IMP

Process View

Homo sapiens

33 genes annotated in human

telomere organization

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "telomere organization"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "telomere organization" (in gray)

Name	Description	Probability	Func Analog Organism
TERF2	telomeric repeat binding factor 2	0.987
WRN	Werner syndrome, RecQ helicase-like	0.985
SLX4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)	0.984
RAD51	RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)	0.975	Yeast
MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	0.956
BLM	Bloom syndrome, RecQ helicase-like	0.949	Mouse
H2AFX	H2A histone family, member X	0.927
TERF1	telomeric repeat binding factor (NIMA-interacting) 1	0.884
NBN	nibrin	0.836
ACD	adrenocortical dysplasia homolog (mouse)	0.661
MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	0.584
BRCA1	breast cancer 1, early onset	0.385
FANCD2	Fanconi anemia, complementation group D2	0.377
UPF1	UPF1 regulator of nonsense transcripts homolog (yeast)	0.377
SMC6	structural maintenance of chromosomes 6	0.365
WDR5	WD repeat domain 5	0.357
RAD51L3	RAD51-like 3 (S. cerevisiae)	0.304
MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	0.303	Fly
RPA1	replication protein A1, 70kDa	0.298
RAD51C	RAD51 homolog C (S. cerevisiae)	0.255
C19orf39	chromosome 19 open reading frame 39	0.236
TNFSF14	tumor necrosis factor (ligand) superfamily, member 14	0.231
PRKDC	protein kinase, DNA-activated, catalytic polypeptide	0.227
TINF2	TERF1 (TRF1)-interacting nuclear factor 2	0.180
TTI1	Tel2 interacting protein 1 homolog (S. pombe)	0.177
TERF2IP	telomeric repeat binding factor 2, interacting protein	0.158
NSMCE1	non-SMC element 1 homolog (S. cerevisiae)	0.141
YY1	YY1 transcription factor	0.128
ASH2L	ash2 (absent, small, or homeotic)-like (Drosophila)	0.117
CBX5	chromobox homolog 5	0.109	Fly
XRCC2	X-ray repair complementing defective repair in Chinese hamster cells 2	0.098
RAD51L1	RAD51-like 1 (S. cerevisiae)	0.094	Yeast
XRCC6	X-ray repair complementing defective repair in Chinese hamster cells 6	0.091
UBR3	ubiquitin protein ligase E3 component n-recognin 3 (putative)	0.088
HIF1AN	hypoxia inducible factor 1, alpha subunit inhibitor	0.087
PINX1	PIN2/TERF1 interacting, telomerase inhibitor 1	0.083
OSGEP	O-sialoglycoprotein endopeptidase	0.079	Yeast
ATRX	alpha thalassemia/mental retardation syndrome X-linked	0.074	Mouse
TERT	telomerase reverse transcriptase	0.074
TOP3A	topoisomerase (DNA) III alpha	0.073
RAD50	RAD50 homolog (S. cerevisiae)	0.070
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.066
RPA2	replication protein A2, 32kDa	0.062
RIF1	RAP1 interacting factor homolog (yeast)	0.061
STAG1	stromal antigen 1	0.057
MSH6	mutS homolog 6 (E. coli)	0.055
XRCC3	X-ray repair complementing defective repair in Chinese hamster cells 3	0.052
SMC1A	structural maintenance of chromosomes 1A	0.050
ATM	ataxia telangiectasia mutated	0.049	Fly
RAD18	RAD18 homolog (S. cerevisiae)	0.046
MDM2	Mdm2 p53 binding protein homolog (mouse)	0.041
CBX1	chromobox homolog 1	0.039	Fly
PCNA	proliferating cell nuclear antigen	0.039
BRCA2	breast cancer 2, early onset	0.037
PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	0.034
ACTR5	ARP5 actin-related protein 5 homolog (yeast)	0.033
PARP1	poly (ADP-ribose) polymerase 1	0.033	Mouse
POLA1	polymerase (DNA directed), alpha 1, catalytic subunit	0.032
PAFAH1B3	platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)	0.031
RPA3	replication protein A3, 14kDa	0.030
XRCC5	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	0.029
RAD52	RAD52 homolog (S. cerevisiae)	0.028	Yeast
CDC45	cell division cycle 45 homolog (S. cerevisiae)	0.027
APLF	aprataxin and PNKP like factor	0.027
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	0.026
BANP	BTG3 associated nuclear protein	0.026
HLTF	helicase-like transcription factor	0.026
NSMCE2	non-SMC element 2, MMS21 homolog (S. cerevisiae)	0.025
HUS1	HUS1 checkpoint homolog (S. pombe)	0.025
GSK3B	glycogen synthase kinase 3 beta	0.024
RAD9A	RAD9 homolog A (S. pombe)	0.024
XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	0.023
HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	0.022	Yeast
SMN1	survival of motor neuron 1, telomeric	0.022
MYST3	MYST histone acetyltransferase (monocytic leukemia) 3	0.021
INO80E	INO80 complex subunit E	0.020
HIST1H3B	histone cluster 1, H3b	0.019
PRIM2	primase, DNA, polypeptide 2 (58kDa)	0.019
MYST1	MYST histone acetyltransferase 1	0.019
MSH3	mutS homolog 3 (E. coli)	0.019
LAGE3	L antigen family, member 3	0.019
RECQL4	RecQ protein-like 4	0.019
TAF2	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa	0.018
ATG12	ATG12 autophagy related 12 homolog (S. cerevisiae)	0.018
BARD1	BRCA1 associated RING domain 1	0.018
INCENP	inner centromere protein antigens 135/155kDa	0.018
DAXX	death-domain associated protein	0.018
ATR	ataxia telangiectasia and Rad3 related	0.018	Yeast Fly
MAPK14	mitogen-activated protein kinase 14	0.017
TP53RK	TP53 regulating kinase	0.017	Yeast
NDNL2	necdin-like 2	0.017
TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	0.017
NVL	nuclear VCP-like	0.017
RBBP8	retinoblastoma binding protein 8	0.017
ORC2	origin recognition complex, subunit 2	0.017
DTL	denticleless homolog (Drosophila)	0.017
YAF2	YY1 associated factor 2	0.016
CHEK1	CHK1 checkpoint homolog (S. pombe)	0.016
H1F0	H1 histone family, member 0	0.016
ORC1	origin recognition complex, subunit 1	0.016
SMG6	Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)	0.016
ZNF775	zinc finger protein 775	0.015
CREBBP	CREB binding protein	0.015
NEK1	NIMA (never in mitosis gene a)-related kinase 1	0.015
CALCOCO2	calcium binding and coiled-coil domain 2	0.015
CHTF18	CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)	0.015
NR3C1	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	0.014
C18orf54	chromosome 18 open reading frame 54	0.014
XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	0.014
HIST2H3C	histone cluster 2, H3c	0.014
MDC1	mediator of DNA-damage checkpoint 1	0.013
FAM190B	family with sequence similarity 190, member B	0.013
SMAD6	SMAD family member 6	0.013
CDCA5	cell division cycle associated 5	0.013
INO80D	INO80 complex subunit D	0.013
HCFC1	host cell factor C1 (VP16-accessory protein)	0.013
FBXO4	F-box protein 4	0.013
CHAF1A	chromatin assembly factor 1, subunit A (p150)	0.013
MLL3	myeloid/lymphoid or mixed-lineage leukemia 3	0.012
WDHD1	WD repeat and HMG-box DNA binding protein 1	0.012
MAX	MYC associated factor X	0.012
RNF19A	ring finger protein 19A	0.012
NCAPH2	non-SMC condensin II complex, subunit H2	0.012
RAD54L	RAD54-like (S. cerevisiae)	0.012	Yeast
CDK2	cyclin-dependent kinase 2	0.012
NSMCE4A	non-SMC element 4 homolog A (S. cerevisiae)	0.012
ZSWIM7	zinc finger, SWIM-type containing 7	0.012
MAPK7	mitogen-activated protein kinase 7	0.011
POGZ	pogo transposable element with ZNF domain	0.011
CHD8	chromodomain helicase DNA binding protein 8	0.011
TPR	translocated promoter region (to activated MET oncogene)	0.011
LENG1	leukocyte receptor cluster (LRC) member 1	0.011
MLLT1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	0.011
LNPEP	leucyl/cystinyl aminopeptidase	0.011
RAD17	RAD17 homolog (S. pombe)	0.011
RNF20	ring finger protein 20	0.011
FNBP1	formin binding protein 1	0.011
TOP2B	topoisomerase (DNA) II beta 180kDa	0.010
UBL7	ubiquitin-like 7 (bone marrow stromal cell-derived)	0.010
FBXW11	F-box and WD repeat domain containing 11	0.010
FANCB	Fanconi anemia, complementation group B	0.010
RAD54B	RAD54 homolog B (S. cerevisiae)	0.010
POLQ	polymerase (DNA directed), theta	0.010
SP140L	SP140 nuclear body protein-like	0.010	Human