The network for 'endodermal cell fate specification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endodermal cell fate specification

The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Vangl2 vang-like 2 (van gogh, Drosophila) 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Fgf8 fibroblast growth factor 8 1.000
Foxc1 forkhead box C1 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 1.000
Gli3 GLI-Kruppel family member GLI3 1.000
Pax3 paired box gene 3 1.000
Hand1 heart and neural crest derivatives expressed transcript 1 1.000
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Bmp4 bone morphogenetic protein 4 1.000
Hand2 heart and neural crest derivatives expressed transcript 2 1.000
Sox2 SRY-box containing gene 2 1.000
Foxc2 forkhead box C2 1.000
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 1.000
Tcfap2a transcription factor AP-2, alpha 0.999
Eya1 eyes absent 1 homolog (Drosophila) 0.999
Jag1 jagged 1 0.999
Tbx1 T-box 1 0.999
Ctnnb1 catenin (cadherin associated protein), beta 1 0.999
Chd7 chromodomain helicase DNA binding protein 7 0.999
Dlx5 distal-less homeobox 5 0.999
Pax2 paired box gene 2 0.999
Tbx3 T-box 3 0.998
Pitx1 paired-like homeodomain transcription factor 1 0.998
Sox9 SRY-box containing gene 9 0.997
Dvl2 dishevelled 2, dsh homolog (Drosophila) 0.997
Gbx2 gastrulation brain homeobox 2 0.997
Prrx1 paired related homeobox 1 0.997
Foxg1 forkhead box G1 0.996
Sall4 sal-like 4 (Drosophila) 0.994
Lrp6 low density lipoprotein receptor-related protein 6 0.992
Hoxa1 homeobox A1 0.992
Sox11 SRY-box containing gene 11 0.989
Gata4 GATA binding protein 4 0.989
Zeb1 zinc finger E-box binding homeobox 1 0.988
Msx1 homeobox, msh-like 1 0.987
Hes1 hairy and enhancer of split 1 (Drosophila) 0.986
Wnt3a wingless-related MMTV integration site 3A 0.985
Isl1 ISL1 transcription factor, LIM/homeodomain 0.983
Nodal nodal 0.978
Alx4 aristaless-like homeobox 4 0.977
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.977
Smo smoothened homolog (Drosophila) 0.976
Efnb2 ephrin B2 0.976
Apc adenomatosis polyposis coli 0.972
Fgf10 fibroblast growth factor 10 0.969
Fgfr1 fibroblast growth factor receptor 1 0.967
Fgfr3 fibroblast growth factor receptor 3 0.960
Runx2 runt related transcription factor 2 0.960
Msx2 homeobox, msh-like 2 0.959
Pou5f1 POU domain, class 5, transcription factor 1 0.953
Meox2 mesenchyme homeobox 2 0.950
Ednra endothelin receptor type A 0.944
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.941
Map3k7 mitogen-activated protein kinase kinase kinase 7 0.941
Chrd chordin 0.941
Tgfb2 transforming growth factor, beta 2 0.941
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.907
Ptch1 patched homolog 1 0.905
Pax6 paired box gene 6 0.894
Gata3 GATA binding protein 3 0.868
Ret ret proto-oncogene 0.861
Acvr1 activin A receptor, type 1 0.859
Smad6 MAD homolog 6 (Drosophila) 0.849
Vangl1 vang-like 1 (van gogh, Drosophila) 0.841
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.838
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.836
Hoxa13 homeobox A13 0.821
Zic3 zinc finger protein of the cerebellum 3 0.806
Smad1 MAD homolog 1 (Drosophila) 0.796
Nf1 neurofibromatosis 1 0.791
Dvl3 dishevelled 3, dsh homolog (Drosophila) 0.789
Pax1 paired box gene 1 0.781
Dll4 delta-like 4 (Drosophila) 0.774
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.765
Emx1 empty spiracles homolog 1 (Drosophila) 0.765
Nog noggin 0.765
Rarg retinoic acid receptor, gamma 0.763
Bmp7 bone morphogenetic protein 7 0.762
Fgf3 fibroblast growth factor 3 0.760
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.759
Hoxd13 homeobox D13 0.758
En1 engrailed 1 0.757
Gsc goosecoid homeobox 0.750
Bmpr1a bone morphogenetic protein receptor, type 1A 0.743
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.741
Otx1 orthodenticle homolog 1 (Drosophila) 0.720
Lmx1a LIM homeobox transcription factor 1 alpha 0.720
Lef1 lymphoid enhancer binding factor 1 0.720
Cd247 CD247 antigen 0.720
Wnt1 wingless-related MMTV integration site 1 0.698
T brachyury 0.678
Hesx1 homeobox gene expressed in ES cells 0.675
Tcra T-cell receptor alpha chain 0.663
Foxn1 forkhead box N1 0.663
Psen1 presenilin 1 0.663
Prrx2 paired related homeobox 2 0.659
Ptk2 PTK2 protein tyrosine kinase 2 0.654
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
chd chordin 1.000
flh floating head 0.984
bmp4 bone morphogenetic protein 4 0.898
tbx1 T-box 1 0.865
fn1 fibronectin 1 0.852
bmp2b bone morphogenetic protein 2b 0.838
pax2a paired box gene 2a 0.835
tbx16 T-box gene 16 0.821
fgf3 fibroblast growth factor 3 0.800
foxi1 forkhead box I1 0.792
her7 hairy and enhancer of split related-7 0.770
hnf1ba HNF1 homeobox Ba 0.745
vent ventral expressed homeobox 0.744
shha sonic hedgehog a 0.743
jag2 jagged 2 0.724
wnt5b wingless-type MMTV integration site family, member 5b 0.704
pcdh8 protocadherin 8 0.698
dusp6 dual specificity phosphatase 6 0.680
ndr2 nodal-related 2 0.677
fgf17 fibroblast growth factor 17 0.652
fgf8a fibroblast growth factor 8 a 0.625
dlc deltaC 0.622
ndr1 nodal-related 1 0.563
ved ventrally expressed dharma/bozozok antagonist 0.527
hand2 heart and neural crest derivatives expressed transcript 2 0.505
cdh2 cadherin 2, neuronal 0.491
emx3 empty spiracles homeobox 3 0.473
lft1 lefty1 0.424
dkk1b dickkopf 1b 0.408
notch1a notch homolog 1a 0.406
lhx1a LIM homeobox 1a 0.373
gbx2 gastrulation brain homeo box 2 0.371
oep one-eyed pinhead 0.369
ntla no tail a 0.353
eya1 eyes absent homolog 1 0.351
myod1 myogenic differentiation 1 0.350
dharma dharma 0.337
snai1a snail homolog 1a (Drosophila) 0.334
cdx4 caudal type homeo box transcription factor 4 0.299
spry4 sprouty (Drosophila) homolog 4 0.298
osr2 odd-skipped related 2 (Drosophila) 0.292
foxd5 forkhead box D5 0.273
foxd3 forkhead box D3 0.271
btg2 B-cell translocation gene 2 0.263
pdgfaa platelet-derived growth factor alpha a 0.260
foxh1 forkhead box H1 0.260
foxg1a forkhead box G1a 0.256
fgfr4 fibroblast growth factor receptor 4 0.248
efnb2a ephrin B2a 0.245
six3a sine oculis homeobox homolog 3a 0.240
gata3 GATA-binding protein 3 0.226
cdh1 cadherin 1, epithelial 0.224
mespa mesoderm posterior a 0.223
dld deltaD 0.214
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.210
wif1 wnt inhibitory factor 1 0.208
fzd5 frizzled homolog 5 0.194
six4b sine oculis homeobox homolog 4b 0.193
sox9a SRY-box containing gene 9a 0.176
jag1b jagged 1b 0.169
evx1 even-skipped homeobox 1 0.164
her1 hairy-related 1 0.161
notch1b notch homolog 1b 0.159
tp63 tumor protein p63 0.156
admp anti-dorsalizing morphogenic protein 0.144
notch2 notch homolog 2 0.143
has2 hyaluronan synthase 2 0.139
sox32 SRY-box containing gene 32 0.132
foxa1 forkhead box A1 0.132
hoxa2b homeo box A2b 0.132
tbx2b T-box 2b 0.131
fgfr1a fibroblast growth factor receptor 1a 0.129
fgf10a fibroblast growth factor 10a 0.128
tbx20 T-box 20 0.126
fzd8b frizzled homolog 8b 0.123
rarab retinoic acid receptor, alpha b 0.122
mmp2 matrix metalloproteinase 2 0.122
fzd10 frizzled homolog 10 0.122
her5 hairy-related 5 0.121
gli1 GLI-Kruppel family member 1 0.120
pitx2 paired-like homeodomain transcription factor 2 0.117
nanos3 nanos homolog 3 0.117
gsc goosecoid 0.116
gli2a GLI-Kruppel family member GLI2a 0.116
ephb4b eph receptor B4b 0.116
ascl1a achaete-scute complex-like 1a (Drosophila) 0.115
irx1b iroquois homeobox protein 1, b 0.115
runx2b runt-related transcription factor 2b 0.114
fli1a friend leukemia integration 1a 0.112
zp2.2 zona pellucida glycoprotein 2.2 0.110
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.109
bon bonnie and clyde 0.108
eomesa eomesodermin homolog a 0.107
pou3f3b POU class 3 homeobox 3b 0.107
sox19b SRY-box containing gene 19b 0.106
otx1a orthodenticle homolog 1a 0.105
hmx4 H6 family homeobox 4 0.104
wnt11 wingless-type MMTV integration site family, member 11 0.103
sox1a SRY-box containing gene 1a 0.103
chrna2a cholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal) 0.102
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
SP1 Sp1 transcription factor 1.000
SMAD7 SMAD family member 7 0.999
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.999
BMP2 bone morphogenetic protein 2 0.999
PAX3 paired box 3 0.998
POU3F2 POU class 3 homeobox 2 0.996
FYN FYN oncogene related to SRC, FGR, YES 0.994
BMPR1A bone morphogenetic protein receptor, type IA 0.994
FOXD3 forkhead box D3 0.985
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.982
SMAD2 SMAD family member 2 0.972
DVL1 dishevelled, dsh homolog 1 (Drosophila) 0.972
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.971
SMAD4 SMAD family member 4 0.963
SOX10 SRY (sex determining region Y)-box 10 0.962
SOX2 SRY (sex determining region Y)-box 2 0.924
SMAD1 SMAD family member 1 0.917
CSNK1E casein kinase 1, epsilon 0.874
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.863
LCK lymphocyte-specific protein tyrosine kinase 0.862
SMAD3 SMAD family member 3 0.846
MALT1 mucosa associated lymphoid tissue lymphoma translocation gene 1 0.811
TAB3 TGF-beta activated kinase 1/MAP3K7 binding protein 3 0.764
BMP7 bone morphogenetic protein 7 0.753
CTNNBIP1 catenin, beta interacting protein 1 0.740
JAG1 jagged 1 0.722
NEDD4 neural precursor cell expressed, developmentally down-regulated 4 0.692
WWP2 WW domain containing E3 ubiquitin protein ligase 2 0.688
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.646
AXIN1 axin 1 0.602
NOG noggin 0.586
MAPK8 mitogen-activated protein kinase 8 0.583
SMAD5 SMAD family member 5 0.558
SYK spleen tyrosine kinase 0.504
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.502
PLCG1 phospholipase C, gamma 1 0.496
RANBP2 RAN binding protein 2 0.492
FSTL1 follistatin-like 1 0.441
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.433
CTNND1 catenin (cadherin-associated protein), delta 1 0.409
GDF5 growth differentiation factor 5 0.407
SNIP1 Smad nuclear interacting protein 1 0.405
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 0.401
WT1 Wilms tumor 1 0.384
NOTCH3 notch 3 0.366
APC adenomatous polyposis coli 0.366
LRP6 low density lipoprotein receptor-related protein 6 0.360
FGF1 fibroblast growth factor 1 (acidic) 0.359
SOX21 SRY (sex determining region Y)-box 21 0.336
MEOX2 mesenchyme homeobox 2 0.263
ZNF512B zinc finger protein 512B 0.260
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.259
FGF2 fibroblast growth factor 2 (basic) 0.249
HCK hemopoietic cell kinase 0.219
SOX11 SRY (sex determining region Y)-box 11 0.210
FGFR2 fibroblast growth factor receptor 2 0.205
UBE2I ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 0.204
TRAF6 TNF receptor-associated factor 6 0.200
LRRK2 leucine-rich repeat kinase 2 0.179
CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 0.176
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.175
SLC9A3R2 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 0.167
SALL2 sal-like 2 (Drosophila) 0.158
CEP164 centrosomal protein 164kDa 0.153
MAML1 mastermind-like 1 (Drosophila) 0.152
NOVA2 neuro-oncological ventral antigen 2 0.151
BBS10 Bardet-Biedl syndrome 10 0.151
SMAD6 SMAD family member 6 0.149
HCFC1 host cell factor C1 (VP16-accessory protein) 0.146
ZFYVE9 zinc finger, FYVE domain containing 9 0.145
GAS7 growth arrest-specific 7 0.142
FOXG1 forkhead box G1 0.136
CLTC clathrin, heavy chain (Hc) 0.136
SOX9 SRY (sex determining region Y)-box 9 0.131
SPRR2A small proline-rich protein 2A 0.128
NOSTRIN nitric oxide synthase trafficker 0.125
DSP desmoplakin 0.118
GTPBP5 GTP binding protein 5 (putative) 0.115
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.114
KLF5 Kruppel-like factor 5 (intestinal) 0.106
MDFI MyoD family inhibitor 0.101
HNF1A HNF1 homeobox A 0.100
CADM4 cell adhesion molecule 4 0.100
POU3F3 POU class 3 homeobox 3 0.098
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.098
SMAD9 SMAD family member 9 0.097
FBXL15 F-box and leucine-rich repeat protein 15 0.096
OTP orthopedia homeobox 0.095
FRS2 fibroblast growth factor receptor substrate 2 0.090
MYB v-myb myeloblastosis viral oncogene homolog (avian) 0.090
BMP4 bone morphogenetic protein 4 0.089
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 0.087
NR0B1 nuclear receptor subfamily 0, group B, member 1 0.086
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.084
KLHL12 kelch-like 12 (Drosophila) 0.083
SKI v-ski sarcoma viral oncogene homolog (avian) 0.082
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.082
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.081
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.081
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 0.079
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism