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Homo sapiens

38 genes annotated in human

neuromuscular disease

DOID:440

A neuropathy that affect the nerves that control the voluntary muscles.

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "neuromuscular disease"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "neuromuscular disease" (in gray)

Name	Description	Probability	Func Analog Organism
GARS	glycyl-tRNA synthetase	0.960
BAG3	BCL2-associated athanogene 3	0.957
MARS	methionyl-tRNA synthetase	0.954
AARS	alanyl-tRNA synthetase	0.938
ASNS	asparagine synthetase (glutamine-hydrolyzing)	0.938
DNM1	dynamin 1	0.933	Human
IARS	isoleucyl-tRNA synthetase	0.883
HSPB8	heat shock 22kDa protein 8	0.815
HSPB1	heat shock 27kDa protein 1	0.806
RXRA	retinoid X receptor, alpha	0.799
CARS	cysteinyl-tRNA synthetase	0.707
CRYAB	crystallin, alpha B	0.698	Human
SARS	seryl-tRNA synthetase	0.629
HSPB2	heat shock 27kDa protein 2	0.453	Human
UBE2R2	ubiquitin-conjugating enzyme E2R 2	0.411
YARS	tyrosyl-tRNA synthetase	0.395
EPRS	glutamyl-prolyl-tRNA synthetase	0.276
HSF1	heat shock transcription factor 1	0.262
EGR3	early growth response 3	0.228	Human
CLASP1	cytoplasmic linker associated protein 1	0.214
RARA	retinoic acid receptor, alpha	0.200
HSPB7	heat shock 27kDa protein family, member 7 (cardiovascular)	0.180
KLC1	kinesin light chain 1	0.167
MARCH5	membrane-associated ring finger (C3HC4) 5	0.167
NCOA1	nuclear receptor coactivator 1	0.161
HSPA1B	heat shock 70kDa protein 1B	0.126
TARS	threonyl-tRNA synthetase	0.119
MAPKAPK2	mitogen-activated protein kinase-activated protein kinase 2	0.111
SPRY2	sprouty homolog 2 (Drosophila)	0.108
GOT1	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1)	0.106
FOS	FBJ murine osteosarcoma viral oncogene homolog	0.105
EGR1	early growth response 1	0.097	Human
PACSIN2	protein kinase C and casein kinase substrate in neurons 2	0.097
ASAP1	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	0.094
DLG4	discs, large homolog 4 (Drosophila)	0.090
LDHA	lactate dehydrogenase A	0.079
CTTN	cortactin	0.065
PCK2	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	0.058
FAM46A	family with sequence similarity 46, member A	0.057
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.056
ATF4	activating transcription factor 4 (tax-responsive enhancer element B67)	0.056
TSG101	tumor susceptibility gene 101	0.055
FLNB	filamin B, beta	0.048
TUBB2B	tubulin, beta 2B	0.048
NINL	ninein-like	0.047
EIF1B	eukaryotic translation initiation factor 1B	0.044
MYO1E	myosin IE	0.041
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	0.040
GORASP2	golgi reassembly stacking protein 2, 55kDa	0.039
LPHN1	latrophilin 1	0.037
PSAT1	phosphoserine aminotransferase 1	0.036
ARHGAP22	Rho GTPase activating protein 22	0.035
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.034
DNM2	dynamin 2	0.033
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide	0.033
TYK2	tyrosine kinase 2	0.033
SH3GL1	SH3-domain GRB2-like 1	0.032
SF3B3	splicing factor 3b, subunit 3, 130kDa	0.031
ACP5	acid phosphatase 5, tartrate resistant	0.030
EFTUD2	elongation factor Tu GTP binding domain containing 2	0.030
SH3GL2	SH3-domain GRB2-like 2	0.029
BHLHE40	basic helix-loop-helix family, member e40	0.029
SH3BP4	SH3-domain binding protein 4	0.028
PRPF8	PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae)	0.028
SQSTM1	sequestosome 1	0.028
SREBF1	sterol regulatory element binding transcription factor 1	0.027
FTSJ1	FtsJ homolog 1 (E. coli)	0.027
CKAP5	cytoskeleton associated protein 5	0.027
DNAJB5	DnaJ (Hsp40) homolog, subfamily B, member 5	0.026
