The network for 'glial cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

glial cell fate commitment

The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.

Mus musculus
Name Description Probability Func Analog Organism
Shh sonic hedgehog 1.000
Sox2 SRY-box containing gene 2 0.999
Emx1 empty spiracles homolog 1 (Drosophila) 0.997
Otx2 orthodenticle homolog 2 (Drosophila) 0.995
Isl1 ISL1 transcription factor, LIM/homeodomain 0.991
Gli3 GLI-Kruppel family member GLI3 0.988
Ntf3 neurotrophin 3 0.988
Hand2 heart and neural crest derivatives expressed transcript 2 0.982
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.980
Bdnf brain derived neurotrophic factor 0.962
Fgfr2 fibroblast growth factor receptor 2 0.960
Neurog2 neurogenin 2 0.935
Fgf8 fibroblast growth factor 8 0.935
Tcfap2a transcription factor AP-2, alpha 0.926
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.923
Hand1 heart and neural crest derivatives expressed transcript 1 0.918
Ptf1a pancreas specific transcription factor, 1a 0.917
Sox11 SRY-box containing gene 11 0.900
Gli2 GLI-Kruppel family member GLI2 0.890
Pax6 paired box gene 6 0.874
Pax3 paired box gene 3 0.869
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.864
Chd7 chromodomain helicase DNA binding protein 7 0.862
Hes5 hairy and enhancer of split 5 (Drosophila) 0.849
Erbb3 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) 0.846
Foxc1 forkhead box C1 0.841
Foxg1 forkhead box G1 0.824
Msx1 homeobox, msh-like 1 0.801
Lhx3 LIM homeobox protein 3 0.792
Foxc2 forkhead box C2 0.766
Notch1 Notch gene homolog 1 (Drosophila) 0.737
Nog noggin 0.699
Hes1 hairy and enhancer of split 1 (Drosophila) 0.663
Nhlh1 nescient helix loop helix 1 0.625
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.623
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.621
En1 engrailed 1 0.608
Bmp4 bone morphogenetic protein 4 0.569
Hoxa1 homeobox A1 0.548
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.544
Alx4 aristaless-like homeobox 4 0.540
Phox2b paired-like homeobox 2b 0.513
Hoxd13 homeobox D13 0.479
Smarca4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.476
Tcf21 transcription factor 21 0.452
Pitx2 paired-like homeodomain transcription factor 2 0.452
Gata4 GATA binding protein 4 0.444
Eya1 eyes absent 1 homolog (Drosophila) 0.442
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.429
Insm1 insulinoma-associated 1 0.407
Lhx5 LIM homeobox protein 5 0.380
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.370
Phox2a paired-like homeobox 2a 0.363
Pthlh parathyroid hormone-like peptide 0.355
Gsc goosecoid homeobox 0.355
Wnt3a wingless-related MMTV integration site 3A 0.316
Col2a1 collagen, type II, alpha 1 0.306
Onecut1 one cut domain, family member 1 0.305
Gdnf glial cell line derived neurotrophic factor 0.304
Meox2 mesenchyme homeobox 2 0.285
Smo smoothened homolog (Drosophila) 0.281
Tcf15 transcription factor 15 0.280
Neurod1 neurogenic differentiation 1 0.276
Pdx1 pancreatic and duodenal homeobox 1 0.273
Prrx1 paired related homeobox 1 0.272
Neurog3 neurogenin 3 0.258
Six3 sine oculis-related homeobox 3 homolog (Drosophila) 0.249
Nkx1-2 NK1 transcription factor related, locus 2 (Drosophila) 0.245
Arx aristaless related homeobox 0.239
Sox3 SRY-box containing gene 3 0.237
Chrd chordin 0.236
Nkx6-1 NK6 homeobox 1 0.232
Pax9 paired box gene 9 0.232
Nkx2-3 NK2 transcription factor related, locus 3 (Drosophila) 0.230
Arid1a AT rich interactive domain 1A (SWI-like) 0.228
Tgfb2 transforming growth factor, beta 2 0.228
Hoxa13 homeobox A13 0.225
Snai1 snail homolog 1 (Drosophila) 0.211
Vax1 ventral anterior homeobox containing gene 1 0.211
Sall4 sal-like 4 (Drosophila) 0.209
Hoxd3 homeobox D3 0.206
Alx3 aristaless-like homeobox 3 0.192
Hoxa5 homeobox A5 0.191
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 0.186
Fgfr3 fibroblast growth factor receptor 3 0.186
Rb1 retinoblastoma 1 0.184
Itgb1 integrin beta 1 (fibronectin receptor beta) 0.184
Fgfr1 fibroblast growth factor receptor 1 0.178
Sall3 sal-like 3 (Drosophila) 0.175
Foxa2 forkhead box A2 0.174
Psen1 presenilin 1 0.171
Tlx3 T-cell leukemia, homeobox 3 0.168
Dll1 delta-like 1 (Drosophila) 0.167
Prrx2 paired related homeobox 2 0.163
Pitx1 paired-like homeodomain transcription factor 1 0.160
Gbx2 gastrulation brain homeobox 2 0.159
Sox4 SRY-box containing gene 4 0.157
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.155
Nkx3-2 NK3 homeobox 2 0.154
Hesx1 homeobox gene expressed in ES cells 0.150
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
ascl1a achaete-scute complex-like 1a (Drosophila) 0.883
sox10 SRY-box containing gene 10 0.881
pax6b paired box gene 6b 0.728
nr2e1 nuclear receptor subfamily 2, group E, member 1 0.626
notch1a notch homolog 1a 0.626
foxa2 forkhead box A2 0.551
foxa1 forkhead box A1 0.486
jag1b jagged 1b 0.401
otx2 orthodenticle homolog 2 0.394
neurog1 neurogenin 1 0.367
six3b sine oculis homeobox homolog 3b 0.365
rx3 retinal homeobox gene 3 0.302
foxg1a forkhead box G1a 0.294
nkx2.2a NK2 transcription factor related 2a 0.257
foxi1 forkhead box I1 0.247
dla deltaA 0.196
pax6a paired box gene 6a 0.192
foxi3b forkhead box I3b 0.190
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.187
gata3 GATA-binding protein 3 0.183
lhx5 LIM homeobox 5 0.183
fezf2 FEZ family zinc finger 2 0.180
neurod neurogenic differentiation 0.177
sox21b SRY-box containing gene 21 b 0.176
lmx1b.1 LIM homeobox transcription factor 1, beta 1 0.161
olig2 oligodendrocyte lineage transcription factor 2 0.160
foxi3a forkhead box I3a 0.152
pitx3 paired-like homeodomain transcription factor 3 0.147
bmper BMP binding endothelial regulator 0.142
dlb deltaB 0.140
bhlhe22 basic helix-loop-helix family, member e22 0.139
emx3 empty spiracles homeobox 3 0.136
dlx4b distal-less homeobox gene 4b 0.134
sox2 SRY-box containing gene 2 0.129
six4b sine oculis homeobox homolog 4b 0.126
eya1 eyes absent homolog 1 0.118
fzd8a frizzled homolog 8a 0.117
sox19a SRY-box containing gene 19a 0.103
nkx2.2b NK2 transcription factor related 2b 0.098
lhx1a LIM homeobox 1a 0.097
dlc deltaC 0.093
gcm2 glial cells missing homolog 2 (Drosophila) 0.091
dct dopachrome tautomerase 0.090
fn1 fibronectin 1 0.088
tfe3b transcription factor binding to IGHM enhancer 3b 0.086
crestin crestin 0.084
isl1 islet1 0.083
vsx2 visual system homeobox 2 0.080
nkx2.9 NK2 transcription factor related, locus 9 (Drosophila) 0.080
mab21l2 mab-21-like 2 0.079
pitx2 paired-like homeodomain transcription factor 2 0.079
hmx4 H6 family homeobox 4 0.073
six3a sine oculis homeobox homolog 3a 0.072
notch3 notch homolog 3 0.066
barx1 BarH-like homeobox 1 0.066
nkx2.1a NK2 homeobox 1a 0.065
gata1a GATA binding protein 1a 0.063
rx2 retinal homeobox gene 2 0.062
zic6 zic family member 6 0.059
tp63 tumor protein p63 0.055
pax2a paired box gene 2a 0.052
nr2f5 nuclear receptor subfamily 2, group F, member 5 0.052
fsta follistatin a 0.049
fgf3 fibroblast growth factor 3 0.049
arx aristaless related homeobox 0.042
gata2a GATA-binding protein 2a 0.038
rx1 retinal homeobox gene 1 0.038
nkx2.1b NK2 homeobox 1b 0.036
tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.036
foxd3 forkhead box D3 0.035
lft1 lefty1 0.035
nkx3.2 NK3 homeobox 2 0.034
foxp2 forkhead box P2 0.032
barhl2 BarH-like 2 0.032
sox1a SRY-box containing gene 1a 0.031
erbb3b v-erb-b2 erythroblastic leukemia viral oncogene homolog 3b 0.029
hlxb9la homeo box HB9 like a 0.027
jag2 jagged 2 0.027
ncs1a neuronal calcium sensor 1a 0.026
her3 hairy-related 3 0.026
cdx4 caudal type homeo box transcription factor 4 0.025
col2a1a collagen type II, alpha-1a 0.025
otx1b orthodenticle homolog 1b 0.025
neurod4 neurogenic differentiation 4 0.025
dlx2a distal-less homeobox gene 2a 0.024
her12 hairy-related 12 0.024
foxj1a forkhead box J1a 0.021
hesx1 homeo box (expressed in ES cells) 1 0.021
efnb2a ephrin B2a 0.021
slc4a1b solute carrier family 4, anion exchanger, member 1b 0.021
eng2a engrailed 2a 0.021
plp1a proteolipid protein 1a 0.021
dlx5a distal-less homeobox gene 5a 0.021
ptch2 patched 2 0.020
nr2e3 nuclear receptor subfamily 2, group E, member 3 0.020
ptch1 patched 1 0.020
cdh2 cadherin 2, neuronal 0.019
plod2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.019
spi1 spleen focus forming virus (SFFV) proviral integration oncogene spi1 0.019
nkx2.3 NK2 transcription factor related 3 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
HLHm7 E(spl) region transcript m7 0.999
E(spl) Enhancer of split 0.993
HLHmgamma E(spl) region transcript mgamma 0.991
HLHmdelta E(spl) region transcript mdelta 0.984
malpha E(spl) region transcript malpha 0.882
HLHmbeta E(spl) region transcript mbeta 0.848
HLHm5 E(spl) region transcript m5 0.739
ac achaete 0.547
HLHm3 E(spl) region transcript m3 0.528
m4 E(spl) region transcript m4 0.510
m2 E(spl) region transcript m2 0.507
wg wingless 0.405
Tom Twin of m4 0.309
ato atonal 0.303
sc scute 0.284
sens senseless 0.251
kuz kuzbanian 0.143
N Notch 0.140
en engrailed 0.108
eyg eyegone 0.096
gcm glial cells missing 0.092
ase asense 0.086
amos absent MD neurons and olfactory sensilla 0.085
Notum CG13076 gene product from transcript CG13076-RB 0.077
brk brinker 0.053
H Hairless 0.053
ptc patched 0.052
sca scabrous 0.045
Ser Serrate 0.044
caz cabeza 0.041
mib1 mind bomb 1 0.039
tap target of Poxn 0.037
Ubx Ultrabithorax 0.036
BobA Brother of Bearded A 0.035
trx trithorax 0.034
argos CG4531 gene product from transcript CG4531-RA 0.029
tll tailless 0.029
hh hedgehog 0.028
bib big brain 0.026
su(f) suppressor of forked 0.025
ara araucan 0.023
Ras85D Ras oncogene at 85D 0.022
dsh dishevelled 0.022
lab labial 0.021
ed echinoid 0.021
hep hemipterous 0.020
sv shaven 0.019
ro rough 0.019
oc ocelliless 0.019
dy dusky 0.019
sim single-minded 0.019
dpp decapentaplegic 0.018
sna snail 0.018
pb proboscipedia 0.018
Trf2 TATA box binding protein-related factor 2 0.017
ci cubitus interruptus 0.017
gro groucho 0.016
salm spalt major 0.015
Gsc Goosecoid 0.014
eg eagle 0.013
m6 E(spl) region transcript m6 0.013
Antp Antennapedia 0.013
pnt pointed 0.013
run runt 0.013
mam mastermind 0.013
CG15365 CG15365 gene product from transcript CG15365-RA 0.013
eya eyes absent 0.011
gcm2 CG3858 gene product from transcript CG3858-RA 0.011
ham hamlet 0.011
Su(H) Suppressor of Hairless 0.011
Abd-B Abdominal B 0.011
spdo sanpodo 0.010
CtBP C-terminal Binding Protein 0.010
toy twin of eyeless 0.010
odd odd skipped 0.010
klu klumpfuss 0.010
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Homo sapiens
Name Description Probability Func Analog Organism
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism