IMP

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Homo sapiens

3 genes annotated in human

negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process

GO:2000059

Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process.

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Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process" (in gray)

Name	Description	Probability	Func Analog Organism
PSEN1	presenilin 1	0.996	Mouse
FLNB	filamin B, beta	0.988
PSEN2	presenilin 2 (Alzheimer disease 4)	0.983	Mouse
NCSTN	nicastrin	0.962
DAXX	death-domain associated protein	0.950
ZNF263	zinc finger protein 263	0.946
TRIM39	tripartite motif containing 39	0.934
GLI1	GLI family zinc finger 1	0.905
SP100	SP100 nuclear antigen	0.879
MED15	mediator complex subunit 15	0.861
APH1A	anterior pharynx defective 1 homolog A (C. elegans)	0.839
TRIM21	tripartite motif containing 21	0.779	Human
UBE2D4	ubiquitin-conjugating enzyme E2D 4 (putative)	0.762
UBE2V1	ubiquitin-conjugating enzyme E2 variant 1	0.726
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.699
TRIM32	tripartite motif containing 32	0.650
PKP4	plakophilin 4	0.636
BCL2L1	BCL2-like 1	0.595
IFI44	interferon-induced protein 44	0.492
TRIM5	tripartite motif containing 5	0.466	Human
RCN3	reticulocalbin 3, EF-hand calcium binding domain	0.426
CDKN2A	cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)	0.360
PEX26	peroxisomal biogenesis factor 26	0.322
MAPK7	mitogen-activated protein kinase 7	0.321
TRIM43	tripartite motif containing 43	0.257
XIAP	X-linked inhibitor of apoptosis	0.229
FAS	Fas (TNF receptor superfamily, member 6)	0.205
UBE2D3	ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)	0.200
ZNRF1	zinc and ring finger 1	0.188
HDAC1	histone deacetylase 1	0.187
TRIM26	tripartite motif containing 26	0.169
BANP	BTG3 associated nuclear protein	0.167
SP110	SP110 nuclear body protein	0.166
ARIH2	ariadne homolog 2 (Drosophila)	0.152
TRIM17	tripartite motif containing 17	0.145	Human
MID1IP1	MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish))	0.142
PML	promyelocytic leukemia	0.132
TRIM41	tripartite motif containing 41	0.132	Human
UBE2D1	ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)	0.131
FLNA	filamin A, alpha	0.130
RNF5	ring finger protein 5	0.129
CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	0.124
QPRT	quinolinate phosphoribosyltransferase	0.120
ZNF764	zinc finger protein 764	0.118
IFI16	interferon, gamma-inducible protein 16	0.115
CDK6	cyclin-dependent kinase 6	0.100
UBE2U	ubiquitin-conjugating enzyme E2U (putative)	0.099
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.097
TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	0.097
TRIM34	tripartite motif containing 34	0.091
APP	amyloid beta (A4) precursor protein	0.086
AXIN1	axin 1	0.076
GLIS3	GLIS family zinc finger 3	0.065
DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	0.065
FHL2	four and a half LIM domains 2	0.062
SRI	sorcin	0.058
TRIM35	tripartite motif containing 35	0.058
TRIM8	tripartite motif containing 8	0.056
ZNF473	zinc finger protein 473	0.055
ZFYVE1	zinc finger, FYVE domain containing 1	0.053
GSK3B	glycogen synthase kinase 3 beta	0.049
IRF2	interferon regulatory factor 2	0.049
TRAF3	TNF receptor-associated factor 3	0.049
TGIF1	TGFB-induced factor homeobox 1	0.048
UBQLN1	ubiquilin 1	0.046
AR	androgen receptor	0.045
MKRN3	makorin ring finger protein 3	0.042
STK36	serine/threonine kinase 36	0.041
MCOLN1	mucolipin 1	0.041
RNF11	ring finger protein 11	0.041
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.040
TRIM52	tripartite motif containing 52	0.039
NMI	N-myc (and STAT) interactor	0.038
ECSIT	ECSIT homolog (Drosophila)	0.037
TRIM4	tripartite motif containing 4	0.036	Human
MAGEA11	melanoma antigen family A, 11	0.035
SREBF1	sterol regulatory element binding transcription factor 1	0.035
MR1	major histocompatibility complex, class I-related	0.034
TERT	telomerase reverse transcriptase	0.034
SYVN1	synovial apoptosis inhibitor 1, synoviolin	0.033
MDM4	Mdm4 p53 binding protein homolog (mouse)	0.032
APBA1	amyloid beta (A4) precursor protein-binding, family A, member 1	0.032
DTX3L	deltex 3-like (Drosophila)	0.032
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.031
PRKCA	protein kinase C, alpha	0.031
SAMD9	sterile alpha motif domain containing 9	0.030
PLSCR1	phospholipid scramblase 1	0.030
USP4	ubiquitin specific peptidase 4 (proto-oncogene)	0.029
CASP1	caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)	0.029
RNF2	ring finger protein 2	0.029
RNF111	ring finger protein 111	0.028
UHRF2	ubiquitin-like with PHD and ring finger domains 2	0.028
BIK	BCL2-interacting killer (apoptosis-inducing)	0.027
TRAF6	TNF receptor-associated factor 6	0.027
CDH1	cadherin 1, type 1, E-cadherin (epithelial)	0.026
RNF185	ring finger protein 185	0.026
DNAJB2	DnaJ (Hsp40) homolog, subfamily B, member 2	0.026
TRIM6-TRIM34	TRIM6-TRIM34 readthrough	0.026
TRIM6	tripartite motif containing 6	0.025	Human
RIC8A	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	0.025
CFLAR	CASP8 and FADD-like apoptosis regulator	0.025
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.025
CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa	0.025
FHL3	four and a half LIM domains 3	0.025
RNF130	ring finger protein 130	0.024
FADD	Fas (TNFRSF6)-associated via death domain	0.024
RNF10	ring finger protein 10	0.024
RERE	arginine-glutamic acid dipeptide (RE) repeats	0.023
CTSO	cathepsin O	0.022
CTBP2	C-terminal binding protein 2	0.022
RNF126	ring finger protein 126	0.021
UBE2Z	ubiquitin-conjugating enzyme E2Z	0.021
HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	0.021
HIPK2	homeodomain interacting protein kinase 2	0.021
PLCD4	phospholipase C, delta 4	0.020
ZBTB8A	zinc finger and BTB domain containing 8A	0.019
USP7	ubiquitin specific peptidase 7 (herpes virus-associated)	0.019
ZNF202	zinc finger protein 202	0.019
PIK3C2B	phosphoinositide-3-kinase, class 2, beta polypeptide	0.019
RNF25	ring finger protein 25	0.019
MLLT6	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6	0.019
BIRC3	baculoviral IAP repeat containing 3	0.018
WHSC1L1	Wolf-Hirschhorn syndrome candidate 1-like 1	0.018
CHFR	checkpoint with forkhead and ring finger domains	0.018
MEX3B	mex-3 homolog B (C. elegans)	0.018
USP42	ubiquitin specific peptidase 42	0.017
SPOP	speckle-type POZ protein	0.016
LGALS8	lectin, galactoside-binding, soluble, 8	0.016
ITGA7	integrin, alpha 7	0.016
SLC2A4	solute carrier family 2 (facilitated glucose transporter), member 4	0.016
MAGEA1	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	0.016
HK2	hexokinase 2	0.016
IRF9	interferon regulatory factor 9	0.016
DYNC1H1	dynein, cytoplasmic 1, heavy chain 1	0.016
TGOLN2	trans-golgi network protein 2	0.016
ATXN3	ataxin 3	0.015
CLU	clusterin	0.015
GNL3L	guanine nucleotide binding protein-like 3 (nucleolar)-like	0.015
OAS2	2'-5'-oligoadenylate synthetase 2, 69/71kDa	0.015
BFAR	bifunctional apoptosis regulator	0.015
BAX	BCL2-associated X protein	0.015
LRSAM1	leucine rich repeat and sterile alpha motif containing 1	0.015
UBTD1	ubiquitin domain containing 1	0.015
TMCO6	transmembrane and coiled-coil domains 6	0.015
SP140L	SP140 nuclear body protein-like	0.014
BIRC8	baculoviral IAP repeat containing 8	0.014
APH1B	anterior pharynx defective 1 homolog B (C. elegans)	0.014
PHF11	PHD finger protein 11	0.014
SETD7	SET domain containing (lysine methyltransferase) 7	0.014
MKRN1	makorin ring finger protein 1	0.014
IL15	interleukin 15	0.014
GIMAP2	GTPase, IMAP family member 2	0.014
MYST1	MYST histone acetyltransferase 1	0.013
GBP3	guanylate binding protein 3	0.013
GSTM4	glutathione S-transferase mu 4	0.013
SPTB	spectrin, beta, erythrocytic	0.013
TDRD7	tudor domain containing 7	0.013
MYL4	myosin, light chain 4, alkali; atrial, embryonic	0.013
ZBTB16	zinc finger and BTB domain containing 16	0.013
TRANK1	tetratricopeptide repeat and ankyrin repeat containing 1	0.013
NLRC5	NLR family, CARD domain containing 5	0.013
DNMT3B	DNA (cytosine-5-)-methyltransferase 3 beta	0.013
FBLIM1	filamin binding LIM protein 1	0.013
UBE2E1	ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)	0.012
MAGEF1	melanoma antigen family F, 1	0.012
RNF4	ring finger protein 4	0.012
CDKN2C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	0.012
HBZ	hemoglobin, zeta	0.012
HSPB1	heat shock 27kDa protein 1	0.012
UBOX5	U-box domain containing 5	0.012
RTP4	receptor (chemosensory) transporter protein 4	0.012
CCND3	cyclin D3	0.012
ZNF420	zinc finger protein 420	0.012
TRIM27	tripartite motif containing 27	0.012	Human
ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2	0.012
TRIM25	tripartite motif containing 25	0.012
TRAF2	TNF receptor-associated factor 2	0.012
MID1	midline 1 (Opitz/BBB syndrome)	0.012
RPS27L	ribosomal protein S27-like	0.012
GYPE	glycophorin E (MNS blood group)	0.012
RHAG	Rh-associated glycoprotein	0.012
ZBTB48	zinc finger and BTB domain containing 48	0.012
DLG4	discs, large homolog 4 (Drosophila)	0.012
TP53BP2	tumor protein p53 binding protein, 2	0.011
UBE2J1	ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)	0.011
MUL1	mitochondrial E3 ubiquitin protein ligase 1	0.011
NR0B2	nuclear receptor subfamily 0, group B, member 2	0.011
BTRC	beta-transducin repeat containing	0.011
DSP	desmoplakin	0.011
BBC3	BCL2 binding component 3	0.011
MED25	mediator complex subunit 25	0.011
MAPK8	mitogen-activated protein kinase 8	0.011
BTN3A3	butyrophilin, subfamily 3, member A3	0.011
CCND1	cyclin D1	0.011
IKBKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	0.010
SPG21	spastic paraplegia 21 (autosomal recessive, Mast syndrome)	0.010
MAGEA2	melanoma antigen family A, 2	0.010
RHD	Rh blood group, D antigen	0.010
PHF7	PHD finger protein 7	0.010
RSAD2	radical S-adenosyl methionine domain containing 2	0.010
PSENEN	presenilin enhancer 2 homolog (C. elegans)	0.010
ING4	inhibitor of growth family, member 4	0.010
HUWE1	HECT, UBA and WWE domain containing 1	0.010
OSBP2	oxysterol binding protein 2	0.010
OTUD5	OTU domain containing 5	0.010

IMP

Homo sapiens

negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process

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