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Mus musculus

2 genes annotated in mouse

negative regulation of gene silencing

Any process that decreases the rate, frequency, or extent of gene silencing, the transcriptional or post-transcriptional process carried out at the cellular level that results in long-term gene inactivation.

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "negative regulation of gene silencing"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "negative regulation of gene silencing" (in gray)

Name	Description	Probability	Func Analog Organism
Sall4	sal-like 4 (Drosophila)	0.914
Suds3	suppressor of defective silencing 3 homolog (S. cerevisiae)	0.569
Arid1a	AT rich interactive domain 1A (SWI-like)	0.562
Nanog	Nanog homeobox	0.403
Hdac1	histone deacetylase 1	0.227
Tcfcp2l1	transcription factor CP2-like 1	0.217
Smarca4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	0.142
Mcm2	minichromosome maintenance deficient 2 mitotin (S. cerevisiae)	0.085
Ap3b1	adaptor-related protein complex 3, beta 1 subunit	0.078
Mcm3	minichromosome maintenance deficient 3 (S. cerevisiae)	0.077
Ncor1	nuclear receptor co-repressor 1	0.066
Kdm5b	lysine (K)-specific demethylase 5B	0.066
Hps4	Hermansky-Pudlak syndrome 4 homolog (human)	0.064
Smarcc1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1	0.062
Sp1	trans-acting transcription factor 1	0.058
Pldn	pallidin	0.058
Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	0.056
Hist1h2bc	histone cluster 1, H2bc	0.055
Arid2	AT rich interactive domain 2 (ARID, RFX-like)	0.051	Fly
Sh3gl2	SH3-domain GRB2-like 2	0.049
Brd4	bromodomain containing 4	0.044
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.042
Rnf220	ring finger protein 220	0.040
Sap25	sin3 associated polypeptide	0.040
Cdk2	cyclin-dependent kinase 2	0.038
Ep300	E1A binding protein p300	0.035
Lig1	ligase I, DNA, ATP-dependent	0.032
Dnmt1	DNA methyltransferase (cytosine-5) 1	0.032
Sox2	SRY-box containing gene 2	0.031
Baz2a	bromodomain adjacent to zinc finger domain, 2A	0.030
Mta1	metastasis associated 1	0.029
Hdac2	histone deacetylase 2	0.029
Pld3	phospholipase D family, member 3	0.029
Ep400	E1A binding protein p400	0.027
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.027
Nr0b1	nuclear receptor subfamily 0, group B, member 1	0.027
Trp53	transformation related protein 53	0.026
Cdt1	chromatin licensing and DNA replication factor 1	0.026
Timeless	timeless homolog (Drosophila)	0.026
Muted	muted	0.025
Esrrb	estrogen related receptor, beta	0.025
Pold1	polymerase (DNA directed), delta 1, catalytic subunit	0.024
Kdm2b	lysine (K)-specific demethylase 2B	0.024
Cnot6	CCR4-NOT transcription complex, subunit 6	0.023
Rcor1	REST corepressor 1	0.023
Pou2f1	POU domain, class 2, transcription factor 1	0.023
Bod1l	biorientation of chromosomes in cell division 1-like	0.023
Blnk	B-cell linker	0.022
Rad21	RAD21 homolog (S. pombe)	0.022
Gatad2a	GATA zinc finger domain containing 2A	0.022
Gtf3c2	general transcription factor IIIC, polypeptide 2, beta	0.022
Ccna2	cyclin A2	0.022
Chd4	chromodomain helicase DNA binding protein 4	0.022
Actn4	actinin alpha 4	0.022
Sall3	sal-like 3 (Drosophila)	0.021
