The network for 'negative regulation of keratinocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of keratinocyte differentiation

Any process that stops, prevents, or reduces the frequency, rate or extent of keratinocyte differentiation.

Mus musculus
Name Description Probability Func Analog Organism
Msx2 homeobox, msh-like 2 0.960
Pax3 paired box gene 3 0.951
Trp63 transformation related protein 63 0.950
Shh sonic hedgehog 0.916
Fgfr2 fibroblast growth factor receptor 2 0.870
Pten phosphatase and tensin homolog 0.807
Sox9 SRY-box containing gene 9 0.714
Prrx1 paired related homeobox 1 0.427
Dlx5 distal-less homeobox 5 0.411
Trp53 transformation related protein 53 0.368
Ctnnb1 catenin (cadherin associated protein), beta 1 0.362
Lef1 lymphoid enhancer binding factor 1 0.305
Runx2 runt related transcription factor 2 0.245
Esr1 estrogen receptor 1 (alpha) 0.226
Trp73 transformation related protein 73 0.224
Bmp7 bone morphogenetic protein 7 0.213
Hr hairless 0.205
Chrd chordin 0.195
Alx4 aristaless-like homeobox 4 0.189
Hand1 heart and neural crest derivatives expressed transcript 1 0.168
Gli3 GLI-Kruppel family member GLI3 0.167
Pax9 paired box gene 9 0.167
Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) 0.163
Egfr epidermal growth factor receptor 0.163
Eya1 eyes absent 1 homolog (Drosophila) 0.154
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.152
Reg1 regenerating islet-derived 1 0.146
2210010C04Rik RIKEN cDNA 2210010C04 gene 0.145
Foxc1 forkhead box C1 0.143
Nog noggin 0.141
Otx2 orthodenticle homolog 2 (Drosophila) 0.139
Cdx2 caudal type homeobox 2 0.117
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.115
Reg2 regenerating islet-derived 2 0.106
Sfn stratifin 0.098
Pitx1 paired-like homeodomain transcription factor 1 0.093
Apc adenomatosis polyposis coli 0.091
Zg16 zymogen granule protein 16 0.090
Reg3b regenerating islet-derived 3 beta 0.089
Reg3g regenerating islet-derived 3 gamma 0.085
Rara retinoic acid receptor, alpha 0.083
Wnt3a wingless-related MMTV integration site 3A 0.074
Reg3d regenerating islet-derived 3 delta 0.072
Tbx3 T-box 3 0.070
Krt14 keratin 14 0.070
Dlx2 distal-less homeobox 2 0.069
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.068
Rxra retinoid X receptor alpha 0.068
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.067
Alx1 ALX homeobox 1 0.062
Prss2 protease, serine, 2 0.062
Hoxa13 homeobox A13 0.061
Plac1 placental specific protein 1 0.059
Srsf2 serine/arginine-rich splicing factor 2 0.059
Sp6 trans-acting transcription factor 6 0.057
Dmbt1 deleted in malignant brain tumors 1 0.057
Gli2 GLI-Kruppel family member GLI2 0.056
Bmp4 bone morphogenetic protein 4 0.056
Muc13 mucin 13, epithelial transmembrane 0.055
Tcfap2a transcription factor AP-2, alpha 0.052
Mmp7 matrix metallopeptidase 7 0.052
Prrx2 paired related homeobox 2 0.050
Pax6 paired box gene 6 0.048
Emx1 empty spiracles homolog 1 (Drosophila) 0.047
Meox2 mesenchyme homeobox 2 0.047
Hnrpdl heterogeneous nuclear ribonucleoprotein D-like 0.046
Gp2 glycoprotein 2 (zymogen granule membrane) 0.046
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.046
Smo smoothened homolog (Drosophila) 0.045
Ms4a10 membrane-spanning 4-domains, subfamily A, member 10 0.044
Ins1 insulin I 0.043
Fgf10 fibroblast growth factor 10 0.041
Prss32 protease, serine, 32 0.041
Cpa1 carboxypeptidase A1 0.041
Tff2 trefoil factor 2 (spasmolytic protein 1) 0.039
Yap1 yes-associated protein 1 0.039
Sycn syncollin 0.039
Itga3 integrin alpha 3 0.039
Tbx15 T-box 15 0.039
Reg3a regenerating islet-derived 3 alpha 0.038
Pklr pyruvate kinase liver and red blood cell 0.038
Elavl1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) 0.038
Gucy2c guanylate cyclase 2c 0.036
Krt4 keratin 4 0.034
Rb1 retinoblastoma 1 0.033
Tff3 trefoil factor 3, intestinal 0.033
Il10 interleukin 10 0.033
Ptf1a pancreas specific transcription factor, 1a 0.032
Hnrnph1 heterogeneous nuclear ribonucleoprotein H1 0.032
Gsc goosecoid homeobox 0.031
Fut2 fucosyltransferase 2 0.031
Gpr87 G protein-coupled receptor 87 0.031
Rnase1 ribonuclease, RNase A family, 1 (pancreatic) 0.030
Foxe3 forkhead box E3 0.030
Dsc3 desmocollin 3 0.029
Ptch1 patched homolog 1 0.029
Braf Braf transforming gene 0.029
Hoxa2 homeobox A2 0.028
Chuk conserved helix-loop-helix ubiquitous kinase 0.028
Lrp6 low density lipoprotein receptor-related protein 6 0.028
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
RNPS1 RNA binding protein S1, serine-rich domain 0.998
HOXB5 homeobox B5 0.992
HOXA10 homeobox A10 0.841
HOXA4 homeobox A4 0.774
HOXB7 homeobox B7 0.665
HOXB6 homeobox B6 0.621
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.611
HOXA11 homeobox A11 0.548
HOXB9 homeobox B9 0.535
HOXA5 homeobox A5 0.497
HOXB3 homeobox B3 0.455
KRT5 keratin 5 0.449
H3F3B H3 histone, family 3B (H3.3B) 0.443
SATB2 SATB homeobox 2 0.419
HOXA6 homeobox A6 0.397
SRPK2 SRSF protein kinase 2 0.331
HOXC10 homeobox C10 0.296
HOXA7 homeobox A7 0.295
HOXA2 homeobox A2 0.243
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 0.227
CABLES1 Cdk5 and Abl enzyme substrate 1 0.212
SRRM2 serine/arginine repetitive matrix 2 0.203
HOXC4 homeobox C4 0.150
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.142
SRRM1 serine/arginine repetitive matrix 1 0.121
HOXC6 homeobox C6 0.114
HOXA1 homeobox A1 0.112
MSX1 msh homeobox 1 0.092
KRT15 keratin 15 0.078
HOXB2 homeobox B2 0.074
KRT6C keratin 6C 0.064
HOXA3 homeobox A3 0.059
MGEA5 meningioma expressed antigen 5 (hyaluronidase) 0.050
TOE1 target of EGR1, member 1 (nuclear) 0.048
HOXC9 homeobox C9 0.041
HOXC5 homeobox C5 0.038
HOXC11 homeobox C11 0.035
SART1 squamous cell carcinoma antigen recognized by T cells 0.034
HOXA13 homeobox A13 0.030
HOXD10 homeobox D10 0.027
NXF1 nuclear RNA export factor 1 0.027
CCNL1 cyclin L1 0.027
MAT2A methionine adenosyltransferase II, alpha 0.026
S1PR5 sphingosine-1-phosphate receptor 5 0.024
HOXC13 homeobox C13 0.023
HOXC8 homeobox C8 0.021
HNRNPCL1 heterogeneous nuclear ribonucleoprotein C-like 1 0.021
SMAD6 SMAD family member 6 0.020
HOXB4 homeobox B4 0.020
PITX2 paired-like homeodomain 2 0.019
FOXL1 forkhead box L1 0.018
HOXD8 homeobox D8 0.018
TERF2IP telomeric repeat binding factor 2, interacting protein 0.016
DLX2 distal-less homeobox 2 0.016
DLX5 distal-less homeobox 5 0.016
GRHL2 grainyhead-like 2 (Drosophila) 0.015
ZNF676 zinc finger protein 676 0.015
NKTR natural killer-tumor recognition sequence 0.015
TWIST1 twist homolog 1 (Drosophila) 0.014
CHERP calcium homeostasis endoplasmic reticulum protein 0.013
HOXB13 homeobox B13 0.012
BNC1 basonuclin 1 0.012
HOXD9 homeobox D9 0.012
TFCP2L1 transcription factor CP2-like 1 0.012
HOXB8 homeobox B8 0.012
HOXD11 homeobox D11 0.011
CIRBP cold inducible RNA binding protein 0.011
FXYD3 FXYD domain containing ion transport regulator 3 0.011
KRT14 keratin 14 0.011
LAD1 ladinin 1 0.011
PRSS8 protease, serine, 8 0.011
FOXD1 forkhead box D1 0.010
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.010
PRR15L proline rich 15-like 0.010
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.010
MAP1A microtubule-associated protein 1A 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism