The network for 'regulation of interleukin 8 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of interleukin 8 production

Any process that modulates the frequency, rate, or extent of interleukin-8 production.

Mus musculus
Name Description Probability Func Analog Organism
Casp1 caspase 1 0.991
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.788
Myd88 myeloid differentiation primary response gene 88 0.787
Aim2 absent in melanoma 2 0.721
Tnf tumor necrosis factor 0.707
Lhx1 LIM homeobox protein 1 0.656
Tlr4 toll-like receptor 4 0.649
Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a 0.582
Il6st interleukin 6 signal transducer 0.493
Casp4 caspase 4, apoptosis-related cysteine peptidase 0.461
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.380
Cd44 CD44 antigen 0.376
Traf3 TNF receptor-associated factor 3 0.373
Cyld cylindromatosis (turban tumor syndrome) 0.343
Ccl2 chemokine (C-C motif) ligand 2 0.288
Ticam1 toll-like receptor adaptor molecule 1 0.263
Il1a interleukin 1 alpha 0.252
Klf6 Kruppel-like factor 6 0.245
Elane elastase, neutrophil expressed 0.244
Fas Fas (TNF receptor superfamily member 6) 0.233
Casp8 caspase 8 0.214
Litaf LPS-induced TN factor 0.209
Socs1 suppressor of cytokine signaling 1 0.202
Arrb2 arrestin, beta 2 0.193
Il1r1 interleukin 1 receptor, type I 0.191
Il12a interleukin 12a 0.174
Card11 caspase recruitment domain family, member 11 0.171
Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b 0.171
Gdf3 growth differentiation factor 3 0.169
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 0.169
Socs3 suppressor of cytokine signaling 3 0.160
Sftpb surfactant associated protein B 0.154
Fut7 fucosyltransferase 7 0.151
Dysf dysferlin 0.149
Nlrp3 NLR family, pyrin domain containing 3 0.147
Wnt10a wingless related MMTV integration site 10a 0.143
Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.142
Klf3 Kruppel-like factor 3 (basic) 0.141
Lgals3 lectin, galactose binding, soluble 3 0.140
Vax1 ventral anterior homeobox containing gene 1 0.136
Wnt4 wingless-related MMTV integration site 4 0.136
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 0.135
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.128
Plaur plasminogen activator, urokinase receptor 0.126
T brachyury 0.124
Pax2 paired box gene 2 0.124
Wnt10b wingless related MMTV integration site 10b 0.123
Tmod3 tropomodulin 3 0.122
Pax8 paired box gene 8 0.120
Selp selectin, platelet 0.116
Treml1 triggering receptor expressed on myeloid cells-like 1 0.116
Fgf21 fibroblast growth factor 21 0.115
Porcn porcupine homolog (Drosophila) 0.115
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 0.113
Fasl Fas ligand (TNF superfamily, member 6) 0.113
Ms4a15 membrane-spanning 4-domains, subfamily A, member 15 0.111
Anxa2 annexin A2 0.109
Atf3 activating transcription factor 3 0.106
Otx1 orthodenticle homolog 1 (Drosophila) 0.105
Fzd10 frizzled homolog 10 (Drosophila) 0.104
Map3k3 mitogen-activated protein kinase kinase kinase 3 0.104
Dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.102
Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105 0.101
Lef1 lymphoid enhancer binding factor 1 0.099
Ms4a3 membrane-spanning 4-domains, subfamily A, member 3 0.099
Ccr2 chemokine (C-C motif) receptor 2 0.096
Birc3 baculoviral IAP repeat-containing 3 0.096
Tbxa2r thromboxane A2 receptor 0.095
Cdx1 caudal type homeobox 1 0.090
Il17a interleukin 17A 0.090
Zap70 zeta-chain (TCR) associated protein kinase 0.089
Cd9 CD9 antigen 0.089
Padi1 peptidyl arginine deiminase, type I 0.089
Spib Spi-B transcription factor (Spi-1/PU.1 related) 0.089
Ikbkg inhibitor of kappaB kinase gamma 0.089
Cebpb CCAAT/enhancer binding protein (C/EBP), beta 0.087
Mmp9 matrix metallopeptidase 9 0.087
Nobox NOBOX oogenesis homeobox 0.085
5830411N06Rik RIKEN cDNA 5830411N06 gene 0.085
Slfn1 schlafen 1 0.084
Zfp36 zinc finger protein 36 0.084
Emx2 empty spiracles homolog 2 (Drosophila) 0.084
Itch itchy, E3 ubiquitin protein ligase 0.083
Siglec1 sialic acid binding Ig-like lectin 1, sialoadhesin 0.083
Rhoh ras homolog gene family, member H 0.083
Ager advanced glycosylation end product-specific receptor 0.083
Stat3 signal transducer and activator of transcription 3 0.082
Fos FBJ osteosarcoma oncogene 0.082
Plscr1 phospholipid scramblase 1 0.082
Mobkl1b MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.081
Mmp8 matrix metallopeptidase 8 0.080
Mgmt O-6-methylguanine-DNA methyltransferase 0.080
Cd14 CD14 antigen 0.080
Mdfic MyoD family inhibitor domain containing 0.079
Ctnna1 catenin (cadherin associated protein), alpha 1 0.079
Lgr4 leucine-rich repeat-containing G protein-coupled receptor 4 0.079
Hif1a hypoxia inducible factor 1, alpha subunit 0.079
Fgf18 fibroblast growth factor 18 0.078
Arsi arylsulfatase i 0.078
Rarb retinoic acid receptor, beta 0.078
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.998
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.982
BCL3 B-cell CLL/lymphoma 3 0.877
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.809
MYD88 myeloid differentiation primary response gene (88) 0.752
ANXA1 annexin A1 0.724
BIRC3 baculoviral IAP repeat containing 3 0.671
SMN1 survival of motor neuron 1, telomeric 0.625
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.421
PLAU plasminogen activator, urokinase 0.409
IL8 interleukin 8 0.406
RELA v-rel reticuloendotheliosis viral oncogene homolog A (avian) 0.398
TRAF1 TNF receptor-associated factor 1 0.384
RIPK2 receptor-interacting serine-threonine kinase 2 0.378
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.285
CRP C-reactive protein, pentraxin-related 0.260
ABI2 abl-interactor 2 0.251
C1QA complement component 1, q subcomponent, A chain 0.250
KLF6 Kruppel-like factor 6 0.237
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.227
RELB v-rel reticuloendotheliosis viral oncogene homolog B 0.221
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.203
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.191
REL v-rel reticuloendotheliosis viral oncogene homolog (avian) 0.174
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.170
KLF4 Kruppel-like factor 4 (gut) 0.161
CASP1 caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase) 0.158
S100A10 S100 calcium binding protein A10 0.151
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.149
C1QC complement component 1, q subcomponent, C chain 0.143
ZNF496 zinc finger protein 496 0.125
BIRC2 baculoviral IAP repeat containing 2 0.107
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin) 0.107
ARRB1 arrestin, beta 1 0.102
DLG1 discs, large homolog 1 (Drosophila) 0.100
ATF3 activating transcription factor 3 0.096
TNIP1 TNFAIP3 interacting protein 1 0.089
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.087
MEFV Mediterranean fever 0.085
TNIP2 TNFAIP3 interacting protein 2 0.085
MAP3K3 mitogen-activated protein kinase kinase kinase 3 0.084
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.083
CARD11 caspase recruitment domain family, member 11 0.078
DUSP1 dual specificity phosphatase 1 0.076
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.075
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.074
CCL20 chemokine (C-C motif) ligand 20 0.074
BMPR1B bone morphogenetic protein receptor, type IB 0.073
C9orf89 chromosome 9 open reading frame 89 0.072
IL1R1 interleukin 1 receptor, type I 0.069
MT2A metallothionein 2A 0.068
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma 0.066
NLRC4 NLR family, CARD domain containing 4 0.063
ITGB5 integrin, beta 5 0.062
IL1R2 interleukin 1 receptor, type II 0.062
IL6 interleukin 6 (interferon, beta 2) 0.062
PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.057
JUN jun proto-oncogene 0.056
SPRR2A small proline-rich protein 2A 0.055
TLR4 toll-like receptor 4 0.053
SOD1 superoxide dismutase 1, soluble 0.052
TICAM2 toll-like receptor adaptor molecule 2 0.052
MARCO macrophage receptor with collagenous structure 0.050
TRAF3 TNF receptor-associated factor 3 0.047
PTAFR platelet-activating factor receptor 0.046
EMP1 epithelial membrane protein 1 0.045
CYBB cytochrome b-245, beta polypeptide 0.045
HDAC7 histone deacetylase 7 0.044
MAPK10 mitogen-activated protein kinase 10 0.044
PYDC2 pyrin domain containing 2 0.043
SNX33 sorting nexin 33 0.043
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.043
S100A11 S100 calcium binding protein A11 0.043
APOE apolipoprotein E 0.042
MAP3K8 mitogen-activated protein kinase kinase kinase 8 0.042
SH3D19 SH3 domain containing 19 0.042
FAS Fas (TNF receptor superfamily, member 6) 0.041
ANXA2 annexin A2 0.040
CAMP cathelicidin antimicrobial peptide 0.040
ANXA4 annexin A4 0.039
ANXA5 annexin A5 0.039
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.037
NLRP3 NLR family, pyrin domain containing 3 0.037
CXCL2 chemokine (C-X-C motif) ligand 2 0.037
CD48 CD48 molecule 0.036
ZFP36 zinc finger protein 36, C3H type, homolog (mouse) 0.036
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.036
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.035
CCR1 chemokine (C-C motif) receptor 1 0.035
PLAUR plasminogen activator, urokinase receptor 0.035
IGSF6 immunoglobulin superfamily, member 6 0.035
USP15 ubiquitin specific peptidase 15 0.035
DBP D site of albumin promoter (albumin D-box) binding protein 0.034
MPO myeloperoxidase 0.034
TLR2 toll-like receptor 2 0.034
PRKCQ protein kinase C, theta 0.034
APOA1 apolipoprotein A-I 0.033
PDCD6IP programmed cell death 6 interacting protein 0.033
GNMT glycine N-methyltransferase 0.032
S100A12 S100 calcium binding protein A12 0.032
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Rattus norvegicus
Name Description Probability Func Analog Organism
Olr1 oxidized low density lipoprotein (lectin-like) receptor 1 0.140
Ccl2 chemokine (C-C motif) ligand 2 0.092
Cxcl1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.039
Ccl3 chemokine (C-C motif) ligand 3 0.037
Pla1a phospholipase A1 member A 0.035
Il1a interleukin 1 alpha 0.033
Il6 interleukin 6 0.025
Hck hemopoietic cell kinase 0.024
Ccl4 chemokine (C-C motif) ligand 4 0.024
Cxcl2 chemokine (C-X-C motif) ligand 2 0.024
Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 0.023
Casp12 caspase 12 0.023
Il1r2 interleukin 1 receptor, type II 0.023
Fosl1 fos-like antigen 1 0.022
Atf3 activating transcription factor 3 0.021
Serpine1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.021
Plaur plasminogen activator, urokinase receptor 0.021
Igsf6 immunoglobulin superfamily, member 6 0.018
Myd88 myeloid differentiation primary response gene 88 0.018
Vcan versican 0.017
Gja5 gap junction protein, alpha 5 0.017
Map3k8 mitogen-activated protein kinase kinase kinase 8 0.017
Plek pleckstrin 0.016
Tlr4 toll-like receptor 4 0.016
Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 0.015
Casp1 caspase 1 0.014
Nradd neurotrophin receptor associated death domain 0.014
Cxcl10 chemokine (C-X-C motif) ligand 10 0.014
Arl11 ADP-ribosylation factor-like 11 0.014
S100a9 S100 calcium binding protein A9 0.014
Vcam1 vascular cell adhesion molecule 1 0.014
Sh2b3 SH2B adaptor protein 3 0.014
Iqgap1 IQ motif containing GTPase activating protein 1 0.014
Dusp1 dual specificity phosphatase 1 0.014
Ltbp3 latent transforming growth factor beta binding protein 3 0.014
C5ar1 complement component 5a receptor 1 0.013
Lilrb4 leukocyte immunoglobulin-like receptor, subfamily B, member 4 0.013
Gpx2 glutathione peroxidase 2 0.013
Xdh xanthine dehydrogenase 0.013
P2ry6 pyrimidinergic receptor P2Y, G-protein coupled, 6 0.012
Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N 0.012
Rhoj ras homolog gene family, member J 0.012
Ctss cathepsin S 0.012
PVR poliovirus receptor 0.012
F2rl2 coagulation factor II (thrombin) receptor-like 2 0.012
Ccr1 chemokine (C-C motif) receptor 1 0.012
Fblim1 filamin binding LIM protein 1 0.011
Rgs1 regulator of G-protein signaling 1 0.011
Klf3 Kruppel-like factor 3 (basic) 0.011
Zfp36l1 zinc finger protein 36, C3H type-like 1 0.011
Ppp1r15a protein phosphatase 1, regulatory (inhibitor) subunit 15A 0.011
Clec10a C-type lectin domain family 10, member A 0.011
Tnf tumor necrosis factor (TNF superfamily, member 2) 0.011
Col12a1 collagen, type XII, alpha 1 0.011
Mmp12 matrix metallopeptidase 12 0.011
Runx1 runt-related transcription factor 1 0.011
Cxcr4 chemokine (C-X-C motif) receptor 4 0.011
Hspa1a heat shock 70kD protein 1A 0.010
Cr1l complement component (3b/4b) receptor 1-like 0.010
Ccl17 chemokine (C-C motif) ligand 17 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism