domain containing 2A 0.381
bmp2b bone morphogenetic protein 2b 0.379
tbx2a T-box gene 2a 0.373
rx1 retinal homeobox gene 1 0.357
mespa mesoderm posterior a 0.352
ahctf1 AT hook containing transcription factor 1 0.343
vent ventral expressed homeobox 0.322
atoh7 atonal homolog 7 0.318
fezf2 FEZ family zinc finger 2 0.299
ahi1 Abelson helper integration site 1 0.294
pde6c phosphodiesterase 6C, cGMP-specific, cone, alpha prime 0.290
sox32 SRY-box containing gene 32 0.270
sox10 SRY-box containing gene 10 0.269
dnmt8 DNA (cytosine-5-)-methyltransferase 8 0.261
her5 hairy-related 5 0.254
ptf1a pancreas specific transcription factor, 1a 0.254
dlx3b distal-less homeobox gene 3b 0.240
rx2 retinal homeobox gene 2 0.224
irx3a iroquois homeobox protein 3a 0.214
lhx3 LIM homeobox 3 0.207
gsc goosecoid 0.200
pdzd7a PDZ domain containing 7a 0.199
pcdh8 protocadherin 8 0.180
foxg1a forkhead box G1a 0.178
her7 hairy and enhancer of split related-7 0.175
irx7 iroquois homeobox protein 7 0.175
dnmt6 DNA (cytosine-5-)-methyltransferase 6 0.174
gli1 GLI-Kruppel family member 1 0.174
irx1a iroquois homeobox protein 1, a 0.170
raraa retinoic acid receptor, alpha a 0.166
ocrl oculocerebrorenal syndrome of Lowe 0.166
lrrc6 leucine rich repeat containing 6 0.165
vsx2 visual system homeobox 2 0.163
gngt2a guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2a 0.163
gbx1 gastrulation brain homeobox 1 0.162
sox9a SRY-box containing gene 9a 0.152
met met proto-oncogene (hepatocyte growth factor receptor) 0.152
traf3ip1 TNF receptor-associated factor 3 interacting protein 1 0.146
isl1 islet1 0.145
fgf8a fibroblast growth factor 8 a 0.143
dharma dharma 0.140
gpr98 G protein-coupled receptor 98 0.136
cdh6 cadherin 6 0.134
ctbp2 C-terminal binding protein 2 0.126
cacnb2b calcium channel, voltage-dependent, beta 2b 0.126
pdlim3a PDZ and LIM domain 3a 0.125
rlbp1a retinaldehyde binding protein 1a 0.123
pnx posterior neuron-specific homeobox 0.122
otpb orthopedia homolog b 0.120
lrrc50 leucine rich repeat containing 50 0.120
irbp interphotoreceptor retinoid-binding protein 0.119
gfi1.2 growth factor independent 1.2 0.116
pcdh17 protocadherin 17 0.114
foxa2 forkhead box A2 0.112
vox ventral homeobox 0.112
rarab retinoic acid receptor, alpha b 0.111
foxd5 forkhead box D5 0.111
bhlhe22 basic helix-loop-helix family, member e22 0.110
isl2a islet2a 0.110
eya1 eyes absent homolog 1 0.109
rxrab retinoid x receptor, alpha b 0.109
bmper BMP binding endothelial regulator 0.108
fsta follistatin a 0.105
pax6a paired box gene 6a 0.105
zgc:112329 zgc:112329 0.104
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Drosophila melanogaster
Name Description Probability Func Analog Organism
ttk tramtrack 1.000
E(spl) Enhancer of split 0.999
amos absent MD neurons and olfactory sensilla 0.990
phyl phyllopod 0.989
crb crumbs 0.989
N Notch 0.987
dsh dishevelled 0.987
sty sprouty 0.986
S6kII RPS6-protein kinase-II 0.985
ed echinoid 0.985
Rala Ras-related protein 0.979
Gug Grunge 0.975
sev sevenless 0.975
ptc patched 0.974
mam mastermind 0.974
hbs hibris 0.970
nej nejire 0.968
csw corkscrew 0.962
sens senseless 0.960
ato atonal 0.958
HLHm7 E(spl) region transcript m7 0.956
Kap-alpha3 karyopherin alpha3 0.954
Nrt Neurotactin 0.950
tkv thickveins 0.950
wg wingless 0.948
klu klumpfuss 0.948
alpha-Adaptin CG4260 gene product from transcript CG4260-RA 0.944
trio CG18214 gene product from transcript CG18214-RA 0.940
bs blistered 0.935
eyg eyegone 0.934
nmo nemo 0.933
Vang Van Gogh 0.923
dac dachshund 0.901
spen split ends 0.901
oc ocelliless 0.900
Ras85D Ras oncogene at 85D 0.898
Fas2 Fasciclin 2 0.895
Egfr Epidermal growth factor receptor 0.887
wts warts 0.886
Gap1 GTPase-activating protein 1 0.884
unk unkempt 0.881
robo roundabout 0.873
argos CG4531 gene product from transcript CG4531-RA 0.866
rg rugose 0.866
vvl ventral veins lacking 0.864
Cbl CG7037 gene product from transcript CG7037-RB 0.860
esg escargot 0.855
HLHmdelta E(spl) region transcript mdelta 0.847
ro rough 0.846
hyd hyperplastic discs 0.842
hh hedgehog 0.841
ac achaete 0.841
rho rhomboid 0.839
Tom Twin of m4 0.839
eya eyes absent 0.837
hdc headcase 0.832
numb CG3779 gene product from transcript CG3779-RB 0.826
WASp CG1520 gene product from transcript CG1520-RA 0.819
HLHm5 E(spl) region transcript m5 0.812
wdb widerborst 0.809
sina seven in absentia 0.795
H Hairless 0.778
ctp cut up 0.762
Ubx Ultrabithorax 0.760
Moe Moesin 0.750
usp ultraspiracle 0.748
shg shotgun 0.743
nub nubbin 0.742
cos costa 0.739
eys eyes shut 0.737
Tsc1 CG6147 gene product from transcript CG6147-RA 0.727
sca scabrous 0.720
HLHmbeta E(spl) region transcript mbeta 0.720
dco discs overgrown 0.705
rst roughest 0.702
Dl Delta 0.701
neur neuralized 0.691
pnt pointed 0.690
Pten CG5671 gene product from transcript CG5671-RB 0.679
cdi center divider 0.665
babo baboon 0.660
m4 E(spl) region transcript m4 0.655
drk downstream of receptor kinase 0.639
Mrtf Myocardin-related transcription factor 0.625
Cdc42 CG12530 gene product from transcript CG12530-RA 0.624
en engrailed 0.618
shi shibire 0.615
bib big brain 0.601
Imp IGF-II mRNA-binding protein 0.600
Rh5 Rhodopsin 5 0.597
sv shaven 0.578
hipk homeodomain interacting protein kinase 0.574
spdo sanpodo 0.562
NFAT NFAT homolog 0.562
chp chaoptic 0.561
pie pineapple eye 0.560
kuz kuzbanian 0.558
ex expanded 0.554
ksr kinase suppressor of ras 0.547
lqfR liquid facets-Related 0.538
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Homo sapiens
Name Description Probability Func Analog Organism
DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 0.989
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7 0.752
C2orf65 chromosome 2 open reading frame 65 0.653
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.464
MED12 mediator complex subunit 12 0.451
PDCD6IP programmed cell death 6 interacting protein 0.447
DYNLT3 dynein, light chain, Tctex-type 3 0.444
NRP1 neuropilin 1 0.386
PCM1 pericentriolar material 1 0.384
CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b 0.353
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.334
BBS1 Bardet-Biedl syndrome 1 0.314
KDR kinase insert domain receptor (a type III receptor tyrosine kinase) 0.289
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.287
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.277
MED20 mediator complex subunit 20 0.272
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.251
CADM4 cell adhesion molecule 4 0.233
CSNK1E casein kinase 1, epsilon 0.232
ITCH itchy E3 ubiquitin protein ligase homolog (mouse) 0.229
SOS1 son of sevenless homolog 1 (Drosophila) 0.225
CDK9 cyclin-dependent kinase 9 0.210
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 0.206
BBS4 Bardet-Biedl syndrome 4 0.198
PARD3 par-3 partitioning defective 3 homolog (C. elegans) 0.189
NCOR1 nuclear receptor corepressor 1 0.183
MED29 mediator complex subunit 29 0.167
APC adenomatous polyposis coli 0.160
SEC31A SEC31 homolog A (S. cerevisiae) 0.152
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.133
HDAC3 histone deacetylase 3 0.129
RXRA retinoid X receptor, alpha 0.126
BBS2 Bardet-Biedl syndrome 2 0.122
NKX2-1 NK2 homeobox 1 0.120
MCC mutated in colorectal cancers 0.118
EGFR epidermal growth factor receptor 0.110
NTF4 neurotrophin 4 0.103
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.101
MYBBP1A MYB binding protein (P160) 1a 0.099
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.097
HDAC1 histone deacetylase 1 0.090
INADL InaD-like (Drosophila) 0.090
MAPT microtubule-associated protein tau 0.090
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.080
CD2AP CD2-associated protein 0.077
BLNK B-cell linker 0.077
SGK3 serum/glucocorticoid regulated kinase family, member 3 0.073
SPC24 SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) 0.072
SKA1 spindle and kinetochore associated complex subunit 1 0.071
BCL3 B-cell CLL/lymphoma 3 0.070
SPRY2 sprouty homolog 2 (Drosophila) 0.069
SH3GL2 SH3-domain GRB2-like 2 0.067
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.067
WDR18 WD repeat domain 18 0.064
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.063
MET met proto-oncogene (hepatocyte growth factor receptor) 0.060
CDH5 cadherin 5, type 2 (vascular endothelium) 0.059
RAP1GAP RAP1 GTPase activating protein 0.059
FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) 0.058
PIAS1 protein inhibitor of activated STAT, 1 0.058
SEC23A Sec23 homolog A (S. cerevisiae) 0.058
TBL3 transducin (beta)-like 3 0.057
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.057
SH3KBP1 SH3-domain kinase binding protein 1 0.056
BBS9 Bardet-Biedl syndrome 9 0.056
MED16 mediator complex subunit 16 0.054
HDAC4 histone deacetylase 4 0.054
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.053
FAM83D family with sequence similarity 83, member D 0.053
PPP2R5D protein phosphatase 2, regulatory subunit B', delta 0.052
TSC2 tuberous sclerosis 2 0.050
ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) 0.049
BICD1 bicaudal D homolog 1 (Drosophila) 0.049
CD2 CD2 molecule 0.047
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.047
FAM110A family with sequence similarity 110, member A 0.047
TUBA1C tubulin, alpha 1c 0.046
CDC25B cell division cycle 25 homolog B (S. pombe) 0.046
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 0.045
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.044
CBY1 chibby homolog 1 (Drosophila) 0.044
SNAP25 synaptosomal-associated protein, 25kDa 0.044
SOX11 SRY (sex determining region Y)-box 11 0.044
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.043
CDK19 cyclin-dependent kinase 19 0.043
STAT5A signal transducer and activator of transcription 5A 0.043
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.042
DTX1 deltex homolog 1 (Drosophila) 0.042
EXOC7 exocyst complex component 7 0.042
LARP1 La ribonucleoprotein domain family, member 1 0.041
RBBP7 retinoblastoma binding protein 7 0.041
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.040
YAP1 Yes-associated protein 1 0.038
SNX18 sorting nexin 18 0.038
MED13 mediator complex subunit 13 0.038
MDFI MyoD family inhibitor 0.038
PARD6B par-6 partitioning defective 6 homolog beta (C. elegans) 0.037
PAX2 paired box 2 0.037
DEPDC1 DEP domain containing 1 0.036
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.036
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism