The network for 'odontogenesis of dentin containing tooth' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

odontogenesis of dentin containing tooth

The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.

Mus musculus
Name Description Probability Func Analog Organism
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 0.999
Pitx2 paired-like homeodomain transcription factor 2 0.997
Sox2 SRY-box containing gene 2 0.997
Pax2 paired box gene 2 0.996
Fgf8 fibroblast growth factor 8 0.989
Rarg retinoic acid receptor, gamma 0.985
Tbx3 T-box 3 0.985
Lef1 lymphoid enhancer binding factor 1 0.985
Csf1 colony stimulating factor 1 (macrophage) 0.970
Tbx1 T-box 1 0.968
Gli3 GLI-Kruppel family member GLI3 0.965
Otx2 orthodenticle homolog 2 (Drosophila) 0.964
Hand1 heart and neural crest derivatives expressed transcript 1 0.954
Pax6 paired box gene 6 0.947
Wnt3a wingless-related MMTV integration site 3A 0.943
Bmp7 bone morphogenetic protein 7 0.942
Pthlh parathyroid hormone-like peptide 0.936
Nodal nodal 0.934
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.928
Hoxa13 homeobox A13 0.926
Gli2 GLI-Kruppel family member GLI2 0.909
Pitx1 paired-like homeodomain transcription factor 1 0.909
Pax8 paired box gene 8 0.903
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.900
Lhx1 LIM homeobox protein 1 0.884
Fgfr3 fibroblast growth factor receptor 3 0.882
Zic3 zinc finger protein of the cerebellum 3 0.882
Prrx1 paired related homeobox 1 0.874
Bmp4 bone morphogenetic protein 4 0.866
Pax9 paired box gene 9 0.861
Sox9 SRY-box containing gene 9 0.861
Wt1 Wilms tumor 1 homolog 0.859
Hoxd13 homeobox D13 0.848
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.844
Fgfr1 fibroblast growth factor receptor 1 0.843
Ctnnb1 catenin (cadherin associated protein), beta 1 0.842
Eda ectodysplasin-A 0.841
Nos3 nitric oxide synthase 3, endothelial cell 0.837
Hoxd11 homeobox D11 0.825
Fgf15 fibroblast growth factor 15 0.811
Fgf10 fibroblast growth factor 10 0.790
Msx1 homeobox, msh-like 1 0.787
Zeb1 zinc finger E-box binding homeobox 1 0.780
Bcl2l11 BCL2-like 11 (apoptosis facilitator) 0.776
Dlx5 distal-less homeobox 5 0.774
Hoxa1 homeobox A1 0.769
Insm1 insulinoma-associated 1 0.763
En1 engrailed 1 0.752
Trp63 transformation related protein 63 0.741
Gata6 GATA binding protein 6 0.731
Pax3 paired box gene 3 0.722
Emx2 empty spiracles homolog 2 (Drosophila) 0.719
Apc adenomatosis polyposis coli 0.714
Gdnf glial cell line derived neurotrophic factor 0.711
Pdx1 pancreatic and duodenal homeobox 1 0.708
Bcl2 B-cell leukemia/lymphoma 2 0.703
Gsc goosecoid homeobox 0.693
Edar ectodysplasin-A receptor 0.669
Chrd chordin 0.666
Chuk conserved helix-loop-helix ubiquitous kinase 0.663
Pbx1 pre B-cell leukemia transcription factor 1 0.659
Vangl2 vang-like 2 (van gogh, Drosophila) 0.642
Smad4 MAD homolog 4 (Drosophila) 0.638
Twist2 twist homolog 2 (Drosophila) 0.636
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.635
Inhba inhibin beta-A 0.633
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.632
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.628
Gata4 GATA binding protein 4 0.619
Pten phosphatase and tensin homolog 0.619
Foxh1 forkhead box H1 0.613
Isl1 ISL1 transcription factor, LIM/homeodomain 0.605
Chd7 chromodomain helicase DNA binding protein 7 0.592
Hand2 heart and neural crest derivatives expressed transcript 2 0.587
Nog noggin 0.581
Tcf21 transcription factor 21 0.580
Lhx3 LIM homeobox protein 3 0.577
Gbx2 gastrulation brain homeobox 2 0.571
Vegfa vascular endothelial growth factor A 0.567
Sall3 sal-like 3 (Drosophila) 0.565
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.548
Dlx6 distal-less homeobox 6 0.548
Alx4 aristaless-like homeobox 4 0.547
Prrx2 paired related homeobox 2 0.542
Eya1 eyes absent 1 homolog (Drosophila) 0.542
Ar androgen receptor 0.534
Pou3f3 POU domain, class 3, transcription factor 3 0.527
Rara retinoic acid receptor, alpha 0.521
Notch2 Notch gene homolog 2 (Drosophila) 0.516
Acvrl1 activin A receptor, type II-like 1 0.513
Col1a1 collagen, type I, alpha 1 0.508
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.506
Emx1 empty spiracles homolog 1 (Drosophila) 0.495
Tgfbr2 transforming growth factor, beta receptor II 0.476
Foxa2 forkhead box A2 0.467
Neurog2 neurogenin 2 0.447
Sox11 SRY-box containing gene 11 0.445
Tbx5 T-box 5 0.444
Dlx2 distal-less homeobox 2 0.440
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.999
sox9a SRY-box containing gene 9a 0.996
tbx1 T-box 1 0.990
fgf8a fibroblast growth factor 8 a 0.989
shha sonic hedgehog a 0.986
chd chordin 0.978
dlx4a distal-less homeobox gene 4a 0.976
ptch1 patched 1 0.935
fgf3 fibroblast growth factor 3 0.878
bmp4 bone morphogenetic protein 4 0.870
dlx4b distal-less homeobox gene 4b 0.837
fn1 fibronectin 1 0.815
dlx6a distal-less homeobox gene 6a 0.804
tp53 tumor protein p53 0.790
wnt5b wingless-type MMTV integration site family, member 5b 0.789
runx2a runt-related transcription factor 2a 0.771
dlx5a distal-less homeobox gene 5a 0.763
nkx3.2 NK3 homeobox 2 0.760
smo smoothened homolog (Drosophila) 0.679
acvr1l activin A receptor, type I like 0.678
runx2b runt-related transcription factor 2b 0.677
foxi1 forkhead box I1 0.675
si:dkeyp-50f5.1 si:dkeyp-50f5.1 0.639
dlx2a distal-less homeobox gene 2a 0.621
prkci protein kinase C, iota 0.613
dlx3b distal-less homeobox gene 3b 0.608
pax2a paired box gene 2a 0.607
mib mind bomb 0.603
msxc muscle segment homeobox C 0.587
emx3 empty spiracles homeobox 3 0.524
dlx1a distal-less homeobox gene 1a 0.495
bmp2a bone morphogenetic protein 2a 0.473
ptch2 patched 2 0.462
gsc goosecoid 0.459
boc brother of CDO 0.458
dkk1b dickkopf 1b 0.456
flh floating head 0.402
jag1b jagged 1b 0.384
ndr2 nodal-related 2 0.383
acvr2a activin receptor IIa 0.378
foxg1a forkhead box G1a 0.374
arx aristaless related homeobox 0.362
eya1 eyes absent homolog 1 0.353
sp7 Sp7 transcription factor 0.351
fgfr1a fibroblast growth factor receptor 1a 0.351
tbx16 T-box gene 16 0.338
vegfc vascular endothelial growth factor c 0.326
hand2 heart and neural crest derivatives expressed transcript 2 0.324
cxcr4a chemokine (C-X-C motif) receptor 4a 0.321
ccm2 cerebral cavernous malformation 2 0.313
atoh1a atonal homolog 1a 0.313
edn1 endothelin 1 0.302
pdgfaa platelet-derived growth factor alpha a 0.298
nkx2.1a NK2 homeobox 1a 0.291
pbx4 pre-B-cell leukemia transcription factor 4 0.290
pdlim3b PDZ and LIM domain 3b 0.287
fgfrl1a fibroblast growth factor receptor-like 1a 0.284
synj1 synaptojanin 1 0.283
lama5 laminin, alpha 5 0.283
cxcl12b chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) 0.280
fgf4 fibroblast growth factor 4 0.269
msxd muscle segment homeobox D 0.268
notch3 notch homolog 3 0.266
eve1 even-skipped-like1 0.266
cdh1 cadherin 1, epithelial 0.251
col14a1 collagen, type XIV, alpha 1 0.241
wnt3 wingless-type MMTV integration site family, member 3 0.239
pard6gb par-6 partitioning defective 6 homolog gamma B (C. elegans) 0.231
ahi1 Abelson helper integration site 1 0.225
bmper BMP binding endothelial regulator 0.225
dlx2b distal-less homeobox gene 2b 0.221
runx1 runt-related transcription factor 1 0.216
six4a sine oculis homeobox homolog 4a 0.208
spns2 spinster homolog 2 (Drosophila) 0.204
gli1 GLI-Kruppel family member 1 0.202
runx3 runt-related transcription factor 3 0.199
wnt11 wingless-type MMTV integration site family, member 11 0.196
tp63 tumor protein p63 0.190
frem2a Fras1 related extracellular matrix protein 2a 0.185
gpr126 G protein-coupled receptor 126 0.174
col10a1 collagen, type X, alpha 1 0.170
lamb1a laminin, beta 1a 0.170
grem2 gremlin 2, cysteine knot superfamily 0.170
pax9 paired box gene 9 0.166
hoxa13b homeo box A13b 0.166
prdm1a PR domain containing 1a, with ZNF domain 0.160
six4b sine oculis homeobox homolog 4b 0.160
pea3 ETS-domain transcription factor pea3 0.160
gata5 GATA-binding protein 5 0.157
rbfox1l RNA binding protein, fox-1 homolog (C. elegans) 1-like 0.157
cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) 0.156
krit1 KRIT1, ankyrin repeat containing 0.154
nkx2.3 NK2 transcription factor related 3 0.148
myod1 myogenic differentiation 1 0.144
rx3 retinal homeobox gene 3 0.141
fgf24 fibroblast growth factor 24 0.138
twist3 twist3 0.138
smad5 MAD homolog 5 (Drosophila) 0.137
bcl2l1 bcl2-like 1 0.133
baxa bcl2-associated X protein, a 0.129
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.000
FHL2 four and a half LIM domains 2 0.957
KLK10 kallikrein-related peptidase 10 0.236
MMS22L MMS22-like, DNA repair protein 0.212
PXN paxillin 0.156
FN1 fibronectin 1 0.155
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.153
PVRL4 poliovirus receptor-related 4 0.105
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.068
TLN1 talin 1 0.065
SCHIP1 schwannomin interacting protein 1 0.064
ENG endoglin 0.055
NCOR2 nuclear receptor corepressor 2 0.043
FSTL1 follistatin-like 1 0.042
POU5F1 POU class 5 homeobox 1 0.042
PDIA3 protein disulfide isomerase family A, member 3 0.041
MSX1 msh homeobox 1 0.040
BCAM basal cell adhesion molecule (Lutheran blood group) 0.035
MYO10 myosin X 0.034
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.033
SNTG2 syntrophin, gamma 2 0.032
KLK5 kallikrein-related peptidase 5 0.032
MSX2 msh homeobox 2 0.031
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.029
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.026
PSEN1 presenilin 1 0.024
PLEC plectin 0.024
KRT6C keratin 6C 0.024
KLK7 kallikrein-related peptidase 7 0.023
EDAR ectodysplasin A receptor 0.021
KLK11 kallikrein-related peptidase 11 0.021
HDAC3 histone deacetylase 3 0.020
BAK1 BCL2-antagonist/killer 1 0.019
PRSS2 protease, serine, 2 (trypsin 2) 0.019
ZFYVE9 zinc finger, FYVE domain containing 9 0.018
ITGB4 integrin, beta 4 0.018
AR androgen receptor 0.017
CD9 CD9 molecule 0.017
CD63 CD63 molecule 0.017
NOTCH3 notch 3 0.016
FOXF2 forkhead box F2 0.016
KRT5 keratin 5 0.016
NOG noggin 0.015
BAD BCL2-associated agonist of cell death 0.015
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.015
FOXC2 forkhead box C2 (MFH-1, mesenchyme forkhead 1) 0.015
CABLES1 Cdk5 and Abl enzyme substrate 1 0.014
FLNB filamin B, beta 0.014
DKK1 dickkopf homolog 1 (Xenopus laevis) 0.014
TRIM29 tripartite motif containing 29 0.014
COL7A1 collagen, type VII, alpha 1 0.013
ITGA6 integrin, alpha 6 0.013
TNRC6B trinucleotide repeat containing 6B 0.013
SFRP1 secreted frizzled-related protein 1 0.013
FGF18 fibroblast growth factor 18 0.013
WNT3A wingless-type MMTV integration site family, member 3A 0.013
GFI1B growth factor independent 1B transcription repressor 0.013
JAG1 jagged 1 0.013
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.012
CDSN corneodesmosin 0.012
WNT1 wingless-type MMTV integration site family, member 1 0.012
FLNA filamin A, alpha 0.012
HIC1 hypermethylated in cancer 1 0.011
COL17A1 collagen, type XVII, alpha 1 0.011
BAX BCL2-associated X protein 0.011
KLK8 kallikrein-related peptidase 8 0.011
PKP1 plakophilin 1 (ectodermal dysplasia/skin fragility syndrome) 0.011
COL2A1 collagen, type II, alpha 1 0.011
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.011
SOX2 SRY (sex determining region Y)-box 2 0.010
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Rattus norvegicus
Name Description Probability Func Analog Organism
Rin1 Ras and Rab interactor 1 0.017
Hist1h1a histone cluster 1, H1a 0.015
Fam120a family with sequence similarity 120A 0.015
Sh3bp1 SH3-domain binding protein 1 0.015
Fgfr2 fibroblast growth factor receptor 2 0.014
Ntrk1 neurotrophic tyrosine kinase, receptor, type 1 0.014
Lrp1 low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) 0.014
Foxe1 forkhead box E1 (thyroid transcription factor 2) 0.013
Tns3 tensin 3 0.012
Nkd1 naked cuticle homolog 1 (Drosophila) 0.011
Ugt2a1 UDP glucuronosyltransferase 2 family, polypeptide A1 0.011
C1r complement component 1, r subcomponent 0.011
Aqp2 aquaporin 2 (collecting duct) 0.011
Vcan versican 0.010
Rabac1 Rab acceptor 1 (prenylated) 0.010
Reln reelin 0.010
Mpz myelin protein zero 0.010
Zp1 zona pellucida glycoprotein 1 (sperm receptor) 0.010
Dnase1 deoxyribonuclease I 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism