IMP
Process View
The network for 'planar cell polarity pathway involved in heart morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.
Multiple Organisms
planar cell polarity pathway involved in heart morphogenesis
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity that contributes to the shaping of the heart.
| Name | Description | Probability | Func Analog Organism |
|---|---|---|---|
| Pax2 | paired box gene 2 | 1.000 | |
| Gli3 | GLI-Kruppel family member GLI3 | 0.999 | |
| Shh | sonic hedgehog | 0.999 | |
| Fgfr2 | fibroblast growth factor receptor 2 | 0.995 | |
| Fgf8 | fibroblast growth factor 8 | 0.995 | |
| Dvl2 | dishevelled 2, dsh homolog (Drosophila) | 0.994 | |
| Vangl2 | vang-like 2 (van gogh, Drosophila) | 0.986 | |
| T | brachyury | 0.979 | |
| Lrp6 | low density lipoprotein receptor-related protein 6 | 0.961 | |
| Dvl3 | dishevelled 3, dsh homolog (Drosophila) | 0.949 | |
| Fgfr1 | fibroblast growth factor receptor 1 | 0.939 | |
| Bmp7 | bone morphogenetic protein 7 | 0.932 | |
| Ptk7 | PTK7 protein tyrosine kinase 7 | 0.910 | |
| Tbx3 | T-box 3 | 0.903 | |
| Rarg | retinoic acid receptor, gamma | 0.900 | |
| Pitx2 | paired-like homeodomain transcription factor 2 | 0.898 | |
| Dkk1 | dickkopf homolog 1 (Xenopus laevis) | 0.887 | |
| Smo | smoothened homolog (Drosophila) | 0.882 | |
| Ctnnb1 | catenin (cadherin associated protein), beta 1 | 0.869 | |
| Bmp4 | bone morphogenetic protein 4 | 0.864 | |
| Dact1 | dapper homolog 1, antagonist of beta-catenin (xenopus) | 0.847 | |
| Foxc1 | forkhead box C1 | 0.822 | |
| Wnt3a | wingless-related MMTV integration site 3A | 0.812 | |
| Ror2 | receptor tyrosine kinase-like orphan receptor 2 | 0.803 | |
| Foxc2 | forkhead box C2 | 0.789 | |
| Otx2 | orthodenticle homolog 2 (Drosophila) | 0.741 | |
| Wnt4 | wingless-related MMTV integration site 4 | 0.723 | |
| Pax3 | paired box gene 3 | 0.716 | |
| Tbx1 | T-box 1 | 0.696 | |
| Nog | noggin | 0.684 | |
| Dvl1 | dishevelled, dsh homolog 1 (Drosophila) | 0.669 | |
| Lhx1 | LIM homeobox protein 1 | 0.661 | |
| Prrx2 | paired related homeobox 2 | 0.658 | |
| Gli2 | GLI-Kruppel family member GLI2 | 0.649 | |
| Pax8 | paired box gene 8 | 0.598 | |
| Meox2 | mesenchyme homeobox 2 | 0.584 | |
| Rarb | retinoic acid receptor, beta | 0.558 | |
| Fgf10 | fibroblast growth factor 10 | 0.549 | |
| Efna4 | ephrin A4 | 0.548 | |
| Lmx1a | LIM homeobox transcription factor 1 alpha | 0.495 | |
| Hoxa1 | homeobox A1 | 0.483 | |
| Pax1 | paired box gene 1 | 0.469 | |
| Itga3 | integrin alpha 3 | 0.456 | |
| Fgfr3 | fibroblast growth factor receptor 3 | 0.449 | |
| Msx2 | homeobox, msh-like 2 | 0.430 | |
| Tbx2 | T-box 2 | 0.414 | |
| Six1 | sine oculis-related homeobox 1 homolog (Drosophila) | 0.408 | |
| Msx1 | homeobox, msh-like 1 | 0.388 | |
| Wnt6 | wingless-related MMTV integration site 6 | 0.385 | |
| Twist2 | twist homolog 2 (Drosophila) | 0.384 | |
| Otx1 | orthodenticle homolog 1 (Drosophila) | 0.374 | |
| Nodal | nodal | 0.373 | |
| Pcsk5 | proprotein convertase subtilisin/kexin type 5 | 0.363 | |
| Vangl1 | vang-like 1 (van gogh, Drosophila) | 0.358 | |
| Mapk8ip1 | mitogen-activated protein kinase 8 interacting protein 1 | 0.357 | |
| Aldh1a2 | aldehyde dehydrogenase family 1, subfamily A2 | 0.350 | |
| Gdnf | glial cell line derived neurotrophic factor | 0.347 | |
| Pou3f3 | POU domain, class 3, transcription factor 3 | 0.345 | |
| Zic3 | zinc finger protein of the cerebellum 3 | 0.344 | |
| Hoxa13 | homeobox A13 | 0.332 | |
| Hoxd11 | homeobox D11 | 0.320 | |
| Gbx2 | gastrulation brain homeobox 2 | 0.316 | |
| Lmx1b | LIM homeobox transcription factor 1 beta | 0.315 | |
| Axin1 | axin 1 | 0.315 | |
| Lrp2 | low density lipoprotein receptor-related protein 2 | 0.307 | |
| Sox11 | SRY-box containing gene 11 | 0.296 | |
| Gli1 | GLI-Kruppel family member GLI1 | 0.291 | |
| Chrd | chordin | 0.289 | |
| Dlx5 | distal-less homeobox 5 | 0.285 | |
| Emx2 | empty spiracles homolog 2 (Drosophila) | 0.266 | |
| Alx4 | aristaless-like homeobox 4 | 0.253 | |
| En1 | engrailed 1 | 0.251 | |
| Col13a1 | collagen, type XIII, alpha 1 | 0.246 | |
| Foxj1 | forkhead box J1 | 0.245 | |
| Fgf3 | fibroblast growth factor 3 | 0.228 | |
| Smad6 | MAD homolog 6 (Drosophila) | 0.223 | |
| Sox9 | SRY-box containing gene 9 | 0.221 | |
| Lama5 | laminin, alpha 5 | 0.221 | |
| Lef1 | lymphoid enhancer binding factor 1 | 0.219 | |
| Trp63 | transformation related protein 63 | 0.219 | |
| Kl | klotho | 0.211 | |
| Mks1 | Meckel syndrome, type 1 | 0.211 | |
| Pcdh12 | protocadherin 12 | 0.207 | |
| Rspo1 | R-spondin homolog (Xenopus laevis) | 0.206 | |
| Cdh16 | cadherin 16 | 0.204 | |
| Foxf1a | forkhead box F1a | 0.201 | |
| Tcfap2a | transcription factor AP-2, alpha | 0.198 | |
| Pitx1 | paired-like homeodomain transcription factor 1 | 0.192 | |
| Fgf18 | fibroblast growth factor 18 | 0.191 | |
| Vstm2b | V-set and transmembrane domain containing 2B | 0.182 | |
| Gpc3 | glypican 3 | 0.176 | |
| Rara | retinoic acid receptor, alpha | 0.174 | |
| Fgf15 | fibroblast growth factor 15 | 0.173 | |
| Igdcc3 | immunoglobulin superfamily, DCC subclass, member 3 | 0.164 | |
| Pax9 | paired box gene 9 | 0.164 | |
| Efnb2 | ephrin B2 | 0.163 | |
| Tgfa | transforming growth factor alpha | 0.162 | |
| Hoxa2 | homeobox A2 | 0.161 | |
| Hoxd13 | homeobox D13 | 0.158 | |
| Ihh | Indian hedgehog | 0.156 |
