IMP

Process View

Homo sapiens

3 genes annotated in human

positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

GO:1902043

Any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway via death domain receptors.

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Known genes in the process in human Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of extrinsic apoptotic signaling pathway via death domain receptors" (in gray)

Name	Description	Probability	Func Analog Organism
CASP8	caspase 8, apoptosis-related cysteine peptidase	1.000
FAS	Fas (TNF receptor superfamily, member 6)	0.891
STK3	serine/threonine kinase 3	0.860	Mouse
CASP10	caspase 10, apoptosis-related cysteine peptidase	0.828
STK4	serine/threonine kinase 4	0.729	Mouse
RASSF5	Ras association (RalGDS/AF-6) domain family member 5	0.726
CFLAR	CASP8 and FADD-like apoptosis regulator	0.683
BCL2L11	BCL2-like 11 (apoptosis facilitator)	0.644
RASSF3	Ras association (RalGDS/AF-6) domain family member 3	0.602
TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	0.584
TNFRSF10B	tumor necrosis factor receptor superfamily, member 10b	0.495
BID	BH3 interacting domain death agonist	0.453
RIPK1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.299
MCL1	myeloid cell leukemia sequence 1 (BCL2-related)	0.292
CRADD	CASP2 and RIPK1 domain containing adaptor with death domain	0.232
SAV1	salvador homolog 1 (Drosophila)	0.183
FASLG	Fas ligand (TNF superfamily, member 6)	0.167
BCL2	B-cell CLL/lymphoma 2	0.167
FGFR1OP2	FGFR1 oncogene partner 2	0.164
BAX	BCL2-associated X protein	0.149
PSEN1	presenilin 1	0.143
DUSP3	dual specificity phosphatase 3	0.132
RASSF1	Ras association (RalGDS/AF-6) domain family member 1	0.132
MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	0.118
TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	0.114
CASP2	caspase 2, apoptosis-related cysteine peptidase	0.114
BCL2L1	BCL2-like 1	0.111
BAK1	BCL2-antagonist/killer 1	0.106
TGFB1	transforming growth factor, beta 1	0.097
ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	0.096
MAPK1	mitogen-activated protein kinase 1	0.078
TNFSF10	tumor necrosis factor (ligand) superfamily, member 10	0.077
SRI	sorcin	0.075
RNF4	ring finger protein 4	0.074
RASSF2	Ras association (RalGDS/AF-6) domain family member 2	0.073
HIPK1	homeodomain interacting protein kinase 1	0.073
CIB1	calcium and integrin binding 1 (calmyrin)	0.070
FLNB	filamin B, beta	0.066
FHL2	four and a half LIM domains 2	0.064
BAD	BCL2-associated agonist of cell death	0.064
MDFI	MyoD family inhibitor	0.062
TRADD	TNFRSF1A-associated via death domain	0.055
BBC3	BCL2 binding component 3	0.054
IGF2	insulin-like growth factor 2 (somatomedin A)	0.051
GDF5	growth differentiation factor 5	0.050
NID1	nidogen 1	0.048
BIK	BCL2-interacting killer (apoptosis-inducing)	0.046
LATS2	LATS, large tumor suppressor, homolog 2 (Drosophila)	0.045
STK38L	serine/threonine kinase 38 like	0.044
UROD	uroporphyrinogen decarboxylase	0.044
COL1A1	collagen, type I, alpha 1	0.041
PDPK1	3-phosphoinositide dependent protein kinase-1	0.035
TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	0.032
UBE2I	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	0.027
DAXX	death-domain associated protein	0.026
HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	0.025
BECN1	beclin 1, autophagy related	0.024
SFRP4	secreted frizzled-related protein 4	0.023
FKBP8	FK506 binding protein 8, 38kDa	0.023
FDXR	ferredoxin reductase	0.023
ASCC2	activating signal cointegrator 1 complex subunit 2	0.022
MYD88	myeloid differentiation primary response gene (88)	0.021
TFPI2	tissue factor pathway inhibitor 2	0.021
CCDC85B	coiled-coil domain containing 85B	0.020
APP	amyloid beta (A4) precursor protein	0.019
TGFBR1	transforming growth factor, beta receptor 1	0.019
MAP2K1	mitogen-activated protein kinase kinase 1	0.019
MTOR	mechanistic target of rapamycin (serine/threonine kinase)	0.019
AMBRA1	autophagy/beclin-1 regulator 1	0.019
AQP1	aquaporin 1 (Colton blood group)	0.018
TDG	thymine-DNA glycosylase	0.018
FAM40A	family with sequence similarity 40, member A	0.018
TGM2	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	0.017
ZFYVE1	zinc finger, FYVE domain containing 1	0.017
TAGLN	transgelin	0.017
SKI	v-ski sarcoma viral oncogene homolog (avian)	0.016
CRLF3	cytokine receptor-like factor 3	0.016
FLNA	filamin A, alpha	0.016
FGF2	fibroblast growth factor 2 (basic)	0.015
THY1	Thy-1 cell surface antigen	0.015
FBLN2	fibulin 2	0.015
COL4A1	collagen, type IV, alpha 1	0.014
MAPK3	mitogen-activated protein kinase 3	0.014
THAP5	THAP domain containing 5	0.014
PPL	periplakin	0.014
ITGB1	integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)	0.014
PLCD3	phospholipase C, delta 3	0.014
TUBB6	tubulin, beta 6	0.014
LRCH2	leucine-rich repeats and calponin homology (CH) domain containing 2	0.014
MYH9	myosin, heavy chain 9, non-muscle	0.013
ITGB1BP3	integrin beta 1 binding protein 3	0.013
DNAJB11	DnaJ (Hsp40) homolog, subfamily B, member 11	0.013
SULF1	sulfatase 1	0.013
SFRP2	secreted frizzled-related protein 2	0.013	Human
IER3	immediate early response 3	0.012
UBR1	ubiquitin protein ligase E3 component n-recognin 1	0.012
CAMSAP1	calmodulin regulated spectrin-associated protein 1	0.012
ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	0.012
FBLN1	fibulin 1	0.012
AEBP1	AE binding protein 1	0.012
FMOD	fibromodulin	0.012
DUSP5	dual specificity phosphatase 5	0.012
CXXC5	CXXC finger protein 5	0.012
MOBKL1B	MOB1, Mps One Binder kinase activator-like 1B (yeast)	0.012
ITGAV	integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)	0.012
COL16A1	collagen, type XVI, alpha 1	0.012
DDB2	damage-specific DNA binding protein 2, 48kDa	0.012
HRK	harakiri, BCL2 interacting protein (contains only BH3 domain)	0.012
IL8	interleukin 8	0.012
TLN1	talin 1	0.011
ATHL1	ATH1, acid trehalase-like 1 (yeast)	0.011
IGF2R	insulin-like growth factor 2 receptor	0.011
DAB2	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	0.011
ATXN3	ataxin 3	0.011
LATS1	LATS, large tumor suppressor, homolog 1 (Drosophila)	0.011
TRIM62	tripartite motif containing 62	0.011
PTPRR	protein tyrosine phosphatase, receptor type, R	0.011
MXRA5	matrix-remodelling associated 5	0.011
SIX1	SIX homeobox 1	0.011
RASSF4	Ras association (RalGDS/AF-6) domain family member 4	0.011
PTPRJ	protein tyrosine phosphatase, receptor type, J	0.011
BMP2	bone morphogenetic protein 2	0.011
SMAD7	SMAD family member 7	0.011
ACTN1	actinin, alpha 1	0.011
ZFP106	zinc finger protein 106 homolog (mouse)	0.011
FNDC1	fibronectin type III domain containing 1	0.011
MAP1S	microtubule-associated protein 1S	0.011
TRAF1	TNF receptor-associated factor 1	0.011
HTRA3	HtrA serine peptidase 3	0.010
HEY1	hairy/enhancer-of-split related with YRPW motif 1	0.010
CSRP1	cysteine and glycine-rich protein 1	0.010
TEAD3	TEA domain family member 3	0.010
SASH1	SAM and SH3 domain containing 1	0.010
TLE1	transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)	0.010
TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	0.010
ZZEF1	zinc finger, ZZ-type with EF-hand domain 1	0.010
TP53BP2	tumor protein p53 binding protein, 2	0.010