The network for 'regulation of endodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of endodermal cell fate specification

Any process that mediates the specification of a cell into an endoderm cell.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Foxc1 forkhead box C1 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.999
Gli3 GLI-Kruppel family member GLI3 0.998
Hand1 heart and neural crest derivatives expressed transcript 1 0.998
Msx1 homeobox, msh-like 1 0.998
Foxc2 forkhead box C2 0.996
Prrx1 paired related homeobox 1 0.996
Smo smoothened homolog (Drosophila) 0.995
Sox9 SRY-box containing gene 9 0.993
Tcfap2a transcription factor AP-2, alpha 0.993
Pax3 paired box gene 3 0.989
Otx2 orthodenticle homolog 2 (Drosophila) 0.989
Pitx2 paired-like homeodomain transcription factor 2 0.987
Tgfb2 transforming growth factor, beta 2 0.979
Bmp4 bone morphogenetic protein 4 0.977
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.971
Ctnnb1 catenin (cadherin associated protein), beta 1 0.970
Tbx1 T-box 1 0.968
Msx2 homeobox, msh-like 2 0.967
Bmp7 bone morphogenetic protein 7 0.966
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.965
Dlx5 distal-less homeobox 5 0.964
Fgfr1 fibroblast growth factor receptor 1 0.964
Fgfr3 fibroblast growth factor receptor 3 0.956
Hes1 hairy and enhancer of split 1 (Drosophila) 0.941
Chrd chordin 0.936
Jag1 jagged 1 0.919
Alx4 aristaless-like homeobox 4 0.915
Prrx2 paired related homeobox 2 0.910
Chd7 chromodomain helicase DNA binding protein 7 0.910
Eya1 eyes absent 1 homolog (Drosophila) 0.904
Meox2 mesenchyme homeobox 2 0.904
Fgf8 fibroblast growth factor 8 0.897
Ednra endothelin receptor type A 0.883
Gli2 GLI-Kruppel family member GLI2 0.851
Foxg1 forkhead box G1 0.845
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.840
Acvr1 activin A receptor, type 1 0.826
Rarg retinoic acid receptor, gamma 0.819
Gata4 GATA binding protein 4 0.808
Nodal nodal 0.792
Gbx2 gastrulation brain homeobox 2 0.787
Gsc goosecoid homeobox 0.785
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.769
Psen1 presenilin 1 0.753
Runx2 runt related transcription factor 2 0.735
Lrp6 low density lipoprotein receptor-related protein 6 0.710
Vangl2 vang-like 2 (van gogh, Drosophila) 0.683
Wnt3a wingless-related MMTV integration site 3A 0.650
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.614
Dll1 delta-like 1 (Drosophila) 0.545
Ptch1 patched homolog 1 0.525
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.370
Vegfa vascular endothelial growth factor A 0.359
En1 engrailed 1 0.346
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.332
Hoxa1 homeobox A1 0.323
Isl1 ISL1 transcription factor, LIM/homeodomain 0.283
Nkx3-2 NK3 homeobox 2 0.282
Lmx1b LIM homeobox transcription factor 1 beta 0.271
Ece1 endothelin converting enzyme 1 0.260
Alx1 ALX homeobox 1 0.214
Notch2 Notch gene homolog 2 (Drosophila) 0.213
Tgfbr2 transforming growth factor, beta receptor II 0.204
Dlx6 distal-less homeobox 6 0.199
Gata6 GATA binding protein 6 0.197
Bmp2 bone morphogenetic protein 2 0.197
Pkd1 polycystic kidney disease 1 homolog 0.196
Emx2 empty spiracles homolog 2 (Drosophila) 0.174
T brachyury 0.167
Pitx1 paired-like homeodomain transcription factor 1 0.159
Zeb1 zinc finger E-box binding homeobox 1 0.158
Efnb2 ephrin B2 0.154
Mn1 meningioma 1 0.146
Nog noggin 0.144
Alx3 aristaless-like homeobox 3 0.108
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.099
Sall4 sal-like 4 (Drosophila) 0.098
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.096
Rarb retinoic acid receptor, beta 0.094
Mesp1 mesoderm posterior 1 0.091
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.082
Fgf15 fibroblast growth factor 15 0.077
Pax2 paired box gene 2 0.076
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.074
Smad6 MAD homolog 6 (Drosophila) 0.063
Sox2 SRY-box containing gene 2 0.062
Chuk conserved helix-loop-helix ubiquitous kinase 0.061
Fgf3 fibroblast growth factor 3 0.059
Hhex hematopoietically expressed homeobox 0.059
Lef1 lymphoid enhancer binding factor 1 0.058
Hoxa2 homeobox A2 0.058
Nkx2-6 NK2 transcription factor related, locus 6 (Drosophila) 0.058
Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.057
Rxra retinoid X receptor alpha 0.057
Pbx1 pre B-cell leukemia transcription factor 1 0.054
Kif3a kinesin family member 3A 0.051
Foxe3 forkhead box E3 0.051
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
chd chordin 0.999
bmp2b bone morphogenetic protein 2b 0.994
fgf3 fibroblast growth factor 3 0.984
pax2a paired box gene 2a 0.975
flh floating head 0.964
cdh2 cadherin 2, neuronal 0.882
ndr2 nodal-related 2 0.850
tbx16 T-box gene 16 0.806
vent ventral expressed homeobox 0.791
gbx2 gastrulation brain homeo box 2 0.784
foxi1 forkhead box I1 0.744
pcdh8 protocadherin 8 0.744
gli1 GLI-Kruppel family member 1 0.692
tll1 tolloid-like 1 0.614
dharma dharma 0.602
emx3 empty spiracles homeobox 3 0.587
wif1 wnt inhibitory factor 1 0.574
fgfr1a fibroblast growth factor receptor 1a 0.571
fgfr4 fibroblast growth factor receptor 4 0.560
her7 hairy and enhancer of split related-7 0.554
lhx1b LIM homeobox 1b 0.540
shha sonic hedgehog a 0.528
her1 hairy-related 1 0.489
bmp4 bone morphogenetic protein 4 0.482
ved ventrally expressed dharma/bozozok antagonist 0.465
tbx6 T-box gene 6 0.448
lhx1a LIM homeobox 1a 0.437
eya1 eyes absent homolog 1 0.437
her5 hairy-related 5 0.432
wnt5b wingless-type MMTV integration site family, member 5b 0.424
sox3 SRY-box containing gene 3 0.407
nkx2.2a NK2 transcription factor related 2a 0.392
atoh1a atonal homolog 1a 0.386
foxg1a forkhead box G1a 0.383
ndr1 nodal-related 1 0.378
fgf8a fibroblast growth factor 8 a 0.374
sox1a SRY-box containing gene 1a 0.370
ascl1a achaete-scute complex-like 1a (Drosophila) 0.356
bmp7a bone morphogenetic protein 7a 0.349
meis3 myeloid ecotropic viral integration site 3 0.340
dkk1b dickkopf 1b 0.339
cdx4 caudal type homeo box transcription factor 4 0.338
sox32 SRY-box containing gene 32 0.335
irx1b iroquois homeobox protein 1, b 0.329
dbx1b developing brain homeobox 1b 0.326
mecom MDS1 and EVI1 complex locus 0.323
jag2 jagged 2 0.320
hmx4 H6 family homeobox 4 0.308
sox19a SRY-box containing gene 19a 0.304
ephb4b eph receptor B4b 0.292
notch1a notch homolog 1a 0.286
msxc muscle segment homeobox C 0.284
fzd8b frizzled homolog 8b 0.259
wnt8b wingless-type MMTV integration site family, member 8b 0.255
dusp6 dual specificity phosphatase 6 0.255
sall4 sal-like 4 (Drosophila) 0.253
osr2 odd-skipped related 2 (Drosophila) 0.251
eve1 even-skipped-like1 0.241
mab21l2 mab-21-like 2 0.224
her12 hairy-related 12 0.220
six4b sine oculis homeobox homolog 4b 0.217
foxh1 forkhead box H1 0.213
jag1b jagged 1b 0.211
otx1a orthodenticle homolog 1a 0.209
lft1 lefty1 0.209
dlc deltaC 0.204
hoxa2b homeo box A2b 0.203
snai1b snail homolog 1b (Drosophila) 0.201
runx2b runt-related transcription factor 2b 0.199
bmp2a bone morphogenetic protein 2a 0.196
gdf6a growth differentiation factor 6a 0.189
runx2a runt-related transcription factor 2a 0.178
spry1 sprouty homolog 1 (Drosophila) 0.167
fzd5 frizzled homolog 5 0.166
hoxb2a homeo box B2a 0.165
fgfr2 fibroblast growth factor receptor 2 0.161
pou2f1a POU class 2 homeobox 1a 0.157
nanos3 nanos homolog 3 0.155
tcf7l2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.154
boc brother of CDO 0.151
msxb muscle segment homeobox B 0.150
pdgfaa platelet-derived growth factor alpha a 0.147
dla deltaA 0.145
foxd5 forkhead box D5 0.143
dlx2a distal-less homeobox gene 2a 0.143
gli2a GLI-Kruppel family member GLI2a 0.143
otpb orthopedia homolog b 0.142
oep one-eyed pinhead 0.140
sp5l Sp5 transcription factor-like 0.134
her8a hairy-related 8a 0.133
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.132
foxd3 forkhead box D3 0.129
spry4 sprouty (Drosophila) homolog 4 0.126
tbx1 T-box 1 0.126
irx3b iroquois homeobox protein 3b 0.122
etv2 ets variant gene 2 0.121
pitx2 paired-like homeodomain transcription factor 2 0.121
twist3 twist3 0.120
six4a sine oculis homeobox homolog 4a 0.115
hoxb5a homeo box B5a 0.115
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 0.986
BMPR1A bone morphogenetic protein receptor, type IA 0.984
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.937
NOTCH3 notch 3 0.851
FRS2 fibroblast growth factor receptor substrate 2 0.748
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.743
MAML1 mastermind-like 1 (Drosophila) 0.727
FGF1 fibroblast growth factor 1 (acidic) 0.694
NOG noggin 0.589
FGF2 fibroblast growth factor 2 (basic) 0.585
PLCG1 phospholipase C, gamma 1 0.555
FSTL1 follistatin-like 1 0.389
XIAP X-linked inhibitor of apoptosis 0.203
BMP2 bone morphogenetic protein 2 0.198
FGFR2 fibroblast growth factor receptor 2 0.121
BMP7 bone morphogenetic protein 7 0.109
LRP6 low density lipoprotein receptor-related protein 6 0.105
NOSTRIN nitric oxide synthase trafficker 0.104
JAG2 jagged 2 0.054
LAT linker for activation of T cells 0.052
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.047
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.038
NOTCH2 notch 2 0.038
DLL1 delta-like 1 (Drosophila) 0.031
SPEN spen homolog, transcriptional regulator (Drosophila) 0.030
MDFI MyoD family inhibitor 0.029
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.028
ZFYVE9 zinc finger, FYVE domain containing 9 0.023
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.021
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.020
DUSP1 dual specificity phosphatase 1 0.019
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.018
SHB Src homology 2 domain containing adaptor protein B 0.017
AHR aryl hydrocarbon receptor 0.014
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.014
INSR insulin receptor 0.014
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.014
ATXN1L ataxin 1-like 0.014
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.014
GFI1B growth factor independent 1B transcription repressor 0.013
WFIKKN1 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 0.013
DUSP5 dual specificity phosphatase 5 0.012
BMPR1B bone morphogenetic protein receptor, type IB 0.012
FGFR3 fibroblast growth factor receptor 3 0.011
CASP9 caspase 9, apoptosis-related cysteine peptidase 0.011
EGR2 early growth response 2 0.010
HNF1A HNF1 homeobox A 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism