The network for 'cardiac chamber development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cardiac chamber development

The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart.

Mus musculus
Name Description Probability Func Analog Organism
Pitx2 paired-like homeodomain transcription factor 2 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Shh sonic hedgehog 1.000
Foxc1 forkhead box C1 1.000
Bmp4 bone morphogenetic protein 4 0.999
Fgf8 fibroblast growth factor 8 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Fgfr2 fibroblast growth factor receptor 2 0.998
Otx2 orthodenticle homolog 2 (Drosophila) 0.998
Nodal nodal 0.998
Ctnnb1 catenin (cadherin associated protein), beta 1 0.997
Foxc2 forkhead box C2 0.997
Gata4 GATA binding protein 4 0.996
Hand2 heart and neural crest derivatives expressed transcript 2 0.996
Tbx1 T-box 1 0.992
Hand1 heart and neural crest derivatives expressed transcript 1 0.992
Jag1 jagged 1 0.992
Pax2 paired box gene 2 0.989
Tbx3 T-box 3 0.987
Pax3 paired box gene 3 0.984
Smad6 MAD homolog 6 (Drosophila) 0.981
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.980
Vangl2 vang-like 2 (van gogh, Drosophila) 0.979
Fgfr1 fibroblast growth factor receptor 1 0.979
Notch1 Notch gene homolog 1 (Drosophila) 0.979
Pitx1 paired-like homeodomain transcription factor 1 0.978
Nog noggin 0.975
Hoxd13 homeobox D13 0.972
Tgfb2 transforming growth factor, beta 2 0.970
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.970
Sox2 SRY-box containing gene 2 0.958
Gata6 GATA binding protein 6 0.955
Prrx1 paired related homeobox 1 0.948
Isl1 ISL1 transcription factor, LIM/homeodomain 0.943
Smad4 MAD homolog 4 (Drosophila) 0.939
Rarg retinoic acid receptor, gamma 0.928
Lhx1 LIM homeobox protein 1 0.924
Sall4 sal-like 4 (Drosophila) 0.924
Vegfa vascular endothelial growth factor A 0.906
Egfr epidermal growth factor receptor 0.902
Foxh1 forkhead box H1 0.900
Chd7 chromodomain helicase DNA binding protein 7 0.893
Hoxa13 homeobox A13 0.891
Foxg1 forkhead box G1 0.885
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.872
Lrp6 low density lipoprotein receptor-related protein 6 0.857
Gpc3 glypican 3 0.856
Tlx3 T-cell leukemia, homeobox 3 0.852
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.842
Smarcc1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.838
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.823
Mesp1 mesoderm posterior 1 0.810
Pax6 paired box gene 6 0.798
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.786
Meox2 mesenchyme homeobox 2 0.781
Foxf1a forkhead box F1a 0.780
Rb1 retinoblastoma 1 0.775
Dll1 delta-like 1 (Drosophila) 0.775
Esrrb estrogen related receptor, beta 0.769
Ntf3 neurotrophin 3 0.768
Bmpr1a bone morphogenetic protein receptor, type 1A 0.767
Tal1 T-cell acute lymphocytic leukemia 1 0.760
Hoxd11 homeobox D11 0.759
Twist2 twist homolog 2 (Drosophila) 0.758
Arid1a AT rich interactive domain 1A (SWI-like) 0.758
Pten phosphatase and tensin homolog 0.753
Tcfap2a transcription factor AP-2, alpha 0.743
Zic3 zinc finger protein of the cerebellum 3 0.735
Lhx3 LIM homeobox protein 3 0.729
Rxra retinoid X receptor alpha 0.728
Scn5a sodium channel, voltage-gated, type V, alpha 0.722
Gli2 GLI-Kruppel family member GLI2 0.718
Wnt11 wingless-related MMTV integration site 11 0.708
Nos3 nitric oxide synthase 3, endothelial cell 0.706
Fgfr3 fibroblast growth factor receptor 3 0.704
Pthlh parathyroid hormone-like peptide 0.694
Fzd2 frizzled homolog 2 (Drosophila) 0.692
Myog myogenin 0.686
Smo smoothened homolog (Drosophila) 0.680
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.677
Tbx2 T-box 2 0.670
Insm1 insulinoma-associated 1 0.653
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.644
Psen1 presenilin 1 0.639
Wnt4 wingless-related MMTV integration site 4 0.636
Sox9 SRY-box containing gene 9 0.630
Pcdh12 protocadherin 12 0.627
She src homology 2 domain-containing transforming protein E 0.622
Nkx3-2 NK3 homeobox 2 0.619
Hes1 hairy and enhancer of split 1 (Drosophila) 0.611
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.607
Pax1 paired box gene 1 0.605
Eya1 eyes absent 1 homolog (Drosophila) 0.604
Uncx UNC homeobox 0.603
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.599
Fgf15 fibroblast growth factor 15 0.580
Axin1 axin 1 0.577
Smad3 MAD homolog 3 (Drosophila) 0.577
Gdnf glial cell line derived neurotrophic factor 0.568
Alx3 aristaless-like homeobox 3 0.559
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
tbx1 T-box 1 0.994
myod1 myogenic differentiation 1 0.842
shha sonic hedgehog a 0.816
isl1 islet1 0.816
fn1 fibronectin 1 0.675
smyhc2 slow myosin heavy chain 2 0.608
spaw southpaw 0.589
alcama activated leukocyte cell adhesion molecule a 0.571
bmp2b bone morphogenetic protein 2b 0.510
pcdh8 protocadherin 8 0.498
spns2 spinster homolog 2 (Drosophila) 0.490
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.454
hhex hematopoietically expressed homeobox 0.440
sox32 SRY-box containing gene 32 0.397
fgf8a fibroblast growth factor 8 a 0.376
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.371
wnt11r wingless-type MMTV integration site family, member 11, related 0.325
smyhc1 slow myosin heavy chain 1 0.318
tal1 T-cell acute lymphocytic leukemia 1 0.303
gpr126 G protein-coupled receptor 126 0.301
foxg1a forkhead box G1a 0.286
tbx20 T-box 20 0.253
sulf1 sulfatase 1 0.231
chd chordin 0.226
oep one-eyed pinhead 0.222
foxi1 forkhead box I1 0.209
lft1 lefty1 0.207
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.193
fgf10a fibroblast growth factor 10a 0.187
pdlim7 PDZ and LIM domain 7 0.179
spon1b spondin 1b 0.178
tnnt2a troponin T2a, cardiac 0.178
tbx18 T-box 18 0.176
bmp3 bone morphogenetic protein 3 0.174
tbx16 T-box gene 16 0.165
klf4 Kruppel-like factor 4 0.164
nkx2.5 NK2 transcription factor related 5 0.158
foxa2 forkhead box A2 0.156
mitfa microphthalmia-associated transcription factor a 0.143
emx3 empty spiracles homeobox 3 0.142
hoxa11a homeo box A11a 0.142
cdh2 cadherin 2, neuronal 0.137
mib mind bomb 0.136
hmx3 homeo box (H6 family) 3 0.132
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.130
actc1a actin, alpha, cardiac muscle 1a 0.129
hoxd11a homeo box D11a 0.129
gata2a GATA-binding protein 2a 0.128
evx1 even-skipped homeobox 1 0.126
plod1a procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1a 0.124
fgf8b fibroblast growth factor 8 b 0.110
nkx3.2 NK3 homeobox 2 0.104
six4b sine oculis homeobox homolog 4b 0.103
smyhc1l slow myosin heavy chain 1, like 0.102
wnt5b wingless-type MMTV integration site family, member 5b 0.101
foxc1a forkhead box C1a 0.097
tbx2a T-box gene 2a 0.096
col9a2 procollagen, type IX, alpha 2 0.095
cxcr4a chemokine (C-X-C motif) receptor 4a 0.094
lmo4a LIM domain only 4a 0.093
ndr2 nodal-related 2 0.091
pax2a paired box gene 2a 0.089
lft2 lefty2 0.085
sgcd sarcoglycan, delta (dystrophin-associated glycoprotein) 0.080
bmp4 bone morphogenetic protein 4 0.080
ntla no tail a 0.080
eng1a engrailed 1a 0.079
dusp5 dual specificity phosphatase 5 0.074
wls wntless homolog (Drosophila) 0.074
edn1 endothelin 1 0.073
slc25a37 solute carrier family 25, member 37 0.072
tnni1b troponin I, skeletal, slow b 0.072
notch3 notch homolog 3 0.070
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.070
tnni2a.4 troponin I, skeletal, fast 2a.4 0.070
gata5 GATA-binding protein 5 0.069
zgc:101782 zgc:101782 0.068
nr5a2 nuclear receptor subfamily 5, group A, member 2 0.067
tjp2a tight junction protein 2a (zona occludens 2) 0.063
hnf1ba HNF1 homeobox Ba 0.063
tnni1al troponin I, skeletal, slow like 0.063
tbx5a T-box 5a 0.062
smyd1b SET and MYND domain containing 1b 0.062
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.062
myl7 myosin, light polypeptide 7, regulatory 0.061
gata3 GATA-binding protein 3 0.060
slc8a1a solute carrier family 8 (sodium/calcium exchanger), member 1a 0.060
tll1 tolloid-like 1 0.059
traf4a tnf receptor-associated factor 4a 0.057
fli1a friend leukemia integration 1a 0.057
sall4 sal-like 4 (Drosophila) 0.055
runx1 runt-related transcription factor 1 0.055
actn3b actinin alpha 3b 0.055
flh floating head 0.054
plcg1 phospholipase C, gamma 1 0.054
tgfb3 transforming growth factor, beta 3 0.053
nkx2.2b NK2 transcription factor related 2b 0.053
pax8 paired box gene 8 0.053
her7 hairy and enhancer of split related-7 0.051
nkx2.7 NK2 transcription factor related 7 0.051
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
TAL1 T-cell acute lymphocytic leukemia 1 0.993
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.989
NOTCH1 notch 1 0.964
TNNC1 troponin C type 1 (slow) 0.960
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.949
EPAS1 endothelial PAS domain protein 1 0.823
JAG1 jagged 1 0.809
GATA4 GATA binding protein 4 0.798
TNNI1 troponin I type 1 (skeletal, slow) 0.793
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.750
ESR1 estrogen receptor 1 0.741
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.644
TBX5 T-box 5 0.569
TGFB1 transforming growth factor, beta 1 0.563
HNF4A hepatocyte nuclear factor 4, alpha 0.558
EP300 E1A binding protein p300 0.521
TPM1 tropomyosin 1 (alpha) 0.512
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.504
MYOD1 myogenic differentiation 1 0.503
GSK3B glycogen synthase kinase 3 beta 0.494
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.488
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.471
BMP2 bone morphogenetic protein 2 0.465
TTR transthyretin 0.450
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.427
TNNT2 troponin T type 2 (cardiac) 0.424
SMYD1 SET and MYND domain containing 1 0.416
RXRA retinoid X receptor, alpha 0.370
ANGPT2 angiopoietin 2 0.365
MAPK8 mitogen-activated protein kinase 8 0.355
CREBBP CREB binding protein 0.354
FKBP1A FK506 binding protein 1A, 12kDa 0.323
ARID1B AT rich interactive domain 1B (SWI1-like) 0.322
SMAD7 SMAD family member 7 0.311
ILK integrin-linked kinase 0.311
NCOR2 nuclear receptor corepressor 2 0.268
CTGF connective tissue growth factor 0.259
SMAD1 SMAD family member 1 0.242
SETD8 SET domain containing (lysine methyltransferase) 8 0.242
ACVR1B activin A receptor, type IB 0.233
HAP1 huntingtin-associated protein 1 0.229
ACTA1 actin, alpha 1, skeletal muscle 0.217
SIRT1 sirtuin 1 0.213
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.210
CSNK1E casein kinase 1, epsilon 0.207
AXIN1 axin 1 0.204
SP1 Sp1 transcription factor 0.203
SMAD9 SMAD family member 9 0.193
MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian) 0.188
