The network for 'pericardium development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pericardium development

The process whose specific outcome is the progression of the pericardium over time, from its formation to the mature structure. The pericardium is a double-walled sac that contains the heart and the roots of the aorta, vena cava and the pulmonary artery.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 0.999
Hand2 heart and neural crest derivatives expressed transcript 2 0.987
Pitx2 paired-like homeodomain transcription factor 2 0.980
Pax2 paired box gene 2 0.979
Jag1 jagged 1 0.974
Tbx3 T-box 3 0.972
Otx2 orthodenticle homolog 2 (Drosophila) 0.968
Fgfr2 fibroblast growth factor receptor 2 0.964
Hoxa1 homeobox A1 0.952
Gli3 GLI-Kruppel family member GLI3 0.952
Notch1 Notch gene homolog 1 (Drosophila) 0.934
Pitx1 paired-like homeodomain transcription factor 1 0.926
Hand1 heart and neural crest derivatives expressed transcript 1 0.923
Fgf8 fibroblast growth factor 8 0.905
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.893
Foxc2 forkhead box C2 0.859
Fgfr1 fibroblast growth factor receptor 1 0.849
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.801
Pax6 paired box gene 6 0.799
Pax3 paired box gene 3 0.793
Msx1 homeobox, msh-like 1 0.790
Foxc1 forkhead box C1 0.766
Prrx1 paired related homeobox 1 0.737
Tbx1 T-box 1 0.681
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.678
Smo smoothened homolog (Drosophila) 0.670
Lhx1 LIM homeobox protein 1 0.666
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.666
Gbx2 gastrulation brain homeobox 2 0.632
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.592
Zic3 zinc finger protein of the cerebellum 3 0.576
Fgf10 fibroblast growth factor 10 0.573
En1 engrailed 1 0.534
Bmp4 bone morphogenetic protein 4 0.531
Nodal nodal 0.501
Trp63 transformation related protein 63 0.497
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.490
Tlx3 T-cell leukemia, homeobox 3 0.452
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.449
T brachyury 0.436
Tbx5 T-box 5 0.430
Lmx1a LIM homeobox transcription factor 1 alpha 0.426
Prrx2 paired related homeobox 2 0.418
Alx4 aristaless-like homeobox 4 0.415
Dll1 delta-like 1 (Drosophila) 0.373
Tcfap2a transcription factor AP-2, alpha 0.365
Ptf1a pancreas specific transcription factor, 1a 0.352
Eya1 eyes absent 1 homolog (Drosophila) 0.344
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.342
Foxg1 forkhead box G1 0.340
Sox2 SRY-box containing gene 2 0.334
Neurod1 neurogenic differentiation 1 0.324
Notch2 Notch gene homolog 2 (Drosophila) 0.320
Kiss1 KiSS-1 metastasis-suppressor 0.311
Msx2 homeobox, msh-like 2 0.310
Tgfb2 transforming growth factor, beta 2 0.309
Gata4 GATA binding protein 4 0.289
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.285
Dll4 delta-like 4 (Drosophila) 0.265
Nkx6-1 NK6 homeobox 1 0.252
Pax9 paired box gene 9 0.246
Hes1 hairy and enhancer of split 1 (Drosophila) 0.240
Hoxa2 homeobox A2 0.240
Wt1 Wilms tumor 1 homolog 0.240
Sox9 SRY-box containing gene 9 0.237
Pax8 paired box gene 8 0.234
Gdf3 growth differentiation factor 3 0.230
Nog noggin 0.225
Pdx1 pancreatic and duodenal homeobox 1 0.215
Dlx5 distal-less homeobox 5 0.211
Emx2 empty spiracles homolog 2 (Drosophila) 0.209
Gli2 GLI-Kruppel family member GLI2 0.203
Smad4 MAD homolog 4 (Drosophila) 0.197
Gsc goosecoid homeobox 0.190
Wnt11 wingless-related MMTV integration site 11 0.183
Col4a3 collagen, type IV, alpha 3 0.180
Sox11 SRY-box containing gene 11 0.179
Alx3 aristaless-like homeobox 3 0.177
Ctnnb1 catenin (cadherin associated protein), beta 1 0.176
Tcf15 transcription factor 15 0.172
Pou5f1 POU domain, class 5, transcription factor 1 0.170
Meox2 mesenchyme homeobox 2 0.167
Gdnf glial cell line derived neurotrophic factor 0.164
Lmx1b LIM homeobox transcription factor 1 beta 0.159
Hoxd3 homeobox D3 0.157
Hoxd11 homeobox D11 0.156
Smad1 MAD homolog 1 (Drosophila) 0.156
Zeb1 zinc finger E-box binding homeobox 1 0.151
Hoxd1 homeobox D1 0.150
Isl1 ISL1 transcription factor, LIM/homeodomain 0.146
Smad6 MAD homolog 6 (Drosophila) 0.143
Pou3f3 POU domain, class 3, transcription factor 3 0.139
Foxa2 forkhead box A2 0.138
Runx2 runt related transcription factor 2 0.136
Hoxa11 homeobox A11 0.136
Gata6 GATA binding protein 6 0.136
Pax7 paired box gene 7 0.133
Dlx2 distal-less homeobox 2 0.133
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.132
Wnt4 wingless-related MMTV integration site 4 0.129
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
kdrl kinase insert domain receptor like 0.995
bmp4 bone morphogenetic protein 4 0.980
chd chordin 0.970
itgav integrin, alpha V 0.947
tbx16 T-box gene 16 0.923
osr2 odd-skipped related 2 (Drosophila) 0.898
plcg1 phospholipase C, gamma 1 0.890
tbx2a T-box gene 2a 0.873
tbx20 T-box 20 0.862
tbx5a T-box 5a 0.840
bmp2b bone morphogenetic protein 2b 0.794
hoxc6a homeo box C6a 0.774
mib mind bomb 0.717
itgb1b.1 integrin, beta 1b.1 0.677
bmp2a bone morphogenetic protein 2a 0.629
hoxa13b homeo box A13b 0.516
tbx1 T-box 1 0.509
tbx18 T-box 18 0.494
itgb1b.2 integrin, beta 1b.2 0.494
hoxd11a homeo box D11a 0.483
ets1a v-ets erythroblastosis virus E26 oncogene homolog 1a 0.435
krit1 KRIT1, ankyrin repeat containing 0.395
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.390
and1 actinodin1 0.389
ccm2 cerebral cavernous malformation 2 0.387
fgf8a fibroblast growth factor 8 a 0.383
ptger2a prostaglandin E receptor 2a (subtype EP2) 0.381
lhx1a LIM homeobox 1a 0.374
hoxa9b homeo box A9b 0.366
nkx2.5 NK2 transcription factor related 5 0.333
igfbp6b insulin-like growth factor binding protein 6b 0.319
hoxa11b homeo box A11b 0.313
prrx1b paired related homeobox 1b 0.307
pkd2 polycystic kidney disease 2 0.307
etv2 ets variant gene 2 0.307
myod1 myogenic differentiation 1 0.303
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.286
fbn2b fibrillin 2b 0.284
hand2 heart and neural crest derivatives expressed transcript 2 0.280
tgfb3 transforming growth factor, beta 3 0.280
igf1rb insulin-like growth factor 1b receptor 0.274
LOC100003330 melanocortin-2 receptor accessory protein 2-like 0.261
tmem2 transmembrane protein 2 0.260
tll1 tolloid-like 1 0.230
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.223
hoxa10b homeo box A10b 0.218
npy8ar neuropeptide Y receptor Y8a 0.211
igfbp6a insulin-like growth factor binding protein 6a 0.204
foxn4 forkhead box N4 0.202
osr1 odd-skipped related 1 (Drosophila) 0.198
has2 hyaluronan synthase 2 0.190
hoxd10a homeo box D10a 0.184
wt1b wilms tumor 1b 0.175
myl7 myosin, light polypeptide 7, regulatory 0.171
bmpr2b bone morphogenetic protein receptor, type II b (serine/threonine kinase) 0.170
myf5 myogenic factor 5 0.165
hoxd12a homeo box D12a 0.163
twist3 twist3 0.162
notch1b notch homolog 1b 0.160
fgf3 fibroblast growth factor 3 0.154
hoxd9a homeo box D9a 0.154
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.152
hnf1bb HNF1 homeobox Bb 0.150
satb2 SATB homeobox 2 0.145
dzip1 DAZ interacting protein 1 0.140
dll4 delta-like 4 (Drosophila) 0.134
insrb insulin receptor b 0.130
znfl2a zinc finger-like gene 2a 0.130
ccbe1 collagen and calcium binding EGF domains 1 0.127
twist1a twist1a 0.121
cdh5 cadherin 5 0.120
prrx1a paired related homeobox 1a 0.119
tcf21 transcription factor 21 0.119
jag2 jagged 2 0.118
aplnrb apelin receptor b 0.111
tbx2b T-box 2b 0.104
evx1 even-skipped homeobox 1 0.104
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.102
gata1a GATA binding protein 1a 0.102
six2a sine oculis-related homeobox 2a 0.100
her1 hairy-related 1 0.098
foxc1a forkhead box C1a 0.095
ren renin 0.095
hnf1ba HNF1 homeobox Ba 0.094
hoxd13a homeo box D13a 0.094
pax2a paired box gene 2a 0.091
dlc deltaC 0.089
rarga retinoic acid receptor gamma a 0.086
wt1a wilms tumor 1a 0.086
trim33 tripartite motif-containing 33 0.085
scn2b sodium channel, voltage-gated, type II, beta 0.084
tie1 endothelium-specific receptor tyrosine kinase 1 0.084
LOC100537340 cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like 0.080
wnt5b wingless-type MMTV integration site family, member 5b 0.078
pcdh8 protocadherin 8 0.077
alx4a aristaless-like homeobox 4a 0.075
calcrla calcitonin receptor-like a 0.075
vdra vitamin D receptor a 0.074
cldn5b claudin 5b 0.074
sema3h semaphorin 3h 0.074
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Drosophila melanogaster
Name Description Probability Func Analog Organism
Dl Delta 0.964
mys myospheroid 0.864
Egfr Epidermal growth factor receptor 0.769
N Notch 0.749
tkv thickveins 0.418
EcR Ecdysone receptor 0.411
wg wingless 0.341
hh hedgehog 0.281
H Hairless 0.227
Ser Serrate 0.168
if inflated 0.165
neur neuralized 0.119
crb crumbs 0.108
dm diminutive 0.107
l(2)gl lethal (2) giant larvae 0.097
rho rhomboid 0.082
fng fringe 0.067
Mef2 Myocyte enhancer factor 2 0.065
Pvr PDGF- and VEGF-receptor related 0.063
wun wunen 0.054
Fas2 Fasciclin 2 0.044
Nrg Neuroglian 0.042
hth homothorax 0.042
stumps CG31317 gene product from transcript CG31317-RC 0.040
sog short gastrulation 0.034
Dad Daughters against dpp 0.031
tou toutatis 0.030
shn schnurri 0.024
mew multiple edematous wings 0.021
p130CAS CG1212 gene product from transcript CG1212-RA 0.020
zip zipper 0.020
InR Insulin-like receptor 0.019
mam mastermind 0.017
eya eyes absent 0.017
kst karst 0.016
Ddc Dopa decarboxylase 0.016
tsh teashirt 0.015
spdo sanpodo 0.015
sd scalloped 0.013
cora coracle 0.013
scb scab 0.013
sr stripe 0.013
Syx1A Syntaxin 1A 0.012
LamC Lamin C 0.011
Nrx-IV Neurexin IV 0.011
RhoL rho-like 0.011
tok tolkin 0.011
dsh dishevelled 0.010
CG30069 CG30069 gene product from transcript CG30069-RA 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.979
EGR1 early growth response 1 0.969
BMPR1A bone morphogenetic protein receptor, type IA 0.938
FLNA filamin A, alpha 0.912
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.888
EGR3 early growth response 3 0.875
JAG1 jagged 1 0.828
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 0.822
MYO10 myosin X 0.802
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.750
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.749
FOS FBJ murine osteosarcoma viral oncogene homolog 0.713
CYTH1 cytohesin 1 0.674
ITGA6 integrin, alpha 6 0.638
FLNB filamin B, beta 0.569
EGR2 early growth response 2 0.567
GATA4 GATA binding protein 4 0.549
SMAD3 SMAD family member 3 0.519
EPS8 epidermal growth factor receptor pathway substrate 8 0.501
ACP5 acid phosphatase 5, tartrate resistant 0.490
PLEC plectin 0.456
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.434
FN1 fibronectin 1 0.391
FSTL1 follistatin-like 1 0.371
RANBP9 RAN binding protein 9 0.324
ICAM1 intercellular adhesion molecule 1 0.321
MAML1 mastermind-like 1 (Drosophila) 0.301
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.278
NOTCH3 notch 3 0.272
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.245
ITGB7 integrin, beta 7 0.214
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.198
SNAI1 snail homolog 1 (Drosophila) 0.196
SMAD7 SMAD family member 7 0.191
SMAD1 SMAD family member 1 0.180
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.171
CLEC4M C-type lectin domain family 4, member M 0.163
PDIA3 protein disulfide isomerase family A, member 3 0.152
SELPLG selectin P ligand 0.143
DLL1 delta-like 1 (Drosophila) 0.117
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 0.109
VCAM1 vascular cell adhesion molecule 1 0.106
FZD1 frizzled homolog 1 (Drosophila) 0.102
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.101
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.092
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.087
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 0.085
COL17A1 collagen, type XVII, alpha 1 0.084
MMP1 matrix metallopeptidase 1 (interstitial collagenase) 0.080
SPEN spen homolog, transcriptional regulator (Drosophila) 0.079
WNT3A wingless-type MMTV integration site family, member 3A 0.078
ATXN1L ataxin 1-like 0.074
NOG noggin 0.073
VAV1 vav 1 guanine nucleotide exchange factor 0.071
TMC8 transmembrane channel-like 8 0.071
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.070
CD63 CD63 molecule 0.070
DUSP6 dual specificity phosphatase 6 0.067
NOTCH2 notch 2 0.066
PXN paxillin 0.065
ANGPTL4 angiopoietin-like 4 0.061
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.059
ZNF205 zinc finger protein 205 0.059
IER2 immediate early response 2 0.056
DUSP2 dual specificity phosphatase 2 0.053
CD52 CD52 molecule 0.051
GSK3B glycogen synthase kinase 3 beta 0.051
MET met proto-oncogene (hepatocyte growth factor receptor) 0.049
HTT huntingtin 0.049
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.049
FHL2 four and a half LIM domains 2 0.048
GPATCH8 G patch domain containing 8 0.045
ITGB1BP1 integrin beta 1 binding protein 1 0.045
F3 coagulation factor III (thromboplastin, tissue factor) 0.045
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.044
NKG7 natural killer cell group 7 sequence 0.043
NCOR1 nuclear receptor corepressor 1 0.040
HBEGF heparin-binding EGF-like growth factor 0.040
CD9 CD9 molecule 0.040
TJP1 tight junction protein 1 (zona occludens 1) 0.040
MSL2 male-specific lethal 2 homolog (Drosophila) 0.040
PHOX2A paired-like homeobox 2a 0.039
NCOA6 nuclear receptor coactivator 6 0.038
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.038
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.038
PRKCB protein kinase C, beta 0.037
SPG20 spastic paraplegia 20 (Troyer syndrome) 0.037
CYR61 cysteine-rich, angiogenic inducer, 61 0.036
LDLR low density lipoprotein receptor 0.036
SMAD6 SMAD family member 6 0.036
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.036
CD7 CD7 molecule 0.035
JAG2 jagged 2 0.035
PALM2-AKAP2 PALM2-AKAP2 readthrough 0.035
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 0.035
TRIB1 tribbles homolog 1 (Drosophila) 0.034
FMNL1 formin-like 1 0.034
BMPR1B bone morphogenetic protein receptor, type IB 0.033
ITGB4 integrin, beta 4 0.033
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism