The network for 'atrioventricular valve morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

atrioventricular valve morphogenesis

The process in which the structure of the atrioventricular valve is generated and organized.

Mus musculus
Name Description Probability Func Analog Organism
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Shh sonic hedgehog 0.999
Gata4 GATA binding protein 4 0.998
Jag1 jagged 1 0.998
Fgf8 fibroblast growth factor 8 0.994
Pax3 paired box gene 3 0.990
Hand2 heart and neural crest derivatives expressed transcript 2 0.989
Hoxa1 homeobox A1 0.988
Hey2 hairy/enhancer-of-split related with YRPW motif 2 0.987
Tbx3 T-box 3 0.987
Otx2 orthodenticle homolog 2 (Drosophila) 0.985
Smad6 MAD homolog 6 (Drosophila) 0.982
Isl1 ISL1 transcription factor, LIM/homeodomain 0.980
Gli3 GLI-Kruppel family member GLI3 0.978
Foxc1 forkhead box C1 0.971
Foxc2 forkhead box C2 0.970
Notch1 Notch gene homolog 1 (Drosophila) 0.958
Tgfb2 transforming growth factor, beta 2 0.952
Tbx1 T-box 1 0.940
Efnb2 ephrin B2 0.937
Pax2 paired box gene 2 0.928
Bmp4 bone morphogenetic protein 4 0.925
Chd7 chromodomain helicase DNA binding protein 7 0.902
Prrx1 paired related homeobox 1 0.898
Hand1 heart and neural crest derivatives expressed transcript 1 0.897
Nodal nodal 0.891
Fgfr2 fibroblast growth factor receptor 2 0.878
Ctnnb1 catenin (cadherin associated protein), beta 1 0.875
Fgf10 fibroblast growth factor 10 0.867
Sox11 SRY-box containing gene 11 0.857
Ntf3 neurotrophin 3 0.852
Neurod1 neurogenic differentiation 1 0.841
Foxg1 forkhead box G1 0.826
Tcfap2a transcription factor AP-2, alpha 0.790
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.768
Pax6 paired box gene 6 0.755
Zic3 zinc finger protein of the cerebellum 3 0.744
Ptpn11 protein tyrosine phosphatase, non-receptor type 11 0.721
Snai1 snail homolog 1 (Drosophila) 0.711
Mesp1 mesoderm posterior 1 0.710
Six1 sine oculis-related homeobox 1 homolog (Drosophila) 0.680
Rxra retinoid X receptor alpha 0.630
Gata1 GATA binding protein 1 0.630
Nos3 nitric oxide synthase 3, endothelial cell 0.623
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.612
Pitx1 paired-like homeodomain transcription factor 1 0.578
Sox9 SRY-box containing gene 9 0.575
Hey1 hairy/enhancer-of-split related with YRPW motif 1 0.557
Hes1 hairy and enhancer of split 1 (Drosophila) 0.531
Neurog2 neurogenin 2 0.488
Smad3 MAD homolog 3 (Drosophila) 0.457
Gata6 GATA binding protein 6 0.453
Bmpr1a bone morphogenetic protein receptor, type 1A 0.432
Gbx2 gastrulation brain homeobox 2 0.425
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.393
Eya1 eyes absent 1 homolog (Drosophila) 0.374
Meox2 mesenchyme homeobox 2 0.371
Hes5 hairy and enhancer of split 5 (Drosophila) 0.366
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.355
Vegfa vascular endothelial growth factor A 0.328
Hspg2 perlecan (heparan sulfate proteoglycan 2) 0.320
Hoxa13 homeobox A13 0.312
Dll4 delta-like 4 (Drosophila) 0.307
Apc adenomatosis polyposis coli 0.298
Smad4 MAD homolog 4 (Drosophila) 0.277
Nog noggin 0.269
Sox2 SRY-box containing gene 2 0.257
Tal1 T-cell acute lymphocytic leukemia 1 0.247
Hoxd13 homeobox D13 0.247
Lhx9 LIM homeobox protein 9 0.242
Wt1 Wilms tumor 1 homolog 0.240
Ptf1a pancreas specific transcription factor, 1a 0.222
Chrd chordin 0.217
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.210
Mycn v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) 0.209
Foxh1 forkhead box H1 0.205
T brachyury 0.205
Zeb1 zinc finger E-box binding homeobox 1 0.195
Gsc goosecoid homeobox 0.185
She src homology 2 domain-containing transforming protein E 0.174
Smad1 MAD homolog 1 (Drosophila) 0.169
Gli2 GLI-Kruppel family member GLI2 0.163
Emx1 empty spiracles homolog 1 (Drosophila) 0.158
Sox7 SRY-box containing gene 7 0.152
Alx4 aristaless-like homeobox 4 0.149
En1 engrailed 1 0.149
Vangl2 vang-like 2 (van gogh, Drosophila) 0.136
Insm1 insulinoma-associated 1 0.134
Gdf3 growth differentiation factor 3 0.131
Meox1 mesenchyme homeobox 1 0.126
Foxd2 forkhead box D2 0.125
Myl2 myosin, light polypeptide 2, regulatory, cardiac, slow 0.124
Gja1 gap junction protein, alpha 1 0.122
Rarg retinoic acid receptor, gamma 0.122
Bdnf brain derived neurotrophic factor 0.121
Gdf1 growth differentiation factor 1 0.120
Bnc1 basonuclin 1 0.119
Rarb retinoic acid receptor, beta 0.118
Acvr1 activin A receptor, type 1 0.117
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp4 bone morphogenetic protein 4 0.897
tbx5a T-box 5a 0.847
tal1 T-cell acute lymphocytic leukemia 1 0.707
tbx20 T-box 20 0.658
hand2 heart and neural crest derivatives expressed transcript 2 0.601
fli1a friend leukemia integration 1a 0.442
tbx2a T-box gene 2a 0.411
gata6 GATA-binding protein 6 0.384
lft2 lefty2 0.381
bmp2b bone morphogenetic protein 2b 0.341
ptch1 patched 1 0.286
nkx2.5 NK2 transcription factor related 5 0.203
cdh2 cadherin 2, neuronal 0.200
hnf1ba HNF1 homeobox Ba 0.162
notch1b notch homolog 1b 0.149
tbx18 T-box 18 0.146
hhex hematopoietically expressed homeobox 0.134
wnt11r wingless-type MMTV integration site family, member 11, related 0.125
dld deltaD 0.117
hey2 hairy/enhancer-of-split related with YRPW motif 2 0.109
nfatc1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 0.103
runx1 runt-related transcription factor 1 0.094
wnt2bb wingless-type MMTV integration site family, member 2Bb 0.091
lft1 lefty1 0.088
her7 hairy and enhancer of split related-7 0.084
kdrl kinase insert domain receptor like 0.082
fn1 fibronectin 1 0.081
bactin1 bactin1 0.074
gsna gelsolin a 0.073
znfl2a zinc finger-like gene 2a 0.069
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.067
myl7 myosin, light polypeptide 7, regulatory 0.061
myod1 myogenic differentiation 1 0.060
irx3a iroquois homeobox protein 3a 0.059
wnt9a wingless-type MMTV integration site family, member 9A 0.052
tbx2b T-box 2b 0.052
tpm4 tropomyosin 4 0.052
alcama activated leukocyte cell adhesion molecule a 0.051
drl draculin 0.051
lmo2 LIM domain only 2 (rhombotin-like 1) 0.050
tgfb3 transforming growth factor, beta 3 0.050
dlc deltaC 0.047
klf2a Kruppel-like factor 2a 0.044
dlx3b distal-less homeobox gene 3b 0.043
mmp2 matrix metalloproteinase 2 0.043
cxcr4a chemokine (C-X-C motif) receptor 4a 0.041
tp63 tumor protein p63 0.037
tbx5b T-box 5b 0.037
tcf21 transcription factor 21 0.035
myf5 myogenic factor 5 0.035
vmhc ventricular myosin heavy chain 0.035
hspb7 heat shock protein family, alpha-crystallin-related, b7 0.035
osr2 odd-skipped related 2 (Drosophila) 0.034
nppa natriuretic peptide precursor A 0.034
crip2 cysteine-rich protein 2 0.033
pitx2 paired-like homeodomain transcription factor 2 0.033
tnni1b troponin I, skeletal, slow b 0.033
foxn4 forkhead box N4 0.032
foxa1 forkhead box A1 0.030
gata2a GATA-binding protein 2a 0.029
tbx1 T-box 1 0.028
myh6 myosin, heavy polypeptide 6, cardiac muscle, alpha 0.027
lhx1a LIM homeobox 1a 0.026
zic2a zic family member 2 (odd-paired homolog, Drosophila), a 0.025
tbx16 T-box gene 16 0.025
vcana versican a 0.025
wnt5b wingless-type MMTV integration site family, member 5b 0.024
robo3 roundabout homolog 3 0.024
bmper BMP binding endothelial regulator 0.023
cmyb transcription factor cmyb 0.023
flot2a flotillin 2a 0.023
prrx1a paired related homeobox 1a 0.023
pkd2 polycystic kidney disease 2 0.022
hspb1 heat shock protein, alpha-crystallin-related, 1 0.022
cdh5 cadherin 5 0.022
gatsl2 GATS protein-like 2 0.022
has2 hyaluronan synthase 2 0.021
her1 hairy-related 1 0.021
pdlim7 PDZ and LIM domain 7 0.021
cdh1 cadherin 1, epithelial 0.019
ndrg4 N-myc downstream regulated gene 4 0.019
aplnrb apelin receptor b 0.019
sox4a SRY-box containing gene 4a 0.018
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.018
osr1 odd-skipped related 1 (Drosophila) 0.017
dhrs3a dehydrogenase/reductase (SDR family) member 3a 0.017
msxc muscle segment homeobox C 0.017
neo1 neogenin 1 0.017
lama5 laminin, alpha 5 0.017
notch2 notch homolog 2 0.017
ttna titin a 0.017
ywhai tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide 0.016
cmlc1 cardiac myosin light chain-1 0.016
fgf17 fibroblast growth factor 17 0.016
tubb5 tubulin, beta 5 0.015
spaw southpaw 0.015
ascl1a achaete-scute complex-like 1a (Drosophila) 0.015
sdprb serum deprivation response b 0.014
shha sonic hedgehog a 0.014
mef2cb myocyte enhancer factor 2cb 0.014
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Drosophila melanogaster
Name Description Probability Func Analog Organism
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Homo sapiens
Name Description Probability Func Analog Organism
JAG1 jagged 1 1.000
FKBP1A FK506 binding protein 1A, 12kDa 0.997
BMPR1A bone morphogenetic protein receptor, type IA 0.992
TGFB1 transforming growth factor, beta 1 0.977
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.974
BMP2 bone morphogenetic protein 2 0.965
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.940
NOTCH1 notch 1 0.897
FSTL1 follistatin-like 1 0.826
SKIL SKI-like oncogene 0.795
NOTCH3 notch 3 0.791
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.686
TAL1 T-cell acute lymphocytic leukemia 1 0.656
GDF5 growth differentiation factor 5 0.637
TGFB3 transforming growth factor, beta 3 0.529
ENG endoglin 0.456
CXXC5 CXXC finger protein 5 0.377
CTNNBIP1 catenin, beta interacting protein 1 0.363
SETD8 SET domain containing (lysine methyltransferase) 8 0.341
DLL1 delta-like 1 (Drosophila) 0.249
MAPK8 mitogen-activated protein kinase 8 0.248
PRKG1 protein kinase, cGMP-dependent, type I 0.247
ACVR1 activin A receptor, type I 0.246
SMAD2 SMAD family member 2 0.228
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.223
SMAD7 SMAD family member 7 0.202
ZMYND11 zinc finger, MYND-type containing 11 0.190
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.179
GATA1 GATA binding protein 1 (globin transcription factor 1) 0.155
MAML1 mastermind-like 1 (Drosophila) 0.137
JAG2 jagged 2 0.135
NRP1 neuropilin 1 0.122
GSK3B glycogen synthase kinase 3 beta 0.118
SKI v-ski sarcoma viral oncogene homolog (avian) 0.112
XIAP X-linked inhibitor of apoptosis 0.106
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.101
GATA4 GATA binding protein 4 0.089
CTGF connective tissue growth factor 0.088
TBX5 T-box 5 0.086
BMP4 bone morphogenetic protein 4 0.081
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.076
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.074
SMAD1 SMAD family member 1 0.070
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like 0.047
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.046
MARCKSL1 MARCKS-like 1 0.046
FBLN1 fibulin 1 0.044
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.042
NOTCH2 notch 2 0.041
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.040
TGFBR1 transforming growth factor, beta receptor 1 0.039
AMOTL2 angiomotin like 2 0.038
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.037
PDGFC platelet derived growth factor C 0.037
DCP1A DCP1 decapping enzyme homolog A (S. cerevisiae) 0.036
NOG noggin 0.034
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.033
SP1 Sp1 transcription factor 0.033
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) 0.033
APC adenomatous polyposis coli 0.028
ANKRD13A ankyrin repeat domain 13A 0.027
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.025
EGFL7 EGF-like-domain, multiple 7 0.024
RBPMS RNA binding protein with multiple splicing 0.023
PIAS1 protein inhibitor of activated STAT, 1 0.022
TCF12 transcription factor 12 0.022
SMAD6 SMAD family member 6 0.022
CTBP2 C-terminal binding protein 2 0.022
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.022
ZFYVE9 zinc finger, FYVE domain containing 9 0.021
CTNND1 catenin (cadherin-associated protein), delta 1 0.021
KLF13 Kruppel-like factor 13 0.021
ZEB2 zinc finger E-box binding homeobox 2 0.021
ATXN1L ataxin 1-like 0.021
WDYHV1 WDYHV motif containing 1 0.021
EFNB2 ephrin-B2 0.021
GADD45B growth arrest and DNA-damage-inducible, beta 0.021
CAMSAP1 calmodulin regulated spectrin-associated protein 1 0.020
NCOR1 nuclear receptor corepressor 1 0.020
HEY1 hairy/enhancer-of-split related with YRPW motif 1 0.019
TGFBR3 transforming growth factor, beta receptor III 0.019
RXRA retinoid X receptor, alpha 0.018
HAND2 heart and neural crest derivatives expressed 2 0.018
GABPA GA binding protein transcription factor, alpha subunit 60kDa 0.018
ELK1 ELK1, member of ETS oncogene family 0.018
FOXF2 forkhead box F2 0.018
RAMP2 receptor (G protein-coupled) activity modifying protein 2 0.017
MKL2 MKL/myocardin-like 2 0.017
YAP1 Yes-associated protein 1 0.016
HES1 hairy and enhancer of split 1, (Drosophila) 0.016
VEGFA vascular endothelial growth factor A 0.016
GATA2 GATA binding protein 2 0.016
TGFB2 transforming growth factor, beta 2 0.016
HIPK1 homeodomain interacting protein kinase 1 0.015
USP15 ubiquitin specific peptidase 15 0.015
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 0.015
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.015
VPS24 vacuolar protein sorting 24 homolog (S. cerevisiae) 0.015
ZBED5 zinc finger, BED-type containing 5 0.015
HOXA5 homeobox A5 0.014
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Rattus norvegicus
Name Description Probability Func Analog Organism
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism