IMP

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Mus musculus

2 genes annotated in mouse

intrahepatic bile duct development

The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).

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Known genes in the process in mouse Include functional analogs

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Gene Predictions

Click on a gene's description to view its network relationships with genes known to be involved in "intrahepatic bile duct development"

Show only novel predictions Show only unknown genes Highlight genes with functional analogs involved in "intrahepatic bile duct development" (in gray)

Name	Description	Probability	Func Analog Organism
Pax2	paired box gene 2	0.984
Gli3	GLI-Kruppel family member GLI3	0.946
Isl1	ISL1 transcription factor, LIM/homeodomain	0.923
Fgfr2	fibroblast growth factor receptor 2	0.908
Bmp4	bone morphogenetic protein 4	0.906
Shh	sonic hedgehog	0.885
Pax3	paired box gene 3	0.831
Six1	sine oculis-related homeobox 1 homolog (Drosophila)	0.784
Rara	retinoic acid receptor, alpha	0.779
Hes1	hairy and enhancer of split 1 (Drosophila)	0.757
Meox2	mesenchyme homeobox 2	0.731
Fgf10	fibroblast growth factor 10	0.699
Fgf8	fibroblast growth factor 8	0.693
Rarb	retinoic acid receptor, beta	0.648
Eya1	eyes absent 1 homolog (Drosophila)	0.606
Emx2	empty spiracles homolog 2 (Drosophila)	0.560
Sox4	SRY-box containing gene 4	0.501	Mouse
Pitx2	paired-like homeodomain transcription factor 2	0.429
Foxg1	forkhead box G1	0.411
Rxra	retinoid X receptor alpha	0.373
Otx2	orthodenticle homolog 2 (Drosophila)	0.360
Rb1	retinoblastoma 1	0.349
Chd7	chromodomain helicase DNA binding protein 7	0.323
Jag1	jagged 1	0.320
Tcfap2a	transcription factor AP-2, alpha	0.289
Onecut2	one cut domain, family member 2	0.255
Otx1	orthodenticle homolog 1 (Drosophila)	0.215
Pax6	paired box gene 6	0.213
She	src homology 2 domain-containing transforming protein E	0.194
Cldn5	claudin 5	0.186
Sox2	SRY-box containing gene 2	0.184	Mouse
Gata3	GATA binding protein 3	0.182
Efnb2	ephrin B2	0.176
Gli2	GLI-Kruppel family member GLI2	0.173
Hhex	hematopoietically expressed homeobox	0.170
Smo	smoothened homolog (Drosophila)	0.156
Zeb1	zinc finger E-box binding homeobox 1	0.155
Ptprb	protein tyrosine phosphatase, receptor type, B	0.151
Mycn	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	0.150
Pou3f3	POU domain, class 3, transcription factor 3	0.150
Tbx2	T-box 2	0.148
Pkd1	polycystic kidney disease 1 homolog	0.144
Hoxa5	homeobox A5	0.142
Tie1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	0.140
Ednra	endothelin receptor type A	0.137
Nf1	neurofibromatosis 1	0.124
Fgfr1	fibroblast growth factor receptor 1	0.113
Nkx6-1	NK6 homeobox 1	0.111
Fgfr3	fibroblast growth factor receptor 3	0.110
Fgf3	fibroblast growth factor 3	0.107
Cys1	cystin 1	0.103
Esam	endothelial cell-specific adhesion molecule	0.101
Gata4	GATA binding protein 4	0.100
Hoxa3	homeobox A3	0.098
Atp6v1c1	ATPase, H+ transporting, lysosomal V1 subunit C1	0.098
