IMP
Process View
The network for 'locus ceruleus development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
locus ceruleus development
The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Shh | sonic hedgehog | 1.000 | |
| Tbx1 | T-box 1 | 1.000 | |
| Eya1 | eyes absent 1 homolog (Drosophila) | 1.000 | |
| Pax3 | paired box gene 3 | 1.000 | |
| Foxc1 | forkhead box C1 | 1.000 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 1.000 | |
| Msx1 | homeobox, msh-like 1 | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 1.000 | |
| Hand2 | heart and neural crest derivatives expressed transcript 2 | 1.000 | |
| Chrd | chordin | 0.999 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.999 | |
| Sox9 | SRY-box containing gene 9 | 0.999 | |
| Dlx5 | distal-less homeobox 5 | 0.999 | |
| Bmp4 | bone morphogenetic protein 4 | 0.999 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.999 | |
| Foxc2 | forkhead box C2 | 0.999 | |
| Isl1 | ISL1 transcription factor, LIM/homeodomain | 0.998 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.996 | |
| Tgfb2 | transforming growth factor, beta 2 | 0.996 | |
| Rarg | retinoic acid receptor, gamma | 0.996 | |
| Pax2 | paired box gene 2 | 0.995 | |
| Hoxa1 | homeobox A1 | 0.994 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.994 | |
| Ednra | endothelin receptor type A | 0.993 | |
| Smo | smoothened homolog (Drosophila) | 0.993 | |
| Bmp7 | bone morphogenetic protein 7 | 0.991 | |
| Foxg1 | forkhead box G1 | 0.988 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.986 | |
| Pdgfra | platelet derived growth factor receptor, alpha polypeptide | 0.978 | |
| Hand1 | heart and neural crest derivatives expressed transcript 1 | 0.978 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.971 | |
| Gsc | goosecoid homeobox | 0.960 | |
| Fgf10 | fibroblast growth factor 10 | 0.957 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.924 | |
| Msx2 | homeobox, msh-like 2 | 0.903 | |
| Zeb1 | zinc finger E-box binding homeobox 1 | 0.899 | |
| Rarb | retinoic acid receptor, beta | 0.847 | |
| Rspo2 | R-spondin 2 homolog (Xenopus laevis) | 0.842 | |
| Fgf8 | fibroblast growth factor 8 | 0.808 | |
| Six4 | sine oculis-related homeobox 4 homolog (Drosophila) | 0.785 | |
| Jag1 | jagged 1 | 0.751 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.749 | |
| Ntf3 | neurotrophin 3 | 0.748 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.730 | |
| Chd7 | chromodomain helicase DNA binding protein 7 | 0.715 | |
| Nkx2-5 | NK2 transcription factor related, locus 5 (Drosophila) | 0.704 | |
| Acvr1 | activin A receptor, type 1 | 0.685 | |
| Hoxa3 | homeobox A3 | 0.659 | |
| Ret | ret proto-oncogene | 0.605 | |
| Hoxa2 | homeobox A2 | 0.600 | |
| Runx2 | runt related transcription factor 2 | 0.597 | |
| Alx4 | aristaless-like homeobox 4 | 0.556 | |
| Pax9 | paired box gene 9 | 0.553 | |
| Pax6 | paired box gene 6 | 0.530 | |
| Bmp2 | bone morphogenetic protein 2 | 0.502 | |
| Nog | noggin | 0.481 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.462 | |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.417 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.384 | |
| Vegfa | vascular endothelial growth factor A | 0.369 | |
| Pbx1 | pre B-cell leukemia transcription factor 1 | 0.362 | |
| Tgfbr2 | transforming growth factor, beta receptor II | 0.354 | |
| Tbx15 | T-box 15 | 0.352 | |
| Dlx6 | distal-less homeobox 6 | 0.289 | |
| Sox11 | SRY-box containing gene 11 | 0.272 | |
| Mesp1 | mesoderm posterior 1 | 0.264 | |
| Dlx2 | distal-less homeobox 2 | 0.257 | |
| Ptpn11 | protein tyrosine phosphatase, non-receptor type 11 | 0.252 | |
| Sox2 | SRY-box containing gene 2 | 0.250 | |
| Rara | retinoic acid receptor, alpha | 0.231 | |
| Erbb3 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 0.214 | |
| Hmx3 | H6 homeobox 3 | 0.207 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.200 | |
| Alx1 | ALX homeobox 1 | 0.191 | |
| Gfra1 | glial cell line derived neurotrophic factor family receptor alpha 1 | 0.183 | |
| Efnb2 | ephrin B2 | 0.183 | |
| Ece1 | endothelin converting enzyme 1 | 0.173 | |
| En1 | engrailed 1 | 0.171 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.169 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.161 | |
| Nrg1 | neuregulin 1 | 0.153 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.150 | |
| Meox2 | mesenchyme homeobox 2 | 0.132 | |
| Col2a1 | collagen, type II, alpha 1 | 0.116 | |
| Hoxd3 | homeobox D3 | 0.111 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.105 | |
| Alx3 | aristaless-like homeobox 3 | 0.103 | |
| Gata4 | GATA binding protein 4 | 0.103 | |
| Mn1 | meningioma 1 | 0.103 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.094 | |
| Ascl1 | achaete-scute complex homolog 1 (Drosophila) | 0.094 | |
| Lhx1 | LIM homeobox protein 1 | 0.093 | |
| Nkx3-2 | NK3 homeobox 2 | 0.087 | |
| Bdnf | brain derived neurotrophic factor | 0.087 | |
| Fgf3 | fibroblast growth factor 3 | 0.086 | |
| Wt1 | Wilms tumor 1 homolog | 0.084 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.084 | |
| Hoxb1 | homeobox B1 | 0.074 | |
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.072 | |
| Mycn | v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) | 0.072 |
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Danio rerio
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| phox2a | paired-like homeobox 2a | 0.926 | |
| fgf10a | fibroblast growth factor 10a | 0.853 | |
| bmp2b | bone morphogenetic protein 2b | 0.817 | |
| twist3 | twist3 | 0.566 | |
| nadl1.1 | neural adhesion molecule L1.1 | 0.481 | |
| il17rd | interleukin 17 receptor D | 0.442 | |
| phox2b | paired-like homeobox 2b | 0.424 | |
| hoxd4a | homeo box D4a | 0.384 | |
| pax2a | paired box gene 2a | 0.293 | |
| tbx1 | T-box 1 | 0.276 | |
| ascl1a | achaete-scute complex-like 1a (Drosophila) | 0.276 | |
| fgfr1a | fibroblast growth factor receptor 1a | 0.253 | |
| fras1 | Fraser syndrome 1 | 0.222 | |
| twist1b | twist1b | 0.206 | |
| gpr126 | G protein-coupled receptor 126 | 0.169 | |
| pea3 | ETS-domain transcription factor pea3 | 0.168 | |
| stm | starmaker | 0.154 | |
| hmx3 | homeo box (H6 family) 3 | 0.151 | |
| atoh1a | atonal homolog 1a | 0.148 | |
| neurog1 | neurogenin 1 | 0.141 | |
| pax9 | paired box gene 9 | 0.136 | |
| prrx1b | paired related homeobox 1b | 0.120 | |
| dlx5a | distal-less homeobox gene 5a | 0.118 | |
| bmp4 | bone morphogenetic protein 4 | 0.116 | |
| foxi1 | forkhead box I1 | 0.110 | |
| bmp2a | bone morphogenetic protein 2a | 0.110 | |
| prdm1a | PR domain containing 1a, with ZNF domain | 0.104 | |
| shha | sonic hedgehog a | 0.101 | |
| entpd3 | ectonucleoside triphosphate diphosphohydrolase 3 | 0.090 | |
| eya1 | eyes absent homolog 1 | 0.090 | |
| lhx6 | LIM homeobox 6 | 0.090 | |
| dlx6a | distal-less homeobox gene 6a | 0.086 | |
| insm1a | insulinoma-associated 1a | 0.086 | |
| cdh6 | cadherin 6 | 0.081 | |
| map2k4a | mitogen-activated protein kinase kinase 4a | 0.080 | |
| fgf18a | fibroblast growth factor 18a | 0.075 | |
| fgf17 | fibroblast growth factor 17 | 0.074 | |
| aldh1a3 | aldehyde dehydrogenase 1 family, member A3 | 0.074 | |
| p2rx2 | purinergic receptor P2X, ligand-gated ion channel, 2 | 0.073 | |
| stmn2b | stathmin-like 2b | 0.071 | |
| wnt1 | wingless-type MMTV integration site family, member 1 | 0.071 | |
| spry1 | sprouty homolog 1 (Drosophila) | 0.068 | |
| loxl2b | lysyl oxidase-like 2b | 0.067 | |
| elavl3 | ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C) | 0.066 | |
| igfbp3 | insulin-like growth factor binding protein 3 | 0.065 | |
| gnao1a | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a | 0.060 | |
| cyp26c1 | cytochrome P450, family 26, subfamily C, polypeptide 1 | 0.057 | |
| barx1 | BarH-like homeobox 1 | 0.055 | |
| gfra2 | glial cell line derived neurotrophic factor family receptor alpha 2 | 0.053 | |
| eng2b | engrailed 2b | 0.053 | |
| dharma | dharma | 0.051 | |
| lmx1b.1 | LIM homeobox transcription factor 1, beta 1 | 0.051 | |
| klf4 | Kruppel-like factor 4 | 0.050 | |
| cxcr4b | chemokine (C-X-C motif), receptor 4b | 0.050 | |
| hoxa13b | homeo box A13b | 0.049 | |
| cntn2 | contactin 2 | 0.047 | |
| hand2 | heart and neural crest derivatives expressed transcript 2 | 0.047 | |
| fgf3 | fibroblast growth factor 3 | 0.046 | |
| fgf4 | fibroblast growth factor 4 | 0.046 | |
| dlx4b | distal-less homeobox gene 4b | 0.046 | |
| irx2a | iroquois homeobox protein 2, a | 0.043 | |
| crestin | crestin | 0.043 | |
| hoxd11a | homeo box D11a | 0.042 | |
| wnt2 | wingless-type MMTV integration site family member 2 | 0.042 | |
| nadl1.2 | neural adhesion molecule L1.2 | 0.042 | |
| hmx2 | H6 family homeobox 2 | 0.042 | |
| plxnb2b | plexin b2b | 0.041 | |
| gfra1b | gdnf family receptor alpha 1b | 0.039 | |
| wnt4a | wingless-type MMTV integration site family, member 4a | 0.038 | |
| tgfb2 | transforming growth factor, beta 2 | 0.038 | |
| otx1b | orthodenticle homolog 1b | 0.038 | |
| tcf7 | transcription factor 7 (T-cell specific, HMG-box) | 0.036 | |
| gpd2 | glycerol-3-phosphate dehydrogenase 2 (mitochondrial) | 0.035 | |
| dlx2b | distal-less homeobox gene 2b | 0.035 | |
| olfm1a | olfactomedin 1a | 0.033 | |
| six2a | sine oculis-related homeobox 2a | 0.033 | |
| wnt8b | wingless-type MMTV integration site family, member 8b | 0.031 | |
| vcanb | versican b | 0.029 | |
| fgf13b | fibroblast growth factor 13b | 0.028 | |
| eng1a | engrailed 1a | 0.028 | |
| sst1.1 | somatostatin 1, tandem duplicate 1 | 0.028 | |
| nipblb | novel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila) | 0.027 | |
| trpa1b | transient receptor potential cation channel, subfamily A, member 1b | 0.027 | |
| tcf21 | transcription factor 21 | 0.026 | |
| og9x | OG9 homeobox gene | 0.026 | |
| col14a1 | collagen, type XIV, alpha 1 | 0.026 | |
| hint2 | histidine triad nucleotide binding protein 2 | 0.025 | |
| nes | nestin | 0.025 | |
| dla | deltaA | 0.024 | |
| pink1 | PTEN induced putative kinase 1 | 0.024 | |
| spry4 | sprouty (Drosophila) homolog 4 | 0.024 | |
| palm | paralemmin | 0.024 | |
| lbx1a | ladybird homeobox 1a | 0.023 | |
| smox | spermine oxidase | 0.023 | |
| eomesa | eomesodermin homolog a | 0.023 | |
| irx5b | iroquois homeobox protein 5b | 0.022 | |
| gle1 | GLE1 RNA export mediator homolog (yeast) | 0.022 | |
| grhl2b | grainyhead-like 2b (Drosophila) | 0.022 | |
| crabp2a | cellular retinoic acid binding protein 2, a | 0.022 | |
| lmx1b.2 | LIM homeobox transcription factor 1, beta 2 | 0.022 |