The network for 'axial mesoderm formation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

axial mesoderm formation

The process that gives rise to the axial mesoderm. This process pertains to the initial formation of the structure from unspecified parts.

Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 0.995
Foxc1 forkhead box C1 0.982
Fgfr2 fibroblast growth factor receptor 2 0.978
Zic3 zinc finger protein of the cerebellum 3 0.978
Bmp4 bone morphogenetic protein 4 0.977
Msx1 homeobox, msh-like 1 0.974
Shh sonic hedgehog 0.971
Efnb2 ephrin B2 0.965
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.959
Smo smoothened homolog (Drosophila) 0.935
Ctnnb1 catenin (cadherin associated protein), beta 1 0.900
Hand1 heart and neural crest derivatives expressed transcript 1 0.899
Prrx1 paired related homeobox 1 0.893
Sox9 SRY-box containing gene 9 0.885
Dlx5 distal-less homeobox 5 0.844
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.828
Epha4 Eph receptor A4 0.827
Smad6 MAD homolog 6 (Drosophila) 0.823
Gli2 GLI-Kruppel family member GLI2 0.818
Rarg retinoic acid receptor, gamma 0.766
Foxc2 forkhead box C2 0.706
Dnahc11 dynein, axonemal, heavy chain 11 0.691
Nodal nodal 0.667
Efnb1 ephrin B1 0.653
Otx2 orthodenticle homolog 2 (Drosophila) 0.629
Lhx1 LIM homeobox protein 1 0.628
Pax2 paired box gene 2 0.608
Fgfr3 fibroblast growth factor receptor 3 0.595
Eya1 eyes absent 1 homolog (Drosophila) 0.579
Tgfb2 transforming growth factor, beta 2 0.559
Gdf5 growth differentiation factor 5 0.556
Fgf8 fibroblast growth factor 8 0.536
Hoxd13 homeobox D13 0.527
Rspo2 R-spondin 2 homolog (Xenopus laevis) 0.511
Hand2 heart and neural crest derivatives expressed transcript 2 0.499
Zeb1 zinc finger E-box binding homeobox 1 0.468
Gpc3 glypican 3 0.455
Pbx1 pre B-cell leukemia transcription factor 1 0.449
Fgfr1 fibroblast growth factor receptor 1 0.417
Gata4 GATA binding protein 4 0.408
Tbx1 T-box 1 0.406
Chrd chordin 0.400
Gata5 GATA binding protein 5 0.397
Msx2 homeobox, msh-like 2 0.394
Tbx15 T-box 15 0.389
Gdf6 growth differentiation factor 6 0.375
Gsc goosecoid homeobox 0.347
Phex phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets) 0.333
Apc adenomatosis polyposis coli 0.332
Smad3 MAD homolog 3 (Drosophila) 0.325
Pax3 paired box gene 3 0.319
Kif3a kinesin family member 3A 0.313
Lrp6 low density lipoprotein receptor-related protein 6 0.306
Vangl2 vang-like 2 (van gogh, Drosophila) 0.297
Tbx3 T-box 3 0.292
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.285
Smad7 MAD homolog 7 (Drosophila) 0.272
Pitx2 paired-like homeodomain transcription factor 2 0.252
Gsk3b glycogen synthase kinase 3 beta 0.246
Irs1 insulin receptor substrate 1 0.242
Alx4 aristaless-like homeobox 4 0.240
Ptk7 PTK7 protein tyrosine kinase 7 0.228
Foxh1 forkhead box H1 0.223
Rnf111 ring finger 111 0.210
Gata6 GATA binding protein 6 0.208
Bmp2 bone morphogenetic protein 2 0.198
Emid2 EMI domain containing 2 0.198
Ptch1 patched homolog 1 0.197
Gas1 growth arrest specific 1 0.193
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.190
Gdf1 growth differentiation factor 1 0.188
Mks1 Meckel syndrome, type 1 0.174
Mn1 meningioma 1 0.173
Efna4 ephrin A4 0.152
Col2a1 collagen, type II, alpha 1 0.151
Alx1 ALX homeobox 1 0.149
Lef1 lymphoid enhancer binding factor 1 0.146
Tead3 TEA domain family member 3 0.145
Cdon cell adhesion molecule-related/down-regulated by oncogenes 0.145
Pthlh parathyroid hormone-like peptide 0.144
Tcfap2a transcription factor AP-2, alpha 0.143
Lrp5 low density lipoprotein receptor-related protein 5 0.140
Prrx2 paired related homeobox 2 0.138
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.135
Pcsk6 proprotein convertase subtilisin/kexin type 6 0.133
Rarb retinoic acid receptor, beta 0.132
Ret ret proto-oncogene 0.130
Kcnk2 potassium channel, subfamily K, member 2 0.120
Bmp7 bone morphogenetic protein 7 0.111
Foxf2 forkhead box F2 0.111
Wnt3a wingless-related MMTV integration site 3A 0.108
Bmpr1b bone morphogenetic protein receptor, type 1B 0.104
Nog noggin 0.102
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.100
Ephb3 Eph receptor B3 0.100
Tbx6 T-box 6 0.100
Zfp503 zinc finger protein 503 0.097
Foxa2 forkhead box A2 0.093
Bmper BMP-binding endothelial regulator 0.087
Hapln1 hyaluronan and proteoglycan link protein 1 0.085
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ntla no tail a 0.998
chd chordin 0.998
oep one-eyed pinhead 0.998
ndr2 nodal-related 2 0.998
flh floating head 0.995
sox32 SRY-box containing gene 32 0.986
tbx16 T-box gene 16 0.975
ndr1 nodal-related 1 0.970
shha sonic hedgehog a 0.968
wnt11 wingless-type MMTV integration site family, member 11 0.960
pou5f1 POU domain, class 5, transcription factor 1 0.948
fgf8a fibroblast growth factor 8 a 0.865
mib mind bomb 0.858
bmp7a bone morphogenetic protein 7a 0.825
dharma dharma 0.786
cdx4 caudal type homeo box transcription factor 4 0.714
smo smoothened homolog (Drosophila) 0.700
foxh1 forkhead box H1 0.644
admp anti-dorsalizing morphogenic protein 0.628
vangl2 vang-like 2 (van gogh, Drosophila) 0.565
gli1 GLI-Kruppel family member 1 0.554
bon bonnie and clyde 0.547
dld deltaD 0.535
ptch1 patched 1 0.484
bmp2b bone morphogenetic protein 2b 0.437
pax2a paired box gene 2a 0.385
gpc4 glypican 4 0.365
dzip1 DAZ interacting protein 1 0.364
lhx1a LIM homeobox 1a 0.349
vent ventral expressed homeobox 0.325
lft1 lefty1 0.310
tbx1 T-box 1 0.305
eve1 even-skipped-like1 0.285
cdh2 cadherin 2, neuronal 0.269
mpp5a membrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a) 0.250
foxi1 forkhead box I1 0.223
wnt5b wingless-type MMTV integration site family, member 5b 0.198
lft2 lefty2 0.192
hnf1ba HNF1 homeobox Ba 0.189
eomesa eomesodermin homolog a 0.178
rx3 retinal homeobox gene 3 0.149
smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.147
tll1 tolloid-like 1 0.144
nanos3 nanos homolog 3 0.143
her7 hairy and enhancer of split related-7 0.138
ptch2 patched 2 0.135
tbx24 T-box 24 0.124
dkk1b dickkopf 1b 0.110
spns2 spinster homolog 2 (Drosophila) 0.110
rerea arginine-glutamic acid dipeptide (RE) repeats a 0.109
lrrc6 leucine rich repeat containing 6 0.108
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.105
foxd3 forkhead box D3 0.105
med12 mediator of RNA polymerase II transcription, subunit 12 homolog 0.102
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.099
scrib scribbled homolog (Drosophila) 0.098
szl sizzled 0.098
smad5 MAD homolog 5 (Drosophila) 0.096
nog1 noggin 1 0.089
tp53 tumor protein p53 0.087
og9x OG9 homeobox gene 0.086
foxa3 forkhead box A3 0.079
foxd5 forkhead box D5 0.077
vasa vasa homolog 0.071
bmpr1aa bone morphogenetic protein receptor, type 1aa 0.067
mxtx2 mix-type homeobox gene 2 0.063
nxph1 neurexophilin 1 0.061
pkd2 polycystic kidney disease 2 0.057
notch1a notch homolog 1a 0.056
sox17 SRY-box containing gene 17 0.052
zgc:193933 zgc:193933 0.052
atoh7 atonal homolog 7 0.051
fn1 fibronectin 1 0.050
col8a1a collagen, type VIII, alpha 1a 0.047
otx1a orthodenticle homolog 1a 0.045
snai1a snail homolog 1a (Drosophila) 0.044
vox ventral homeobox 0.044
acvr1b activin A receptor, type IB 0.044
cdc25 cell division cycle 25 homolog 0.043
sim1a single-minded homolog 1a (Drosophila) 0.042
tfap2a transcription factor AP-2 alpha 0.042
cftr cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) 0.038
scube2 signal peptide, CUB domain, EGF-like 2 0.037
cdh1 cadherin 1, epithelial 0.036
foxa2 forkhead box A2 0.036
acvr1l activin A receptor, type I like 0.033
sst1.1 somatostatin 1, tandem duplicate 1 0.033
bmp4 bone morphogenetic protein 4 0.033
lrrc50 leucine rich repeat containing 50 0.032
dla deltaA 0.032
fzd8b frizzled homolog 8b 0.030
fezf2 FEZ family zinc finger 2 0.030
msgn1 mesogenin 1 0.030
nkx6.1 NK6 transcription factor related, locus 1 (Drosophila) 0.029
fgf3 fibroblast growth factor 3 0.028
wnt4b wingless-type MMTV integration site family, member 4b 0.028
arnt2 aryl hydrocarbon receptor nuclear translocator 2 0.028
fzd5 frizzled homolog 5 0.027
hand2 heart and neural crest derivatives expressed transcript 2 0.026
apc adenomatosis polyposis coli 0.026
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism