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Homo sapiens

22 genes annotated in human

synucleinopathy

DOID:0050890

A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "synucleinopathy"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "synucleinopathy" (in gray)

Name	Description	Probability	Func Analog Organism
PINK1	PTEN induced putative kinase 1	0.965
SNCA	synuclein, alpha (non A4 component of amyloid precursor)	0.661
LAMP1	lysosomal-associated membrane protein 1	0.632
FBXO7	F-box protein 7	0.631
ZNF746	zinc finger protein 746	0.492
DNM1	dynamin 1	0.421
DCTN1	dynactin 1	0.419
AMPH	amphiphysin	0.361
SOD1	superoxide dismutase 1, soluble	0.326
SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	0.309
TAF1	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	0.307
MAPT	microtubule-associated protein tau	0.286
GAK	cyclin G associated kinase	0.172	Human
XPO6	exportin 6	0.170
GSK3B	glycogen synthase kinase 3 beta	0.150
TAF12	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa	0.134
SNCAIP	synuclein, alpha interacting protein	0.129
TAF1B	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	0.120
LRRK2	leucine-rich repeat kinase 2	0.117
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.116
AAK1	AP2 associated kinase 1	0.115
TAF4	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	0.095
NUP54	nucleoporin 54kDa	0.094
PARK2	parkinson protein 2, E3 ubiquitin protein ligase (parkin)	0.088
EIF4A1	eukaryotic translation initiation factor 4A1	0.081
AKT1	v-akt murine thymoma viral oncogene homolog 1	0.076
BAG2	BCL2-associated athanogene 2	0.075
PABPC1	poly(A) binding protein, cytoplasmic 1	0.072
SORBS2	sorbin and SH3 domain containing 2	0.070
MARK1	MAP/microtubule affinity-regulating kinase 1	0.066
LRP6	low density lipoprotein receptor-related protein 6	0.065
MAP2K6	mitogen-activated protein kinase kinase 6	0.064
TAF1C	TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa	0.058
SH3GL2	SH3-domain GRB2-like 2	0.057
TAF1A	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa	0.053
UBE2J2	ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)	0.052
RAB5B	RAB5B, member RAS oncogene family	0.048
TUBA1A	tubulin, alpha 1a	0.047
NXF1	nuclear RNA export factor 1	0.045
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.044	Human
MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	0.043
HDAC6	histone deacetylase 6	0.043
IRF3	interferon regulatory factor 3	0.040
HSPA1B	heat shock 70kDa protein 1B	0.036
MARK2	MAP/microtubule affinity-regulating kinase 2	0.036
DVL3	dishevelled, dsh homolog 3 (Drosophila)	0.033
ARHGEF7	Rho guanine nucleotide exchange factor (GEF) 7	0.032
APLP1	amyloid beta (A4) precursor-like protein 1	0.031
MAP1B	microtubule-associated protein 1B	0.031
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.029
PSMF1	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)	0.028
MYO1E	myosin IE	0.028
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.026
PDCD2	programmed cell death 2	0.026
SYT11	synaptotagmin XI	0.026
TUBB	tubulin, beta	0.025
PCBP1	poly(rC) binding protein 1	0.024
TAF7	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa	0.024
VIM	vimentin	0.023
TPPP	tubulin polymerization promoting protein	0.021
DOCK7	dedicator of cytokinesis 7	0.021
DVL1	dishevelled, dsh homolog 1 (Drosophila)	0.021
APC	adenomatous polyposis coli	0.021
APP	amyloid beta (A4) precursor protein	0.021
AP3D1	adaptor-related protein complex 3, delta 1 subunit	0.020
SPTBN1	spectrin, beta, non-erythrocytic 1	0.020
DIABLO	diablo, IAP-binding mitochondrial protein	0.019
CYLD	cylindromatosis (turban tumor syndrome)	0.019
EIF3I	eukaryotic translation initiation factor 3, subunit I	0.017
KIAA1967	KIAA1967	0.017
DIS3L	DIS3 mitotic control homolog (S. cerevisiae)-like	0.017
GTF2A1	general transcription factor IIA, 1, 19/37kDa	0.017
SYN1	synapsin I	0.016
ADH1B	alcohol dehydrogenase 1B (class I), beta polypeptide	0.016
A1BG	alpha-1-B glycoprotein	0.015
KIAA0100	KIAA0100	0.015
CHPF	chondroitin polymerizing factor	0.015
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.015
TRAF2	TNF receptor-associated factor 2	0.015
ZNF512B	zinc finger protein 512B	0.014
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.014
LMAN2	lectin, mannose-binding 2	0.014
PACRG	PARK2 co-regulated	0.014
BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	0.014
WDTC1	WD and tetratricopeptide repeats 1	0.013
PAG1	phosphoprotein associated with glycosphingolipid microdomains 1	0.013
GPR21	G protein-coupled receptor 21	0.013
FKBP8	FK506 binding protein 8, 38kDa	0.013
RBM12	RNA binding motif protein 12	0.013
CAMK2B	calcium/calmodulin-dependent protein kinase II beta	0.013
PPM1G	protein phosphatase, Mg2+/Mn2+ dependent, 1G	0.013
WRAP73	WD repeat containing, antisense to TP73	0.012
RABAC1	Rab acceptor 1 (prenylated)	0.012
CSK	c-src tyrosine kinase	0.012
CALCOCO1	calcium binding and coiled-coil domain 1	0.012
TAF3	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	0.012
ARHGAP32	Rho GTPase activating protein 32	0.012
LDHB	lactate dehydrogenase B	0.011
FAM192A	family with sequence similarity 192, member A	0.011
MARK4	MAP/microtubule affinity-regulating kinase 4	0.011
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.011
WASL	Wiskott-Aldrich syndrome-like	0.011
PABPC3	poly(A) binding protein, cytoplasmic 3	0.011
NUP214	nucleoporin 214kDa	0.011
GSPT2	G1 to S phase transition 2	0.011
HECTD3	HECT domain containing 3	0.011
SND1	staphylococcal nuclease and tudor domain containing 1	0.010
UBE2L3	ubiquitin-conjugating enzyme E2L 3	0.010
PDK2	pyruvate dehydrogenase kinase, isozyme 2	0.010
TRADD	TNFRSF1A-associated via death domain	0.010
KPNA6	karyopherin alpha 6 (importin alpha 7)	0.010
FES	feline sarcoma oncogene	0.010
HTRA2	HtrA serine peptidase 2	0.005
COQ2	coenzyme Q2 homolog, prenyltransferase (yeast)	0.004
ADH1C	alcohol dehydrogenase 1C (class I), gamma polypeptide	0.004
PDE8B	phosphodiesterase 8B	0.004
SNCB	synuclein, beta	0.003
GBA	glucosidase, beta, acid	0.002
GIGYF2	GRB10 interacting GYF protein 2	0.002
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.002
SYNJ1	synaptojanin 1	0.002
DNAJC6	DnaJ (Hsp40) homolog, subfamily C, member 6	0.002
PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	0.001
ATP13A2	ATPase type 13A2	0.001
VPS35	vacuolar protein sorting 35 homolog (S. cerevisiae)	0.001
NUP62	nucleoporin 62kDa	0.001
TBP	TATA box binding protein	0.001
PARK7	Parkinson disease (autosomal recessive, early onset) 7	0.000