The network for 'somite development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

somite development

The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.

Mus musculus
Name Description Probability Func Analog Organism
Nodal nodal 0.999
Gli3 GLI-Kruppel family member GLI3 0.999
Otx2 orthodenticle homolog 2 (Drosophila) 0.997
Pitx2 paired-like homeodomain transcription factor 2 0.997
Foxc1 forkhead box C1 0.997
Pax3 paired box gene 3 0.995
Notch1 Notch gene homolog 1 (Drosophila) 0.992
Ctnnb1 catenin (cadherin associated protein), beta 1 0.992
Wnt3a wingless-related MMTV integration site 3A 0.991
Fgf8 fibroblast growth factor 8 0.990
Hes1 hairy and enhancer of split 1 (Drosophila) 0.989
Pax6 paired box gene 6 0.984
Dlx5 distal-less homeobox 5 0.977
Tbx3 T-box 3 0.973
Shh sonic hedgehog 0.972
Rb1 retinoblastoma 1 0.972
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.965
Fgfr2 fibroblast growth factor receptor 2 0.964
Psen1 presenilin 1 0.962
Nog noggin 0.960
Hoxa1 homeobox A1 0.938
Lef1 lymphoid enhancer binding factor 1 0.931
Rarg retinoic acid receptor, gamma 0.929
Fgfr1 fibroblast growth factor receptor 1 0.925
Sox2 SRY-box containing gene 2 0.916
Eya1 eyes absent 1 homolog (Drosophila) 0.916
Msx1 homeobox, msh-like 1 0.913
Smad6 MAD homolog 6 (Drosophila) 0.910
Meox2 mesenchyme homeobox 2 0.909
Prrx1 paired related homeobox 1 0.904
Six4 sine oculis-related homeobox 4 homolog (Drosophila) 0.901
Hoxa2 homeobox A2 0.898
Emx1 empty spiracles homolog 1 (Drosophila) 0.889
Gata4 GATA binding protein 4 0.882
Ptch1 patched homolog 1 0.881
Tbx1 T-box 1 0.879
Hand1 heart and neural crest derivatives expressed transcript 1 0.878
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.873
Pten phosphatase and tensin homolog 0.872
Dll4 delta-like 4 (Drosophila) 0.862
Otx1 orthodenticle homolog 1 (Drosophila) 0.860
T brachyury 0.857
En1 engrailed 1 0.845
Smad3 MAD homolog 3 (Drosophila) 0.835
Lmx1a LIM homeobox transcription factor 1 alpha 0.819
Fgf10 fibroblast growth factor 10 0.801
Tgfb2 transforming growth factor, beta 2 0.800
Gdnf glial cell line derived neurotrophic factor 0.799
Foxc2 forkhead box C2 0.788
Emx2 empty spiracles homolog 2 (Drosophila) 0.779
Pax9 paired box gene 9 0.775
Lrp6 low density lipoprotein receptor-related protein 6 0.737
Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 0.729
Hand2 heart and neural crest derivatives expressed transcript 2 0.721
Dll1 delta-like 1 (Drosophila) 0.720
Snai1 snail homolog 1 (Drosophila) 0.717
Bmp7 bone morphogenetic protein 7 0.717
Grb10 growth factor receptor bound protein 10 0.716
Pax7 paired box gene 7 0.713
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.699
Zic3 zinc finger protein of the cerebellum 3 0.697
Smad4 MAD homolog 4 (Drosophila) 0.689
Zeb1 zinc finger E-box binding homeobox 1 0.682
Sox3 SRY-box containing gene 3 0.679
Foxd1 forkhead box D1 0.670
Foxh1 forkhead box H1 0.669
Tbx2 T-box 2 0.665
Pax2 paired box gene 2 0.639
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.599
Smad1 MAD homolog 1 (Drosophila) 0.593
Vegfa vascular endothelial growth factor A 0.587
Sox11 SRY-box containing gene 11 0.578
Msx2 homeobox, msh-like 2 0.572
Arhgef11 Rho guanine nucleotide exchange factor (GEF) 11 0.570
Acvr1 activin A receptor, type 1 0.568
Notch3 Notch gene homolog 3 (Drosophila) 0.561
Ece1 endothelin converting enzyme 1 0.551
Notch2 Notch gene homolog 2 (Drosophila) 0.547
Bmp4 bone morphogenetic protein 4 0.539
Fzd1 frizzled homolog 1 (Drosophila) 0.538
Ntf3 neurotrophin 3 0.507
Eng endoglin 0.506
Neurog2 neurogenin 2 0.506
Wt1 Wilms tumor 1 homolog 0.502
Tcf15 transcription factor 15 0.493
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.493
Smo smoothened homolog (Drosophila) 0.486
Pbx1 pre B-cell leukemia transcription factor 1 0.482
Fzd8 frizzled homolog 8 (Drosophila) 0.478
Apc adenomatosis polyposis coli 0.478
Pitx1 paired-like homeodomain transcription factor 1 0.476
Nf1 neurofibromatosis 1 0.475
Bnc1 basonuclin 1 0.466
Tcfap2a transcription factor AP-2, alpha 0.462
Rxra retinoid X receptor alpha 0.462
Twist2 twist homolog 2 (Drosophila) 0.461
Hoxc8 homeobox C8 0.451
Chd7 chromodomain helicase DNA binding protein 7 0.449
Hoxb6 homeobox B6 0.446
Wnt1 wingless-related MMTV integration site 1 0.435
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
dlc deltaC 0.999
myhz1.1 myosin, heavy polypeptide 1.1, skeletal muscle 0.996
dld deltaD 0.988
myf5 myogenic factor 5 0.987
tbx1 T-box 1 0.980
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.973
gli1 GLI-Kruppel family member 1 0.967
wnt11 wingless-type MMTV integration site family, member 11 0.958
wnt3a wingless-type MMTV integration site family, member 3A 0.943
wnt1 wingless-type MMTV integration site family, member 1 0.942
wnt4a wingless-type MMTV integration site family, member 4a 0.928
wnt5b wingless-type MMTV integration site family, member 5b 0.919
dkk1b dickkopf 1b 0.903
bmp2b bone morphogenetic protein 2b 0.897
smyhc1 slow myosin heavy chain 1 0.895
hnf1ba HNF1 homeobox Ba 0.894
foxd5 forkhead box D5 0.892
mespa mesoderm posterior a 0.886
her7 hairy and enhancer of split related-7 0.874
notch1a notch homolog 1a 0.867
cdh2 cadherin 2, neuronal 0.856
bmp4 bone morphogenetic protein 4 0.853
tbx16 T-box gene 16 0.850
dla deltaA 0.835
hes6 hairy and enhancer of split 6 (Drosophila) 0.835
tbx24 T-box 24 0.806
cdx4 caudal type homeo box transcription factor 4 0.804
gli2a GLI-Kruppel family member GLI2a 0.790
boc brother of CDO 0.786
her1 hairy-related 1 0.781
pdlim3a PDZ and LIM domain 3a 0.759
mef2cb myocyte enhancer factor 2cb 0.759
dag1 dystroglycan 1 0.754
has2 hyaluronan synthase 2 0.754
hspb1 heat shock protein, alpha-crystallin-related, 1 0.733
lratb lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b) 0.717
sema3aa semaphorin 3aa 0.712
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.709
prickle1a prickle-like 1 (Drosophila) a 0.703
myod1 myogenic differentiation 1 0.697
her5 hairy-related 5 0.659
lef1 lymphocyte enhancer binding factor 1 0.651
pdlim3b PDZ and LIM domain 3b 0.628
hhip hedgehog interacting protein 0.618
fbn2b fibrillin 2b 0.614
ntla no tail a 0.610
ndr2 nodal-related 2 0.607
fn1 fibronectin 1 0.602
myhz2 myosin, heavy polypeptide 2, fast muscle specific 0.591
lama5 laminin, alpha 5 0.588
col2a1a collagen type II, alpha-1a 0.577
msgn1 mesogenin 1 0.573
her15.1 hairy and enhancer of split-related 15.1 0.569
wnt9a wingless-type MMTV integration site family, member 9A 0.567
fezf2 FEZ family zinc finger 2 0.562
lamb1a laminin, beta 1a 0.549
nrarpa notch-regulated ankyrin repeat protein a 0.536
gata5 GATA-binding protein 5 0.534
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.529
hand2 heart and neural crest derivatives expressed transcript 2 0.527
sox17 SRY-box containing gene 17 0.523
snai1b snail homolog 1b (Drosophila) 0.495
scube2 signal peptide, CUB domain, EGF-like 2 0.493
myog myogenin 0.491
tll1 tolloid-like 1 0.486
osr2 odd-skipped related 2 (Drosophila) 0.480
fgf3 fibroblast growth factor 3 0.480
her3 hairy-related 3 0.478
tp63 tumor protein p63 0.473
ptch1 patched 1 0.469
sp5l Sp5 transcription factor-like 0.463
ripply1 ripply1 0.460
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.455
frem3 Fras1 related extracellular matrix 3 0.453
fgfr1b fibroblast growth factor receptor 1b 0.442
fgf19 fibroblast growth factor 19 0.437
tnni1al troponin I, skeletal, slow like 0.435
pdlim7 PDZ and LIM domain 7 0.434
spry4 sprouty (Drosophila) homolog 4 0.422
fgf17 fibroblast growth factor 17 0.410
jag2 jagged 2 0.406
msxb muscle segment homeobox B 0.403
traf4a tnf receptor-associated factor 4a 0.400
shha sonic hedgehog a 0.397
dmrt2a doublesex and mab-3 related transcription factor 2a 0.397
chrnb3a cholinergic receptor, nicotinic, beta polypeptide 3a 0.396
zbtb4 zinc finger and BTB domain containing 4 0.394
sulf1 sulfatase 1 0.393
lhx1a LIM homeobox 1a 0.391
pax2a paired box gene 2a 0.388
eng2a engrailed 2a 0.385
foxi1 forkhead box I1 0.382
emx3 empty spiracles homeobox 3 0.381
gdnf glial cell derived neurotrophic factor 0.380
notch2 notch homolog 2 0.376
desma desmin a 0.376
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.373
apobec2a apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2a 0.369
ptenb phosphatase and tensin homolog B (mutated in multiple advanced cancers 1) 0.368
flh floating head 0.364
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
BMP2 bone morphogenetic protein 2 0.580
MEOX2 mesenchyme homeobox 2 0.574
SMAD3 SMAD family member 3 0.524
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.495
SRPK2 SRSF protein kinase 2 0.339
JAG1 jagged 1 0.291
ENG endoglin 0.246
MAPK8 mitogen-activated protein kinase 8 0.210
PSEN1 presenilin 1 0.192
PAX1 paired box 1 0.164
MEOX1 mesenchyme homeobox 1 0.120
PAX3 paired box 3 0.107
NOTCH3 notch 3 0.104
EXOC7 exocyst complex component 7 0.099
CTGF connective tissue growth factor 0.098
BBS10 Bardet-Biedl syndrome 10 0.077
NOTCH1 notch 1 0.077
FZD1 frizzled homolog 1 (Drosophila) 0.074
SMO smoothened homolog (Drosophila) 0.068
TRRAP transformation/transcription domain-associated protein 0.064
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 0.061
SOX10 SRY (sex determining region Y)-box 10 0.061
ZFYVE9 zinc finger, FYVE domain containing 9 0.052
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.047
PGK1 phosphoglycerate kinase 1 0.045
SMAD2 SMAD family member 2 0.042
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 0.041
BBS2 Bardet-Biedl syndrome 2 0.040
ZFX zinc finger protein, X-linked 0.033
TRIM63 tripartite motif containing 63 0.028
ATXN7 ataxin 7 0.028
SKI v-ski sarcoma viral oncogene homolog (avian) 0.027
MSN moesin 0.026
ITGB1BP3 integrin beta 1 binding protein 3 0.026
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.025
SPDEF SAM pointed domain containing ets transcription factor 0.025
MED24 mediator complex subunit 24 0.023
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 0.023
TCF4 transcription factor 4 0.023
PCM1 pericentriolar material 1 0.023
BMP1 bone morphogenetic protein 1 0.023
LRP6 low density lipoprotein receptor-related protein 6 0.022
XIAP X-linked inhibitor of apoptosis 0.021
ERBB2IP erbb2 interacting protein 0.021
WNT1 wingless-type MMTV integration site family, member 1 0.021
MAML1 mastermind-like 1 (Drosophila) 0.021
HDAC4 histone deacetylase 4 0.020
CSNK1E casein kinase 1, epsilon 0.019
TBK1 TANK-binding kinase 1 0.019
CYR61 cysteine-rich, angiogenic inducer, 61 0.019
SFRP1 secreted frizzled-related protein 1 0.019
MDFI MyoD family inhibitor 0.018
GPI glucose-6-phosphate isomerase 0.018
BMP7 bone morphogenetic protein 7 0.017
FGF18 fibroblast growth factor 18 0.017
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.017
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.016
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 0.016
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.016
BBS9 Bardet-Biedl syndrome 9 0.016
AZI2 5-azacytidine induced 2 0.016
TTN titin 0.015
LDHA lactate dehydrogenase A 0.015
NCK2 NCK adaptor protein 2 0.015
FOXF2 forkhead box F2 0.015
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.014
BMP4 bone morphogenetic protein 4 0.014
IGF2R insulin-like growth factor 2 receptor 0.014
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.014
USP9X ubiquitin specific peptidase 9, X-linked 0.014
MED15 mediator complex subunit 15 0.014
NCSTN nicastrin 0.013
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.013
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.013
HIPK2 homeodomain interacting protein kinase 2 0.013
BCAT2 branched chain amino-acid transaminase 2, mitochondrial 0.013
GSK3B glycogen synthase kinase 3 beta 0.012
PXN paxillin 0.012
FERMT2 fermitin family member 2 0.012
FZD7 frizzled homolog 7 (Drosophila) 0.011
NOTCH2 notch 2 0.011
ZMYND11 zinc finger, MYND-type containing 11 0.011
FBLN1 fibulin 1 0.010
PTEN phosphatase and tensin homolog 0.010
MED12 mediator complex subunit 12 0.010
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.010
DVL3 dishevelled, dsh homolog 3 (Drosophila) 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism