IMP

Process View

Homo sapiens

24 genes annotated in human

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regulation of translational initiation

GO:0006446

Any process that modulates the frequency, rate or extent of translational initiation.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "regulation of translational initiation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "regulation of translational initiation" (in gray)

Name	Description	Probability	Func Analog Organism
PABPC1	poly(A) binding protein, cytoplasmic 1	1.000	Yeast
EIF4G1	eukaryotic translation initiation factor 4 gamma, 1	0.916
EIF4A1	eukaryotic translation initiation factor 4A1	0.763
DDX3X	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	0.761
HNRNPD	heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)	0.714
TNRC6A	trinucleotide repeat containing 6A	0.626
EIF4G2	eukaryotic translation initiation factor 4 gamma, 2	0.582
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	0.528
EIF2C2	eukaryotic translation initiation factor 2C, 2	0.391
MAPK14	mitogen-activated protein kinase 14	0.343
YBX1	Y box binding protein 1	0.314	Zebrafish
HNRNPK	heterogeneous nuclear ribonucleoprotein K	0.232
CUL3	cullin 3	0.206
EIF3A	eukaryotic translation initiation factor 3, subunit A	0.181
EIF3B	eukaryotic translation initiation factor 3, subunit B	0.181
RPTOR	regulatory associated protein of MTOR, complex 1	0.176
EIF2C1	eukaryotic translation initiation factor 2C, 1	0.176	Human
EIF2C4	eukaryotic translation initiation factor 2C, 4	0.172	Human
RXRA	retinoid X receptor, alpha	0.160	Mouse
EIF3H	eukaryotic translation initiation factor 3, subunit H	0.144
EIF3D	eukaryotic translation initiation factor 3, subunit D	0.135
EIF3I	eukaryotic translation initiation factor 3, subunit I	0.121
DHX9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	0.120
MED25	mediator complex subunit 25	0.116
EIF4E	eukaryotic translation initiation factor 4E	0.111
EIF2S1	eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa	0.079	Mouse
PAN3	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	0.079
HNRNPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	0.075
PCBP2	poly(rC) binding protein 2	0.071
HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	0.071
TNRC6C	trinucleotide repeat containing 6C	0.070
EIF2S2	eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa	0.069
KLHL12	kelch-like 12 (Drosophila)	0.067	Human
EIF2AK2	eukaryotic translation initiation factor 2-alpha kinase 2	0.066
G3BP1	GTPase activating protein (SH3 domain) binding protein 1	0.066
EIF2B5	eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa	0.063	Yeast Rat
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.063
COASY	CoA synthase	0.062
RICTOR	RPTOR independent companion of MTOR, complex 2	0.053
EIF4A2	eukaryotic translation initiation factor 4A2	0.052
TOP1	topoisomerase (DNA) I	0.049
MAPK1	mitogen-activated protein kinase 1	0.048
DAZ1	deleted in azoospermia 1	0.047
SRPK2	SRSF protein kinase 2	0.046
WNK4	WNK lysine deficient protein kinase 4	0.046
DAPK1	death-associated protein kinase 1	0.044
EIF2C3	eukaryotic translation initiation factor 2C, 3	0.043	Human
EIF3C	eukaryotic translation initiation factor 3, subunit C	0.042
EIF3F	eukaryotic translation initiation factor 3, subunit F	0.041
MKNK1	MAP kinase interacting serine/threonine kinase 1	0.041	Rat
STAU1	staufen, RNA binding protein, homolog 1 (Drosophila)	0.040
EIF3G	eukaryotic translation initiation factor 3, subunit G	0.040
SF1	splicing factor 1	0.039
MAP3K7	mitogen-activated protein kinase kinase kinase 7	0.038
EIF2B2	eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa	0.037
CSNK2A1	casein kinase 2, alpha 1 polypeptide	0.037
LNX1	ligand of numb-protein X 1	0.035
PRMT1	protein arginine methyltransferase 1	0.035
EIF4B	eukaryotic translation initiation factor 4B	0.035
EIF4EBP3	eukaryotic translation initiation factor 4E binding protein 3	0.034
EIF4G3	eukaryotic translation initiation factor 4 gamma, 3	0.034	Human
MAPK3	mitogen-activated protein kinase 3	0.033
ESF1	ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)	0.033
EIF4ENIF1	eukaryotic translation initiation factor 4E nuclear import factor 1	0.033
PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme	0.032
SMC5	structural maintenance of chromosomes 5	0.032
KLHL2	kelch-like 2, Mayven (Drosophila)	0.032	Human
PCBP1	poly(rC) binding protein 1	0.031
PRRC2C	proline-rich coiled-coil 2C	0.030
FBXO33	F-box protein 33	0.029
GSK3B	glycogen synthase kinase 3 beta	0.028
USP46	ubiquitin specific peptidase 46	0.028
EIF1AY	eukaryotic translation initiation factor 1A, Y-linked	0.027
MAPK8IP2	mitogen-activated protein kinase 8 interacting protein 2	0.027
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	0.027
DDAH2	dimethylarginine dimethylaminohydrolase 2	0.024
C17orf85	chromosome 17 open reading frame 85	0.023
PARN	poly(A)-specific ribonuclease (deadenylation nuclease)	0.023
DCUN1D1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	0.022
EEF2K	eukaryotic elongation factor-2 kinase	0.021
NFE2L2	nuclear factor (erythroid-derived 2)-like 2	0.021
SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein	0.020
GSPT1	G1 to S phase transition 1	0.019
HNRNPM	heterogeneous nuclear ribonucleoprotein M	0.018
DDX17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	0.018
KHDRBS3	KH domain containing, RNA binding, signal transduction associated 3	0.017	Human
CYFIP2	cytoplasmic FMR1 interacting protein 2	0.017
TARDBP	TAR DNA binding protein	0.017
IPO8	importin 8	0.016
RXRB	retinoid X receptor, beta	0.016
DDX1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	0.016
STAG2	stromal antigen 2	0.015
RPS6KB1	ribosomal protein S6 kinase, 70kDa, polypeptide 1	0.015
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.015
THOC2	THO complex 2	0.015
VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	0.014
MPP1	membrane protein, palmitoylated 1, 55kDa	0.014
CCAR1	cell division cycle and apoptosis regulator 1	0.014
UPF3B	UPF3 regulator of nonsense transcripts homolog B (yeast)	0.014
HNRNPA0	heterogeneous nuclear ribonucleoprotein A0	0.013
PTBP2	polypyrimidine tract binding protein 2	0.013
CYFIP1	cytoplasmic FMR1 interacting protein 1	0.013
C19orf46	chromosome 19 open reading frame 46	0.013
SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	0.013
RNF19A	ring finger protein 19A	0.012
ATXN3	ataxin 3	0.012
PRKRA	protein kinase, interferon-inducible double stranded RNA dependent activator	0.012
UBA6	ubiquitin-like modifier activating enzyme 6	0.012
MED28	mediator complex subunit 28	0.011
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.011
GNL2	guanine nucleotide binding protein-like 2 (nucleolar)	0.011
SMS	spermine synthase	0.011
CEP350	centrosomal protein 350kDa	0.011
TNPO1	transportin 1	0.011
NCOA1	nuclear receptor coactivator 1	0.011
BOLL	bol, boule-like (Drosophila)	0.010
EPRS	glutamyl-prolyl-tRNA synthetase	0.010
LYAR	Ly1 antibody reactive homolog (mouse)	0.010
PRKAA1	protein kinase, AMP-activated, alpha 1 catalytic subunit	0.010
CCDC47	coiled-coil domain containing 47	0.010
PABPC4	poly(A) binding protein, cytoplasmic 4 (inducible form)	0.010	Yeast
DICER1	dicer 1, ribonuclease type III	0.010
MASP1	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	0.010