IMP

Process View

Homo sapiens

22 genes annotated in human

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regulation of defense response to virus by host

GO:0050691

Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of defense response to virus by host"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of defense response to virus by host" (in gray)

Name	Description	Probability	Func Analog Organism
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.984
RELA	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.982
IFIT1	interferon-induced protein with tetratricopeptide repeats 1	0.977
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.935	Fly
IFIT3	interferon-induced protein with tetratricopeptide repeats 3	0.879	Human
IFIT5	interferon-induced protein with tetratricopeptide repeats 5	0.852	Human
LILRA6	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6	0.841
NFKBIA	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	0.798
IFIT2	interferon-induced protein with tetratricopeptide repeats 2	0.797	Human
STAT1	signal transducer and activator of transcription 1, 91kDa	0.775
NLRC4	NLR family, CARD domain containing 4	0.739
CREBBP	CREB binding protein	0.713
IFI44L	interferon-induced protein 44-like	0.683
DDX58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	0.682
NMI	N-myc (and STAT) interactor	0.603
IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	0.601
NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	0.582	Fly
MAVS	mitochondrial antiviral signaling protein	0.526
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.454
NFKBIB	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	0.443
IL23A	interleukin 23, alpha subunit p19	0.434
IKBKE	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon	0.422
REL	v-rel reticuloendotheliosis viral oncogene homolog (avian)	0.416
IFI44	interferon-induced protein 44	0.411
PILRA	paired immunoglobin-like type 2 receptor alpha	0.402
IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	0.400
IL4R	interleukin 4 receptor	0.363
RELB	v-rel reticuloendotheliosis viral oncogene homolog B	0.334
TMEM173	transmembrane protein 173	0.327
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.299
DICER1	dicer 1, ribonuclease type III	0.298	Human
NFKBIE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	0.267
LILRA1	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	0.254	Human
XAF1	XIAP associated factor 1	0.219
PTPN6	protein tyrosine phosphatase, non-receptor type 6	0.208
LILRB2	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	0.197	Human
HIPK2	homeodomain interacting protein kinase 2	0.188
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.183	Human
NFKB2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	0.180	Fly
LILRB3	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3	0.162	Human
PTPN1	protein tyrosine phosphatase, non-receptor type 1	0.145
HERC5	hect domain and RLD 5	0.144
RABAC1	Rab acceptor 1 (prenylated)	0.141
SAMD9	sterile alpha motif domain containing 9	0.139
SP110	SP110 nuclear body protein	0.138
LILRB1	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	0.129
ISG15	ISG15 ubiquitin-like modifier	0.126
STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	0.119	Fly
SP100	SP100 nuclear antigen	0.117
RTP4	receptor (chemosensory) transporter protein 4	0.106
SIGLEC7	sialic acid binding Ig-like lectin 7	0.092
PLSCR1	phospholipid scramblase 1	0.092
STAT3	signal transducer and activator of transcription 3 (acute-phase response factor)	0.088
TYMP	thymidine phosphorylase	0.074
LILRA2	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2	0.066
MEFV	Mediterranean fever	0.062
MOV10	Mov10, Moloney leukemia virus 10, homolog (mouse)	0.062
INSR	insulin receptor	0.061
DAXX	death-domain associated protein	0.059
TARBP2	TAR (HIV-1) RNA binding protein 2	0.059
LGALS3	lectin, galactoside-binding, soluble, 3	0.058
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.057
MAP3K14	mitogen-activated protein kinase kinase kinase 14	0.053
USP18	ubiquitin specific peptidase 18	0.051
OASL	2'-5'-oligoadenylate synthetase-like	0.050
NLRP3	NLR family, pyrin domain containing 3	0.044
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.043
LAP3	leucine aminopeptidase 3	0.041
PARP9	poly (ADP-ribose) polymerase family, member 9	0.037
TRIM25	tripartite motif containing 25	0.036
CYLD	cylindromatosis (turban tumor syndrome)	0.035
MBOAT7	membrane bound O-acyltransferase domain containing 7	0.034
TDRD7	tudor domain containing 7	0.034
CSK	c-src tyrosine kinase	0.033
BCL3	B-cell CLL/lymphoma 3	0.033
RIPK2	receptor-interacting serine-threonine kinase 2	0.033
IL15RA	interleukin 15 receptor, alpha	0.032
TRIM22	tripartite motif containing 22	0.030
STAP2	signal transducing adaptor family member 2	0.030
TNIP2	TNFAIP3 interacting protein 2	0.029
RSAD2	radical S-adenosyl methionine domain containing 2	0.029
EPOR	erythropoietin receptor	0.028
HK3	hexokinase 3 (white cell)	0.027
ZC3HAV1	zinc finger CCCH-type, antiviral 1	0.027
ELF4	E74-like factor 4 (ets domain transcription factor)	0.025
TRIM21	tripartite motif containing 21	0.025
MAP3K8	mitogen-activated protein kinase kinase kinase 8	0.025
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.025
LILRA3	leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3	0.024	Human
BAX	BCL2-associated X protein	0.024
STX8	syntaxin 8	0.023
PTAFR	platelet-activating factor receptor	0.023
CSF2RB	colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	0.022
GBP1	guanylate binding protein 1, interferon-inducible	0.022
NOD2	nucleotide-binding oligomerization domain containing 2	0.021
APOL6	apolipoprotein L, 6	0.021
OAS3	2'-5'-oligoadenylate synthetase 3, 100kDa	0.021
IFI16	interferon, gamma-inducible protein 16	0.020
IL2RB	interleukin 2 receptor, beta	0.020
CD33	CD33 molecule	0.019
ZFP28	zinc finger protein 28 homolog (mouse)	0.019
OAS1	2',5'-oligoadenylate synthetase 1, 40/46kDa	0.017
MECP2	methyl CpG binding protein 2 (Rett syndrome)	0.016
ZNFX1	zinc finger, NFX1-type containing 1	0.016
IL12A	interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	0.016
SETD7	SET domain containing (lysine methyltransferase) 7	0.016
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.016	Fly
TREM1	triggering receptor expressed on myeloid cells 1	0.016
SURF4	surfeit 4	0.016
PIAS4	protein inhibitor of activated STAT, 4	0.016
DTX3L	deltex 3-like (Drosophila)	0.016
IFIH1	interferon induced with helicase C domain 1	0.016	Human
NR2E3	nuclear receptor subfamily 2, group E, member 3	0.015
TNIP1	TNFAIP3 interacting protein 1	0.015
FAS	Fas (TNF receptor superfamily, member 6)	0.015
MX1	myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)	0.015
TYK2	tyrosine kinase 2	0.014
ABL1	c-abl oncogene 1, non-receptor tyrosine kinase	0.014
TFEC	transcription factor EC	0.014
JAK2	Janus kinase 2	0.014
IRF1	interferon regulatory factor 1	0.014
SIRPB1	signal-regulatory protein beta 1	0.014
CD300C	CD300c molecule	0.013
AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	0.013
SEC61A1	Sec61 alpha 1 subunit (S. cerevisiae)	0.013
GCH1	GTP cyclohydrolase 1	0.013
DHX58	DEXH (Asp-Glu-X-His) box polypeptide 58	0.013	Human
GBP4	guanylate binding protein 4	0.013
JAK1	Janus kinase 1	0.013
AOAH	acyloxyacyl hydrolase (neutrophil)	0.013
CASP5	caspase 5, apoptosis-related cysteine peptidase	0.013	Fly
FCAR	Fc fragment of IgA, receptor for	0.012	Human
LAIR1	leukocyte-associated immunoglobulin-like receptor 1	0.012	Human
CD274	CD274 molecule	0.012
TMEM140	transmembrane protein 140	0.011
ELK1	ELK1, member of ETS oncogene family	0.011
CDC37	cell division cycle 37 homolog (S. cerevisiae)	0.011
RNF144B	ring finger protein 144B	0.011
CXCL10	chemokine (C-X-C motif) ligand 10	0.011
BRMS1	breast cancer metastasis suppressor 1	0.011
EPSTI1	epithelial stromal interaction 1 (breast)	0.010