MED31	mediator complex subunit 31	0.026
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.026
SH3GL3	SH3-domain GRB2-like 3	0.026
PSMD2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	0.025
FLNA	filamin A, alpha	0.025
SPRR2A	small proline-rich protein 2A	0.025
WASL	Wiskott-Aldrich syndrome-like	0.025
G6PD	glucose-6-phosphate dehydrogenase	0.024
PLEC	plectin	0.024
S100A10	S100 calcium binding protein A10	0.024
PIAS4	protein inhibitor of activated STAT, 4	0.024
GRIN2B	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	0.024
PTPN23	protein tyrosine phosphatase, non-receptor type 23	0.024
RABEP1	rabaptin, RAB GTPase binding effector protein 1	0.023
FH	fumarate hydratase	0.023
SH3BP2	SH3-domain binding protein 2	0.023
PTN	pleiotrophin	0.023
LTBP4	latent transforming growth factor beta binding protein 4	0.022
NFATC2	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	0.022
HSPA1A	heat shock 70kDa protein 1A	0.022
MGAT4B	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B	0.022
NDUFS2	NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)	0.021
SNRNP40	small nuclear ribonucleoprotein 40kDa (U5)	0.021
MEGF8	multiple EGF-like-domains 8	0.021
NDUFS1	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	0.021
NR4A2	nuclear receptor subfamily 4, group A, member 2	0.021
KCNA4	potassium voltage-gated channel, shaker-related subfamily, member 4	0.020	Human
IDH3A	isocitrate dehydrogenase 3 (NAD+) alpha	0.020
ABCA2	ATP-binding cassette, sub-family A (ABC1), member 2	0.020
WARS	tryptophanyl-tRNA synthetase	0.019
NARS	asparaginyl-tRNA synthetase	0.019
NOXA1	NADPH oxidase activator 1	0.019
BLMH	bleomycin hydrolase	0.019
HIST2H3C	histone cluster 2, H3c	0.019
RASAL2	RAS protein activator like 2	0.019
MAN1B1	mannosidase, alpha, class 1B, member 1	0.019
BZRAP1	benzodiazapine receptor (peripheral) associated protein 1	0.018
DLGAP1	discs, large (Drosophila) homolog-associated protein 1	0.018
LONP1	lon peptidase 1, mitochondrial	0.018
DFFA	DNA fragmentation factor, 45kDa, alpha polypeptide	0.018
AHNAK	AHNAK nucleoprotein	0.018	Human
EMD	emerin	0.018
APOO	apolipoprotein O	0.017
IGSF21	immunoglobin superfamily, member 21	0.017
IK	IK cytokine, down-regulator of HLA II	0.017
CD151	CD151 molecule (Raph blood group)	0.017
CEBPG	CCAAT/enhancer binding protein (C/EBP), gamma	0.017
MEGF6	multiple EGF-like-domains 6	0.017
SLC7A5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	0.017
GOT2	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)	0.017
ITGB4	integrin, beta 4	0.017
SYNJ2	synaptojanin 2	0.017
VPS11	vacuolar protein sorting 11 homolog (S. cerevisiae)	0.017
ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.017
NLGN1	neuroligin 1	0.017
RAB7A	RAB7A, member RAS oncogene family	0.017
MED16	mediator complex subunit 16	0.016
OCRL	oculocerebrorenal syndrome of Lowe	0.016
TIAM2	T-cell lymphoma invasion and metastasis 2	0.016
MYH9	myosin, heavy chain 9, non-muscle	0.016
TLE3	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	0.016
TRIP10	thyroid hormone receptor interactor 10	0.016
DDN	dendrin	0.016
MAP4	microtubule-associated protein 4	0.016
FOSB	FBJ murine osteosarcoma viral oncogene homolog B	0.016
CBLB	Cas-Br-M (murine) ecotropic retroviral transforming sequence b	0.016
CABP1	calcium binding protein 1	0.016
ALOX12	arachidonate 12-lipoxygenase	0.016
SRRM4	serine/arginine repetitive matrix 4	0.016
PSEN2	presenilin 2 (Alzheimer disease 4)	0.016
ILK	integrin-linked kinase	0.015
DLAT	dihydrolipoamide S-acetyltransferase	0.015
STIP1	stress-induced-phosphoprotein 1	0.015
SH3KBP1	SH3-domain kinase binding protein 1	0.015
PSMD1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	0.015
MED12	mediator complex subunit 12	0.015
PRKCG	protein kinase C, gamma	0.015
INPP5D	inositol polyphosphate-5-phosphatase, 145kDa	0.014
EIF2B3	eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa	0.014
TMBIM1	transmembrane BAX inhibitor motif containing 1	0.014
RAB5A	RAB5A, member RAS oncogene family	0.014
VAC14	Vac14 homolog (S. cerevisiae)	0.014
DNAJA3	DnaJ (Hsp40) homolog, subfamily A, member 3	0.014
PDHA1	pyruvate dehydrogenase (lipoamide) alpha 1	0.014
NME2	non-metastatic cells 2, protein (NM23B) expressed in	0.014
TRIB3	tribbles homolog 3 (Drosophila)	0.014
MED26	mediator complex subunit 26	0.014
FASN	fatty acid synthase	0.014
NONO	non-POU domain containing, octamer-binding	0.014
TSC22D1	TSC22 domain family, member 1	0.014
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.013
ECD	ecdysoneless homolog (Drosophila)	0.013
COQ9	coenzyme Q9 homolog (S. cerevisiae)	0.013
SNX9	sorting nexin 9	0.013
GFI1B	growth factor independent 1B transcription repressor	0.013
NELL1	NEL-like 1 (chicken)	0.013
SUN2	Sad1 and UNC84 domain containing 2	0.013
WDR92	WD repeat domain 92	0.013
MIPEP	mitochondrial intermediate peptidase	0.013
HSPB6	heat shock protein, alpha-crystallin-related, B6	0.013	Human
DOT1L	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	0.013
PDCD6IP	programmed cell death 6 interacting protein	0.013
BLNK	B-cell linker	0.013
ACTN1	actinin, alpha 1	0.013
TUBB6	tubulin, beta 6	0.013
NDEL1	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	0.013
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.013
C1QTNF1	C1q and tumor necrosis factor related protein 1	0.013
SNAP25	synaptosomal-associated protein, 25kDa	0.013
NAB2	NGFI-A binding protein 2 (EGR1 binding protein 2)	0.013
NPLOC4	nuclear protein localization 4 homolog (S. cerevisiae)	0.013
HUWE1	HECT, UBA and WWE domain containing 1	0.013
NRD1	nardilysin (N-arginine dibasic convertase)	0.012
AMIGO2	adhesion molecule with Ig-like domain 2	0.012
PRPSAP1	phosphoribosyl pyrophosphate synthetase-associated protein 1	0.012
RNF115	ring finger protein 115	0.012
SLC3A2	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	0.012
MTMR12	myotubularin related protein 12	0.012	Human
IDE	insulin-degrading enzyme	0.012
SDC4	syndecan 4	0.012
HECW1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	0.012
CRYAA	crystallin, alpha A	0.012	Human
EMP3	epithelial membrane protein 3	0.012	Human
HAX1	HCLS1 associated protein X-1	0.012
MED9	mediator complex subunit 9	0.012
RILP	Rab interacting lysosomal protein	0.012
RXRG	retinoid X receptor, gamma	0.012
TARS2	threonyl-tRNA synthetase 2, mitochondrial (putative)	0.012
MAFF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog F (avian)	0.012
ACTN4	actinin, alpha 4	0.011
CRYBB2	crystallin, beta B2	0.011
GNG2	guanine nucleotide binding protein (G protein), gamma 2	0.011
KIF1C	kinesin family member 1C	0.011	Human
C16orf80	chromosome 16 open reading frame 80	0.011
ME2	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.011
ERC1	ELKS/RAB6-interacting/CAST family member 1	0.011
CYB5B	cytochrome b5 type B (outer mitochondrial membrane)	0.011
MTHFD2	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase	0.011
PHF21A	PHD finger protein 21A	0.011
ODC1	ornithine decarboxylase 1	0.011
FAM178B	family with sequence similarity 178, member B	0.011
MATK	megakaryocyte-associated tyrosine kinase	0.011
NDUFAF1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 1	0.011
GRIN2C	glutamate receptor, ionotropic, N-methyl D-aspartate 2C	0.011
PDLIM1	PDZ and LIM domain 1	0.011
TRIM74	tripartite motif containing 74	0.011
MED29	mediator complex subunit 29	0.011
DCTN1	dynactin 1	0.011
MAOA	monoamine oxidase A	0.011
PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)	0.011
GPD1	glycerol-3-phosphate dehydrogenase 1 (soluble)	0.011
RIN1	Ras and Rab interactor 1	0.011
RAB6A	RAB6A, member RAS oncogene family	0.011
RTN4IP1	reticulon 4 interacting protein 1	0.011
PEX14	peroxisomal biogenesis factor 14	0.011
SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	0.011
OGDH	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	0.011
CD97	CD97 molecule	0.011
PPP2R1B	protein phosphatase 2, regulatory subunit A, beta	0.011
PHGDH	phosphoglycerate dehydrogenase	0.011
NEFM	neurofilament, medium polypeptide	0.011
CSRP1	cysteine and glycine-rich protein 1	0.011
MAP3K4	mitogen-activated protein kinase kinase kinase 4	0.011
FOSL2	FOS-like antigen 2	0.011
TIAM1	T-cell lymphoma invasion and metastasis 1	0.011
GADD45G	growth arrest and DNA-damage-inducible, gamma	0.011
MED19	mediator complex subunit 19	0.011
CDK19	cyclin-dependent kinase 19	0.011
GOLGA2	golgin A2	0.011
MCCC1	methylcrotonoyl-CoA carboxylase 1 (alpha)	0.011
SHB	Src homology 2 domain containing adaptor protein B	0.011
UBA1	ubiquitin-like modifier activating enzyme 1	0.010
GRIK5	glutamate receptor, ionotropic, kainate 5	0.010
AP2B1	adaptor-related protein complex 2, beta 1 subunit	0.010
PARP3	poly (ADP-ribose) polymerase family, member 3	0.010
ZW10	ZW10, kinetochore associated, homolog (Drosophila)	0.010
EMP1	epithelial membrane protein 1	0.010	Human
AMN	amnionless homolog (mouse)	0.010
CDHR5	cadherin-related family member 5	0.010
TJP1	tight junction protein 1 (zona occludens 1)	0.010
OLIG1	oligodendrocyte transcription factor 1	0.010
FDX1	ferredoxin 1	0.010
CCNY	cyclin Y	0.010
RWDD2B	RWD domain containing 2B	0.010
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	0.010
MATN2	matrilin 2	0.010
RNF41	ring finger protein 41	0.010
MAP1A	microtubule-associated protein 1A	0.010
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.010
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.009
PMP22	peripheral myelin protein 22	0.007
MFN2	mitofusin 2	0.007
CACNB4	calcium channel, voltage-dependent, beta 4 subunit	0.007
SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	0.007
FGD4	FYVE, RhoGEF and PH domain containing 4	0.006
KIF1B	kinesin family member 1B	0.006
MPZ	myelin protein zero	0.006
LITAF	lipopolysaccharide-induced TNF factor	0.006
FIG4	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	0.006
GDAP1	ganglioside-induced differentiation-associated protein 1	0.006
PRX	periaxin	0.006
PRPS1	phosphoribosyl pyrophosphate synthetase 1	0.006
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.005
SBF2	SET binding factor 2	0.005
KCNA1	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	0.005
NEFL	neurofilament, light polypeptide	0.005
INF2	inverted formin, FH2 and WH2 domain containing	0.005
ATP2A1	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1	0.005
GJB1	gap junction protein, beta 1, 32kDa	0.005
TRPV4	transient receptor potential cation channel, subfamily V, member 4	0.005
EGR2	early growth response 2	0.005
AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	0.004
SH3TC2	SH3 domain and tetratricopeptide repeats 2	0.004
NDRG1	N-myc downstream regulated 1	0.004
GNB4	guanine nucleotide binding protein (G protein), beta polypeptide 4	0.004
CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	0.004
PLEKHG5	pleckstrin homology domain containing, family G (with RhoGef domain) member 5	0.004
MED25	mediator complex subunit 25	0.004
LMNA	lamin A/C	0.004
MTMR2	myotubularin related protein 2	0.003