The network for 'limb development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

limb development

The process whose specific outcome is the progression of a limb over time, from its formation to the mature structure. A limb is an appendage of an animal used for locomotion or grasping. Examples include legs, arms or some types of fin.

Mus musculus
Name Description Probability Func Analog Organism
Gli3 GLI-Kruppel family member GLI3 1.000
Fgfr2 fibroblast growth factor receptor 2 1.000
Shh sonic hedgehog 1.000
Pitx2 paired-like homeodomain transcription factor 2 1.000
Pax2 paired box gene 2 1.000
Msx2 homeobox, msh-like 2 1.000
Tcfap2a transcription factor AP-2, alpha 1.000
Pax3 paired box gene 3 1.000
Gli2 GLI-Kruppel family member GLI2 1.000
Rarg retinoic acid receptor, gamma 1.000
Otx2 orthodenticle homolog 2 (Drosophila) 0.999
Hand1 heart and neural crest derivatives expressed transcript 1 0.999
Fgfr1 fibroblast growth factor receptor 1 0.999
Foxc1 forkhead box C1 0.999
Hoxa10 homeobox A10 0.999
Tbx3 T-box 3 0.999
Dlx5 distal-less homeobox 5 0.999
Pitx1 paired-like homeodomain transcription factor 1 0.999
Alx4 aristaless-like homeobox 4 0.999
Wnt5a wingless-related MMTV integration site 5A 0.999
Bmp7 bone morphogenetic protein 7 0.999
Pax6 paired box gene 6 0.998
Ror2 receptor tyrosine kinase-like orphan receptor 2 0.998
Hoxa11 homeobox A11 0.997
Prrx1 paired related homeobox 1 0.997
Pten phosphatase and tensin homolog 0.997
Hoxd13 homeobox D13 0.997
Bmp4 bone morphogenetic protein 4 0.996
Runx2 runt related transcription factor 2 0.996
Lef1 lymphoid enhancer binding factor 1 0.996
Hoxa13 homeobox A13 0.996
Nodal nodal 0.995
Sox9 SRY-box containing gene 9 0.995
Fgf8 fibroblast growth factor 8 0.994
Rara retinoic acid receptor, alpha 0.993
Tbx15 T-box 15 0.993
Lhx1 LIM homeobox protein 1 0.992
Foxc2 forkhead box C2 0.992
Chrd chordin 0.991
Rxra retinoid X receptor alpha 0.990
Pkd1 polycystic kidney disease 1 homolog 0.989
Hand2 heart and neural crest derivatives expressed transcript 2 0.989
Fgf10 fibroblast growth factor 10 0.989
Prrx2 paired related homeobox 2 0.987
Pcsk5 proprotein convertase subtilisin/kexin type 5 0.986
Tgfbr2 transforming growth factor, beta receptor II 0.985
Smo smoothened homolog (Drosophila) 0.984
Isl1 ISL1 transcription factor, LIM/homeodomain 0.981
En1 engrailed 1 0.980
Sall4 sal-like 4 (Drosophila) 0.979
Rarb retinoic acid receptor, beta 0.972
Gsc goosecoid homeobox 0.969
Msx1 homeobox, msh-like 1 0.968
Wnt3a wingless-related MMTV integration site 3A 0.965
Pdgfra platelet derived growth factor receptor, alpha polypeptide 0.965
Fgfr3 fibroblast growth factor receptor 3 0.964
Hoxd11 homeobox D11 0.961
Pax8 paired box gene 8 0.960
Hoxd10 homeobox D10 0.959
Thra thyroid hormone receptor alpha 0.955
Fuz fuzzy homolog (Drosophila) 0.953
Gdf5 growth differentiation factor 5 0.952
Rbpj recombination signal binding protein for immunoglobulin kappa J region 0.951
Tgfb2 transforming growth factor, beta 2 0.949
Nkx2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.945
Twist1 twist homolog 1 (Drosophila) 0.945
Fbn1 fibrillin 1 0.943
Sox2 SRY-box containing gene 2 0.941
Pax9 paired box gene 9 0.937
Pou3f3 POU domain, class 3, transcription factor 3 0.935
Zic3 zinc finger protein of the cerebellum 3 0.933
Neurog3 neurogenin 3 0.930
Hoxa9 homeobox A9 0.928
Tbx4 T-box 4 0.926
Foxd3 forkhead box D3 0.922
Dkk1 dickkopf homolog 1 (Xenopus laevis) 0.920
Nog noggin 0.917
Twist2 twist homolog 2 (Drosophila) 0.917
Trp63 transformation related protein 63 0.904
Wnt6 wingless-related MMTV integration site 6 0.901
Nr5a1 nuclear receptor subfamily 5, group A, member 1 0.892
Tbx5 T-box 5 0.877
Dlx1 distal-less homeobox 1 0.876
Sox10 SRY-box containing gene 10 0.870
Tbx1 T-box 1 0.870
Ascl1 achaete-scute complex homolog 1 (Drosophila) 0.867
Acvr1 activin A receptor, type 1 0.860
Lhx9 LIM homeobox protein 9 0.855
Igdcc3 immunoglobulin superfamily, DCC subclass, member 3 0.854
Tcf15 transcription factor 15 0.854
Col1a1 collagen, type I, alpha 1 0.847
Fzd2 frizzled homolog 2 (Drosophila) 0.846
Mmp14 matrix metallopeptidase 14 (membrane-inserted) 0.845
Alx3 aristaless-like homeobox 3 0.841
Foxh1 forkhead box H1 0.839
Notch1 Notch gene homolog 1 (Drosophila) 0.838
Foxf1a forkhead box F1a 0.834
Sema6a sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.832
Pbx1 pre B-cell leukemia transcription factor 1 0.831
Eya1 eyes absent 1 homolog (Drosophila) 0.826
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Caenorhabditis elegans
Name Description Probability Func Analog Organism
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Danio rerio
Name Description Probability Func Analog Organism
bmp2b bone morphogenetic protein 2b 0.975
wnt5b wingless-type MMTV integration site family, member 5b 0.602
dlx2a distal-less homeobox gene 2a 0.583
dlx5a distal-less homeobox gene 5a 0.523
fgf24 fibroblast growth factor 24 0.483
shha sonic hedgehog a 0.429
hoxa9b homeo box A9b 0.419
hoxd13a homeo box D13a 0.313
hoxa11b homeo box A11b 0.300
osr2 odd-skipped related 2 (Drosophila) 0.257
hand2 heart and neural crest derivatives expressed transcript 2 0.253
hoxa13b homeo box A13b 0.238
gli2a GLI-Kruppel family member GLI2a 0.221
hoxd11a homeo box D11a 0.203
hoxa11a homeo box A11a 0.203
msxd muscle segment homeobox D 0.193
sox9a SRY-box containing gene 9a 0.186
gbx2 gastrulation brain homeo box 2 0.173
chd chordin 0.162
tbx18 T-box 18 0.134
bmp4 bone morphogenetic protein 4 0.124
msxc muscle segment homeobox C 0.119
fgf10a fibroblast growth factor 10a 0.118
gsc goosecoid 0.117
neo1 neogenin 1 0.110
aldh1a2 aldehyde dehydrogenase 1 family, member A2 0.107
prrx1a paired related homeobox 1a 0.105
hoxa9a homeo box A9a 0.092
hoxa10b homeo box A10b 0.092
robo3 roundabout homolog 3 0.085
fgf8a fibroblast growth factor 8 a 0.081
pax9 paired box gene 9 0.072
bmp2a bone morphogenetic protein 2a 0.071
hoxd10a homeo box D10a 0.066
hoxd12a homeo box D12a 0.065
msxb muscle segment homeobox B 0.063
mib mind bomb 0.062
msxe muscle segment homeobox E 0.062
hoxd9a homeo box D9a 0.053
fgf3 fibroblast growth factor 3 0.051
cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 0.050
dlx3b distal-less homeobox gene 3b 0.050
hoxa13a homeo box A13a 0.047
col2a1a collagen type II, alpha-1a 0.047
dusp6 dual specificity phosphatase 6 0.047
hoxc6a homeo box C6a 0.045
pcdh8 protocadherin 8 0.041
dact2 dapper homolog 2, antagonist of beta-catenin (xenopus) 0.039
snai1a snail homolog 1a (Drosophila) 0.039
dlx4b distal-less homeobox gene 4b 0.038
tfap2a transcription factor AP-2 alpha 0.038
vcanb versican b 0.038
tbx2b T-box 2b 0.037
tbx2a T-box gene 2a 0.035
wnt11 wingless-type MMTV integration site family, member 11 0.034
spry4 sprouty (Drosophila) homolog 4 0.032
lef1 lymphocyte enhancer binding factor 1 0.032
notch1a notch homolog 1a 0.031
vcana versican a 0.031
osr1 odd-skipped related 1 (Drosophila) 0.031
prdm16 PR domain containing 16 0.030
hey1 hairy/enhancer-of-split related with YRPW motif 1 0.030
col1a1a collagen, type I, alpha 1a 0.030
dact1 dapper homolog 1, antagonist of beta-catenin (xenopus) 0.029
twist3 twist3 0.029
dkk1b dickkopf 1b 0.028
barx2 BarH-like homeobox 2 0.028
meis3 myeloid ecotropic viral integration site 3 0.027
tbx16 T-box gene 16 0.027
pea3 ETS-domain transcription factor pea3 0.026
eya1 eyes absent homolog 1 0.025
tcf7 transcription factor 7 (T-cell specific, HMG-box) 0.024
sox9b SRY-box containing gene 9b 0.024
gli3 GLI-Kruppel family member GLI3 0.024
aldh1a3 aldehyde dehydrogenase 1 family, member A3 0.023
bmpr2a bone morphogenetic protein receptor, type II a (serine/threonine kinase) 0.023
pitx3 paired-like homeodomain transcription factor 3 0.022
tbx5a T-box 5a 0.022
sparc secreted acidic cysteine rich glycoprotein 0.022
ihha Indian hedgehog homolog a 0.021
and1 actinodin1 0.021
si:ch211-173o4.2 si:ch211-173o4.2 0.021
notch3 notch homolog 3 0.021
smad9 MAD homolog 9 (Drosophila) 0.021
runx2b runt-related transcription factor 2b 0.020
ascl1a achaete-scute complex-like 1a (Drosophila) 0.020
fgf17 fibroblast growth factor 17 0.020
crabp2b cellular retinoic acid binding protein 2, b 0.020
rxraa retinoid X receptor, alpha a 0.020
hoxb1b homeo box B1b 0.019
znf503 zinc finger protein 503 0.019
smo smoothened homolog (Drosophila) 0.019
etv5b ets variant 5b 0.019
eve1 even-skipped-like1 0.019
tbx15 T-box 15 0.019
tcf12 transcription factor 12 0.018
prrx1b paired related homeobox 1b 0.018
nkx2.5 NK2 transcription factor related 5 0.018
dcc deleted in colorectal carcinoma 0.018
pcsk5b proprotein convertase subtilisin/kexin type 5b 0.018
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Drosophila melanogaster
Name Description Probability Func Analog Organism
wg wingless 0.949
en engrailed 0.629
dally division abnormally delayed 0.461
ci cubitus interruptus 0.447
fng fringe 0.361
vvl ventral veins lacking 0.340
dpp decapentaplegic 0.321
kn knot 0.306
Egfr Epidermal growth factor receptor 0.293
slp1 sloppy paired 1 0.261
ara araucan 0.245
hh hedgehog 0.227
sog short gastrulation 0.227
Dll Distal-less 0.220
odd odd skipped 0.217
tld tolloid 0.204
al aristaless 0.199
nkd naked cuticle 0.197
shg shotgun 0.196
pan pangolin 0.189
dsh dishevelled 0.183
Doc2 Dorsocross2 0.178
bi bifid 0.171
mirr mirror 0.162
gcm glial cells missing 0.159
esg escargot 0.159
tin tinman 0.154
amos absent MD neurons and olfactory sensilla 0.151
Ser Serrate 0.142
acj6 abnormal chemosensory jump 6 0.141
Cdk4 Cyclin-dependent kinase 4 0.137
in inturned 0.130
kni knirps 0.127
lolal lola like 0.126
argos CG4531 gene product from transcript CG4531-RA 0.125
twi twist 0.125
Dad Daughters against dpp 0.107
shn schnurri 0.103
Ubx Ultrabithorax 0.100
Wnt2 Wnt oncogene analog 2 0.096
tkv thickveins 0.095
if inflated 0.094
rk rickets 0.091
O-fut1 O-fucosyltransferase 1 0.089
drm drumstick 0.088
bnl branchless 0.088
ed echinoid 0.087
Ptp69D Protein tyrosine phosphatase 69D 0.086
E(spl) Enhancer of split 0.085
opa odd paired 0.084
csw corkscrew 0.083
18w 18 wheeler 0.082
fas faint sausage 0.082
fz frizzled 0.081
dap dacapo 0.080
fz2 frizzled 2 0.078
pnr pannier 0.075
Lim3 CG10699 gene product from transcript CG10699-RB 0.074
slmb supernumerary limbs 0.072
hbs hibris 0.071
dsf dissatisfaction 0.070
elB elbow B 0.070
spdo sanpodo 0.069
CG32372 CG32372 gene product from transcript CG32372-RA 0.069
ck crinkled 0.068
rpr reaper 0.068
dve defective proventriculus 0.068
por porcupine 0.067
mid midline 0.064
pb proboscipedia 0.064
sca scabrous 0.063
lbl ladybird late 0.062
ems empty spiracles 0.060
Pli Pellino 0.059
lab labial 0.059
eve even skipped 0.059
nompC no mechanoreceptor potential C 0.058
sli slit 0.058
btl breathless 0.057
Notum CG13076 gene product from transcript CG13076-RB 0.057
pain painless 0.057
put punt 0.056
disco disconnected 0.056
sr stripe 0.056
klu klumpfuss 0.055
CG32556 CG32556 gene product from transcript CG32556-RB 0.055
tsh teashirt 0.055
grh grainy head 0.055
Btk29A Btk family kinase at 29A 0.054
Myd88 CG2078 gene product from transcript CG2078-RA 0.054
sd scalloped 0.052
Poxn Pox neuro 0.052
tsg twisted gastrulation 0.051
Tollo CG6890 gene product from transcript CG6890-RA 0.051
smo smoothened 0.051
hth homothorax 0.050
Su(var)3-7 Suppressor of variegation 3-7 0.050
ato atonal 0.050
nub nubbin 0.049
rempA reduced mechanoreceptor potential A 0.049
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Homo sapiens
Name Description Probability Func Analog Organism
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.991
FHL2 four and a half LIM domains 2 0.970
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.555
ZNF43 zinc finger protein 43 0.542
JAG1 jagged 1 0.535
FN1 fibronectin 1 0.507
PAX3 paired box 3 0.437
SMAD3 SMAD family member 3 0.434
ZFYVE9 zinc finger, FYVE domain containing 9 0.380
TGFB1 transforming growth factor, beta 1 0.361
ZNF253 zinc finger protein 253 0.336
APP amyloid beta (A4) precursor protein 0.315
ENG endoglin 0.258
ZNF273 zinc finger protein 273 0.215
COL1A1 collagen, type I, alpha 1 0.207
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.196
NKX2-5 NK2 transcription factor related, locus 5 (Drosophila) 0.192
BMP2 bone morphogenetic protein 2 0.178
MEIS1 Meis homeobox 1 0.136
ITGAV integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51) 0.134
ZNF675 zinc finger protein 675 0.132
SUFU suppressor of fused homolog (Drosophila) 0.130
FLNB filamin B, beta 0.123
FKBP1A FK506 binding protein 1A, 12kDa 0.114
SMO smoothened homolog (Drosophila) 0.111
PML promyelocytic leukemia 0.102
CHD7 chromodomain helicase DNA binding protein 7 0.098
ELL2 elongation factor, RNA polymerase II, 2 0.096
MMP2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) 0.095
HOXA10 homeobox A10 0.093
SMAD2 SMAD family member 2 0.086
ARRB1 arrestin, beta 1 0.080
THBS1 thrombospondin 1 0.077
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) 0.076
COL2A1 collagen, type II, alpha 1 0.065
SETD8 SET domain containing (lysine methyltransferase) 8 0.064
SKIL SKI-like oncogene 0.057
SIN3A SIN3 homolog A, transcription regulator (yeast) 0.057
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.054
ZNF430 zinc finger protein 430 0.052
EIF2C2 eukaryotic translation initiation factor 2C, 2 0.052
FBLN1 fibulin 1 0.052
MLLT1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 0.052
BMPR1A bone morphogenetic protein receptor, type IA 0.052
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.049
SOX2 SRY (sex determining region Y)-box 2 0.048
HOXD13 homeobox D13 0.048
ZNF254 zinc finger protein 254 0.048
FSTL1 follistatin-like 1 0.047
GATA4 GATA binding protein 4 0.047
HTT huntingtin 0.046
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.046
PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog) 0.045
TLN1 talin 1 0.044
TJP1 tight junction protein 1 (zona occludens 1) 0.044
MDFI MyoD family inhibitor 0.044
YY1 YY1 transcription factor 0.044
MMP14 matrix metallopeptidase 14 (membrane-inserted) 0.042
ZNF117 zinc finger protein 117 0.042
FGF1 fibroblast growth factor 1 (acidic) 0.041
MEIS2 Meis homeobox 2 0.040
BAK1 BCL2-antagonist/killer 1 0.039
ZNF708 zinc finger protein 708 0.038
SMAD4 SMAD family member 4 0.038
FGF18 fibroblast growth factor 18 0.038
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) 0.038
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.037
EIF2C1 eukaryotic translation initiation factor 2C, 1 0.036
MDM2 Mdm2 p53 binding protein homolog (mouse) 0.036
MMP11 matrix metallopeptidase 11 (stromelysin 3) 0.035
HOXC8 homeobox C8 0.035
FOXF2 forkhead box F2 0.033
FOXC1 forkhead box C1 0.033
PSEN1 presenilin 1 0.032
BMP4 bone morphogenetic protein 4 0.032
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.032
PDZD11 PDZ domain containing 11 0.032
TGFB3 transforming growth factor, beta 3 0.031
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 0.031
DLX4 distal-less homeobox 4 0.030
HDAC1 histone deacetylase 1 0.030
ACAN aggrecan 0.029
ZNF93 zinc finger protein 93 0.029
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.029
HOXD9 homeobox D9 0.029
SFRP1 secreted frizzled-related protein 1 0.029
COL17A1 collagen, type XVII, alpha 1 0.028
HOXD11 homeobox D11 0.028
MSX2 msh homeobox 2 0.027
NRP1 neuropilin 1 0.027
DAB2 disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) 0.027
ITGB4 integrin, beta 4 0.027
ZNF680 zinc finger protein 680 0.027
LRP6 low density lipoprotein receptor-related protein 6 0.026
FLNA filamin A, alpha 0.026
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.026
HOXC6 homeobox C6 0.026
COL1A2 collagen, type I, alpha 2 0.026
RARG retinoic acid receptor, gamma 0.026
COL11A1 collagen, type XI, alpha 1 0.025
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Rattus norvegicus
Name Description Probability Func Analog Organism
Glg1 golgi apparatus protein 1 0.057
Col12a1 collagen, type XII, alpha 1 0.056
Nfib nuclear factor I/B 0.048
Igfbp5 insulin-like growth factor binding protein 5 0.046
Nkd1 naked cuticle homolog 1 (Drosophila) 0.043
Msx1 msh homeobox 1 0.037
Ankrd1 ankyrin repeat domain 1 (cardiac muscle) 0.035
Cald1 caldesmon 1 0.031
Mmp13 matrix metallopeptidase 13 0.029
Shox2 short stature homeobox 2 0.027
Fgf7 fibroblast growth factor 7 0.024
Fgfr2 fibroblast growth factor receptor 2 0.022
Tacr1 tachykinin receptor 1 0.020
Itpr3 inositol 1,4,5-triphosphate receptor, type 3 0.020
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 0.018
Nedd4 neural precursor cell expressed, developmentally down-regulated 4 0.017
Lef1 lymphoid enhancer binding factor 1 0.015
Jak1 Janus kinase 1 0.014
Bmp4 bone morphogenetic protein 4 0.014
Tgfb2 transforming growth factor, beta 2 0.013
Mrgprf MAS-related GPR, member F 0.011
Ptpn14 protein tyrosine phosphatase, non-receptor type 14 0.011
Ubtf upstream binding transcription factor, RNA polymerase I 0.011
Ccna1 cyclin A1 0.011
Phex phosphate regulating endopeptidase homolog, X-linked 0.010
Snrpd2 small nuclear ribonucleoprotein D2 polypeptide 0.010
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Saccharomyces cerevisiae
Name Description Probability Func Analog Organism