The network for 'oocyte maturation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

oocyte maturation

A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.

Mus musculus
Name Description Probability Func Analog Organism
Efnb2 ephrin B2 0.968
Cdc25c cell division cycle 25 homolog C (S. pombe) 0.947
Cdk1 cyclin-dependent kinase 1 0.907
Amhr2 anti-Mullerian hormone type 2 receptor 0.863
Cdc20 cell division cycle 20 homolog (S. cerevisiae) 0.863
Ccna2 cyclin A2 0.659
Nab2 Ngfi-A binding protein 2 0.609
Ar androgen receptor 0.602
Nos3 nitric oxide synthase 3, endothelial cell 0.498
Apc adenomatosis polyposis coli 0.473
Kif20a kinesin family member 20A 0.433
Brca1 breast cancer 1 0.396
Amh anti-Mullerian hormone 0.349
Fshr follicle stimulating hormone receptor 0.343
Cebpa CCAAT/enhancer binding protein (C/EBP), alpha 0.336
Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) 0.331
Esr1 estrogen receptor 1 (alpha) 0.324
Ube2c ubiquitin-conjugating enzyme E2C 0.277
Gata5 GATA binding protein 5 0.266
Kiss1 KiSS-1 metastasis-suppressor 0.259
Pten phosphatase and tensin homolog 0.250
Atf2 activating transcription factor 2 0.244
Add1 adducin 1 (alpha) 0.244
Mdm2 transformed mouse 3T3 cell double minute 2 0.236
Birc5 baculoviral IAP repeat-containing 5 0.227
Cdca8 cell division cycle associated 8 0.196
Plk1 polo-like kinase 1 (Drosophila) 0.196
Cdc25b cell division cycle 25 homolog B (S. pombe) 0.189
Efnb1 ephrin B1 0.188
Cdc25a cell division cycle 25 homolog A (S. pombe) 0.185
Kras v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 0.183
Ccnb1 cyclin B1 0.171
Npc1 Niemann Pick type C1 0.170
Cdkn1b cyclin-dependent kinase inhibitor 1B 0.168
Ahr aryl-hydrocarbon receptor 0.166
Epha4 Eph receptor A4 0.165
Foxo1 forkhead box O1 0.162
Notch1 Notch gene homolog 1 (Drosophila) 0.161
Prc1 protein regulator of cytokinesis 1 0.159
Ephb3 Eph receptor B3 0.157
Atm ataxia telangiectasia mutated homolog (human) 0.148
Ctnnb1 catenin (cadherin associated protein), beta 1 0.143
Gata4 GATA binding protein 4 0.141
Prkaca protein kinase, cAMP dependent, catalytic, alpha 0.132
Kif11 kinesin family member 11 0.122
Src Rous sarcoma oncogene 0.121
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.120
Egr1 early growth response 1 0.117
Ptch1 patched homolog 1 0.117
Kif22 kinesin family member 22 0.116
Itpr3 inositol 1,4,5-triphosphate receptor 3 0.113
Mapk1 mitogen-activated protein kinase 1 0.112
Sox18 SRY-box containing gene 18 0.109
Homer1 homer homolog 1 (Drosophila) 0.105
Ngfr nerve growth factor receptor (TNFR superfamily, member 16) 0.104
Pthlh parathyroid hormone-like peptide 0.102
Fos FBJ osteosarcoma oncogene 0.101
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.100
Top2a topoisomerase (DNA) II alpha 0.100
Ckap2 cytoskeleton associated protein 2 0.097
Chst8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.094
Ptgs2 prostaglandin-endoperoxide synthase 2 0.094
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.091