Pias1	protein inhibitor of activated STAT 1	0.021
Asxl1	additional sex combs like 1 (Drosophila)	0.021
Foxp1	forkhead box P1	0.021
Parp14	poly (ADP-ribose) polymerase family, member 14	0.021
Rrm1	ribonucleotide reductase M1	0.020
Sall1	sal-like 1 (Drosophila)	0.020
2210018M11Rik	RIKEN cDNA 2210018M11 gene	0.020
Zfp42	zinc finger protein 42	0.020
Pml	promyelocytic leukemia	0.020
Fzr1	fizzy/cell division cycle 20 related 1 (Drosophila)	0.020
Crebbp	CREB binding protein	0.019
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.019
Nisch	nischarin	0.019
Mll5	myeloid/lymphoid or mixed-lineage leukemia 5	0.019
Tcf3	transcription factor 3	0.019
Phf12	PHD finger protein 12	0.019
Dync1i1	dynein cytoplasmic 1 intermediate chain 1	0.019
Numa1	nuclear mitotic apparatus protein 1	0.018
Cabin1	calcineurin binding protein 1	0.018
Tnrc6a	trinucleotide repeat containing 6a	0.018
Hcfc1	host cell factor C1	0.018
Tet1	tet oncogene 1	0.018
Nfatc3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3	0.018
Myst2	MYST histone acetyltransferase 2	0.018
Pum2	pumilio 2 (Drosophila)	0.018
Smad4	MAD homolog 4 (Drosophila)	0.017
Pmaip1	phorbol-12-myristate-13-acetate-induced protein 1	0.017
Tcte2	t-complex-associated testis expressed 2	0.017
Nipbl	Nipped-B homolog (Drosophila)	0.017
Dlgap4	discs, large homolog-associated protein 4 (Drosophila)	0.017
Rfc5	replication factor C (activator 1) 5	0.017
Yy1	YY1 transcription factor	0.017
Tk1	thymidine kinase 1	0.017
Mcm7	minichromosome maintenance deficient 7 (S. cerevisiae)	0.017
Ammecr1l	AMME chromosomal region gene 1-like	0.017
Ccne1	cyclin E1	0.017
Atp6v0d1	ATPase, H+ transporting, lysosomal V0 subunit D1	0.017
Gabarap	gamma-aminobutyric acid receptor associated protein	0.017
Sycp1	synaptonemal complex protein 1	0.017
Flot1	flotillin 1	0.016
Lyst	lysosomal trafficking regulator	0.016
Prkd3	protein kinase D3	0.016
Actn3	actinin alpha 3	0.016
Maml1	mastermind like 1 (Drosophila)	0.016
Naa11	N(alpha)-acetyltransferase 11, NatA catalytic subunit	0.016
Pbrm1	polybromo 1	0.016	Fly
Kdm1a	lysine (K)-specific demethylase 1A	0.016
Zmynd8	zinc finger, MYND-type containing 8	0.016
Tm2d2	TM2 domain containing 2	0.016
Angel2	angel homolog 2 (Drosophila)	0.016
Rtp4	receptor transporter protein 4	0.015
Myo1c	myosin IC	0.015
Irf8	interferon regulatory factor 8	0.015
Casp2	caspase 2	0.015
Mpeg1	macrophage expressed gene 1	0.015
Terf2	telomeric repeat binding factor 2	0.015
Rreb1	ras responsive element binding protein 1	0.015
Mta3	metastasis associated 3	0.015
Nono	non-POU-domain-containing, octamer binding protein	0.015
Stat2	signal transducer and activator of transcription 2	0.015
Stx5a	syntaxin 5A	0.015
Fam111a	family with sequence similarity 111, member A	0.015
Cubn	cubilin (intrinsic factor-cobalamin receptor)	0.015
Pi4kb	phosphatidylinositol 4-kinase, catalytic, beta polypeptide	0.015
Mta2	metastasis-associated gene family, member 2	0.015
Tex264	testis expressed gene 264	0.015
Polr2a	polymerase (RNA) II (DNA directed) polypeptide A	0.014
Zbtb10	zinc finger and BTB domain containing 10	0.014
Rcor2	REST corepressor 2	0.014
Rnf31	ring finger protein 31	0.014
Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	0.014
Txnip	thioredoxin interacting protein	0.014
Tsx	testis specific X-linked gene	0.014
Cno	cappuccino	0.014
Dctn2	dynactin 2	0.014
Ctbp2	C-terminal binding protein 2	0.014
Scaf8	SR-related CTD-associated factor 8	0.014
Gba	glucosidase, beta, acid	0.014
Foxk1	forkhead box K1	0.013
Rab4b	RAB4B, member RAS oncogene family	0.013
Mia3	melanoma inhibitory activity 3	0.013
Prdm1	PR domain containing 1, with ZNF domain	0.013
Ndst2	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	0.013
Ldb1	LIM domain binding 1	0.013
Dbnl	drebrin-like	0.013
Ubn2	ubinuclein 2	0.013
Rnf2	ring finger protein 2	0.013
Rest	RE1-silencing transcription factor	0.013
Rnf38	ring finger protein 38	0.013
Rrm2	ribonucleotide reductase M2	0.013
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.013
Rabac1	Rab acceptor 1 (prenylated)	0.013
Taf4a	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor	0.013
Mll1	myeloid/lymphoid or mixed-lineage leukemia 1	0.013
Rad50	RAD50 homolog (S. cerevisiae)	0.013
Ncoa6	nuclear receptor coactivator 6	0.013
Pole	polymerase (DNA directed), epsilon	0.013
Ddx4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4	0.013
Unc93b1	unc-93 homolog B1 (C. elegans)	0.012
Gnb2	guanine nucleotide binding protein (G protein), beta 2	0.012
Grina	glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)	0.012
Adrbk1	adrenergic receptor kinase, beta 1	0.012
Nlrp4c	NLR family, pyrin domain containing 4C	0.012
Tmem115	transmembrane protein 115	0.012
Smarcd1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	0.012
L3mbtl2	l(3)mbt-like 2 (Drosophila)	0.012
Scn4a	sodium channel, voltage-gated, type IV, alpha	0.012
Mnt	max binding protein	0.012
Plekha5	pleckstrin homology domain containing, family A member 5	0.012
Tbc1d20	TBC1 domain family, member 20	0.012
Dnmt3l	DNA (cytosine-5-)-methyltransferase 3-like	0.012
Nfrkb	nuclear factor related to kappa B binding protein	0.012
Eif4g3	eukaryotic translation initiation factor 4 gamma, 3	0.012
Npepps	aminopeptidase puromycin sensitive	0.012
Sap130	Sin3A associated protein	0.012
Tex13	testis expressed gene 13	0.012
Rara	retinoic acid receptor, alpha	0.012
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.012
Sufu	suppressor of fused homolog (Drosophila)	0.012
Phkb	phosphorylase kinase beta	0.012
Tlr1	toll-like receptor 1	0.012
Cdk6	cyclin-dependent kinase 6	0.012
Clgn	calmegin	0.012
Napa	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.012
Supt16h	suppressor of Ty 16 homolog (S. cerevisiae)	0.012
Nacc1	nucleus accumbens associated 1, BEN and BTB (POZ) domain containing	0.012
Daxx	Fas death domain-associated protein	0.012
Sin3a	transcriptional regulator, SIN3A (yeast)	0.012	Yeast
Sfpi1	SFFV proviral integration 1	0.011
Mcl1	myeloid cell leukemia sequence 1	0.011
Tbc1d4	TBC1 domain family, member 4	0.011
Otud5	OTU domain containing 5	0.011
Rybp	RING1 and YY1 binding protein	0.011
Tor3a	torsin family 3, member A	0.011
Lgals3	lectin, galactose binding, soluble 3	0.011
Tapbp	TAP binding protein	0.011
Crisp2	cysteine-rich secretory protein 2	0.011
Vasp	vasodilator-stimulated phosphoprotein	0.011
Tulp2	tubby-like protein 2	0.011
Atf7ip	activating transcription factor 7 interacting protein	0.011
Capns1	calpain, small subunit 1	0.011
Tmem131	transmembrane protein 131	0.011
Ikzf1	IKAROS family zinc finger 1	0.011
Rela	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	0.011
R3hdm1	R3H domain 1 (binds single-stranded nucleic acids)	0.011
Tcta	T-cell leukemia translocation altered gene	0.011
Gadd45a	growth arrest and DNA-damage-inducible 45 alpha	0.011
Mbtps1	membrane-bound transcription factor peptidase, site 1	0.011
Piwil2	piwi-like homolog 2 (Drosophila)	0.011
Ctcf	CCCTC-binding factor	0.011
Tom1	target of myb1 homolog (chicken)	0.011
Irf9	interferon regulatory factor 9	0.011
Dpep3	dipeptidase 3	0.011
Etv6	ets variant gene 6 (TEL oncogene)	0.011
Atg13	ATG13 autophagy related 13 homolog (S. cerevisiae)	0.011
Tmem173	transmembrane protein 173	0.011
Ripk3	receptor-interacting serine-threonine kinase 3	0.011
Ilk	integrin linked kinase	0.011
Ube2r2	ubiquitin-conjugating enzyme E2R 2	0.011
Sra1	steroid receptor RNA activator 1	0.011
Ckmt2	creatine kinase, mitochondrial 2	0.011
Pum1	pumilio 1 (Drosophila)	0.011
Zcchc8	zinc finger, CCHC domain containing 8	0.011
Inpp5k	inositol polyphosphate 5-phosphatase K	0.011
Tex14	testis expressed gene 14	0.011
4932425I24Rik	RIKEN cDNA 4932425I24 gene	0.011
S100pbp	S100P binding protein	0.011
Fam160b1	family with sequence similarity 160, member B1	0.011
Cyct	cytochrome c, testis	0.011
Jarid2	jumonji, AT rich interactive domain 2	0.011
Trim26	tripartite motif-containing 26	0.011
Med23	mediator complex subunit 23	0.011
Phkg1	phosphorylase kinase gamma 1	0.011
Cramp1l	Crm, cramped-like (Drosophila)	0.011
Hmgxb4	HMG box domain containing 4	0.011
Tsn	translin	0.010
Sag	retinal S-antigen	0.010
Bri3	brain protein I3	0.010
Fbxo5	F-box protein 5	0.010
Utf1	undifferentiated embryonic cell transcription factor 1	0.010
Lta	lymphotoxin A	0.010
Frs3	fibroblast growth factor receptor substrate 3	0.010
Kdm3a	lysine (K)-specific demethylase 3A	0.010
Kdm3b	KDM3B lysine (K)-specific demethylase 3B	0.010
Dmc1	DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination (yeast)	0.010
Styx	serine/threonine/tyrosine interaction protein	0.010
Zfp513	zinc finger protein 513	0.010
Huwe1	HECT, UBA and WWE domain containing 1	0.010
Pts	6-pyruvoyl-tetrahydropterin synthase	0.010
Ttc15	tetratricopeptide repeat domain 15	0.010
Zfp422	zinc finger protein 422	0.010
Ppargc1b	peroxisome proliferative activated receptor, gamma, coactivator 1 beta	0.010
Hist1h2ao	histone cluster 1, H2ao	0.010
Cirbp	cold inducible RNA binding protein	0.010
Mitf	microphthalmia-associated transcription factor	0.010
Insrr	insulin receptor-related receptor	0.010
Fam193a	family with sequence similarity 193, member A	0.010
Smc1b	structural maintenance of chromosomes 1B	0.010
Pura	purine rich element binding protein A	0.010
Tnp1	transition protein 1	0.010
Kdm4a	lysine (K)-specific demethylase 4A	0.010
Zic2	zinc finger protein of the cerebellum 2	0.010
Tcfe3	transcription factor E3	0.010
Zfp292	zinc finger protein 292	0.010
Mier3	mesoderm induction early response 1, family member 3	0.010
Coro1a	coronin, actin binding protein 1A	0.010
Kifc2	kinesin family member C2	0.010