Ikbkap	inhibitor of kappa light polypeptide enhancer in B-cells, kinase complex-associated protein	0.095
Sox9	SRY-box containing gene 9	0.094
Sox11	SRY-box containing gene 11	0.093	Mouse
Vangl2	vang-like 2 (van gogh, Drosophila)	0.092
Foxc2	forkhead box C2	0.091
Lef1	lymphoid enhancer binding factor 1	0.087
Tgfb2	transforming growth factor, beta 2	0.086
Rasip1	Ras interacting protein 1	0.085
Ezh2	enhancer of zeste homolog 2 (Drosophila)	0.085
Sox18	SRY-box containing gene 18	0.084	Mouse
Lhx1	LIM homeobox protein 1	0.084
Insm1	insulinoma-associated 1	0.084
Sall3	sal-like 3 (Drosophila)	0.082
Bmper	BMP-binding endothelial regulator	0.077
Eng	endoglin	0.077
Hdac1	histone deacetylase 1	0.073
Hesx1	homeobox gene expressed in ES cells	0.072
Alx4	aristaless-like homeobox 4	0.068
Emcn	endomucin	0.068
Nog	noggin	0.066
Trp53	transformation related protein 53	0.066
Foxc1	forkhead box C1	0.063
Tbx1	T-box 1	0.061
Cdh5	cadherin 5	0.061
Hes5	hairy and enhancer of split 5 (Drosophila)	0.058
Aplnr	apelin receptor	0.056
Fgf4	fibroblast growth factor 4	0.056
Hand1	heart and neural crest derivatives expressed transcript 1	0.055
Bmp7	bone morphogenetic protein 7	0.053
Onecut1	one cut domain, family member 1	0.052	Zebrafish
Kdr	kinase insert domain protein receptor	0.051
Hey1	hairy/enhancer-of-split related with YRPW motif 1	0.051
Gbx2	gastrulation brain homeobox 2	0.049
Pou3f1	POU domain, class 3, transcription factor 1	0.048
Hspg2	perlecan (heparan sulfate proteoglycan 2)	0.048
Nanog	Nanog homeobox	0.046
Pofut1	protein O-fucosyltransferase 1	0.045
Atp6v1a	ATPase, H+ transporting, lysosomal V1 subunit A	0.045
Tek	endothelial-specific receptor tyrosine kinase	0.044
Kit	kit oncogene	0.044
Rarg	retinoic acid receptor, gamma	0.043	Zebrafish
Tbx10	T-box 10	0.042
Tbx3	T-box 3	0.042
Atp6v1d	ATPase, H+ transporting, lysosomal V1 subunit D	0.042
Trp63	transformation related protein 63	0.042
Itgb1	integrin beta 1 (fibronectin receptor beta)	0.041
Sox7	SRY-box containing gene 7	0.041	Mouse
Smad6	MAD homolog 6 (Drosophila)	0.041
Bcl6b	B-cell CLL/lymphoma 6, member B	0.041
Nkx2-2	NK2 transcription factor related, locus 2 (Drosophila)	0.041
Sox17	SRY-box containing gene 17	0.041	Mouse
Ephb2	Eph receptor B2	0.039
Zfp703	zinc finger protein 703	0.039
Crebbp	CREB binding protein	0.038
Pitx1	paired-like homeodomain transcription factor 1	0.038
Erbb3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	0.038
Wnt9b	wingless-type MMTV integration site 9B	0.038
Ushbp1	Usher syndrome 1C binding protein 1	0.037
Btbd17	BTB (POZ) domain containing 17	0.037
Bicc1	bicaudal C homolog 1 (Drosophila)	0.037
Tcfap2c	transcription factor AP-2, gamma	0.037
Lmx1b	LIM homeobox transcription factor 1 beta	0.037
Olig2	oligodendrocyte transcription factor 2	0.035
Neurod1	neurogenic differentiation 1	0.035
Kitl	kit ligand	0.035
Adcy4	adenylate cyclase 4	0.034
Nkx2-3	NK2 transcription factor related, locus 3 (Drosophila)	0.034
Sfn	stratifin	0.034
Ascl1	achaete-scute complex homolog 1 (Drosophila)	0.033
Meox1	mesenchyme homeobox 1	0.033
Alx3	aristaless-like homeobox 3	0.033
Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	0.033
Dll4	delta-like 4 (Drosophila)	0.032
Pou5f1	POU domain, class 5, transcription factor 1	0.032
Hoxa13	homeobox A13	0.031
Ebf3	early B-cell factor 3	0.030
Uhrf1	ubiquitin-like, containing PHD and RING finger domains, 1	0.030
Kcnq1	potassium voltage-gated channel, subfamily Q, member 1	0.030
Prdm16	PR domain containing 16	0.030
Icam2	intercellular adhesion molecule 2	0.029
Pax8	paired box gene 8	0.029
Pbx1	pre B-cell leukemia transcription factor 1	0.029
Ednrb	endothelin receptor type B	0.028
Hoxa2	homeobox A2	0.028
Hoxb3	homeobox B3	0.028
Col2a1	collagen, type II, alpha 1	0.028
Sdcbp	syndecan binding protein	0.028
Edar	ectodysplasin-A receptor	0.027
Lhx6	LIM homeobox protein 6	0.027
Pdgfb	platelet derived growth factor, B polypeptide	0.027
Ret	ret proto-oncogene	0.027
Gja4	gap junction protein, alpha 4	0.027
Notch3	Notch gene homolog 3 (Drosophila)	0.027
Tmeff2	transmembrane protein with EGF-like and two follistatin-like domains 2	0.026
Nkx2-1	NK2 homeobox 1	0.026
Asah1	N-acylsphingosine amidohydrolase 1	0.026
Tcf15	transcription factor 15	0.025
Hoxb13	homeobox B13	0.025
Wnt4	wingless-related MMTV integration site 4	0.025
Fgfrl1	fibroblast growth factor receptor-like 1	0.025
Nos3	nitric oxide synthase 3, endothelial cell	0.025
Foxf1a	forkhead box F1a	0.024
Prrx1	paired related homeobox 1	0.024
Hoxd13	homeobox D13	0.024
Pdx1	pancreatic and duodenal homeobox 1	0.023
Jag2	jagged 2	0.022
Lmx1a	LIM homeobox transcription factor 1 alpha	0.022
Gas1	growth arrest specific 1	0.022
Gsc	goosecoid homeobox	0.022
Ramp2	receptor (calcitonin) activity modifying protein 2	0.022
Odf2	outer dense fiber of sperm tails 2	0.021
Msx1	homeobox, msh-like 1	0.021
Stx7	syntaxin 7	0.021
Slc9a3r2	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2	0.020
Mcm6	minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)	0.020
Ctnnb1	catenin (cadherin associated protein), beta 1	0.020
Vegfa	vascular endothelial growth factor A	0.020
Mpv17	MpV17 mitochondrial inner membrane protein	0.020
Ptch1	patched homolog 1	0.019
Epas1	endothelial PAS domain protein 1	0.019
Cux1	cut-like homeobox 1	0.019
Col1a1	collagen, type I, alpha 1	0.019
Atp6ap1	ATPase, H+ transporting, lysosomal accessory protein 1	0.019
Dlx1	distal-less homeobox 1	0.019
Bmp6	bone morphogenetic protein 6	0.019
Mta1	metastasis associated 1	0.019
Tuba1b	tubulin, alpha 1B	0.019
Zic3	zinc finger protein of the cerebellum 3	0.018
Stx1b	syntaxin 1B	0.018
Arid3b	AT rich interactive domain 3B (BRIGHT-like)	0.018
Pou4f2	POU domain, class 4, transcription factor 2	0.018
Cldn3	claudin 3	0.018
Kcnk2	potassium channel, subfamily K, member 2	0.018
Gata6	GATA binding protein 6	0.018
Tshz3	teashirt zinc finger family member 3	0.017
Epha4	Eph receptor A4	0.017
Efna1	ephrin A1	0.017
Satb2	special AT-rich sequence binding protein 2	0.017
Wnt3a	wingless-related MMTV integration site 3A	0.017
Robo4	roundabout homolog 4 (Drosophila)	0.017
Acvrl1	activin A receptor, type II-like 1	0.017
Barhl2	BarH-like 2 (Drosophila)	0.017
Ntf3	neurotrophin 3	0.017
Traf4	TNF receptor associated factor 4	0.017
Clic3	chloride intracellular channel 3	0.017
Ppara	peroxisome proliferator activated receptor alpha	0.017
Cxcl12	chemokine (C-X-C motif) ligand 12	0.017
Rspo2	R-spondin 2 homolog (Xenopus laevis)	0.016
Gata2	GATA binding protein 2	0.016
Foxa2	forkhead box A2	0.016
Efnb1	ephrin B1	0.016
Flt4	FMS-like tyrosine kinase 4	0.016
Ltbp4	latent transforming growth factor beta binding protein 4	0.016
Bmp5	bone morphogenetic protein 5	0.016
Gdf11	growth differentiation factor 11	0.016
Sin3a	transcriptional regulator, SIN3A (yeast)	0.016
Rgnef	Rho-guanine nucleotide exchange factor	0.016
Nrg3	neuregulin 3	0.016
Hoxa1	homeobox A1	0.016
Sfrp2	secreted frizzled-related protein 2	0.016
Wnt6	wingless-related MMTV integration site 6	0.015
Ldb2	LIM domain binding 2	0.015
Rfc2	replication factor C (activator 1) 2	0.015
Tox3	TOX high mobility group box family member 3	0.015
Foxj1	forkhead box J1	0.015
Eda	ectodysplasin-A	0.015
Flt1	FMS-like tyrosine kinase 1	0.015
Lhx9	LIM homeobox protein 9	0.015
Vstm2b	V-set and transmembrane domain containing 2B	0.015
Lhx3	LIM homeobox protein 3	0.014
Skor1	SKI family transcriptional corepressor 1	0.014
Xpo4	exportin 4	0.014
Vipr1	vasoactive intestinal peptide receptor 1	0.014
Plxnd1	plexin D1	0.014
Six4	sine oculis-related homeobox 4 homolog (Drosophila)	0.014
Tgfa	transforming growth factor alpha	0.014
Rcor2	REST corepressor 2	0.014
Tcf21	transcription factor 21	0.014
Gucy1b3	guanylate cyclase 1, soluble, beta 3	0.014
Fgd5	FYVE, RhoGEF and PH domain containing 5	0.014
Sall1	sal-like 1 (Drosophila)	0.014
Cd34	CD34 antigen	0.014
Twist2	twist homolog 2 (Drosophila)	0.014
Ugt8a	UDP galactosyltransferase 8A	0.013
Epha1	Eph receptor A1	0.013
Fzd8	frizzled homolog 8 (Drosophila)	0.013
Atoh7	atonal homolog 7 (Drosophila)	0.013
Hoxb5	homeobox B5	0.013
Axin2	axin2	0.013
Efna2	ephrin A2	0.013
Dll1	delta-like 1 (Drosophila)	0.013
Mest	mesoderm specific transcript	0.013
Mmrn2	multimerin 2	0.013
Krt17	keratin 17	0.013
Hspa12b	heat shock protein 12B	0.013
Six3	sine oculis-related homeobox 3 homolog (Drosophila)	0.013
Msx3	homeobox, msh-like 3	0.013
Hoxa4	homeobox A4	0.013
Foxi3	forkhead box I3	0.013
Mcm4	minichromosome maintenance deficient 4 homolog (S. cerevisiae)	0.013
Clec14a	C-type lectin domain family 14, member a	0.013
Lamp2	lysosomal-associated membrane protein 2	0.013
Wdr78	WD repeat domain 78	0.013
Mapk12	mitogen-activated protein kinase 12	0.013
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	0.013
Hdac7	histone deacetylase 7	0.013
Alx1	ALX homeobox 1	0.012
Adamts20	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 20	0.012
Sox3	SRY-box containing gene 3	0.012	Mouse
Lrp2	low density lipoprotein receptor-related protein 2	0.012
Myl7	myosin, light polypeptide 7, regulatory	0.012
Gh	growth hormone	0.012
Mfsd1	major facilitator superfamily domain containing 1	0.012
Cmtm8	CKLF-like MARVEL transmembrane domain containing 8	0.012
Fgf18	fibroblast growth factor 18	0.012
Foxa3	forkhead box A3	0.012
Gak	cyclin G associated kinase	0.012
Pou3f4	POU domain, class 3, transcription factor 4	0.012
Rspo1	R-spondin homolog (Xenopus laevis)	0.012
4930548H24Rik	RIKEN cDNA 4930548H24 gene	0.012
Tgif2	TGFB-induced factor homeobox 2	0.012
Dlx5	distal-less homeobox 5	0.012
Msi1	Musashi homolog 1(Drosophila)	0.012
Kank3	KN motif and ankyrin repeat domains 3	0.012
Hmx1	H6 homeobox 1	0.012
Nup155	nucleoporin 155	0.012
Emx1	empty spiracles homolog 1 (Drosophila)	0.012
Tbx15	T-box 15	0.012
Rrm2	ribonucleotide reductase M2	0.012
Chmp5	chromatin modifying protein 5	0.012
Elfn1	leucine rich repeat and fibronectin type III, extracellular 1	0.011
Cxcr4	chemokine (C-X-C motif) receptor 4	0.011
Jarid2	jumonji, AT rich interactive domain 2	0.011
Ptafr	platelet-activating factor receptor	0.011
Trim28	tripartite motif-containing 28	0.011
Sncg	synuclein, gamma	0.011
Klk8	kallikrein related-peptidase 8	0.011
Ptf1a	pancreas specific transcription factor, 1a	0.011
Sstr2	somatostatin receptor 2	0.011
Sema5b	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B	0.011
Kif26a	kinesin family member 26A	0.011
Irx2	Iroquois related homeobox 2 (Drosophila)	0.011
Fbxo41	F-box protein 41	0.011
Ror2	receptor tyrosine kinase-like orphan receptor 2	0.011
Gdnf	glial cell line derived neurotrophic factor	0.011
Pecam1	platelet/endothelial cell adhesion molecule 1	0.011
Sh2b3	SH2B adaptor protein 3	0.011
Tcf7l1	transcription factor 7-like 1 (T-cell specific, HMG box)	0.011
Grik4	glutamate receptor, ionotropic, kainate 4	0.011
Tcte2	t-complex-associated testis expressed 2	0.011
Zic1	zinc finger protein of the cerebellum 1	0.011
Cdh8	cadherin 8	0.011
Cabp7	calcium binding protein 7	0.011
Mcam	melanoma cell adhesion molecule	0.010
En2	engrailed 2	0.010
Rfx2	regulatory factor X, 2 (influences HLA class II expression)	0.010
Mmp15	matrix metallopeptidase 15	0.010
Egfl7	EGF-like domain 7	0.010
Acan	aggrecan	0.010
Lamc1	laminin, gamma 1	0.010
Zbtb7b	zinc finger and BTB domain containing 7B	0.010
Pnma2	paraneoplastic antigen MA2	0.010
Bai3	brain-specific angiogenesis inhibitor 3	0.010
Ddx39	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39	0.010
Arap3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	0.010
Ptpn11	protein tyrosine phosphatase, non-receptor type 11	0.010
Hhip	Hedgehog-interacting protein	0.010
Hey2	hairy/enhancer-of-split related with YRPW motif 2	0.010
Smpd3	sphingomyelin phosphodiesterase 3, neutral	0.010
Id4	inhibitor of DNA binding 4	0.010
Jup	junction plakoglobin	0.010
Mitf	microphthalmia-associated transcription factor	0.010
Arid1a	AT rich interactive domain 1A (SWI-like)	0.010
Map3k4	mitogen-activated protein kinase kinase kinase 4	0.010
Cdx1	caudal type homeobox 1	0.010
Hoxd3	homeobox D3	0.010
Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	0.010
Rgs5	regulator of G-protein signaling 5	0.010
Rlbp1	retinaldehyde binding protein 1	0.010
Shank1	SH3/ankyrin domain gene 1	0.010