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2 0.185
TTN titin 0.179
RARA retinoic acid receptor, alpha 0.176
NCOR1 nuclear receptor corepressor 1 0.174
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 0.165
FSTL1 follistatin-like 1 0.155
CKM creatine kinase, muscle 0.154
MYH9 myosin, heavy chain 9, non-muscle 0.152
ENG endoglin 0.151
SMAD2 SMAD family member 2 0.150
NOTCH3 notch 3 0.140
ACVR1 activin A receptor, type I 0.137
TNNI2 troponin I type 2 (skeletal, fast) 0.136
CXXC5 CXXC finger protein 5 0.135
SMAD4 SMAD family member 4 0.133
MYBPC2 myosin binding protein C, fast type 0.128
TNNT3 troponin T type 3 (skeletal, fast) 0.126
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.126
FGF1 fibroblast growth factor 1 (acidic) 0.125
SMAD6 SMAD family member 6 0.125
NCOA1 nuclear receptor coactivator 1 0.117
TRIM63 tripartite motif containing 63 0.116
GATA2 GATA binding protein 2 0.107
SPTB spectrin, beta, erythrocytic 0.104
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.104
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.101
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 0.099
TGFBR1 transforming growth factor, beta receptor 1 0.098
AKAP12 A kinase (PRKA) anchor protein 12 0.098
SMAD3 SMAD family member 3 0.097
RUNX1 runt-related transcription factor 1 0.096
MYOG myogenin (myogenic factor 4) 0.095
WNT3A wingless-type MMTV integration site family, member 3A 0.094
TPM2 tropomyosin 2 (beta) 0.094
STK3 serine/threonine kinase 3 0.092
CAV1 caveolin 1, caveolae protein, 22kDa 0.090
GDF5 growth differentiation factor 5 0.089
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.084
FGF10 fibroblast growth factor 10 0.083
MARK3 MAP/microtubule affinity-regulating kinase 3 0.081
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.081
SIX6 SIX homeobox 6 0.079
ARNT aryl hydrocarbon receptor nuclear translocator 0.077
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.073
HIC1 hypermethylated in cancer 1 0.072
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.072
KRT14 keratin 14 0.071
DLL1 delta-like 1 (Drosophila) 0.071
FGFR1 fibroblast growth factor receptor 1 0.071
CALD1 caldesmon 1 0.071
ZFPM1 zinc finger protein, multitype 1 0.069
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Rattus norvegicus
Name Description Probability Func Analog Organism
Myh6 myosin, heavy chain 6, cardiac muscle, alpha 0.740
Actc1 actin, alpha, cardiac muscle 1 0.662
Casq2 calsequestrin 2 (cardiac muscle) 0.469
Myh7 myosin, heavy chain 7, cardiac muscle, beta 0.382
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.361
Foxi2 forkhead box I2 0.354
Klk1c10 T-kininogenase 0.231
Agtr2 angiotensin II receptor, type 2 0.225
Tpo thyroid peroxidase 0.215
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.206
Scn5a sodium channel, voltage-gated, type V, alpha subunit 0.202
Actn2 actinin alpha 2 0.187
Hand2 heart and neural crest derivatives expressed 2 0.181
Fcer2 Fc fragment of IgE, low affinity II, receptor for (CD23) 0.166
Gata6 GATA binding protein 6 0.159
Andpro androgen regulated protein 0.155
Ppp2r2a protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform 0.150
Tgfb3 transforming growth factor, beta 3 0.147
Bmp7 bone morphogenetic protein 7 0.132
Ltbp1 latent transforming growth factor beta binding protein 1 0.129
Gja3 gap junction protein, alpha 3 0.120
Htr2c 5-hydroxytryptamine (serotonin) receptor 2C 0.119
Fzd1 frizzled homolog 1 (Drosophila) 0.118
Nfic nuclear factor I/C 0.118
Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.115
Igf2 insulin-like growth factor 2 0.113
Nek9 NIMA (never in mitosis gene a)- related kinase 9 0.112
Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 0.104
Jub jub, ajuba homolog (Xenopus laevis) 0.103
Mprip myosin phosphatase Rho interacting protein 0.101
Myl7 myosin, light chain 7, regulatory 0.098
Gpc1 glypican 1 0.095
Adora1 adenosine A1 receptor 0.094
Col4a5 collagen, type IV, alpha 5 0.093
Tnni3 troponin I type 3 (cardiac) 0.088
Gnrhr gonadotropin releasing hormone receptor 0.088
Klk1l kallikrein 1-like peptidase 0.087
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.086
Fgf16 fibroblast growth factor 16 0.085
Ednra endothelin receptor type A 0.084
Chd4 chromodomain helicase DNA binding protein 4 0.084
Pgam2 phosphoglycerate mutase 2 (muscle) 0.084
Nrap nebulin-related anchoring protein 0.084
Myl3 myosin, light chain 3, alkali; ventricular, skeletal, slow 0.083
Ptp4a1 protein tyrosine phosphatase type IVA, member 1 0.083
Tgfbr2 transforming growth factor, beta receptor II 0.082
Alx1 ALX homeobox 1 0.080
Ttn titin 0.079
Dbh dopamine beta-hydroxylase (dopamine beta-monooxygenase) 0.079
Nptn neuroplastin 0.077
Plagl1 pleiomorphic adenoma gene-like 1 0.076
Pacs1 phosphofurin acidic cluster sorting protein 1 0.076
Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit 0.074
Hes3 hairy and enhancer of split 3 (Drosophila) 0.072
Dchs1 dachsous 1 (Drosophila) 0.071
Accn2 amiloride-sensitive cation channel 2, neuronal 0.069
Hoxb7 homeo box B7 0.068
Mdfic MyoD family inhibitor domain containing 0.067
Klk1c10l2 kallikrein 1-related peptidase c10-like 2 0.066
RY2G5 potential ligand-binding protein 0.066
Grb10 growth factor receptor bound protein 10 0.066
Myh3 myosin, heavy chain 3, skeletal muscle, embryonic 0.065
Myoz2 myozenin 2 0.065
Uox urate oxidase 0.064
Fbln5 fibulin 5 0.062
Dbn1 drebrin 1 0.062
Myom1 myomesin 1 0.062
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.062
Prpg1 proline-rich proteoglycan 1 0.061
Fat1 FAT tumor suppressor homolog 1 (Drosophila) 0.061
Efnb1 ephrin B1 0.060
Arrb1 arrestin, beta 1 0.059
F2r coagulation factor II (thrombin) receptor 0.057
Il13 interleukin 13 0.057
Wt1 Wilms tumor 1 0.057
Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 0.056
Nr2f2 nuclear receptor subfamily 2, group F, member 2 0.056
Pitpna phosphatidylinositol transfer protein, alpha 0.056
Nexn nexilin (F actin binding protein) 0.056
Figf c-fos induced growth factor 0.056
Hlf hepatic leukemia factor 0.056
Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 0.055
Ptgir prostaglandin I2 (prostacyclin) receptor (IP) 0.055
Ets1 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) 0.054
Cox6a2 cytochrome c oxidase, subunit VIa, polypeptide 2 0.054
Dcc deleted in colorectal carcinoma 0.054
Fry furry homolog (Drosophila) 0.054
S1pr2 sphingosine-1-phosphate receptor 2 0.054
Rest RE1-silencing transcription factor 0.054
Erbb4 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) 0.053
Syt8 synaptotagmin VIII 0.053
Hoxc4 homeo box C4 0.052
Obp2b odorant binding protein 2B 0.052
Efemp1 EGF-containing fibulin-like extracellular matrix protein 1 0.052
Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 0.052
St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 0.051
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.050
Prdm2 PR domain containing 2, with ZNF domain 0.050
Pou2f2 POU class 2 homeobox 2 0.050
Wbp2 WW domain binding protein 2 0.049
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism