IMP

Process View

Mus musculus

2 genes annotated in mouse

positive regulation of fever generation by positive regulation of prostaglandin secretion

Any process that increases the rate or extent of fever generation via positive regulation of the frequency, rate or extent of the regulated release of a prostaglandin from a cell.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "positive regulation of fever generation by positive regulation of prostaglandin secretion"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "positive regulation of fever generation by positive regulation of prostaglandin secretion" (in gray)

Name	Description	Probability	Func Analog Organism
Tnf	tumor necrosis factor	0.993	Mouse
Lta	lymphotoxin A	0.964	Mouse
Pik3cd	phosphatidylinositol 3-kinase catalytic delta polypeptide	0.942
Il10	interleukin 10	0.941
Map3k14	mitogen-activated protein kinase kinase kinase 14	0.935
Cd40	CD40 antigen	0.914	Mouse
Ifng	interferon gamma	0.768
Igh	immunoglobulin heavy chain complex	0.715
Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	0.684
Nfkb2	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p100	0.659
Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	0.558	Mouse
Traf2	TNF receptor-associated factor 2	0.484
Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a	0.423
Nos2	nitric oxide synthase 2, inducible	0.416
Bcl3	B-cell leukemia/lymphoma 3	0.389
Tnfsf11	tumor necrosis factor (ligand) superfamily, member 11	0.347
Traf6	TNF receptor-associated factor 6	0.314
Cebpb	CCAAT/enhancer binding protein (C/EBP), beta	0.308
Il6	interleukin 6	0.260
Ccl2	chemokine (C-C motif) ligand 2	0.238
Ptgs2	prostaglandin-endoperoxide synthase 2	0.171
Btk	Bruton agammaglobulinemia tyrosine kinase	0.169
Ccl4	chemokine (C-C motif) ligand 4	0.143
Il1r1	interleukin 1 receptor, type I	0.133
Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	0.109	Mouse
Bcl6	B-cell leukemia/lymphoma 6	0.099
Spp1	secreted phosphoprotein 1	0.093
Tnfaip3	tumor necrosis factor, alpha-induced protein 3	0.092
Tlr4	toll-like receptor 4	0.069
Cd40lg	CD40 ligand	0.067	Mouse
Pdcd1	programmed cell death 1	0.054
Pou2af1	POU domain, class 2, associating factor 1	0.053
Il7	interleukin 7	0.051
Myd88	myeloid differentiation primary response gene 88	0.048
Ikbkg	inhibitor of kappaB kinase gamma	0.046
Tnfrsf13c	tumor necrosis factor receptor superfamily, member 13c	0.045
Il4	interleukin 4	0.045
Irg1	immunoresponsive gene 1	0.044
Tnfrsf9	tumor necrosis factor receptor superfamily, member 9	0.042
Il1rn	interleukin 1 receptor antagonist	0.041
S1pr2	sphingosine-1-phosphate receptor 2	0.038
Casp4	caspase 4, apoptosis-related cysteine peptidase	0.037
Ltb	lymphotoxin B	0.037
Il1b	interleukin 1 beta	0.032
Mx2	myxovirus (influenza virus) resistance 2	0.032
Icos	inducible T-cell co-stimulator	0.031
Ptges	prostaglandin E synthase	0.029
Gpr132	G protein-coupled receptor 132	0.029
Prkcd	protein kinase C, delta	0.028
Batf2	basic leucine zipper transcription factor, ATF-like 2	0.028
Rel	reticuloendotheliosis oncogene	0.027
Cd80	CD80 antigen	0.026
Fas	Fas (TNF receptor superfamily member 6)	0.025
Trem1	triggering receptor expressed on myeloid cells 1	0.024
Ubd	ubiquitin D	0.023
Hrh2	histamine receptor H2	0.022
Socs1	suppressor of cytokine signaling 1	0.021
Oas3	2'-5' oligoadenylate synthetase 3	0.019
Tox	thymocyte selection-associated high mobility group box	0.019
Elf4	E74-like factor 4 (ets domain transcription factor)	0.019
Aicda	activation-induced cytidine deaminase	0.019
Il12b	interleukin 12b	0.018
Cd160	CD160 antigen	0.018
Prap1	proline-rich acidic protein 1	0.017
Cxcl2	chemokine (C-X-C motif) ligand 2	0.017
Lag3	lymphocyte-activation gene 3	0.017
Tinagl1	tubulointerstitial nephritis antigen-like 1	0.016
Tap1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	0.016
Tnfsf8	tumor necrosis factor (ligand) superfamily, member 8	0.016
Eif2ak2	eukaryotic translation initiation factor 2-alpha kinase 2	0.016
Fasl	Fas ligand (TNF superfamily, member 6)	0.015	Mouse
Ticam1	toll-like receptor adaptor molecule 1	0.015
Tnfrsf14	tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)	0.015	Mouse
Il22	interleukin 22	0.015
Ccl22	chemokine (C-C motif) ligand 22	0.014
Irf7	interferon regulatory factor 7	0.014
Lif	leukemia inhibitory factor	0.013
Ltbr	lymphotoxin B receptor	0.013	Mouse
Itk	IL2-inducible T-cell kinase	0.013
Aoah	acyloxyacyl hydrolase	0.013
Csf1	colony stimulating factor 1 (macrophage)	0.012
Siglece	sialic acid binding Ig-like lectin E	0.012
Il12rb1	interleukin 12 receptor, beta 1	0.012
Cxcl10	chemokine (C-X-C motif) ligand 10	0.012
Pten	phosphatase and tensin homolog	0.012
Klrg1	killer cell lectin-like receptor subfamily G, member 1	0.012
Tcf3	transcription factor 3	0.012
Prss30	protease, serine, 30	0.012
Ccrl2	chemokine (C-C motif) receptor-like 2	0.012
Birc3	baculoviral IAP repeat-containing 3	0.011
Il1a	interleukin 1 alpha	0.011
Ikbkb	inhibitor of kappaB kinase beta	0.011
Pax5	paired box gene 5	0.011
Fadd	Fas (TNFRSF6)-associated via death domain	0.011
Cxcl1	chemokine (C-X-C motif) ligand 1	0.011
Mmp14	matrix metallopeptidase 14 (membrane-inserted)	0.010
Ifih1	interferon induced with helicase C domain 1	0.010
Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	0.010
Pdcd1lg2	programmed cell death 1 ligand 2	0.010