IMP

Process View

Mus musculus

10 genes annotated in mouse

primitive streak formation

The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "primitive streak formation"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "primitive streak formation" (in gray)

Name	Description	Probability	Func Analog Organism
Shh	sonic hedgehog	1.000
Gli3	GLI-Kruppel family member GLI3	1.000
Pax2	paired box gene 2	1.000
Fgf8	fibroblast growth factor 8	0.998
Pitx2	paired-like homeodomain transcription factor 2	0.998
Fgfr2	fibroblast growth factor receptor 2	0.996
Otx2	orthodenticle homolog 2 (Drosophila)	0.995
Lhx1	LIM homeobox protein 1	0.991
Nodal	nodal	0.989
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.989
Foxc1	forkhead box C1	0.984	Mouse
Bmp4	bone morphogenetic protein 4	0.983	Mouse
Nog	noggin	0.982
Pax3	paired box gene 3	0.978
Tbx1	T-box 1	0.978
Emx2	empty spiracles homolog 2 (Drosophila)	0.967
Gbx2	gastrulation brain homeobox 2	0.966
Pax8	paired box gene 8	0.963
Eya1	eyes absent 1 homolog (Drosophila)	0.960
Msx1	homeobox, msh-like 1	0.956
Hand1	heart and neural crest derivatives expressed transcript 1	0.951
Lmx1a	LIM homeobox transcription factor 1 alpha	0.948	Mouse
Foxc2	forkhead box C2	0.947	Mouse
Fgfr1	fibroblast growth factor receptor 1	0.909
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.905
Dlx5	distal-less homeobox 5	0.896
En1	engrailed 1	0.888
Bmp7	bone morphogenetic protein 7	0.879	Mouse
Prrx1	paired related homeobox 1	0.876
Gata4	GATA binding protein 4	0.867
Chrd	chordin	0.850
Gli2	GLI-Kruppel family member GLI2	0.837
Wnt3a	wingless-related MMTV integration site 3A	0.794	Mouse
Rarg	retinoic acid receptor, gamma	0.787
Pdgfra	platelet derived growth factor receptor, alpha polypeptide	0.784
Prrx2	paired related homeobox 2	0.782
Smo	smoothened homolog (Drosophila)	0.762
Hand2	heart and neural crest derivatives expressed transcript 2	0.757
Wnt1	wingless-related MMTV integration site 1	0.756	Mouse
Foxa2	forkhead box A2	0.735
Msx2	homeobox, msh-like 2	0.727
Dkk1	dickkopf homolog 1 (Xenopus laevis)	0.722
Isl1	ISL1 transcription factor, LIM/homeodomain	0.711	Mouse
Zic3	zinc finger protein of the cerebellum 3	0.697
Hoxa1	homeobox A1	0.691
Pax6	paired box gene 6	0.688
Otx1	orthodenticle homolog 1 (Drosophila)	0.673	Mouse
Hoxd11	homeobox D11	0.574
Gdnf	glial cell line derived neurotrophic factor	0.555
Rarb	retinoic acid receptor, beta	0.543
T	brachyury	0.511
Meox2	mesenchyme homeobox 2	0.446
Fgf3	fibroblast growth factor 3	0.438
Tgfb2	transforming growth factor, beta 2	0.436
Nr5a1	nuclear receptor subfamily 5, group A, member 1	0.432
Sox9	SRY-box containing gene 9	0.412
Fgfr3	fibroblast growth factor receptor 3	0.404
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.390
Hoxd13	homeobox D13	0.387
Hmx3	H6 homeobox 3	0.355
Wt1	Wilms tumor 1 homolog	0.347
Alx4	aristaless-like homeobox 4	0.344
Lmx1b	LIM homeobox transcription factor 1 beta	0.342	Mouse
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.325
Hes1	hairy and enhancer of split 1 (Drosophila)	0.324
Tbx15	T-box 15	0.309
Onecut1	one cut domain, family member 1	0.298
Nkx2-1	NK2 homeobox 1	0.290
Gsc	goosecoid homeobox	0.287
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.277
Fgf10	fibroblast growth factor 10	0.274
Vangl2	vang-like 2 (van gogh, Drosophila)	0.266
Twist2	twist homolog 2 (Drosophila)	0.266
Tcfap2a	transcription factor AP-2, alpha	0.262
Sox3	SRY-box containing gene 3	0.248
Ctnnb1	catenin (cadherin associated protein), beta 1	0.246
Tbx3	T-box 3	0.243
Pitx1	paired-like homeodomain transcription factor 1	0.238
Hoxa13	homeobox A13	0.234
Myod1	myogenic differentiation 1	0.223
Gata6	GATA binding protein 6	0.223
Tbx2	T-box 2	0.217
Zeb1	zinc finger E-box binding homeobox 1	0.216
Gas1	growth arrest specific 1	0.212
Hoxa2	homeobox A2	0.209
Cdx1	caudal type homeobox 1	0.197
Foxh1	forkhead box H1	0.187
Wnt4	wingless-related MMTV integration site 4	0.182	Mouse
Wnt3	wingless-related MMTV integration site 3	0.173	Mouse
Lef1	lymphoid enhancer binding factor 1	0.172
Col13a1	collagen, type XIII, alpha 1	0.172
Sox11	SRY-box containing gene 11	0.168
Hoxa11	homeobox A11	0.157
Neurog1	neurogenin 1	0.150
Cyp26a1	cytochrome P450, family 26, subfamily a, polypeptide 1	0.141
Sox2	SRY-box containing gene 2	0.140
Smad6	MAD homolog 6 (Drosophila)	0.138
Ret	ret proto-oncogene	0.136
Pbx1	pre B-cell leukemia transcription factor 1	0.136
Sox7	SRY-box containing gene 7	0.135
Fgf15	fibroblast growth factor 15	0.132
Lhx3	LIM homeobox protein 3	0.131	Mouse
Runx2	runt related transcription factor 2	0.127
Six2	sine oculis-related homeobox 2 homolog (Drosophila)	0.124
Matn3	matrilin 3	0.124
Hoxd9	homeobox D9	0.122
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.119
Lrp6	low density lipoprotein receptor-related protein 6	0.112
Hoxc8	homeobox C8	0.111
Foxf2	forkhead box F2	0.110
Alx3	aristaless-like homeobox 3	0.106
Emid2	EMI domain containing 2	0.106
Acvr1	activin A receptor, type 1	0.104
Foxd3	forkhead box D3	0.100	Mouse
Gdf5	growth differentiation factor 5	0.100	Mouse
Eya4	eyes absent 4 homolog (Drosophila)	0.097
Neurog2	neurogenin 2	0.093
Zic1	zinc finger protein of the cerebellum 1	0.093
Ihh	Indian hedgehog	0.090
Hoxd3	homeobox D3	0.090
Pax1	paired box gene 1	0.090
Pax9	paired box gene 9	0.089
Bnc1	basonuclin 1	0.088
Ednra	endothelin receptor type A	0.083
Hoxc6	homeobox C6	0.082
Jag1	jagged 1	0.082
Amhr2	anti-Mullerian hormone type 2 receptor	0.082
Hoxa9	homeobox A9	0.079
Hoxa10	homeobox A10	0.078
Foxd2	forkhead box D2	0.078	Mouse
Sox1	SRY-box containing gene 1	0.077
Ntf3	neurotrophin 3	0.076
Hmx1	H6 homeobox 1	0.075
Pax7	paired box gene 7	0.075
En2	engrailed 2	0.075
Hoxb6	homeobox B6	0.073
Hes5	hairy and enhancer of split 5 (Drosophila)	0.073
Twist1	twist homolog 1 (Drosophila)	0.072
Foxa1	forkhead box A1	0.072	Mouse
Nkx1-2	NK1 transcription factor related, locus 2 (Drosophila)	0.071
Pcsk5	proprotein convertase subtilisin/kexin type 5	0.070
Fgf4	fibroblast growth factor 4	0.070
Emx1	empty spiracles homolog 1 (Drosophila)	0.069
Bmp2	bone morphogenetic protein 2	0.067	Mouse
Dlx6	distal-less homeobox 6	0.065
Foxg1	forkhead box G1	0.064	Mouse
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.064
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.062
Phox2b	paired-like homeobox 2b	0.061
Gdf6	growth differentiation factor 6	0.060	Mouse
Rara	retinoic acid receptor, alpha	0.060
Nkx2-5	NK2 transcription factor related, locus 5 (Drosophila)	0.060
Pou3f3	POU domain, class 3, transcription factor 3	0.059
Fzd10	frizzled homolog 10 (Drosophila)	0.059
Gja3	gap junction protein, alpha 3	0.059
Nr2f1	nuclear receptor subfamily 2, group F, member 1	0.058
Igdcc3	immunoglobulin superfamily, DCC subclass, member 3	0.057
Foxb1	forkhead box B1	0.057
Pitx3	paired-like homeodomain transcription factor 3	0.056
Skor1	SKI family transcriptional corepressor 1	0.055
Gpc3	glypican 3	0.055
Hoxa4	homeobox A4	0.054
Chd7	chromodomain helicase DNA binding protein 7	0.053
Rax	retina and anterior neural fold homeobox	0.052
Wnt6	wingless-related MMTV integration site 6	0.051	Mouse
Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	0.050
Barx1	BarH-like homeobox 1	0.049
Ptk7	PTK7 protein tyrosine kinase 7	0.049
Dlx1	distal-less homeobox 1	0.049
Ndst1	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	0.048
Hoxb9	homeobox B9	0.048
Wnt11	wingless-related MMTV integration site 11	0.047	Mouse
Foxf1a	forkhead box F1a	0.047
Vstm2b	V-set and transmembrane domain containing 2B	0.047
Tgfa	transforming growth factor alpha	0.047
Hoxd1	homeobox D1	0.047
Arx	aristaless related homeobox	0.047
Adra2b	adrenergic receptor, alpha 2b	0.046
Fgf18	fibroblast growth factor 18	0.044
Uncx	UNC homeobox	0.044
Pthlh	parathyroid hormone-like peptide	0.043
Insm1	insulinoma-associated 1	0.042
Sim2	single-minded homolog 2 (Drosophila)	0.042
Cldn6	claudin 6	0.042
Srebf2	sterol regulatory element binding factor 2	0.041
Fzd8	frizzled homolog 8 (Drosophila)	0.041
Nobox	NOBOX oogenesis homeobox	0.041
Tal2	T-cell acute lymphocytic leukemia 2	0.041
Bmper	BMP-binding endothelial regulator	0.041
Wnt10b	wingless related MMTV integration site 10b	0.041	Mouse
Gli1	GLI-Kruppel family member GLI1	0.040
Rdh10	retinol dehydrogenase 10 (all-trans)	0.039
Tcf21	transcription factor 21	0.039
Alx1	ALX homeobox 1	0.038
Osr1	odd-skipped related 1 (Drosophila)	0.037
Mapk8ip1	mitogen-activated protein kinase 8 interacting protein 1	0.037
Npr3	natriuretic peptide receptor 3	0.037
Vax1	ventral anterior homeobox containing gene 1	0.036
Sox17	SRY-box containing gene 17	0.036
Ptch1	patched homolog 1	0.035
Sall4	sal-like 4 (Drosophila)	0.035
Gpr50	G-protein-coupled receptor 50	0.035
Lhx5	LIM homeobox protein 5	0.034	Mouse
Pou4f2	POU domain, class 4, transcription factor 2	0.033
Tulp1	tubby like protein 1	0.032
Hoxd8	homeobox D8	0.031
Snai1	snail homolog 1 (Drosophila)	0.031
Lhx9	LIM homeobox protein 9	0.031	Mouse
Hoxb3	homeobox B3	0.031
Grem1	gremlin 1	0.031
Fgfrl1	fibroblast growth factor receptor-like 1	0.030
Zfp503	zinc finger protein 503	0.029
Fzd1	frizzled homolog 1 (Drosophila)	0.029
Zic2	zinc finger protein of the cerebellum 2	0.029
Hsd11b2	hydroxysteroid 11-beta dehydrogenase 2	0.028
Cdkn2a	cyclin-dependent kinase inhibitor 2A	0.027
Shox2	short stature homeobox 2	0.027
Etv2	ets variant gene 2	0.026	Mouse
Efna2	ephrin A2	0.026
Tcfap2c	transcription factor AP-2, gamma	0.026
Il11	interleukin 11	0.026
Dlx2	distal-less homeobox 2	0.025
Tead3	TEA domain family member 3	0.025
Col2a1	collagen, type II, alpha 1	0.025
Col22a1	collagen, type XXII, alpha 1	0.024
Neurod1	neurogenic differentiation 1	0.024
Dact1	dapper homolog 1, antagonist of beta-catenin (xenopus)	0.024
Mip	major intrinsic protein of eye lens fiber	0.024
Hoxa5	homeobox A5	0.024
Pcdh12	protocadherin 12	0.024
Ror1	receptor tyrosine kinase-like orphan receptor 1	0.023
Klk4	kallikrein related-peptidase 4 (prostase, enamel matrix, prostate)	0.023
Six6	sine oculis-related homeobox 6 homolog (Drosophila)	0.023
Psen1	presenilin 1	0.023
Fosl2	fos-like antigen 2	0.023
Hoxb13	homeobox B13	0.023
Hes3	hairy and enhancer of split 3 (Drosophila)	0.023
Smad3	MAD homolog 3 (Drosophila)	0.022
Atoh1	atonal homolog 1 (Drosophila)	0.022
Hoxc4	homeobox C4	0.022
Tdgf1	teratocarcinoma-derived growth factor 1	0.022
Hoxb2	homeobox B2	0.022
Amh	anti-Mullerian hormone	0.022
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.022
Pou3f2	POU domain, class 3, transcription factor 2	0.022
Pou3f1	POU domain, class 3, transcription factor 1	0.022
Evx1	even skipped homeotic gene 1 homolog	0.021
She	src homology 2 domain-containing transforming protein E	0.021
Hmga2	high mobility group AT-hook 2	0.021
Wnt2b	wingless related MMTV integration site 2b	0.021	Mouse
Otog	otogelin	0.020
Axin1	axin 1	0.020
Zfhx4	zinc finger homeodomain 4	0.020
Tlx2	T-cell leukemia, homeobox 2	0.020
Fgf17	fibroblast growth factor 17	0.020
Lefty1	left right determination factor 1	0.020
Lhx4	LIM homeobox protein 4	0.020	Mouse
Hoxc9	homeobox C9	0.019
Foxd1	forkhead box D1	0.019	Mouse
Ebf3	early B-cell factor 3	0.019
Sfrp2	secreted frizzled-related protein 2	0.018
Mn1	meningioma 1	0.018
Bmpr1b	bone morphogenetic protein receptor, type 1B	0.018
Gata3	GATA binding protein 3	0.018
Sim1	single-minded homolog 1 (Drosophila)	0.018
Fgf5	fibroblast growth factor 5	0.018
Pdx1	pancreatic and duodenal homeobox 1	0.018
Batf3	basic leucine zipper transcription factor, ATF-like 3	0.017
Wnt9b	wingless-type MMTV integration site 9B	0.017	Mouse
Wnt5b	wingless-related MMTV integration site 5B	0.017	Mouse
Sh3pxd2a	SH3 and PX domains 2A	0.017
Rxra	retinoid X receptor alpha	0.017
Cer1	cerberus 1 homolog (Xenopus laevis)	0.017
Hoxd4	homeobox D4	0.017
Hesx1	homeobox gene expressed in ES cells	0.017
Foxl2	forkhead box L2	0.017	Mouse
Tpbg	trophoblast glycoprotein	0.016
Fli1	Friend leukemia integration 1	0.016
Lrp5	low density lipoprotein receptor-related protein 5	0.016	Mouse
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.016
Kiss1	KiSS-1 metastasis-suppressor	0.016
Mnx1	motor neuron and pancreas homeobox 1	0.016
Tlx3	T-cell leukemia, homeobox 3	0.016
Myog	myogenin	0.016
Agtr2	angiotensin II receptor, type 2	0.015
Hoxd10	homeobox D10	0.015
Mesp1	mesoderm posterior 1	0.015
Art5	ADP-ribosyltransferase 5	0.015
Myf6	myogenic factor 6	0.015
Slc16a8	solute carrier family 16 (monocarboxylic acid transporters), member 8	0.015
Neurog3	neurogenin 3	0.015
Pygo1	pygopus 1	0.015
Padi3	peptidyl arginine deiminase, type III	0.015
Bcl2	B-cell leukemia/lymphoma 2	0.015
Foxe3	forkhead box E3	0.015	Mouse
Cxcl12	chemokine (C-X-C motif) ligand 12	0.015
Wnt9a	wingless-type MMTV integration site 9A	0.014	Mouse
Hic1	hypermethylated in cancer 1	0.014
Tcl1	T-cell lymphoma breakpoint 1	0.014
Plac1	placental specific protein 1	0.014
Fzd7	frizzled homolog 7 (Drosophila)	0.014
Apaf1	apoptotic peptidase activating factor 1	0.014
Pkdcc	protein kinase domain containing, cytoplasmic	0.014
Glra1	glycine receptor, alpha 1 subunit	0.013
Tcf15	transcription factor 15	0.013
Nrtn	neurturin	0.013
Hs3st3a1	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	0.013
Ascl2	achaete-scute complex homolog 2 (Drosophila)	0.013
Gsx1	GS homeobox 1	0.013
Etv4	ets variant gene 4 (E1A enhancer binding protein, E1AF)	0.013	Mouse
Foxd4	forkhead box D4	0.013	Mouse
Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	0.013
Hoxd12	homeobox D12	0.013
Ldb2	LIM domain binding 2	0.013
Smad7	MAD homolog 7 (Drosophila)	0.012
Nr2e1	nuclear receptor subfamily 2, group E, member 1	0.012
Kcne1l	potassium voltage-gated channel, Isk-related family, member 1-like, pseudogene	0.012
Cldn3	claudin 3	0.012
Lbx2	ladybird homeobox homolog 2 (Drosophila)	0.012	Mouse
Dkk2	dickkopf homolog 2 (Xenopus laevis)	0.012
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Arnt2	aryl hydrocarbon receptor nuclear translocator 2	0.012
Cdx2	caudal type homeobox 2	0.012
Bdkrb2	bradykinin receptor, beta 2	0.012
Vegfa	vascular endothelial growth factor A	0.012
Bmp5	bone morphogenetic protein 5	0.012	Mouse
Evx2	even skipped homeotic gene 2 homolog	0.012
Myf5	myogenic factor 5	0.012
Hoxa3	homeobox A3	0.012
Hoxb5	homeobox B5	0.011
Col25a1	collagen, type XXV, alpha 1	0.011
Chrdl2	chordin-like 2	0.011
Cfc1	cripto, FRL-1, cryptic family 1	0.011
Sall3	sal-like 3 (Drosophila)	0.011
Fut7	fucosyltransferase 7	0.011
BC024139	cDNA sequence BC024139	0.011
Wnt5a	wingless-related MMTV integration site 5A	0.011
Vax2	ventral anterior homeobox containing gene 2	0.011
Igfbpl1	insulin-like growth factor binding protein-like 1	0.011
Sost	sclerostin	0.011
Magel2	melanoma antigen, family L, 2	0.011
Zfpm2	zinc finger protein, multitype 2	0.011
Hoxb1	homeobox B1	0.011
Meis2	Meis homeobox 2	0.010
Lama1	laminin, alpha 1	0.010
Efna4	ephrin A4	0.010
Tulp2	tubby-like protein 2	0.010
Tnni2	troponin I, skeletal, fast 2	0.010
Nkx2-4	NK2 transcription factor related, locus 4 (Drosophila)	0.010
Prop1	paired like homeodomain factor 1	0.010
Nkx3-2	NK3 homeobox 2	0.010
Smad2	MAD homolog 2 (Drosophila)	0.010
Cbln3	cerebellin 3 precursor protein	0.010
Col4a3	collagen, type IV, alpha 3	0.010