Rb1 retinoblastoma 1 0.087
Nf2 neurofibromatosis 2 0.087
Itpr2 inositol 1,4,5-triphosphate receptor 2 0.087
Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 0.086
Mapk3 mitogen-activated protein kinase 3 0.085
Asap1 ArfGAP with SH# domain, ankyrin repeat and PH domain1 0.084
Fosb FBJ osteosarcoma oncogene B 0.080
Aurka aurora kinase A 0.080
Gli2 GLI-Kruppel family member GLI2 0.078
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.077
Nfatc2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.076
Tnfrsf8 tumor necrosis factor receptor superfamily, member 8 0.076
Pgr progesterone receptor 0.074
Irs1 insulin receptor substrate 1 0.070
Flt4 FMS-like tyrosine kinase 4 0.070
Racgap1 Rac GTPase-activating protein 1 0.067
Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 0.066
Sox9 SRY-box containing gene 9 0.065
E2f8 E2F transcription factor 8 0.065
Tlx2 T-cell leukemia, homeobox 2 0.064
Nf1 neurofibromatosis 1 0.063
Zfpm2 zinc finger protein, multitype 2 0.060
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.060
Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 0.059
Jup junction plakoglobin 0.059
Rad51 RAD51 homolog (S. cerevisiae) 0.058
Ntf3 neurotrophin 3 0.058
Tyro3 TYRO3 protein tyrosine kinase 3 0.055
Cenpj centromere protein J 0.055
Tnks1bp1 tankyrase 1 binding protein 1 0.054
Adam17 a disintegrin and metallopeptidase domain 17 0.053
H2afx H2A histone family, member X 0.053
Prox1 prospero-related homeobox 1 0.051
Plk4 polo-like kinase 4 (Drosophila) 0.051
Wnt6 wingless-related MMTV integration site 6 0.051
Kif4 kinesin family member 4 0.050
Tbx2 T-box 2 0.050
Loading network...
Caenorhabditis elegans
Name Description Probability Func Analog Organism
Loading network...
Danio rerio
Name Description Probability Func Analog Organism
nanos3 nanos homolog 3 0.988
ccnb1 cyclin B1 0.775
vasa vasa homolog 0.699
smad1 MAD homolog 1 (Drosophila) 0.672
tbpl2 TATA box binding protein like 2 0.658
gro1 groucho 1 0.613
piwil2 piwi-like 2 (Drosophila) 0.536
brd2a bromodomain-containing 2a 0.516
bmp15 bone morphogenetic protein 15 0.485
aurkb aurora kinase B 0.479
cyp26c1 cytochrome P450, family 26, subfamily C, polypeptide 1 0.478
zgc:193933 zgc:193933 0.477
efnb3b ephrin B3b 0.465
cldng claudin g 0.462
mespb mesoderm posterior b 0.457
fzd5 frizzled homolog 5 0.440
hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 0.434
crim1 cysteine rich transmembrane BMP regulator 1 (chordin like) 0.428
rest RE1-silencing transcription factor 0.383
hells helicase, lymphoid-specific 0.376
dhfr dihydrofolate reductase 0.340
ccnb2 cyclin B2 0.331
dazl daz-like gene 0.330
acvr1b activin A receptor, type IB 0.312
mespa mesoderm posterior a 0.307
depdc1a DEP domain containing 1a 0.305
per2 period homolog 2 (Drosophila) 0.300
sema3d semaphorin 3d 0.298
gli1 GLI-Kruppel family member 1 0.296
hoxa2b homeo box A2b 0.294
sox9b SRY-box containing gene 9b 0.293
racgap1 Rac GTPase-activating protein 1 0.288
prickle2 prickle-like 2 (Drosophila) 0.283
dharma dharma 0.277
cdc20 cell division cycle 20 homolog 0.277
ptprk protein tyrosine phosphatase, receptor type, K 0.270
egr1 early growth response 1 0.260
pnx posterior neuron-specific homeobox 0.250
otul OTU like protein 0.248
foxh1 forkhead box H1 0.245
ndr1 nodal-related 1 0.244
dnd dead end 0.240
pou5f1 POU domain, class 5, transcription factor 1 0.233
frem3 Fras1 related extracellular matrix 3 0.232
mmp15b matrix metallopeptidase 15b 0.230
dlgap5 discs, large (Drosophila) homolog-associated protein 5 0.227
wnt1 wingless-type MMTV integration site family, member 1 0.226
cep55l centrosomal protein 55 like 0.225
bon bonnie and clyde 0.223
org oogenesis-related gene 0.220
ccna2 cyclin A2 0.220
igf1 insulin-like growth factor 1 0.218
si:dkeyp-117h8.4 si:dkeyp-117h8.4 0.217
zar1 zygote arrest 1 0.216
sb:cb730 sb:cb730 0.208
nbl1 neuroblastoma, suppression of tumorigenicity 1 0.207
bambia BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a 0.206
plk1 polo-like kinase 1 (Drosophila) 0.203
ext1a exostoses (multiple) 1a 0.201
gdf6b growth differentiation factor 6b 0.195
mos v-mos Moloney murine sarcoma viral oncogene homolog 0.194
sass6 spindle assembly 6 homolog (C. elegans) 0.194
tdrd7 tudor domain containing 7 0.193
cldnd claudin d 0.184
lepr leptin receptor 0.183
fstl1b follistatin-like 1b 0.182
gsc goosecoid 0.181
lhx1b LIM homeobox 1b 0.180
dvr1 decapentaplegic and Vg-related 1 0.178
foxi1 forkhead box I1 0.175
si:ch211-69g19.2 si:ch211-69g19.2 0.175
btg2 B-cell translocation gene 2 0.174
vent ventral expressed homeobox 0.170
elavl2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B) 0.167
piwil1 piwi-like 1 (Drosophila) 0.165
top2a topoisomerase (DNA) II alpha 0.164
eif4e1b eukaryotic translation initiation factor 4e 1b 0.162
tbx16 T-box gene 16 0.159
gro2 groucho 2 0.158
efna5b ephrin A5b 0.153
zgc:101616 zgc:101616 0.151
fgfr1a fibroblast growth factor receptor 1a 0.151
nog1 noggin 1 0.149
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.147
pif1 PIF1 5'-to-3' DNA helicase homolog (S. cerevisiae) 0.145
efna5a ephrin A5a 0.145
nrg2a neuregulin 2a 0.143
mapk1 mitogen-activated protein kinase 1 0.140
birc5b baculoviral IAP repeat-containing 5B 0.140
egr2a early growth response 2a 0.140
mll myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 0.138
brca2 breast cancer 2, early onset 0.137
aurka aurora kinase A 0.135
sall4 sal-like 4 (Drosophila) 0.134
fzd8b frizzled homolog 8b 0.134
sox19b SRY-box containing gene 19b 0.133
ephb3a eph receptor B3a 0.131
zgc:112211 zgc:112211 0.130
rxrbb retinoid x receptor, beta b 0.129
zgc:55521 zgc:55521 0.128
Loading network...
Drosophila melanogaster
Name Description Probability Func Analog Organism
CycA Cyclin A 0.998
CycB Cyclin B 0.967
CycE Cyclin E 0.930
brat brain tumor 0.912
polo CG12306 gene product from transcript CG12306-RA 0.895
piwi CG6122 gene product from transcript CG6122-RA 0.795
bam bag of marbles 0.755
asp abnormal spindle 0.697
vas vasa 0.633
spn-E spindle E 0.603
nos nanos 0.602
thr three rows 0.595
Pten CG5671 gene product from transcript CG5671-RB 0.565
aub aubergine 0.553
pim pimples 0.541
orb oo18 RNA-binding protein 0.537
Su(H) Suppressor of Hairless 0.534
osk oskar 0.491
otu ovarian tumor 0.489
Cks30A Cyclin-dependent kinase subunit 30A 0.429
swa swallow 0.427
tws twins 0.404
stai stathmin 0.351
mael maelstrom 0.312
CkIIalpha Casein kinase II alpha subunit 0.260
wisp wispy 0.251
CycB3 Cyclin B3 0.238
fzy fizzy 0.238
Ptp69D Protein tyrosine phosphatase 69D 0.232
Rca1 Regulator of cyclin A1 0.226
stwl stonewall 0.221
Ephrin CG1862 gene product from transcript CG1862-RA 0.214
zpg zero population growth 0.212
sxc super sex combs 0.198
armi armitage 0.182
Sse Separase 0.170
wee CG4488 gene product from transcript CG4488-RA 0.169
dap dacapo 0.165
lok loki 0.164
cnn centrosomin 0.158
rl rolled 0.156
cmet CENP-meta 0.147
bsk basket 0.146
ewg erect wing 0.142
ana3 anastral spindle 3 0.142
stet stem cell tumor 0.129
Dap160 Dynamin associated protein 160 0.126
rap retina aberrant in pattern 0.125
Itp-r83A Inositol 1,4,5,-tris-phosphate receptor 0.125
Dsor1 Downstream of raf1 0.124
Klp3A Kinesin-like protein at 3A 0.121
Galpha49B G protein alpha49B 0.121
gus gustavus 0.118
mi minus 0.117
dhd deadhead 0.113
Dhc64C Dynein heavy chain 64C 0.107
CG4771 CG4771 gene product from transcript CG4771-RA 0.105
hb hunchback 0.104
Acsl Acyl-CoA synthetase long-chain 0.102
Rbf Retinoblastoma-family protein 0.101
gl glass 0.097
Orc2 Origin recognition complex subunit 2 0.093
htl heartless 0.090
rux roughex 0.089
CdsA CDP diglyceride synthetase 0.084
Nup154 Nucleoporin 154 0.082
sls sallimus 0.081
bcd bicoid 0.079
Xpd Xeroderma pigmentosum D 0.077
hts hu li tai shao 0.076
egg eggless 0.074
pigeon CG10739 gene product from transcript CG10739-RB 0.074
Cap-G CG34438 gene product from transcript CG34438-RF 0.074
stumps CG31317 gene product from transcript CG31317-RC 0.073
cutlet CG33122 gene product from transcript CG33122-RA 0.069
aret arrest 0.069
Su(var)2-10 Suppressor of variegation 2-10 0.069
for foraging 0.067
rhi rhino 0.066
asun asunder 0.065
Pabp2 CG2163 gene product from transcript CG2163-RA 0.064
ncd non-claret disjunctional 0.064
BubR1 Bub1-related kinase 0.064
RanGap Ran GTPase activating protein 0.063
krimp krimper 0.063
Dref DNA replication-related element factor 0.063
vnd ventral nervous system defective 0.063
cup CG11181 gene product from transcript CG11181-RB 0.062
CG9925 CG9925 gene product from transcript CG9925-RA 0.061
slmb supernumerary limbs 0.061
hdc headcase 0.059
Cul-5 Cullin-5 0.058
barr barren 0.058
dnc dunce 0.058
pav pavarotti 0.057
CaMKII Calcium/calmodulin-dependent protein kinase II 0.057
chico CG5686 gene product from transcript CG5686-RB 0.057
mth methuselah 0.056
glec gliolectin 0.056
pum pumilio 0.056
Loading network...
Homo sapiens
Name Description Probability Func Analog Organism
CDK2 cyclin-dependent kinase 2 1.000
CCNA2 cyclin A2 0.998
CDK1 cyclin-dependent kinase 1 0.997
CCNB1 cyclin B1 0.997
SP1 Sp1 transcription factor 0.982
BRCA2 breast cancer 2, early onset 0.981
CKS2 CDC28 protein kinase regulatory subunit 2 0.975
CKS1B CDC28 protein kinase regulatory subunit 1B 0.922
BRCA1 breast cancer 1, early onset 0.898
CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.891
CDT1 chromatin licensing and DNA replication factor 1 0.882
CCNB2 cyclin B2 0.855
CCNE1 cyclin E1 0.838
SKP2 S-phase kinase-associated protein 2 (p45) 0.825
RAD51 RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae) 0.822
ZNF746 zinc finger protein 746 0.654
CDC6 cell division cycle 6 homolog (S. cerevisiae) 0.622
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.562
FANCD2 Fanconi anemia, complementation group D2 0.540
DAZ1 deleted in azoospermia 1 0.488
FOXM1 forkhead box M1 0.486
PLK1 polo-like kinase 1 0.479
PALB2 partner and localizer of BRCA2 0.462
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.414
E2F1 E2F transcription factor 1 0.385
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide 0.350
CDKN3 cyclin-dependent kinase inhibitor 3 0.312
CDC27 cell division cycle 27 homolog (S. cerevisiae) 0.300
DMC1 DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast) 0.287
EFNA1 ephrin-A1 0.273
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.266
CDC25C cell division cycle 25 homolog C (S. pombe) 0.247
EGR3 early growth response 3 0.233
CDC25A cell division cycle 25 homolog A (S. pombe) 0.215
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) 0.212
CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae) 0.205
DUSP3 dual specificity phosphatase 3 0.187
GRB7 growth factor receptor-bound protein 7 0.180
ERBB3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.176
FANCG Fanconi anemia, complementation group G 0.172
AKAP11 A kinase (PRKA) anchor protein 11 0.171
EGR2 early growth response 2 0.167
RBL1 retinoblastoma-like 1 (p107) 0.163
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.145
MAPK14 mitogen-activated protein kinase 14 0.142
ABL1 c-abl oncogene 1, non-receptor tyrosine kinase 0.140
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3 0.138
ORC1 origin recognition complex, subunit 1 0.129
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 0.120
NELL2 NEL-like 2 (chicken) 0.118
FYN FYN oncogene related to SRC, FGR, YES 0.117
CHEK2 CHK2 checkpoint homolog (S. pombe) 0.115
FOS FBJ murine osteosarcoma viral oncogene homolog 0.112
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 0.112
HDAC6 histone deacetylase 6 0.110
FANCA Fanconi anemia, complementation group A 0.099
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide 0.097
FANCE Fanconi anemia, complementation group E 0.096
PCNA proliferating cell nuclear antigen 0.092
CCNE2 cyclin E2 0.091
AKIP1 A kinase (PRKA) interacting protein 1 0.091
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta 0.090
SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) 0.089
DUSP1 dual specificity phosphatase 1 0.087
SYCP3 synaptonemal complex protein 3 0.086
RACGAP1 Rac GTPase activating protein 1 0.085
FBXO5 F-box protein 5 0.085
GMNN geminin, DNA replication inhibitor 0.084
IER2 immediate early response 2 0.084
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.082
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 0.082
MAP2K1 mitogen-activated protein kinase kinase 1 0.081
RAF1 v-raf-1 murine leukemia viral oncogene homolog 1 0.080
HMGA1 high mobility group AT-hook 1 0.075
AKAP10 A kinase (PRKA) anchor protein 10 0.074
RYR2 ryanodine receptor 2 (cardiac) 0.073
SNAI1 snail homolog 1 (Drosophila) 0.072
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) 0.069
EEF2K eukaryotic elongation factor-2 kinase 0.065
WEE1 WEE1 homolog (S. pombe) 0.065
HCFC1 host cell factor C1 (VP16-accessory protein) 0.062
FANCC Fanconi anemia, complementation group C 0.060
PRC1 protein regulator of cytokinesis 1 0.059
CLSPN claspin 0.058
MATK megakaryocyte-associated tyrosine kinase 0.057
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 0.057
PRKCA protein kinase C, alpha 0.056
TP53BP2 tumor protein p53 binding protein, 2 0.056
PRKCE protein kinase C, epsilon 0.052
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.050
FOXO1 forkhead box O1 0.049
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.049
MAPK3 mitogen-activated protein kinase 3 0.048
NFYA nuclear transcription factor Y, alpha 0.047
CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence 0.047
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 0.046
LIMK1 LIM domain kinase 1 0.045
ADAM15 ADAM metallopeptidase domain 15 0.045
RAD52 RAD52 homolog (S. cerevisiae) 0.044
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.043
Loading network...
Rattus norvegicus
Name Description Probability Func Analog Organism
Loading network...
Saccharomyces cerevisiae
Name Description Probability Func Analog Organism